Myocarditis as a cause of neonate’s circulatory failure during delivery - case study

Myocarditis (MCI) is a heart pathology characterized by its rare occurrence and a possible fatal course. In the natural history of the disease inflammatory cell infiltrates are present. There are subtypes of MCI depending on the predominant cell type in the biopsy sampls. One of them is eosinophilic myocarditis. In eosinophilic myocarditis more that 50% of the cells are eosinophils. In the later phases of the disease the myocardium is infiltrated by fibrous tissue and the heart vessels are often affected by thrombosis. Cardiomyopathy is a common long-term complication of the MCI.   Reported case presents a death of a male neonate. The neonate was delivered by vaginal delivery. Both prenatal development and all the prenatal tests indicated proper development of the fetus. At the delivery the neonate weight was 3900 grams and was evaluated with only 1 point on the Apgar score. Moreover, the neonate presented a complete acute cardiorespiratory failure at birth. Despite the 2 hour-long cardio-pulmonary resuscitation no return of spontaneous circulation was observed. The neonate’s remains were pathologically as well as histologically examined. The microscopic examination of the neonate’s heart samples contained many inflammatory cell infiltrations. Microabscesses with Charcot-Leyden crystals inside were also observed. Furthermore, the presence of atypical, polynuclear cells was noted. On the basis of the morphological image, it was recognized as an eosinophilic MCI

SGLT2 inhibitors - a breakthrough in treatment of heart failure and their multipotential beneficial role in cardiology, diabetology, nephrology and neurology

Inhibitors of the sodium-glucose cotransporter 2 (SGLT2 inhibitors) are relatively new andinnovative antihyperglycemic drugs which by inhibiting sodium-glucose cotransporter 2 minimalisereabsorption of glucose in nephrones. Due to this process, SGLT2 inhibitors became a first-choicedrugs in diabetology. Flozins were a turning point in many clinical trials and currently consequentlyconquer pharmacoterapy in cardiology. In the past years, clinical studies proved vast role of SGLT2inhibitors in other fields of medicine. Flosins protect heart muscle and kidneys among patients with orwithout type diabetes mellitus type 2. They have positive effect on hypertension, arteries and braintissue.Cardiological condition with the lowest long-term outcome in patients is heart failure with reducedejection fraction. Until flozins, treatment in heart failure with reduced ejection fraction was based onfour groups of drugs: β-blocker, inhibitors of the renin-angiotensin aldosterone system (RAA),including angiotensin converting enzyme ACE/ARB inhibitors, angiotensin and neprilysin receptorblockers (ARNI) and mineralocorticoid receptor antagonists (MRA). It was an appropriate HFrEFtreatment over the last years. However thanks to large-scale researches a role of flozins in cardiologyhave been established and they became hope for a change in the course of heart failure.The following article presents aspects of using flozins in treatment of patients with HFrEF,multipotential usage, vast benefits for patients, not solely cardiologic, and side effects of thesemiraculous group of drugs

Indications of Platelet-Rich Plasma (PRP) in Dermatology

Introduction: PRP is an autologous serum containing high concentrations of platelets and growth factors. It is used in dermatology for a variety of purposes, including hair growth, skin renewal, the removal of acne scars, dermal augmentation, and the treatment of striae distensae. The origins of PRP trace back to the 1970s, originating within the field of hematology as a treatment for patients grappling with thrombocytopenia. The subsequent decades, specifically the 1980s and 1990s, witnessed the integration of PRP into surgical procedures, notably in maxillofacial and plastic surgeries. The rationale underlying the employment and therapeutic potential of a concentrated platelet solution hinges upon their remarkable ability to furnish elevated levels of vital growth factors, thus instigating a regenerative impetus that facilitates repair in tissues characterized by limited innate healing capabilities. This comprehensive review delves into the multifaceted facets of PRP, encompassing mechanisms of action, prevailing indications, existing clinical substantiation, safety considerations, and the burgeoning spectrum of potential applications within the domain of skin condition treatments. Aim of the study: To review the current literature on the use of PRP in the field of dermatology Materials and Methods: We reviewed the literature available in PubMed, using the key words “platelet rich plasma”, “prp”, “autologous platelet rich plasma”, “alopecia”, “anti-aging” Results: PRP has a lot of potential in dermatology and its therapeutic uses are growing. Future research should standardize PRP therapy procedures for particular reasons. Summary: The versatile action of PRP has made it the subject of intense research. However, the reports in the literature to date on its use require further studies on larger groups of people to confirm its effects

One step closer – the impact of daily step count on health and how many steps should be taken per day

Introduction: Physical activity is an essential component of a healthy lifestyle. Walking is an open-accessed form of physical activity that requires no specialized equipment and can be performed at practically any moment of the day. In recent years, it has gained increasing interest and stands out as one of the most widely recommended forms of exercise. Since the beginning of the 21st century, the number of studies focusing on the impact of mean daily step count on health has been growing each year, with a significant surge observed since 2017. Undoubtedly, this topic is relevant to current health trends. Hitherto, there are no evidence-based recommendations regarding the number of steps that should be taken per day. Within this review, we conducted an analysis on the impact of daily step count on the risk of death and the incidence of selected diseases. Aim of the study: The aim of our study is to review of current literature on the influence of daily step count on both physical and mental health. Materials and Methods: We reviewed the literature available in PubMed, using the key words: „daily step count”, „step count mental health”, „ physical activity”, „pedometr”. Results: The daily step count can prominently impact the improvement and maintenance of human health and significant health benefits can be achieved by taking 4000-10000 steps per day. Summary: Research has shown that individuals who take more steps throughout the day are less prone to certain diseases, experience milder symptoms, exhibit better overall physical fitness, and have a lower risk of all-cause mortality. In the upcoming years, we can expect further studies aimed at identifying the most optimal daily step count

Physical activity of patients with chronic kidney disease

Introduction: The main causes of chronic kidney disease (CKD) are diabetic and hypertensive nephropathy. The incidence of civilization diseases is increasing, which also indirectly affects the increase in the incidence of CKD. The patient's therapy after the diagnosis should include the care of a multi-specialist therapeutic team that will remove as many restrictions as possible in everyday functioning and ensure a high quality of life. In addition to the selection of individual renal replacement therapy, i.a. physical rehabilitation. Despite the fact that in the course of chronic kidney disease physical activity is impaired by numerous pathophysiological processes, the patient should be encouraged to undertake physical activity in order to reduce the risk of death due to cardiovascular diseases, as well as to eliminate many other adverse health effects of the disease. The following paper aims to analyze the impact of physical activity on CKD patients and the pathophysiological causes of low physical activity in this group of patients and the possibility of implementing rehabilitation as an element of comprehensive therapy. Aim of the study: To review the current literature on the physical activity of patients with chronic kidney disease Materials and Methods: A review of the publications available in PubMed, using the key words „chronic kidney disease”, „psychical activity in chronic kidney disease”, physical activity”, „kidney failure”, „dialysis”, „renal rehabilitation”, „quality of life

Etiology, Epidemiology, and Therapeutic Approaches for Primary Sclerosing Cholangitis in the Context of Concurrent Non-specific Inflammatory Bowel Diseases

Introduction: Primary sclerosing cholangitis (PSC) is a chronic, idiopathic disease characterized by persistent and progressive inflammation of the intrahepatic and/or extrahepatic bile ducts. This leads to fibrosis, cholestatic complications, and liver failure. In over 70% of patients, non-specific intestinal inflammations coexist, particularly ulcerative colitis, and sporadically Crohn's disease. Aim: Our study aimed to assess current literature on primary sclerosing cholangitis (PSC), covering its causes, symptoms, treatment methods, and the connection between PSC and inflammatory bowel disease (IBD) co-occurrence. Materials and methods: We conducted a PubMed literature review using keywords like "primary sclerosing cholangitis pathogenesis," "primary sclerosing cholangitis and inflammatory bowel disease," and "primary sclerosing cholangitis and ulcerative colitis.” Results: Our research extensively covered PSC epidemiology, pathogenesis, and treatment options. Emphasis was placed on the heightened prevalence of inflammatory bowel diseases, including ulcerative colitis, among PSC patients. Summary: Primary sclerosing cholangitis (PSC) is a disease causing gradual damage to bile ducts within or outside the liver. Over 70% of patients also experience inflammatory bowel disease (IBD), mainly ulcerative colitis. The exact causes of PSC and its connection to IBD remain unclear. The theories involve hyperactive "intestinal" T cells or the impact of gut microbiome on their growth. Presently, a liver transplant stands as the sole remedy

Porównanie in vivo cewników aspiracyjnych o różnej średnicy u pacjentów z zawałem mięśnia sercowego z uniesieniem odcinka ST

INTRODUCTION: Aspiration thrombectomy is recommended only in selected patients with ST elevation myocardial infarction (STEMI). Optical coherence tomography analysis revealed limitations of some aspiration catheters in thrombus removal. Additionally, in vitro tests show significant differences in their effectiveness depending on the design of the distal tip and their internal diameter. The aim of this study is to compare the results of percutaneous coronary intervention (PCI) alone and adjunctive aspiration thrombectomy using catheters with small and large cross-sectional areas, compare the effectiveness of coronary angioplasty with and without aspiration thrombectomy, as well as check the effectiveness of different catheters depending on their internal diameter. MATERIAL AND METHODS: 773 patients with STEMI were enrolled in the study: 586 patients with PCI alone (Ctrl group), and 187 patients with PCI and aspiration thrombectomy. All the aspiration catheters were categorized as large-bore – 146 patients (LB group) and small-bore – 41 patients (SB group). Myocardial perfusion, left ventricular ejection fraction (LVEF) and the long-term all-cause mortality were compared. Statistical analysis was based on non-parametrical, ANOVA and Kaplan-Meier survival analysis. RESULTS: The groups were significantly biased with respect to demographics and the angiographic presentation of myocardial infarction. In comparison with the Ctrl group the LB and SB groups were younger and presented worse epicardial flow and thrombus burden according to the Thrombolysis in Myocardial Infarction (TIMI) classification. There is an insignificant trend towards inferior myocardial perfusion in the SB group in comparison with the Ctrl group. The LB group had a lower pre-discharge LVEF in comparison to the Ctrl group. The long-term all-cause mortality was comparable across the groups. CONCLUSIONS: There is not enough evidence to prove that SB catheters are less effective. A positive observation is the fact that the long-term all-cause mortality in the group of patients with adjunctive aspiration thrombectomy is comparable to the control group. However, this observation requires confirmation in future studies.WSTĘP: Trombektomia aspiracyjna jest zalecana jedynie u wybranych pacjentów z zawałem mięśnia sercowe-go z uniesieniem odcinka ST (ST elevation myocardial infarction – STEMI). Analiza z wykorzystaniem op-tycznej tomografii koherencyjnej wykazała ograniczenia niektórych cewników aspiracyjnych w usuwaniu skrzepliny. Ponadto testy in vitro wskazują na istotne różnice w ich skuteczności zależnie od konstrukcji końcówki dystalnej oraz wewnętrznej średnicy. Celem pracy jest porównanie skuteczności przezskórnej interwencji wieńcowej (percutaneous coronary intervention – PCI) z zastosowaniem trombektomii aspiracyjnej oraz bez jej użycia, a także sprawdzenie skuteczności różnych cewników w zależności od ich wewnętrznej średnicy. MATERIAŁ I METODY: Badaniem objęto 773 chorych ze STEMI: 586 chorych tylko po PCI (grupa Ctrl) oraz 187 chorych po PCI i trombektomii. Cewniki podzielono na te o dużym otworze (large-bore – LB), zastosowane u 146 pacjentów (grupa LB), oraz te o wąskim otworze (small-bore – SB) – u 41 pacjentów (grupa SB). Porównano perfuzję mięśnia sercowego, frakcję wyrzutową lewej komory (left ventricular ejection fraction – LVEF) i długoterminową śmiertelność z jakiejkolwiek przyczyny. Analizę statystyczną oparto na nieparametrycznej analizie przeżycia ANOVA oraz Kaplana i Meiera. WYNIKI: Grupy charakteryzowała stronniczość wyboru w odniesieniu do danych demograficznych oraz prezentacji angiograficznej zawału mięśnia sercowego. W porównaniu z grupą Ctrl grupy LB i SB były młodsze, prezentowały wolniejszy przepływ nasierdziowy i większy materiał zakrzepowy w klasyfikacji TIMI (Thrombolysis in Myocardial Infarction). W grupie SB, w porównaniu z grupą Ctrl, obserwowano nieistotny trend w kierunku gorszej perfuzji mięśnia sercowego. Grupa LB miała niższą LVEF przed wypisem w porównaniu z grupą Ctrl. Długoterminowa umieralność z przyczyn ogólnych była porównywalna we wszystkich grupach. WNIOSKI: Nie mamy wystarczających dowodów na to, że cewniki SB są mniej skuteczne. Pozytywną obserwacją jest fakt, że długoterminowa śmiertelność z jakiejkolwiek przyczyny w grupie pacjentów po trombektomii aspiracyjnej jest porównywalna z tą w grupie kontrolnej, wymaga ona jednak potwierdzenia w przyszłych badaniach

In Vitro Comparison of Several Thrombus Removal Tools

Background: Although the routine use of thrombus aspiration is not recommended, the thrombectomy technique still might be considered for a selected population of patients. Therefore, the assessment of the effectiveness of commercially available thrombectomy devices is still clinically relevant. Aim: Here, we present an in vitro comparison of several different types of catheters that can be used for thrombus aspiration or removal. Methods: Through the removal of 6 h and 24 h human blood clots in an in vitro model, four catheters were compared: the Launcher, Pronto V4, Vasco+ and the stent-retriever Catchview. The aspiration efficacy was expressed as a percentage of the initial thrombus weight. The effectiveness of the patient’s aspiration was dependent on the time of thrombus formation and was significantly higher for a thrombus formed over 24 h (58.5 ± 26.5%) than for one formed over 6 h (48.0 ± 22.5%; p < 0.001). In the presented in vitro model, Pronto V4 and Launcher showed the highest efficiency. Conclusions: Large-bore aspiration catheters were found to be more effective than narrow-bore catheters or stent-retrievers in an in vitro model of thrombus removal. The thrombus aspiration efficacy increases with longer thrombus formation times

Paraneoplastic syndromes in dermatology - cutaneous manifestations of internal malignancy

MATYJA, Karolina, BERNER, Aleksandra, STENCEL, Katarzyna, PĘKAŁA, Maciej, OLSZEWSKA, Anna, STELMASZAK, Karina, MARCZYK, Klaudia, POLAK, Paulina, POLASZEK, Monika and BOGOWSKA, Marta. Paraneoplastic syndromes in dermatology - cutaneous manifestations of internal malignancy. Journal of Education, Health and Sport. 2023;19(1):214-226. eISSN 2391-8306. http://dx.doi.org/10.12775/JEHS.2023.19.01.019 https://apcz.umk.pl/JEHS/article/view/45949 https://zenodo.org/record/8362402 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 17.07.2023 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 17.07.2023 Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 28.08.2023. Revised: 15.09.2023. Accepted: 20.09.2023. Published: 26.09.2023. Paraneoplastic syndromes in dermatology - cutaneous manifestations of internal malignancy Zespoły paraneoplastyczne w dermatologii - skórne manifestacje toczących się procesów nowotworowych Karolina Matyja Wojewódzki Szpital Specjalistyczny MEGREZ Sp. z o. o., Edukacji 102, 43-100 Tychy [email protected] https://orcid.org/0009-0006-8073-0477 Aleksandra Berner Wojewódzki Szpital Specjalistyczny MEGREZ Sp. z o. o., Edukacji 102, 43-100 Tychy [email protected] https://orcid.org/0009-0001-8252-3782 Katarzyna Stencel Wojewódzki Szpital Specjalistyczny MEGREZ Sp z o o, Edukacji 102, 43-100 Tychy [email protected] https://orcid.org/0009-0006-9574-9277 Maciej Pękała Wojewódzki Szpital Specjalistyczny MEGREZ Sp. z o.o. , Edukacji 102, 43-100 Tychy [email protected] https://orcid.org/0000-0002-6679-649X Anna Olszewska Medical University of Silesia, ul. Poniatowskiego 15, 40-055 Katowice [email protected] https://orcid.org/0009-0006-0314-5258 Karina Stelmaszak Medical University of Silesia, ul. Poniatowskiego 15, 40-055 Katowice [email protected] https://orcid.org/0009-0006-3877-2753 Klaudia Marczyk Wojewódzki Szpital Specjalistyczny MEGREZ Sp. z o. o., Edukacji 102, 43-100 Tychy [email protected] https://orcid.org/0009-0007-1304-3498 Paulina Polak Wojewódzki Szpital Specjalistyczny nr 4 w Bytomiu, aleja Legionów 10, 41-902 Bytom [email protected] https://orcid.org/0009-0007-0006-8768 Monika Polaszek Dolnośląski Szpital Specjalistyczny im. T. Marciniaka - Centrum Medycyny Ratunkowej, Fieldorfa 2, 54-049 Wrocław [email protected] https://orcid.org/0009-0000-0964-2454 Marta Bogowska Samodzielny Publiczny Szpital Wojewódzki im. Papieża Jana Pawła II w Zamościu, aleje Jana Pawła II 10, 22-400 Zamość [email protected] https://orcid.org/0009-0000-3134-9940 Abstract Introduction: Cutaneous manifestations linked with internal malignancies can exhibit a wide range of appearances.The ideal paraneoplastic marker is one that exclusively appears with a tumor, vanishes upon tumor treatment, and can potentially reemerge with tumor recurrence or metastasis. They are divided into two main categories: acquired and genetic conditions. Among acquired paraneoplastic syndromes a few are strongly correlated with internal malignancies, others have less pronounced associations. Aim of the study: To review the current literature on the topic of dermatological paraneoplastic syndromes. Materials and Methods: We reviewed the literature available in PubMed, using the key words: “paraneoplastic syndromes”, “paraneoplastic dermatoses”, “paraneoplastic syndromes in dermatology”. Results: We presented the most common, selected skin paraneoplastic syndromes. We indicated the types of neoplasms associated with these dermatoses and described their clinical appearance along with potential mechanisms of development. Summary: Timely recognition of paraneoplastic skin manifestations is crucial as they can provide an opportunity for diagnosing and treating the underlying neoplasm. That’s why dermatologists and clinicians should be familiar with this topic to perform an early diagnosis of the underlying malignancy. Key words: “paraneoplastic syndromes”, “paraneoplastic dermatoses”, “paraneoplastic syndromes in dermatology”, “cutaneous signs of neoplasm” Abstrakt Wprowadzenie: Związane z obecnością procesów nowotworowych objawy skórne znane są jako dermatologiczne zespoły paranowotworowe i mogą przybierać różnorodne postacie. Praktykujący klinicyści powinni być zaznajomieni z dermatozami paraneoplastycznymi, aby ułatwić wczesne diagnozowanie ukrytych nowotworów. Niezauważenie wskaźników skórnych toczących się procesów nowotworowych może prowadzić do opóźnień w diagnozowaniu i leczeniu ich. Modelowym markerem paraneoplastycznym jest taki, który pojawia się wyłącznie w obecności guza, zanika po jego wyleczeniu i może ponownie pojawić się w przypadku nawrotu lub przerzutów guza. Wczesne rozpoznanie objawów skórnych zespołów paranowotworowych ma ogromne znaczenie, ponieważ może umożliwić wczesne diagnozowanie i leczenie nowotworów. Skórne zespoły paraneoplastyczne dzielą się na dwie główne kategorie: nabyte i genetyczne. Wśród grupy nabytych pewne choroby ściśle korelują z określonymi nowotworami. Są to między innymi: acanthosis nigricans, paraneoplastic acrokeratosis Bazex, paraneoplastic pemphigus i erythema gyratum repens. Dodatkowo, istnieją rewelatory skórne o słabszej korelacji z nowotworami, na przykład zespół Sweeta. W naszej pracy przedstawiliśmy wybrane dermatozy paranowotworowe i omówiliśmy ich przyczyny, częstość występowania i objawy kliniczne Cel pracy: Celem naszej pracy był przegląd obecnej literatury na temat dermatologicznych zespołów paranowotworowych. Niniejszy artykuł wyczerpująco analizuje najważniejsze zespoły paranowotworowe wraz z ich objawami i diagnozą. Materiały i metody: Dokonaliśmy przeglądu literatury dostępnej w PubMed, używając słów kluczy: “paraneoplastic syndromes”, “paraneoplastic dermatoses”, “paraneoplastic syndromes in dermatology”, “cutaneous signs of neoplasm” Wyniki: W naszej pracy omówiliśmy wybrane spośród najczęściej występujących skórnych zespołów paraneoplastycznych. Uwagę poświęciliśmy takim jednostkom jak rogowacenie ciemne, acrokeratosis Bazex, pęcherzyca paraneoplastyczna, erythema geratum repens i zespół Sweeta. W pracy wskazaliśmy na rodzaj nowotworów, którym towarzyszą te dermatozy, opisaliśmy ich obraz kliniczny i możliwe mechanizmy powstawania. Podsumowanie: Objawy skórne związane z nowotworami są różnorodne. Umiejętność ich rozpoznawania może prowadzić do szybszego wykrycia raka i wczesnego rozpoczęcia odpowiedniej terapii. Dlatego też dermatolodzy i klinicyści powinni być zaznajomieni z tematem dermatologicznych zespołów paraneoplastycznych, aby móc przeprowadzić wczesne diagnozowanie ukrytego nowotworu. Słowa klucze: “paraneoplastic syndromes”, “paraneoplastic dermatoses”, “paraneoplastic syndromes in dermatology”, “cutaneous signs of neoplasm

Myocarditis as a cause of neonate's circulatory failure during delivery - case study

PĘKAŁA, Maciej, STENCEL, Katarzyna, BERNER, Aleksandra, OLSZEWSKA, Anna, STELMASZAK, Karina, POLAK, Paulina, POLASZEK, Monika, BOGOWSKA, Marta, MATYJA, Karolina and MARCZYK, Klaudia. Myocarditis as a cause of neonate’s circulatory failure during delivery - case study. Journal of Education, Health and Sport. 2023;19(1):202-213. eISSN 2391-8306. http://dx.doi.org/10.12775/JEHS.2023.19.01.018 https://apcz.umk.pl/JEHS/article/view/45948 https://zenodo.org/record/8362359 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 17.07.2023 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 17.07.2023 Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 28.08.2023. Revised: 15.09.2023. Accepted: 20.09.2023. Published: 26.09.2023. Myocarditis as a cause of neonate’s circulatory failure during delivery - case study Maciej Pękała Wojewódki szpital specjalistyczny MEGREZ Sp. z o.o. , Edukacji 102, 43-100 Tychy [email protected] https://orcid.org/0000-0002-6679-649X Katarzyna Stencel Wojewódki szpital specjalistyczny MEGREZ Sp. z o.o. , Edukacji 102, 43-100 Tychy [email protected] https://orcid.org/0009-0006-9574-9277 Aleksandra Berner Wojewódki szpital specjalistyczny MEGREZ Sp. z o.o. , Edukacji 102, 43-100 Tychy [email protected] https://orcid.org/0009-0001-8252-3782 Anna Olszewska Medical University of Silesia, ul. Poniatowskiego 15, 40-055 Katowice [email protected] https://orcid.org/0009-0006-0314-5258 Karina Stelmaszak Medical University of Silesia, ul. Poniatowskiego 15, 40-055 Katowice [email protected] https://orcid.org/0009-0006-3877-2753 Paulina Polak Wojewódzki Szpital Specjalsityczny nr 4 in Bytom, aleja Legionów 10, 41-902 Bytom [email protected] https://orcid.org/0009-0007-0006-8768 Monika Polaszek Dolnośląski Szpital Specjalistyczny im. T. Marciniaka - Centrum Medycyny Ratunkowej, Fieldorfa 2, 54-049 Wrocław [email protected] https://orcid.org/0009-0000-0964-2454 Marta Bogowska Samodzielny Publiczny Szpital Wojewódzki im. Papieża Jana Pawła II w Zamościu, aleje Jana Pawła II 10, 22-400 Zamość [email protected] https://orcid.org/0009-0000-3134-9940 Karolina Matyja Wojewódki szpital specjalistyczny MEGREZ Sp. z o.o. , Edukacji 102, 43-100 Tychy [email protected] https://orcid.org/0009-0006-8073-0477 Klaudia Marczyk Wojewódki szpital specjalistyczny MEGREZ Sp. z o.o. , Edukacji 102, 43-100 Tychy [email protected] https://orcid.org/0009-0007-1304-3498 Abstract: Myocarditis (MCI) is a heart pathology characterized by its rare occurrence and a possible fatal course. In the natural history of the disease inflammatory cell infiltrates are present. There are subtypes of MCI depending on the predominant cell type in the biopsy sampls. One of them is eosinophilic myocarditis. In eosinophilic myocarditis more that 50% of the cells are eosinophils. In the later phases of the disease the myocardium is infiltrated by fibrous tissue and the heart vessels are often affected by thrombosis. Cardiomyopathy is a common long-term complication of the MCI. Reported case presents a death of a male neonate. The neonate was delivered by vaginal delivery. Both prenatal development and all the prenatal tests indicated proper development of the fetus. At the delivery the neonate weight was 3900 grams and was evaluated with only 1 point on the Apgar score. Moreover the neonate presented a complete acute cardiorespiratory failure at birth. Despite the 2 hour-long cardio-pulmonary resuscitation no return of spontaneous circulation was observed. The neonate’s remains were pathologically as well as histologically examined. The microscopic examination of the neonate’s heart samples contained many inflammatory cell infiltrations. Microabscesses with Charcot-Leyden crystals inside were also observed. Furthermore, the presence of atypical, polynuclear cells was noted. On the basis of the morphological image, it was recognized as an eosinophilic MCI. Described case is an example that even advanced obstetric diagnosing tools can be insufficient in some cases. Keywords: myocarditis, eosinophilic myocarditi