Minimum Wages, Labor Market Institutions, and Female Employment

The authors investigate the employment consequences of minimum wage regulation in 16 OECD countries, 1970-2008. Their treatment is motivated by Neumark and Wascher’s (2004) seminal cross-country study. Apart from the longer time interval examined, a major departure is the authors’ focus on prime-age females, a group often neglected in the minimum wage literature. Another is their deployment of time-varying policy and institutional regressors. The average effects they report are consistent with minimum wages causing material employment losses among the target group. Their secondary finding is that minimum wage increases are more associated with (reduced) participation rates than with elevated joblessness. Further, although the authors find common ground with Neumark and Wascher as regards the role of some individual labor market institutions and policies, they do not observe the same patterns in the institutional data. Specifically, prime-age females do not exhibit stronger employment losses in countries with the least regulated markets.Minimum wages, minimum wage institutions, prime-age females, disemployment, participation, unemployment, employment protection, labor standards, labor market policies, unions

Minimum Wages, Labor Market Institutions, and Female Employment and Unemployment: A Cross-Country Analysis

This paper estimates the effect of minimum wage regulation in 16 OECD countries, 1970-2008. Our treatment is motivated by Neumark and Wascher's (2004) seminal cross-country study using panel methods to estimate minimum wage effects among teenagers and young adults. Apart from the longer time interval examined here, a major departure of the present study is the focus on prime-age females, a group typically neglected in the component minimum wage literature. Another is our deployment of time-varying policy and institutional regressors. Yet another is our examination of unemployment and participation outcomes in addition to employment effects. We report strong evidence of adverse employment effects among adult females and lower participation, even if the unemployment effects are muted. Although we report some similar findings to Neumark and Wascher as to the role of labor market institutions and policies, we do not observe the same patterns in the institutional data; in particular, we can reject for our target group their finding of stronger disemployment effects in countries with the least regulated markets.minimum wages, wage fixing machinery, prime-age females, employment, unemployment, participation, cross-section time-series data, OECD countries, labor market flexibility, labor market institutions and policies

p53 mutation as a source of aberrant β-catenin accumulation in cancer cells

β-catenin is involved in both cell-cell interactions and wnt pathway-dependent cell fate determination through its interactions with E-cadherin and TCF/LEF transcription factors, respectively. Cytoplasmic/nuclear levels of β-catenin are important in regulated transcriptional activation of TCF/LEF target genes. Normally, these levels are kept low by proteosomal degradation of β-catenin through Axin1- and APC-dependent phosphorylation by CKI and GSK-3β. Deregulation of β-catenin degradation results in its aberrant accumulation, often leading to cancer. Accordingly, aberrant accumulation of β-catenin is observed at high frequency in many cancers. This accumulation correlates with either mutational activation of CTNNB1 (β-catenin) or mutational inactivation of APC and Axin1 genes in some tumors. However, there are many tumors that display β-catenin accumulation in the absence of a mutation in these genes. Thus, there must be additional sources for aberrant β-catenin accumulation in cancer cells. Here, we provide experimental evidence that wild-type β-catenin accumulates in hepatocellular carcinoma (HCC) cells in association with mutational inactivation of p53 gene. We also show that worldwide p53 and β-catenin mutation rates are inversely correlated in HCC. These data suggest that inactivation of p53 is an important cause of aberrant accumulation of β-catenin in cancer cells

Comparisons of environmental effects and productivity by road construction machines in forest areas in Turkey

In this study, forest road construction techniques, environmental damages, cross sections and productivity by using hydraulic excavator and bulldozer were investigated in forested lands in Antalya and Eskisehir region in Turkey. Maximum length of fill slope for bulldozer and excavator were found 17 m on 80% slope gradient and 11 m on same slope gradient, respectively. The costs of forest roads for bulldozer and excavator were calculated to be 21.8 US dollars/m and 8.5 US dollars/m, respectively. Productivity of bulldozer and excavator were found to be 105.8 and 66.2 m3/h, respectively. The types of environmental damages on trees were determined and found to be wounded, bending and crushing. In this study, 23% of trees under the forest road construction by excavator are damaged and 40% of trees by bulldozer are damaged for 45 - 90% ground slope.Key words: Hydraulic excavator, bulldozer, forest road, road construction, environmental damage, construction cost

A novel KIF11 mutation in a Turkish patient with microcephaly, lymphedema, and chorioretinal dysplasia from a consanguineous family.

Microcephaly–lymphedema–chorioretinal dysplasia (MLCRD) syndrome is a rare syndrome that was first described in 1992. Characteristic craniofacial features include severe microcephaly, upslanting palpebral fissures, prominent ears, a broad nose, and a long philtrum with a pointed chin. Recently, mutations in KIF11 have been demonstrated to cause dominantly inherited MLCRD syndrome. Herein, we present a patient with MLCRD syndrome whose parents were first cousins. The parents are unaffected, and thus a recessive mode of inheritance for the disorder was considered likely. However, the propositus carries a novel, de novo nonsense mutationinexon2 of KIF11. The patient also had midline cleft tongue which has not previously been described in this syndrome

Microwave-induced nonequilibrium temperature in a suspended carbon nanotube

Antenna-coupled suspended single carbon nanotubes exposed to 108 GHz microwave radiation are shown to be selectively heated with respect to their metal contacts. This leads to an increase in the conductance as well as to the development of a power-dependent DC voltage. The increased conductance stems from the temperature dependence of tunneling into a one-dimensional electron system. The DC voltage is interpreted as a thermovoltage, due to the increased temperature of the electron liquid compared to the equilibrium temperature in the leads

The exon 13 duplication in the BRCA1 gene is a founder mutation present in geographically diverse populations

Cataloged from PDF version of article.Recently, a 6-kb duplication of exon 13, which creates a frameshift in the coding sequence of the BRCA1 gene, has been described in three unrelated U.S. families of European ancestry and in one Portuguese family. Here, our goal was to estimate the frequency and geographic diversity of carriers of this duplication. To do this, a collaborative screening study was set up that involved 39 institutions from 19 countries and included 3,580 unrelated individuals with a family history of the disease and 934 early-onset breast and/or ovarian cancer cases. A total of 11 additional families carrying this mutation were identified in Australia (1), Belgium (1), Canada (1), Great Britain (6), and the United States (2). Haplotyping showed that they are likely to derive from a common ancestor, possibly of northern British origin. Our results demonstrate that it is strongly advisable, for laboratories carrying out screening either in English-speaking countries or in countries with historical links with Britain, to include within their BRCA1 screening protocols the polymerase chain reaction-based assay described in this report

Experimental Study of the Effects of Periodic Unsteady Wakes on Flow Separation in Low Pressure Turbines

The present study, which is the first of a series of investigations of low pressure turbine (LPT) boundary layer aerodynamics, is aimed at providing detailed unsteady boundary layer flow information to understand the underlying physics of the inception, onset, and extent of the separation zone. A detailed experimental study on the behavior of the separation zone on the suction surface of a highly loaded LPT-blade under periodic unsteady wake flow is presented. Experimental investigations were performed on a large-scale, high-subsonic unsteady turbine cascade research facility with an integrated wake generator and test section unit. Blade Pak B geometry was used in the cascade. The wakes were generated by continuously moving cylindrical bars device. Boundary layer investigations were performed using hot wire anemometry at Reynolds number of 110,000, based on the blade suction surface length and the exit velocity, for one steady and two unsteady inlet flow conditions, with the corresponding passing frequencies, wake velocities, and turbulence intensities. The reduced frequencies cover the entire operation range of LP-turbines. In addition to the unsteady boundary layer measurements, blade surface pressure measurements were performed at Re = 50,000, 75,000, 100,000, 110,000, and 125,000. For each Reynolds number, surface pressure measurements are carried out at one steady and two periodic unsteady inlet flow conditions. Detailed unsteady boundary layer measurement identifies the onset and extension of the separation zone as well as its behavior under unsteady wake flow. The results, presented in ensemble-averaged and contour plot forms, help to understand the physics of the separation phenomenon under periodic unsteady wake flow

Identification of genes induced by BRCA1 in breast cancer cells

Cataloged from PDF version of article.Inherited mutations of the BRCA1 gene predispose to breast, ovarian, and other cancers. The role of the BRCA1 gene in the maintenance of chromosomal integrity is linked to a number of biological properties of its protein product, including transcriptional regulation. In the present study, we have used suppression subtractive hybridisation (SSH) to identify genes induced by BRCA1 by comparing control MCF7 breast carcinoma cells (driver) with MCF7 cells ectopically expressing BRCA1 (tester) and generated a forward subtracted cDNA library. We screened 500 putative positive clones from this library. Two hundred and ten of these clones were positive by differential screening with forward and reverse subtracted probes and the 65 cDNA clones which showed more than fivefold increase were selected for sequencing analysis. We clustered 46 different genes that share high homology with sequences in the GenBank/EMBL databases. Among these, 30 were genes whose function had been previously identified while the remaining 16 clones were genes with,unknown functions. Of particular interest, BRCA1 gene induces the expression of genes encoding DNA repair proteins RAD21 and MSH2, ERBB2/HER2 interacting protein ERBIN, meningioma-associated protein MAC30, and a candidate ovarian tumour-suppressor OVCA1. Northern and Western blot analyses confirmed that the expression of these five genes are up-regulated following BRCA1 overexpression in MCF7 and UBR60-bcl2 cells. This is the first study reporting a set of BRCA1-induced genes in breast carcinoma cells by the SSH technique. We suggest that some known genes identified in this study may provide new insights into the tumour-suppressor function of BRCA1. (C) 2002 Elsevier Science (USA). All rights reserved