Dislexia e ensino-aprendizagem de língua portuguesa : um estudo de caso

Monografia (graduação)—Universidade de Brasília, Instituto de Letras, 2013.Esta pesquisa trata da dislexia e do ensino-aprendizagem de Língua Portuguesa para disléxicos, com base em um estudo de caso com estudante disléxico da rede pública de ensino do Plano Piloto. Dentre as questões abordadas, estão as definições da dislexia, seus tipos e possíveis tratamentos, além da discussão do espaço que tal distúrbio de aprendizagem tem na educação, a sugestão de inclusão da dislexia na Educação Especial e, consequentemente, nas salas de recursos e a adequação da metodologia de ensino, baseada na exploração dos gêneros textuais e dos multiletramentos, dentro da perspectiva Sociointeracionista de Vygotsky e da proposta de professor libertador, de Paulo Freire

Processing, Mechanical and Nuclear Characterization of Boron Carbide Ceramics Consolidated by Spark Plasma Sintering

Boron carbide (B₄C) ceramics were produced by spark plasma sintering technique with 5, 10, 15, and 20 vol.% aluminum (Al) in order to improve sintering behaviours of B₄C ceramics. B₄C ceramics were produced, having square cross-section and 50 × 50 × 5 mm³ dimensions. The sintering process was carried out at different temperatures by applying 40 MPa of pressure with 100°C/min under vacuum. The effects of various amounts of Al additive and sintering temperature on density, vickers hardness, fracture toughness and microstructure were examined. The hardness and fracture toughness of the samples were evaluated by the Vickers indentation technique. Microstructures of the samples were characterized by scanning electron microscopy technique. Fast neutron attenuation properties of the ceramics having highest density were also investigated

Elevated Interleukin-17A expression in amlodipine-induced gingival overgrowth

Background and objectives: Amlodipine, a calcium channel blocker derivative, is frequently used by patients with high blood pressure. Studies reported that it can induce gingival overgrowth. However, the underlying mechanism is not fully described yet. Interleukin-17A (IL-17A) is known as a proinflammatory cytokine, but current studies indicate that it has a role in fibrotic disorders and epithelial-mesenchymal transition (EMT). The aim of this study was to figure out the possible role of IL-17A in amlodipine-induced gingival overgrowth. Materials and methods: Twenty-nine (29) individuals participated in the study, and they were assigned into 3 groups based on medical status and clinical periodontal examination; 9 patients with amlodipine-induced gingival overgrowth, 11 patients with inflammatory gingival overgrowth, and 9 healthy individuals as a control group. Clinical periodontal parameters including plaque index (PI), gingival index (GI), and gingival overgrowth index (GOI) were recorded. Blood and gingival crevicular fluid (GCF) samples were obtained. Gingival tissues were taken by appropriate periodontal surgery following initial periodontal therapy. To detect IL-17A on tissue samples, immunohistochemistry (IHC) was performed. Quantitative analysis was done, and the expression level of IL-17A was given as the percent positively stained cells. Enzyme-linked immunosorbent assay (ELISA) kits were used to analyze IL-17A in serum and GCF samples. Results: All recorded clinical parameters were significantly higher in gingival overgrowth groups compared with control. Evaluation of inflammation on tissue sections did not show any significant change within the groups. Immunohistochemistry findings showed that IL-17A expression was increased in amlodipine samples (81.90%) compared with control samples (42.35%) (P <.001). There was an increase in the inflammatory group (66.08%) which is significantly less than the amlodipine group (P <.05). IL-17A levels in serum and GCF samples were not different within the study groups. Conclusion: In this study, elevated IL-17A expression regardless of inflammation shows that amlodipine might cause an increase of IL-17A in gingival tissues. This increase might induce fibrotic changes and EMT in gingival overgrowth tissues. The association of IL-17A with fibrosis and EMT in gingival tissues requires further investigation. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons LtdTürkiye Bilimsel ve Teknolojik Araştirma Kurumu: 115C014This study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK?project number: 115C014). The authors declare that no financial or other potential interests exist with regard to this study

Assessment of patients with Takayasu arteritis in routine practice with Indian Takayasu clinical activity score

PubMed ID: 26136490Objective. To assess the Indian Takayasu Clinical Activity Score (ITAS2010) in followup of Takayasu arteritis (TA). Methods. ITAS2010 forms were filled in prospectively (n = 144). Clinical activity was assessed with physician's global assessment (PGA) and criteria defined by Kerr, et al. Results. ITAS2010 was significantly higher in patients with active disease. Total agreement between ITAS2010 and PGA was 66.4%, and between ITAS2010 and Kerr, et al was 82.8%. During followup, 14 of 15 patients showing vascular progression with imaging were categorized as having inactive disease according to ITAS2010. Conclusion. ITAS2010 was discriminatory for activity during the followup, but the agreement between PGA and ITAS2010 was moderate. Future work should include the incorporation of advanced vascular imaging and demonstration of ITAS2010 as a scalable measure and not simply a dichotomous measure of activity/flare versus remission. © 2015 The Journal of Rheumatology. All rights reserved

Turkey

Objectives. Takayasu's arteritis (TA) is a chronic arterial inflammation of unknown etiology involving mainly the aorta and its major branches. Based on the associations of programmed death-1 (PD-1) protein encoding gene (PDCD1) with connective tissue diseases and vasculitides, PDCD1 polymorphisms are studied for susceptibility to TA in this study.Methods. The study group is made up of TA patients (n=229) fulfilling the 1990 ACR classification criteria and compared to 193 healthy controls (HC). PD-1.3, PD-1.5 and PD-1.6 single nucleotide polymorphisms of PDCD1 gene are genotyped by polymerase chain reaction and restriction analysis (PCR-RFLP).Results. The distribution of PD-1.5 polymorphism in TA patients and HC revealed a similar presence of TT genotype in patients and controls (13.3% vs. 11.4%). PD-1.3 and PD-1.6 were less polymorphic and did not differ between the groups. Rare AA genotype of PD-1.3 (1.4% vs. 1.0%) and AG genotype of PD-1.6 was again similarly (22.4% vs. 19.2%) present in TA and HC.Conclusion. PD-1.3, 1.5 and 1.6 polymorphisms of PDCD1 gene, which were shown to be associated with various autoimmune disorders and vasculitides, are not associated with a susceptibility to TA in Turkish population