219 research outputs found

    TICdb: a collection of gene-mapped translocation breakpoints in cancer

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    BACKGROUND: Despite the importance of chromosomal translocations in the initiation and/or progression of cancer, a comprehensive catalog of translocation breakpoints in which these are precisely located on the reference sequence of the human genome is not available at present. DESCRIPTION: We have created a database that describes the genomic location of 1,225 translocation breakpoints in human tumors, corresponding to 247 different genes, using information from publicly available sources. Junction sequences from reciprocal translocations were obtained from 655 different references (either from the literature or from nucleotide databases), and were mapped onto the reference sequence of the human genome using BLAST. All translocation breakpoints were thus referred to precise nucleotide positions (949 breakpoints) or gene fragments (introns or exons, 276 breakpoints) within specific Ensembl transcripts. CONCLUSION: TICdb is a comprehensive collection of finely mapped translocation breakpoints, freely available at . It should facilitate the analysis of sequences encompassing translocation breakpoints and the identification of factors driving translocation events in human tumors

    Spanish shrimp (Pandalus borealis) fishery in Flemish Cap in 1997.

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    In 1997 one Spanish trawler have been involved in the shrimp fishery in Flemish Cap (NAFO Div. 3M) from March to May. A scientific observer remained on board this trawler during all the fishing period, providing information on the fishing activity and carrying out biological sampling. The gear used was a twin trawl, with a 19 mm bar spacing sorting grate. In this paper, the main results of this fishery are presented

    Chapter 19. The Blackspot seabream fishery in the Strait of Gibraltar: lessons and future perspectives of shared marine resource

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    The Blackspot seabream (Pagellus bogaraveo) is one of the most important commercially-exploited fish species for the Spanish and Moroccan fleets which operate in the Strait of Gibraltar. In recent years, landings of Blackspot seabream in the main ports have decreased significantly respect previous periods of maximum catches, which makes it necessary to properly assess the abundance before establishing a management plan to make the fishery sustainable over time. In this chapter, we describe three different approaches to assess the abundance of this species in the Strait of Gibraltar. The results of three approaches tested (LCA/VPA, Gadget model and SimFish model) point out that from the 2010 the stock is kept at very low levels that oscillate between 900 and 1600 t, which supposes that the total biomass is between a 16% and 29% of the potential biomass. Additionally, the reference point values estimated by LCA/VPA and Gadget (F0.1 = 0.12-0.17) imply a clear overexploitation of the resource what is reinforced by the SimFish model results indicating that at least the 64% of abundance variation is a consequence of the fishery component.En prens

    Biology (growth and reproduction) of the Mediterranean deep-water rose shrimp (Parapenaeus longirostris (Lucas, 1846), Crustacea, Decapoda) from the Alicante Gulf (s.e. Spain).

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    The deep-water rose shrimp (Parapenaeus longirostris) is a demersal species and an important resource for the trawl fishery in the Alicante Gulf (S.E. Spain). This paper describes, for first time in this area, certain biometric relationships, as well as growth parameters and reproductive patterns of the species. The results showed a sexual size dimorphism, with a negative allometry of relative growth and high rates of absolute growth, both particularly in males. However, females dominated in the catch proportion. The spawning period occurred throughout the year, but especially in June-July and in October-November and the maturation stage for females takes place within the second year of life
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