The time-varying nature of the overreaction effect: evidence from the UK

Previous studies on the overreaction effect in the UK show that prior losers consistently outperform prior winners in the period 1975 to 1990. This paper extends current knowledge by assessing the above phenomenon in the UK market for the period 1987 to 2007. In contrast to earlier research, we produce evidence of a weak presence of the overreaction effect for the latest test period. Further, we show that, after adjusting for size, the overreaction effect almost disappears and any additional excess post-formation return to prior-losers is attributable to market cycles. This study implies that the presence of the overreaction effect in the UK stock market is time-varying and difficult to exploit in practice

Amylin in the periphery II: An updated mini-review

Amylin is a polypeptide that is cosecreted with insulin from the beta cells of the pancreas. Therefore, in states of diabetes in which the beta-cell mass is largely depleted or dysfunctional, insulin and amylin secretion are also lost or dysregulated. While the soluble monomeric form of amylin acts as a hormone that alters physiological responses related to feeding and acts as a specific growth factor, there has been renewed interest in the less-soluble oligomeric and insoluble polymeric forms of human (also monkey and cat) amylin that may contribute to the establishment of a pathophysiological pathway to overt diabetes. With this discovery has grown the hope of minimizing, with appropriate therapy, these toxic forms to preserve the functional (c) not-cell mass. Human beta cells may also be more vulnerable to these forms and one risk factor, a higher fat diet, may promote toxic forms. The generation and utilities of transgenic rodent models, which express enhanced levels of human amylin, have been accompanied by strategies that may lead to the reduction of toxic forms and associated risk factors. The successful definition and faithful expression of the physiological receptors (and complexes) for amylin that may differ for each target organ is an important development in the field of amylin research generally. Besides the heuristic value for the understanding of the molecular biology of receptors, the opportunity to screen and identify nonpeptide analogues that bind the physiological receptors has important implications for biomedicine and clinical practice in relation to treatments for diabetic complications, bone diseases, and eating disorders. In particular, in their capacities to mimic the effects of amylin as a growth factor, amylin analogues may prove useful in the stimulation of beta-cell mass (in conjunction with other factors), reduce the activity of the osteoclast population, and stimulate the regeneration of proximal tubules following toxic insult (and thus avoid the development of renal insufficiency)

On the origin of the λ\lambda-transition in liquid Sulphur

Developing a novel experimental technique, we applied photon correlation spectroscopy using infrared radiation in liquid Sulphur around $T_\lambda$, i.e. in the temperature range where an abrupt increase in viscosity by four orders of magnitude is observed upon heating within few degrees. This allowed us - overcoming photo-induced and absorption effects at visible wavelengths - to reveal a chain relaxation process with characteristic time in the ms range. These results do rehabilitate the validity of the Maxwell relation in Sulphur from an apparent failure, allowing rationalizing the mechanical and thermodynamic behavior of this system within a viscoelastic scenario.Comment: 5 pages, 4 eps figures, accepted in Phys. Rev. Let

Pressure screening in the interior of primary shells in double-wall carbon nanotubes

The pressure response of double-wall carbon nanotubes has been investigated by means of Raman spectroscopy up to 10 GPa. The intensity of the radial breathing modes of the outer tubes decreases rapidly but remain observable up to 9 GPa, exhibiting a behavior similar (but less pronounced) to that of single-wall carbon nanotubes, which undergo a shape distortion at higher pressures. In addition, the tangential band of the external tubes broadens and decreases in amplitude. The corresponding Raman features of the internal tubes appear to be considerably less sensitive to pressure. All findings lead to the conclusion that the outer tubes act as a protection shield for the inner tubes whereas the latter increase the structural stability of the outer tubes upon pressure application.Comment: PDF with 15 pages, 3 figures, 1 table; submitted to Physical Review

Conversion as an option

The following thesis examines conversion as a suitable option in response to market requirements, as an alternative to building a new or to acquiring an existing vessel. While conversions often appear as an option in the industry, little has been said about them and the methodology they should follow. The thesis investigates and proposes a methodology that can be used to evaluate the techno-economic feasibility of converting a vessel. The thesis begins by discussing why and in which cases a conversion may be considered and examines why they should be looked upon with favour. It is acknowledged that conversions are not a new thing but have played a significant role thought maritime history by presenting several examples. A number of noteworthy conversion projects that have taken place in the industry, in more recent days, are then presented and discussed. The reasons behind conversion are examined and identified, and conversions are categorised in a number of types. A methodology is next presented for considering the conversion of a vessel. The methodology begins by evaluating the conversion option against building or acquiring an existing vessel. After the decision for conversion has been taken, a process that will shape the conversion and prepare the ground for analyzing the investment commences. In order to define the conversion characteristics, the reasons for conversion are thoroughly investigated and in combination with a broader market analysis a set of factors influencing the conversion are identified. Based on these factors conversion candidates are evaluated and a decision for conversion is taken on a cost and time basis while also considering other possible implications. The effectiveness of the methodology proposed is further examined in two case studies. Case study I considers a conversion targeting a certain cargo while Case study II considers a conversion as a result of regulation change. The outcome of the thesis investigation is discussed concluding that even though each conversion is unique and will heavily depend on the experiences of the individuals involved, a certain methodology for evaluating them can be followed that appears as a result of rational thinking.The following thesis examines conversion as a suitable option in response to market requirements, as an alternative to building a new or to acquiring an existing vessel. While conversions often appear as an option in the industry, little has been said about them and the methodology they should follow. The thesis investigates and proposes a methodology that can be used to evaluate the techno-economic feasibility of converting a vessel. The thesis begins by discussing why and in which cases a conversion may be considered and examines why they should be looked upon with favour. It is acknowledged that conversions are not a new thing but have played a significant role thought maritime history by presenting several examples. A number of noteworthy conversion projects that have taken place in the industry, in more recent days, are then presented and discussed. The reasons behind conversion are examined and identified, and conversions are categorised in a number of types. A methodology is next presented for considering the conversion of a vessel. The methodology begins by evaluating the conversion option against building or acquiring an existing vessel. After the decision for conversion has been taken, a process that will shape the conversion and prepare the ground for analyzing the investment commences. In order to define the conversion characteristics, the reasons for conversion are thoroughly investigated and in combination with a broader market analysis a set of factors influencing the conversion are identified. Based on these factors conversion candidates are evaluated and a decision for conversion is taken on a cost and time basis while also considering other possible implications. The effectiveness of the methodology proposed is further examined in two case studies. Case study I considers a conversion targeting a certain cargo while Case study II considers a conversion as a result of regulation change. The outcome of the thesis investigation is discussed concluding that even though each conversion is unique and will heavily depend on the experiences of the individuals involved, a certain methodology for evaluating them can be followed that appears as a result of rational thinking

Continuous Monitoring in Evolving Business Networks

The literature on continuous monitoring of cross-organizational processes, executed within virtual enterprises or business networks, considers monitoring as an issue regarding the network formation, since what can be monitored during process execution is fixed when the network is established. In particular, the impact of evolving agreements in such networks on continuous monitoring is not considered. Also, monitoring is limited to process execution progress and simple process data. In this paper, we extend the possible monitoring options by linking monitoring requirements to generic clauses in agreements established across a network and focus on the problem of preserving the continuous monitorability of these clauses when the agreements evolve, i.e. they are introduced, dropped, or updated. We discuss mechanisms to preserve continuous monitorability in a business network for different types of agreement evolution and we design a conceptual and technical architecture for a continuous monitoring IT infrastructure that implements the requirements derived from such mechanisms

Coupling between the TRPC3 ion channel and the NCX1 transporter contributed to VEGF-induced ERK1/2 activation and angiogenesis in human primary endothelial cells

This work was directly funded by the Barts and the London National Institute of Health Research (NIHR) Cardiovascular Biomedical Research Unit. Support to PA and MMY by the Barts Health “Diabetic Kidney Disease Centre,” supported and funded by the Barts and the London Charity (Grant Number 577-2348) is gratefully acknowledged. SAE receives funding from The Institute of Cancer Research and Cancer Research United Kingdom Grant C309/A8274. The authors wish to thank Sam Ranasinghe (University College London) for assistance with the FLIPR – Tetra assays

Cloud migration patterns: a multi-cloud service architecture perspective

Many organizations migrate their on-premise software systems to the cloud. However, current coarse-grained cloud migration solutions have made a transparent migration of on-premise applications to the cloud a difficult, sometimes trial-and-error based endeavor. This paper suggests a catalogue of fine-grained service-based cloud architecture migration patterns that target multi-cloud settings and are specified with architectural notations. The proposed migration patterns are based on empirical evi-dence from a number of migration projects, best practices for cloud architectures and a systematic literature review of existing research. The pattern catalogue allows an or-ganization to (1) select appropriate architecture migration patterns based on their ob-jectives, (2) compose them to define a migration plan, and (3) extend them based on the identification of new patterns in new contexts

Critical analysis of vendor lock-in and its impact on cloud computing migration: a business perspective

Vendor lock-in is a major barrier to the adoption of cloud computing, due to the lack of standardization. Current solutions and efforts tackling the vendor lock-in problem are predominantly technology-oriented. Limited studies exist to analyse and highlight the complexity of vendor lock-in problem in the cloud environment. Consequently, most customers are unaware of proprietary standards which inhibit interoperability and portability of applications when taking services from vendors. This paper provides a critical analysis of the vendor lock-in problem, from a business perspective. A survey based on qualitative and quantitative approaches conducted in this study has identified the main risk factors that give rise to lock-in situations. The analysis of our survey of 114 participants shows that, as computing resources migrate from on-premise to the cloud, the vendor lock-in problem is exacerbated. Furthermore, the findings exemplify the importance of interoperability, portability and standards in cloud computing. A number of strategies are proposed on how to avoid and mitigate lock-in risks when migrating to cloud computing. The strategies relate to contracts, selection of vendors that support standardised formats and protocols regarding standard data structures and APIs, developing awareness of commonalities and dependencies among cloud-based solutions. We strongly believe that the implementation of these strategies has a great potential to reduce the risks of vendor lock-in