The relationship of depression and malnutrition with healthy eating index in elderly individuals

Depression, malnutrition, and the healthy eating index were assessed in this study of people aged 65 and up who sought treatment at an outpatient clinic for internal medicine. Participants were elderly people from Malatya, Turkiye, who had applied to the outpatient clinic for internal medicine. The three-day dietary recall method was used to obtain the records of food consumption among the elderly. The calculation of Healthy Eating Index-2015 (HEI-2015) scores from food consumption. Geriatric Depression Scale (GDS) was used to define probable depression, and Mini Nutrition Questionnaire-Short Form (MNA-SF) was used to determine nutritional status, using face-to-face interviews. The study were 185 individuals included. The mean age of individuals was 72.19±6.92 years. According to MNA-SF results, 32.3% of women and 27.4% of men were found to be malnourished. The mean body mass ındex (BMI) value of the individuals was 25.73±2.85 kg/cm2, and the BMI value of 56.22% of the individuals was within the normal range. The depression score mean was 8.86±4.73. Depression scores are higher in women, those with low monthly education and income, those who use multiple drugs, those with a low HEI-2015 score, and those who use them. There is a relationship between depression score and eating score. As the nutrition score and the HEI-2015 score decrease, the depression score increases. This study indicates that depressed older people consume less food. Early detection of depression and malnutrition is beneficial. Older adults should routinely use brief, easy-to-obtain diagnostic tools such as the MNA and GDS questionnaires to treat these related health issues quickly and effectively. [Med-Science 2023; 12(3.000): 922-8

Dasatinib-induced pulmonary arterial hypertension

Drug-induced (group 1) pulmonary hypertension (PH) is an important subgroup of PH involving dasatinib as a likely related agent, which is a second-generation tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukaemia (CML). The mechanism of dasatinib-induced pulmonary arterial hypertension (PAH) is unclear. However, the occurrence of PAH with late onset in CML patients suggests a chronic pathological mechanism with an insidious onset rather than an acute inflammatory or cardiac aetiology. Dasatinib has a broader effect than other TKIs; the major known difference between dasatinib and other TKIs is the additional inhibition of Src family kinases. Therefore, Src inhibition was thought to play a role in the development of dasatinib-induced PAH. However, recently, it was also speculated that chronic dasatinib therapy may cause pulmonary endothelial damage, attenuate hypoxic pulmonary vasoconstriction responses and increase susceptibility to PAH independently of the Src family kinase-induced mechanism. Dasatinib-induced PAH usually seems to be reversible with the cessation of the drug, and sometimes with PAH-specific treatment strategies. Transthoracic echocardiography can be recommended as a routine screening prior to dasatinib initiation, and this non-invasive procedure can be utilized in patients having signs and symptoms attributable to PAH during dasatinib treatment

The evaluation of serum apelin levels in patients complicated with preeclampsia.

Objective The aim of this study was to investigate the serum levels of mild, severe preeclamptic pregnants and normotensive pregnant women to determine whether there is a correlation between preeclampsia and their serum levels. Methods This prospective case-control study included 48 preeclamptic and 39 healthy normotensive pregnants. The control group was composed of body mass index and age matched pregnant women. Preeclamptic patients were divided into two groups as mild preeclampsia and severe preeclampsia. Serum apelin levels were determined by EnzymeImmunometricAssay (EIA) biochemical test. Results Serum apelin levels were found to be significantly lower in the preeclampsia group. It was 0.75 +/- 0.24 ng/ml in mild preeclampsia and 0.55 +/- 0.18 ng/ml in the severe preeclampsia and 0.91 +/- 0.20 ng/ml in the control group. There was a strong inverse correlation between serum apelin levels and Systolic Blood Pressure (SBP) (r: -0.429p: 0.002). Conclusions In conclusion, the role of apelin and apelinergic system in cardiovascular system and placental development and their place in preeclampsia is still an issue. In preeclampsia, the deterioration of the cardiovascular protective effect of apelin by other enzymes may also contribute to the deterioration of fetal development. More detailed studies are needed

Candidal psoas abscess following persistent pyuria in a renal transplant recipient

Candidal infections occur commonly in renal transplant recipients especially in genitourinary system. Although the epidemiology of candiduria has not been well characterized in renal transplant population, it is the most common cause of fungal infections. However, candidal psoas abscess is very rare in the literature. We report a 42-year-old male renal transplant recipient with prolonged pyuria and candiduria followed by candidal psoas abscess formation. The treatment consisted of prolonged antifungal therapy along with percutaneous drainage. However, eventually, a surgical drainage had to be performed for the successful eradication

The value of hepatic diffusion-weighted MR imaging in demonstrating hepatic congestion secondary to pulmonary hypertension

Abstract Background Congestive hepatomegaly might be the first sign for pulmonary hypertension. Apparent diffusion coefficient (ADC) value obtained with quantitative diffusion-weighted magnetic resonance imaging (DW-MRI) is affected by liver fibrosis and perfusion. We aimed to evaluate the diagnostic value of DW-MRI in cooperation with biochemical markers, ultrasonography (US) and echocardiography (TTE) in determining the degree of hepatic congestion secondary to pulmonary hypertension (PHT). Methods 35 patients with PHT and 26 control subjects were included in the study. PHT was diagnosed if pulmonary artery systolic pressure (PASP) was measured above 35 mmHg with TTE. Study group was classified into mild and moderate PHT. DW-MRI was performed with b-factors of 0, 500 and 1000 sec/mm². Mean ADC, ADC-II (Average of the ADC values of right lobe anterior and posterior segments), US, TTE and blood biochemical parameters of both groups were compared. Results There exists a positive correlation between liver size and the diameters of vena cava inferior, right atrium, right hepatic vein(RHV), mid-hepatic vein(MHV), left hepatic vein(LHV) (p Conclusions Congestion due to moderate PHT might be diagnosed with DW-MRI. As PASP increase; mean ADC and ADC-II values increase.</p

The value of hepatic diffusion-weighted MR imaging in demonstrating hepatic congestion secondary to pulmonary hypertension

Background: Congestive hepatomegaly might be the first sign for pulmonary hypertension. Apparent diffusion coefficient (ADC) value obtained with quantitative diffusion-weighted magnetic resonance imaging (DW-MRI) is affected by liver fibrosis and perfusion. We aimed to evaluate the diagnostic value of DW-MRI in cooperation with biochemical markers, ultrasonography (US) and echocardiography (TTE) in determining the degree of hepatic congestion secondary to pulmonary hypertension (PHT)

Depletion of BIK led to decreased mitochondrial cell death priming in HCT-116 wt cells.

<p>(A) HCT-116 wt and (B) HCT-116 p53 -/- cells were untreated (upper panels) or transiently transfected with BIK siRNA (lower panels) and mitochondrial depolarization was measured following incubation of cells with DMSO, BIM, BID, BAD, PUMA, BMF and NOXA peptides at 100 μM and FCCP at 10 μM. Graphs are shown as mean±SEM, n = 3 and sample mitochondrial potential (ΔΨm) kinetic tracings are provided. (C) Microplate-based BH3 profiles were confirmed by ELISA-based cytochrome c release assays following incubation of isolated mitochondria with DMSO, BIM, BID, BAD, PUMA, BMF and NOXA peptides at 100 μM (mean±SEM, n = 3).</p

Cisplatin induces early LMP in HCT-116 p53 -/- cells.

<p>(A) HCT-116 wt and HCT-116 p53-/- cells were treated with cisplatin (20 μM) for 1h. HCT-116 p53 -/- cells were TIRON (10 mM) for 2h and then treated with cisplatin for 1h to examine the effect of TIRON on cisplatin-induced LMP. Cells were stained for galectin-3 to evaluate the lysosomal membrane permeabilization. (B) HCT-116 wt and HCT-116 p53 -/- cells were transfected with BIK siRNA or scrambled siRNA for 24h. Cells were treated with cisplatin (20 μM) or UV (100 mJ/cm²) for 1h and the Cathepsin B/L activity was measured in untransfected and transfected cells (mean RFU±SEM, n = 3). (C) HCT-116 p53 -/- cells were pretreated with CA-074Me (100 μM) or Z-FA-FMK (10 μM) for 2h and then treated with cisplatin (20 μM) or UV (100 mJ/cm²) for 48h. Cell viability was determined by CellTiterGlo assay and expressed as % of untreated control (mean±SEM, n = 3, *P<0.05, **P<0.01).</p