A rare case of acute coronary syndrome in a patient with turner syndrome

Introduction: In Turner syndrome, cardiovascular complications are the most important causes of early mortality. Congenital cardiovascular abnormalities are found in approximately one third of Turner syndrome patients. Developments in diagnosis and treatment have decreased the rate of mortality related to these abnormalities. In recent years, many papers have mentioned that coronary artery disease developing at early ages in patients with Turner syndrome causes sudden deaths. Case Presentation: The patient, a 27-year-old female was admitted to the emergency room with chest pain at rest. She was diagnosed with Turner Syndrome in her teenage years due to amenorrhea. Patients with ECG changes and cardiac enzyme elevations were treated with acute coronary syndrome. Conclusions: The young woman with Turner Syndrome have several risk factors for early Coronary Artery Disease development. In such cases, dramatic results like sudden death or heart attack at an early age may occur in cases of insufficient follow-up and treatment

Oxidative Stress in Patients with Scalp Seborrheic Dermatitis

Seborrhoeic dermatitis (SD) is a common, chronic inflammatory skin disease that mainly affects the scalp. The objective of this study was to evaluate the activities of superoxide dismutase (SOD) and catalase (CAT) and,  levels of malondialdehyde (MDA) in scraping samples of patients with scalp SD. Thirty consecutive patients with a diagnosis of scalp SD and thirty one healthy volunteers were enrolled. The samples were obtained by scraping the skin surface of scalp. SOD and CAT activities and MDA levels were measured in scraping samples as spectrophotometric. SOD and CAT activities and MDA levels of the patients were significantly higher than in the controls (all p0.05). Cutaneous oxidative stress in patients with SD may play an important role in pathogenesis of the disease. Further clinical and laboratory evaluation of oxidant/antioxidant system in patients with SD is warranted.</p

First report of Neoscytalidium novaehollandiae on common sage (Salvia officinalis)

In June 2020, many plants exhibited symptoms of root rot and foliar blight in the experimental field of common sage in Sanliurfa province, Turkey. The pathogen was identified as Neoscytalidium novaehollandiae based on morphological characteristics and phylogenetic analysis of partial sequence of the transcription elongation factor 1-alpha gene and the internal transcribed spacer of rDNA. Koch's postulates were fulfilled by successful re-isolation of the pathogen from inoculated plants in the pathogenicity assay. To our best knowledge, this is the first report of N. novaehollandiae causing root rot and foliar blight of common sage worldwide

Ethical and Methodological Challenges in Research with Hard-to-Reach Groups: Examples from Research on Family Caregivers for Migrant Older Adults Living with Dementia

Tezcan-Guntekin H, Ozer-Erdogdu I, Yilmaz-Aslan Y, Aksakal T, Bird R. Ethical and Methodological Challenges in Research with Hard-to-Reach Groups: Examples from Research on Family Caregivers for Migrant Older Adults Living with Dementia. The Gerontologist. 2021.Family caregivers of migrants with dementia constitute a population group that is hard to reach for research participation due to factors such as shame about the disease and past experiences of discrimination. In this paper, research-ethical challenges associated with participant recruitment and qualitative data collection among relatives of migrants with dementia are discussed. Over a period of 8 years, three studies were conducted to investigate the experiences of family caregivers for persons with dementia of Turkish descent in Germany. Across these studies, a total of 32 family caregivers were interviewed. In this paper, based on the "Principles of Biomedical Ethics" according to Beauchamp and Childress (2009), research-ethical conflicts associated with sampling methods and the presence of third parties during qualitative interviews are discussed. The potential risks emanating from sampling strategies and the presence of third parties during interviews regarding the voluntary nature of study participation are examined. Additionally, this paper formulates recommendations for ensuring truly voluntary participation and protecting both the participants (family caregivers) and third parties (especially relatives with dementia) from harm. These practical recommendations aim to help future researchers to avoid ethical pitfalls and represent a roadmap for making necessary methodological decisions. © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America

Genomic analysis reveals the biotechnological and industrial potential of levan producing halophilic extremophile, Halomonas smyrnensis AAD6T

Halomonas smyrnensis AAD6T is a gram negative, aerobic, and moderately halophilic bacterium, and is known to produce high levels of levan with many potential uses in foods, feeds, cosmetics, pharmaceutical and chemical industries due to its outstanding properties. Here, the whole-genome analysis was performed to gain more insight about the biological mechanisms, and the whole-genome organization of the bacterium. Industrially crucial genes, including the levansucrase, were detected and the genome-scale metabolic model of H. smyrnensis AAD6T was reconstructed. The bacterium was found to have many potential applications in biotechnology not only being a levan producer, but also because of its capacity to produce Pel exopolysaccharide, polyhydroxyalkanoates, and osmoprotectants. The genomic information presented here will not only provide additional information to enhance our understanding of the genetic and metabolic network of halophilic bacteria, but also accelerate the research on systematical design of engineering strategies for biotechnology applications