ON APPROXIMATION PROPERTIES OF TWO VARIABLES OF MODIFIED KANTOROVICH-TYPE OPERATORS

WOS: 000463698900015In the present paper, we introduce certain modification of Szasz-Mirakyan-Kantorovich-type operators in polynomial weighted spaces of continuous functions of two variables. Then we research some approximation properties of these operators. We give some inequalities for the operators by means of the weighted modulus of continuity and also obtain a Voronovskaya-type theorem. Furthermore, in the paper we show that our operators give better degree of approximation of functions belonging to weighted spaces than classical Szasz-Mirakyan operators.Scientific Research Project Coordination Unit(BAP) in Kirikkale University [2015/7]This paper is supported by the Scientific Research Project Coordination Unit(BAP) in Kirikkale University(Grant code: 2015/7)

Comparison of GST Isoenzyme Expression in Normal and Neoplastic Breast Tissue: Correlation with Clinical and Prognostic Factors

Sak, Serpil/0000-0003-3666-3095WOS: 000266892000001Glutathione S-transferases in breast tissue play an important role in the susceptibility to the mutagenic effects of chemical carcinogens and in the response of breast tumors to chemotherapy. In this study the immunohistochemical staining characteristics of glutathione S-transferase isoenzymes (alpha, mu, pi, and theta) were investigated in invasive duct carcinomas and in normal breast tissue of 43 patients. The relationships between the expression of the GST isoenzymes and some clinicopathological features were also examined. Diffuse cytoplasmic staining of varying intensity was observed for GST alpha, theta, and pi in normal and tumorous breast tissue in 100% of the samples. In normal epithelium there was a stronger intensity of staining for GST alpha, mu. and pi expression than in invasive tumor tissues (P 0.05). In this study significant relationships were observed between microcalcification status and GST mu, between menopause status and GST alpha, and between tumor grade and GST mu expression (P 0.05).Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); British CouncilThis study was supported by grants from the Scientific and Technological Research Council of Turkey (TUBITAK), and the British Council

Expression of glutathione-S-transferases isoenzymes and p53 in exfoliated human bladder cancer cells

WOS: 000295609000011PubMed: 19926314Objectives: This study investigates the usefulness of glutathione-S-transferases (GST) isoenzymes and p53 immunostaining as a marker of malignancy in urinary cytology, and evaluates their potential effect in increasing diagnostic accuracy in a series of urine cytologic samples. They are also correlated with cytopathology diagnosis and histopathologic diagnosis. Materials and methods: In this study, the slides from 124 bladder carcinoma patients prepared by the cytocentrifugation method were observed. The cytomorphologic properties of these cancer cells were determined. Moreover, the immunocytochemical distributions of GST alpha (GSTA), pi (GSTP), mu (GSTM4), theta (GSTT1) isoenzymes and p53 protein were studied for the patients. Results: The urothelial cancer cells had small cytoplasm and rough nuclear membrane. The chromatin granules were heterogeneously distributed in each malignant cell's nucleus. There was a pleomorphism of the malignant cells' nuclei. According to immunocytopathologic observations, the urothelial cancer cells had stronger staining intensity than the benign cells had in 48% of cases for GSTA, 46% of cases for GSTP, 38% of cases for GSTM4, and 42% of cases for GSTT1. For all papillary cases, the malignant cells were stained negative, while the benign cells were positive. For 83% of patients, the malignant cells were stained positive for p53. There was a significant difference in GSTA (P = 0.006), GSTT1 (P = 0.004), GSTP (P = 0.000) and p53 (P = 0.000) expressions for benign cells whereas, a non-statistical difference in the malignant cells for GSTA, GSTT1, GSTP, GSTM4, and p53 expressions (P > 0.05). Conclusions: GST isoenzymes and p53 immunostaining were not found to be markers of malignancy in urinary cytology. (C) 2011 Elsevier Inc. All rights reserved.Kirikkale UniversityKirikkale University [02/03.04.04]This work was supported by the Research Fund of the Kirikkale University, project number: 02/03.04.04

Immunohistochemical Localization of Glutathione S-Transferase Isoenzymes (GSTA, GSTP, GSTM4, and GSTT1) and Tumour Marker p53 in Matched Tissue from Normal Larynx and Laryngeal Carcinoma: Correlations with Prognostic Factors

Objective: The immunohistochemical staining characteristics of glutathione S-transferase (GST) alpha (GSTA), pi (GSTP), mu (GSTM4), and theta (GSTT1) and P53 were investigated in laryngeal squamous cell carcinoma (LSCC) cases and normal laryngeal tissue from 46 patients. The relationships between expression of the GST isoenzymes and some clinicopathologic features were also examined

Immunohistochemical Localization of Glutathione S-Transferase Isoenzymes (GSTA, GSTP, GSTM4, and GSTT1) and Tumour Marker p53 in Matched Tissue from Normal Larynx and Laryngeal Carcinoma: Correlations with Prognostic Factors

aydin, sedat/0000-0003-4939-5026WOS: 000284047200023PubMed: 20828517Objective: The immunohistochemical staining characteristics of glutathione S-transferase (GST) alpha (GSTA), pi (GSTP), mu (GSTM4), and theta (GSTT1) and P53 were investigated in laryngeal squamous cell carcinoma (LSCC) cases and normal laryngeal tissue from 46 patients. The relationships between expression of the GST isoenzymes and some clinicopathologic features were also examined. Patients and Methods: For immunohistochemical studies, tissues from 46 patients with LSCC at the Dr. Lutfi Kirdar Kartal Education and Research Hospital were used. The relationship between expression of the GST isoenzymes and P53 in normal and tumour tissue was analyzed using the Wilcoxon signed rank test. The correlation between GST isoenzymes and P53 and clinicopathologic data was also examined using the Spearman rank test. Results: When the normal and tumour tissues of these cases were compared according to their staining intensity and percentage of positive staining, GSTA expression in normal cells was significantly higher than in tumour cells, and GSTP and P53 expression was higher in tumour cells (p .05). There was no correlation between P53 and GST expression in patients with LSCC. When the immunohistochemical results of GST isoenzymes and P53 were correlated with the clinical parameters, GSTA expression was increased in poorly differentiated laryngeal tumour, but GSTM4 and GSTT1 expression was decreased (p < .05). Conclusion: According to these results, GST-A, -P, and T1 and P53 were important in the diagnosis of LSCC.Kirikkale UniversityKirikkale University [2006/5]Financial disclosure of authors: This work was supported by the Research Fund of Kirikkale University (project number 2006/5)