Diagnóstico inicial do nível de boas práticas agropecuárias nas UPL do Programa Leite Seguro.

O objetivo desse trabalho é apresentar o diagnóstico das práticas adotadas e o nível de conformidade frente aos indicadores de BPA utilizados na Ferramenta Protambo na etapa inicial do acompanhamento das UPL participantes do Programa Leite Seguro

Diagnóstico inicial do nível de boas práticas agropecuárias nas UPL do Programa Leite Seguro.

O objetivo desse trabalho é apresentar o diagnóstico das práticas adotadas e o nível de conformidade frente aos indicadores de BPA utilizados na Ferramenta Protambo na etapa inicial do acompanhamento das UPL participantes do Programa Leite Seguro

Advancing Long-Term Care Science Through Using Common Data Elements: Candidate Measures for Care Outcomes of Personhood, Well-Being, and Quality of Life

To support the development of internationally comparable common data elements (CDEs) that can be used to measure essential aspects of long-term care (LTC) across low-, middle-, and high-income countries, a group of researchers in medicine, nursing, behavioral, and social sciences from 21 different countries have joined forces and launched the Worldwide Elements to Harmonize Research in LTC Living Environments (WE-THRIVE) initiative. This initiative aims to develop a common data infrastructure for international use across the domains of organizational context, workforce and staffing, person-centered care, and care outcomes, as these are critical to LTC quality, experiences, and outcomes. This article reports measurement recommendations for the care outcomes domain, focusing on previously prioritized care outcomes concepts of well-being, quality of life (QoL), and personhood for residents in LTC. Through literature review and expert ranking, we recommend nine measures of well-being, QoL, and personhood, as a basis for developing CDEs for long-term care outcomes across countries. Data in LTC have often included deficit-oriented measures; while important, reductions do not necessarily mean that residents are concurrently experiencing well-being. Enhancing measurement efforts with the inclusion of these positive LTC outcomes across countries would facilitate international LTC research and align with global shifts toward healthy aging and person-centered LTC models

Identification of Critical Amino Acids in an Immunodominant IgE Epitope of Pen c 13, a Major Allergen from Penicillium citrinum

Background: Pen c 13, identified as a 33-kDa alkaline serine protease, is a major allergen secreted by Penicillium citrinum. Detailed knowledge about the epitopes responsible for IgE binding would help inform the diagnosis/prognosis of fungal allergy and facilitate the rational design of hypoallergenic candidate vaccines. The goal of the present study was to characterize the IgE epitopes of Pen c 13. Methodology/Principal Findings: Serum samples were collected from 10 patients with mold allergy and positive Pen c 13 skin test results. IgE-binding epitopes on rPen c 13 were mapped using an enzymatic digestion and chemical cleavage method, followed by dot-blotting and mass spectrometry. A B-cell epitope-predicting server and molecular modeling were used to predict the residues most likely involved in IgE binding. Theoretically predicted IgE-binding regions were further confirmed by site-directed mutagenesis assays. At least twelve different IgE-binding epitopes located throughout Pen c 13 were identified. Of these, peptides S16 (A 148 –E 166) and S22 (A 243 –K 274) were recognized by sera from 90 % and 100 % of the patients tested, and were further confirmed by inhibition assays. Peptide S22 was selected for further analysis of IgE-binding ability. The results of serum screening showed that the majority of IgE-binding ability resided in the C-terminus. One Pen c 13 mutant, G270A (T 261 –K 274), exhibited clearly enhanced IgE reactivity, whereas another, K274A, exhibited dramatically reduced IgE reactivity

Green crime and victimization: Tensions between social and environmental justice

In 2011, Rio-Tinto Alcan, one of the world’s largest producers of aluminium, announced the closure of the smelter at Lynemouth, Northumberland, North East England. The plant, a major local employer, finally closed in March, 2013. This article examines global concerns about environmental emission standards and the costs of compliance. This plants closure is a success in green terms. However, where closure is officially considered a compliance option, costs to deprived communities are high. From a (green) victimological perspective, the article contemplates the hidden costs of closure on already deprived local and regional communities. The discussion focuses on how green crime and green compliance creates victimisation and reflects on the moral and ethical challenges this presents for a green criminology