Development and Role in Therapy of Canakinumab in Adult-Onset Still's Disease

Adult-onset Still's disease (AOSD) is a rare inflammatory disease of unknown etiology typically characterized by episodes of spiking fever, evanescent rash, arthralgia, leukocytosis, and hyperferritinemia. The pivotal role of interleukin (IL)-1 and other pro-inflammatory cytokines gives rise to the development of new targeted therapies. Currently, AOSD patients can benefit from efficient and well tolerated biologic agents, such as IL-1, IL-6, and tumour necrosis factor (TNF)-\u3b1 antagonists. Canakinumab, a human monoclonal anti-IL-1\u3b2 antibody, is indicated for the treatment of different autoinflammatory syndromes in adults, adolescents, and children and it has recently been approved for AOSD treatment. In this article, we summarize the structural and biochemical data describing the molecular interactions between Canakinumab and its target antigen. Some special considerations of the pharmacological properties of Canakinumab are included. We also review the safety, efficacy and tolerability of this drug for the treatment of AOSD

Correlation between Gamma-Ray bursts and Gravitational Waves

The cosmological origin of $\gamma$-ray bursts (GRBs) is now commonly accepted and, according to several models for the central engine, GRB sources should also emit at the same time gravitational waves bursts (GWBs). We have performed two correlation searches between the data of the resonant gravitational wave detector AURIGA and GRB arrival times collected in the BATSE 4B catalog. No correlation was found and an upper limit \bbox{$h_{\text{RMS}} \leq 1.5 \times 10^{-18}$} on the averaged amplitude of gravitational waves associated with $\gamma$-ray bursts has been set for the first time.Comment: 7 pages, 3 figures, submitted to Phys. Rev.

Dynamics and stability of vortex-antivortex fronts in type II superconductors

The dynamics of vortices in type II superconductors exhibit a variety of patterns whose origin is poorly understood. This is partly due to the nonlinearity of the vortex mobility which gives rise to singular behavior in the vortex densities. Such singular behavior complicates the application of standard linear stability analysis. In this paper, as a first step towards dealing with these dynamical phenomena, we analyze the dynamical stability of a front between vortices and antivortices. In particular we focus on the question of whether an instability of the vortex front can occur in the absence of a coupling to the temperature. Borrowing ideas developed for singular bacterial growth fronts, we perform an explicit linear stability analysis which shows that, for sufficiently large front velocities and in the absence of coupling to the temperature, such vortex fronts are stable even in the presence of in-plane anisotropy. This result differs from previous conclusions drawn on the basis of approximate calculations for stationary fronts. As our method extends to more complicated models, which could include coupling to the temperature or to other fields, it provides the basis for a more systematic stability analysis of nonlinear vortex front dynamics.Comment: 13 pages, 8 figure

Training-induced inversion of spontaneous exchange bias field on La1.5Ca0.5CoMnO6

In this work we report the synthesis and structural, electronic and magnetic properties of La1.5Ca0.5CoMnO6 double-perovskite. This is a re-entrant spin cluster material which exhibits a non-negligible negative exchange bias effect when it is cooled in zero magnetic field from an unmagnetized state down to low temperature. X-ray powder diffraction, X-ray photoelectron spectroscopy and magnetometry results indicate mixed valence state at Co site, leading to competing magnetic phases and uncompensated spins at the magnetic interfaces. We compare the results for this Ca-doped material with those reported for the resemblant compound La1.5Sr0.5CoMnO6, and discuss the much smaller spontaneous exchange bias effect observed for the former in terms of its structural and magnetic particularities. For La1.5Ca0.5CoMnO6, when successive magnetization loops are carried, the spontaneous exchange bias field inverts its sign from negative to positive from the first to the second measurement. We discuss this behavior based on the disorder at the magnetic interfaces, related to the presence of a glassy phase. This compound also exhibits a large conventional exchange bias, for which there is no sign inversion of the exchange bias field for consecutive cycles

Exchange-spring behavior in bimagnetic CoFe2O4/CoFe2 nanocomposite

In this work we report a study of the magnetic behavior of ferrimagnetic oxide CoFe2O4 and ferrimagnetic oxide/ferromagnetic metal CoFe2O4/CoFe2 nanocomposites. The latter compound is a good system to study hard ferrimagnet/soft ferromagnet exchange coupling. Two steps were used to synthesize the bimagnetic CoFe2O4/CoFe2 nanocomposites: (i) first preparation of CoFe2O4 nanoparticles using the a simple hydrothermal method and (ii) second reduction reaction of cobalt ferrite nanoparticles using activated charcoal in inert atmosphere and high temperature. The phase structures, particle sizes, morphology, and magnetic properties of CoFe2O4 nanoparticles have been investigated by X-Ray diffraction (XRD), Mossbauer spectroscopy (MS), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM) with applied field up to 3.0 kOe at room temperature and 50K. The mean diameter of CoFe2O4 particles is about 16 nm. Mossbauer spectra reveal two sites for Fe3+. One site is related to Fe in an octahedral coordination and the other one to the Fe3+ in a tetrahedral coordination, as expected for a spinel crystal structure of CoFe2O4. TEM measurements of nanocomposite show the formation of a thin shell of CoFe2 on the cobalt ferrite and indicate that the nanoparticles increase to about 100 nm. The magnetization of nanocomposite showed hysteresis loop that is characteristic of the exchange spring systems. A maximum energy product (BH)max of 1.22 MGOe was achieved at room temperature for CoFe2O4/CoFe2 nanocomposites, which is about 115% higher than the value obtained for CoFe2O4 precursor. The exchange-spring interaction and the enhancement of product (BH)max in nanocomposite CoFe2O4/CoFe2 have been discussed.Comment: 9 pages, 10 figure

Chi-square test on candidate events from CW signal coherent searches

In a blind search for continuous gravitational wave signals scanning a wide frequency band one looks for candidate events with significantly large values of the detection statistic. Unfortunately, a noise line in the data may also produce a moderately large detection statistic. In this paper, we describe how we can distinguish between noise line events and actual continuous wave (CW) signals, based on the shape of the detection statistic as a function of the signal's frequency. We will analyze the case of a particular detection statistic, the F statistic, proposed by Jaranowski, Krolak, and Schutz. We will show that for a broad-band 10 hour search, with a false dismissal rate smaller than 1e-6, our method rejects about 70 % of the large candidate events found in a typical data set from the second science run of the Hanford LIGO interferometer.Comment: proceedings of GWDAW8, 2003 conference, 12pages, 6 figure