Nitrogen K-shell photoabsorption

Reliable atomic data have been computed for the spectral modeling of the nitrogen K lines, which may lead to useful astrophysical diagnostics. Data sets comprise valence and K-vacancy level energies, wavelengths, Einstein $A$-coefficients, radiative and Auger widths and K-edge photoionization cross sections. An important issue is the lack of measurements which are usually employed to fine-tune calculations so as to attain spectroscopic accuracy. In order to estimate data quality, several atomic structure codes are used and extensive comparisons with previous theoretical data have been carried out. In the calculation of K photoabsorption with the Breit--Pauli $R$-matrix method, both radiation and Auger damping, which cause the smearing of the K edge, are taken into account. This work is part of a wider project to compute atomic data in the X-ray regime to be included in the database of the popular {\sc xstar} modeling code

The X-ray spectrum of Fe XVII revisited with a multi-ion model

The theoretical intensities of the soft X-ray Fe XVII lines arising from 2l-3l' transitions are reexamined using a three-ion collisional-radiative model that includes the contributions to line formation of radiative recombination (RR), dielectronic recombination (DR), resonant excitation (RE), and inner-shell collisional ionization (CI), in addition to the usual contribution of collisional excitation (CE). These additional processes enhance mostly the 2p-3s lines and not the 2p-3d lines. Under coronal equilibrium conditions, in the electron temperature range of 400 to 600 eV where the Fe XVII line emissivities peak, the combined effect of the additional processes is to enhance the 2p-3s lines at 16.78, 17.05, and 17.10 A, by ~ 25%, 30%, and 55%, respectively, compared with their traditional, single-ion CE values. The weak 2p-3d line at 15.45 A is also enhanced by up to 20%, while the other 2p-3d lines are almost unaffected. The effects of DR and RE are found to be dominant in this temperature range (400 - 600 eV), while that of CI is 3% at the most, and the contribution of RR is less than 1%. At lower temperatures, where the Fe XVII / Fe XVIII abundance ratio is high, the RE effect dominates. However, as the temperature rises and the Fe XVIII abundance increases, the DR effect takes over. The newly calculated line powers can reproduce most of the often observed high values of the (I17.05 + I17.10) / I15.01 intensity ratio. The importance of ionization and recombination processes to the line strengths also helps to explain why laboratory measurements in which CE is essentially the sole mechanism agree well with single-ion calculations, but do not reproduce the astrophysically observed ratios.Comment: Submitted to Ap

Accretion onto the Companion of Eta Carinae During the Spectroscopic Event: II. X-Ray Emission Cycle

We calculate the X-ray luminosity and light curve for the stellar binary system Eta Carinae for the entire orbital period of 5.54 years. By using a new approach we find, as suggested before, that the collision of the winds blown by the two stars can explain the X-ray emission and temporal behavior. Most X-ray emission in the 2-10 \kev band results from the shocked secondary stellar wind. The observed rise in X-ray luminosity just before minimum is due to increase in density and subsequent decrease in radiative cooling time of the shocked fast secondary wind. Absorption, particularly of the soft X-rays from the primary wind, increases as the system approaches periastron and the shocks are produced deep inside the primary wind. However, absorption can not account for the drastic X-ray minimum. The 70 day minimum is assumed to result from the collapse of the collision region of the two winds onto the secondary star. This process is assumed to shut down the secondary wind, hence the main X-ray source. We show that this assumption provides a phenomenological description of the X-ray behavior around the minimum.Comment: The Astrophysical Journal, in pres

Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control [preprint]

In humans and nonhuman primates, Mycobacterium tuberculosis lung infection yields a complex multicellular structure—the tuberculosis granuloma. All granulomas are not equivalent, however, even within the same host: in some, local immune activity promotes bacterial clearance, while in others, it allows persistence or outgrowth. Here, we used single-cell RNA-sequencing to define holistically cellular responses associated with control in cynomolgus macaques. Granulomas that facilitated bacterial killing contained significantly higher proportions of CD4+ and CD8+ T cells expressing hybrid Type1-Type17 immune responses or stem-like features and CD8-enriched T cells with specific cytotoxic functions; failure to control correlated with mast cell, plasma cell and fibroblast abundance. Co-registering these data with serial PET-CT imaging suggests that a degree of early immune control can be achieved through cytotoxic activity, but that more robust restriction only arises after the priming of specific adaptive immune responses, defining new targets for vaccination and treatment

A genetic contribution from the Far East into Ashkenazi Jews via the ancient Silk Road

Contemporary Jews retain a genetic imprint from their Near Eastern ancestry, but obtained substantial genetic components from their neighboring populations during their history. Whether they received any genetic contribution from the Far East remains unknown, but frequent communication with the Chinese has been observed since the Silk Road period. To address this issue, mitochondrial DNA (mtDNA) variation from 55,595 Eurasians are analyzed. The existence of some eastern Eurasian haplotypes in eastern Ashkenazi Jews supports an East Asian genetic contribution, likely from Chinese. Further evidence indicates that this connection can be attributed to a gene flow event that occurred less than 1.4 kilo-years ago (kya), which falls within the time frame of the Silk Road scenario and fits well with historical records and archaeological discoveries. This observed genetic contribution from Chinese to Ashkenazi Jews demonstrates that the historical exchange between Ashkenazim and the Far East was not confined to the cultural sphere but also extended to an exchange of genes

Population expansion in the North African Late Pleistocene signalled by mitochondrial DNA haplogroup U6

Background <br/> The archaeology of North Africa remains enigmatic, with questions of population continuity versus discontinuity taking centre-stage. Debates have focused on population transitions between the bearers of the Middle Palaeolithic Aterian industry and the later Upper Palaeolithic populations of the Maghreb, as well as between the late Pleistocene and Holocene. <br/> Results Improved resolution of the mitochondrial DNA (mtDNA) haplogroup U6 phylogeny, by the screening of 39 new complete sequences, has enabled us to infer a signal of moderate population expansion using Bayesian coalescent methods. To ascertain the time for this expansion, we applied both a mutation rate accounting for purifying selection and one with an internal calibration based on four approximate archaeological dates: the settlement of the Canary Islands, the settlement of Sardinia and its internal population re-expansion, and the split between haplogroups U5 and U6 around the time of the first modern human settlement of the Near East. <br/> Conclusions <br/> A Bayesian skyline plot placed the main expansion in the time frame of the Late Pleistocene, around 20 ka, and spatial smoothing techniques suggested that the most probable geographic region for this demographic event was to the west of North Africa. A comparison with U6's European sister clade, U5, revealed a stronger population expansion at around this time in Europe. Also in contrast with U5, a weak signal of a recent population expansion in the last 5,000 years was observed in North Africa, pointing to a moderate impact of the late Neolithic on the local population size of the southern Mediterranean coast

Digital Synthetic-Aperture Acoustic Imaging System

A real-time 32-element synthetic aperture acoustic imaging system has been developed. We can test new ideas for the system by using an acoustic array and carrying out image reconstruction on a computer. Contour plots of simple images are shown to illustrate the resolution (0.4 - 0.5 mm in range and transverse resolution) and sidelobe levels obtained with this synthetic-aperture technique. Rayleigh wave images of surface cracks and holes in metal samples have been obtained and a new type of monolithic edgebonded acoustic transducer array has been developed for use in Rayleigh wave imaging. A number of techniques for reducing the sidelobe levels and improving the resolution have been investigated. The results obtained with a new 32-tap digital delay line for deconvolving the pulse response of a transducer in real time are described