Expression of antimicrobial peptides in recurrent adenotonsillitis

Kilic, Murat/0000-0002-1377-2021; aydin, sedat/0000-0003-4939-5026; demir, mehmet/0000-0002-0609-6782WOS: 000393197500008Background: Recurrent acute tonsillitis is one of the most frequent otorhinolaryngology clinic referrals, yet its pathogenesis remains poorly understood. Antimicrobial cationic peptides are components of the innate system. They are generally small, highly positively charged peptides with broad spectrum antimicrobial activity which function as the body's "natural antibiotics". Our aim is to investigate the role of antimicrobial cationic peptides in the susceptibility of patients to recurrent acute tonsillitis. Materials and methods: The study is done with 100 children who had a history of recurrent adenotonsillitis as subject group and 100 children with adenotonsillar hypertrophy as control group. Tonsillar and adenoid tissues are dissected into parts as deep and surface epithelium and investigated semiquantitatively with immunohistochemistry. Human beta defensin (hBD) 1-3 and cathelecidin (LL-37) levels are compared with microscopically. Results: Immunohistochemistry revealed a strong expression of hBD-1, hBD-2 and hBD-3 in tonsillar tissue. Quantification of hBD-1, hBD-2 and hBD-3 expressions are shown more in tonsillar tissue than in adenoids. LL-37 is one of the antimicrobial peptides found in human tonsillar tissue and adenoids, that participates in the innate immune system of these tissues. Statistically, hBD-1, hBD-3 and LL-37 expressions were different in recurrent tonsillitis tissue than control (p < 0.05). Moreover hBD-2 expression was different in adenoid tissue than control (p < 0.05). Conclusion: Antimicrobial peptides have key role in adenotonsillar infections and this defense mechanism increases susceptibility to recurrent infections in upper respiratory tract

Determining the Relationship between Obesity and Problematic Internet Use among Adolescents

Background: Obesity has become widespread among adolescents throughout the world. This study aimed to determine the relationship between problematic internet use and obesity among 10-19 yr old adolescents. Methods: The descriptive study was carried out in a private elementary and high school in Gaziantep Province in the Eastern Turkey in 2016-2017. Overall, 474 adolescents and 938 their parents were enrolled. Data collection form consisted of three parts. The first part included questions about sociodemographic characteristics of the adolescent and his/her parents. The second part included data on anthropometrical measurements, dietary habits and physical activity level. Third part of the data collection form included Problematic Internet Usage Scale. First, anthropometrical measurements of the adolescents were recorded. Then, the data collection forms were applied to adolescents and their parents. Results: 34.8% of adolescents were overweight and obese. Approximately four out of ten male adolescents and three out of ten female adolescents were overweight or obese (P<0.05). Girls had less problematic internet use behaviors (P<0.05). There were statistically significant differences between age, sex, socioeconomic status, unhealthy eating habits and problem internet usage (P<0.05). Conclusion: Periodic screening should be done to determine the prevalence of obesity and problematic internet usage. Training programs on regular physical activity and healthy nutrition should be prepared and guidance services should be provided for the reduction of obesity rates and the protection of ideal weight

Palladium-catalyzed Heck reaction of aryl bromides in aqueous media using tris(N-heterocyclic carbene) ligands

WOS: 000246081100007A highly effective, easy to handle and environmentally benign process for palladium-mediated Heck reaction was developed. The in situ prepared three-component system composed of palladium(II) acetate, a tris(azolinium) bromide and potassium tert-butoxide, quantitatively catalyzes the Heck reaction of aryl bromides in aqueous media

Novel tetrahydropyrimidinium/palladium system as a convenient catalyst: Suzuki coupling reactions of aryl chlorides

WOS: 000251574200010Four bis(3,4,5,6-tetrahydropyrimidinium) chlorides(2a-d) have been prepared and characterized by conventional spectroscopic methods and elemental analyses. A highly effective, easy to handle and environmentally benign process for palladium mediated Suzuki cross-coupling was developed. The in situ prepared three- component system Pd(OAc)(2) / bis( 3,4,5,6tetrahydropyrimidinium) chlorides (2a-d) and K2CO3 catalyses quantitatively the Suzuki crosscoupling of deactivated aryl chlorides

Determining Bioecological and Biometric Properties of Freshwater Mussels (Unio crassus Philipsson, 1788)

WOS: 000461800200088Population characteristics of Unio crassus, an endangered freshwater mussel in many countries, are very important. In this study, we have attempted to determine the environmental conditions of Aydin-Cine Creek and the biometric properties of U. crassus. The largest length during the study period was 92.50 mm in February, and the smallest length was 37.03 mm in April. In addition, the heaviest individual was found to be 124.15 g in February, while the smallest individual was 6.69 g in April. It was found that 141 individuals were found in a group of 70.0-79.99 mm at maximum in the distribution frequency of U. crassus in Cine Creek. The water temperature was measured at 9.8-24.0 degrees C, and oxygen value was 6.0-10.4 mg/L during the study. In the current environmental conditions in Cine Creek, various sizes and population development of U. crassus have been identified.Scientific and Technological Research Council of Turkey under the University Student Scholarship ProgramThis study was partly supported by the Scientific and Technological Research Council of Turkey under the University Student Scholarship Program. The authors would like to thank Unsal Orhan for help in field observations

Development And Psychometric Testing Of The Turkish Immunosuppressive Medication Adherence Scale

Objective: The monitoring of immunosuppressive medication adherence is an important issue for solid organ transplant patients. In Turkey, there has been no valid and reliable measurement tool specific to transplantation for evaluation of medication adherence. The aim of this methodological study was to develop and psychometrically test Immunosuppressive Medication Adherence Scale. Materials and Methods: The Immunosuppressive Medication Adherence Scale was developed, and its validity and reliability were examined using data from 200 solid organ transplant patients. An expert panel evaluated the content validity, and factor analysis was used to evaluate the construct validity. Internal consistency analysis was performed to evaluate the reliability of the scale, and item-total correlations were evaluated. Results: As a result of exploratory factor analysis, all 11 items were found to be collected in a single dimension, and factor loadings varied between 0.32 and 0.87. All scale items had a good positive significant correlation with the total scale score. Content validity was evidenced by obtaining the views of 13 experts (0.80 content validity index). Cronbach's a was 0.61. Conclusion: The Immunosuppressive Medication Adherence Scale has acceptable internal consistency, good content, and construct validity. The scale is appropriate for use in clinical practice settings and research to evaluate immunosuppressive medication adherence of solid organ transplant patients.Wo

Perspectives of Young Adult Men Regarding Violence against Women: A Cross-sectional Study from Turkey

Women are often victims of male-to-female intimate partner violence. The sample in this study consisted of 637 participants who were conscripted soldiers at Gulhane Military Medical Academy in Ankara, Turkey. This research examined the perspectives and perceptions of young adult men toward violence against women and identified potential risk factors for violence. In this study, 8.8 % of the participants reported perpetrating violence against women. Multivariate analysis indicated young adult males whose father acted violently against their mother were 3.5 times more likely to commit violence against women than young men without violent fathers. It is suggested public health nurses could effectively prevent violence by providing health education

Palladium(II)-NHC complexes containing benzimidazole ligand as a catalyst for C-N bond formation

WOS: 000287164100001The reaction of 2-(2-bromoethyl)-1,3-dioxane with 1-alkylbenzimidazole derivatives results in the formation of the new benzimidazoliumsalts (1). The reaction of Pd(OAc)(2) with1,3-dialkylbenzimidazoliumsalts(1a-c) yields palladium N-heterocyclic carbene (NHC) complexes (2a-c). All synthesized compounds were characterized by (HNMR)-H-1, (CNMR)-C-13, IR and elemental analysis techniques which support the proposed structures. As catalysts, these new palladium complexes offer a simple and efficient methodology for the synthesis of triarylamines and secondary amines from anilines and amines and in a single step with potassium tertiary butoxide as a base. Copyright (C) 2010 John Wiley & Sons, Ltd.Technological and Scientific Research Council of Turkey TUBITAK-CNRS (France)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TBAG-U/181 (106T716)]; Inonu UniversityInonu University [IU BAP: 2009/10]This work was financially supported by the Technological and Scientific Research Council of Turkey TUBITAK-CNRS (France) [TBAG-U/181 (106T716)] and Inonu University Research Fund (IU BAP: 2009/10)

Evaluation of the efficacy of an exercise program for pregnant women with low back and pelvic pain: a prospective randomized controlled trial

AimTo evaluate the effect of exercise programs on pregnant women with pregnancy-related low back and pelvic pain. BackgroundLow back and pelvic pain during pregnancy is a major health problem due to its frequent occurrence and such pain can limit pregnant women in many of their daily activities. DesignA randomized trial with a control group (n=48) and an intervention group (n=48). Trial registration number NCT02189356. MethodsDepartment of Obstetrics and Gynecology, between December 2011-May 2012, an Education and Research Hospital in Turkey. Based on the intention-to-treat principle, all pregnant women were analysed according to the group they were assigned to, regardless of whether they received the intervention or not. Participants in the intervention group received health counselling and exercised regarding low back and pelvic pain for four weeks. The pregnant women in the control group received usual care, comprised of routine clinical practice for pregnancy-related low back and pelvic pain. ResultsAccording to Mann-Whitney U test analysis results, there was a statistically significant difference between the control and intervention groups' Visual Analogue Scale during relaxation scores and Visual Analogue Scale during activity scores at the end of the study. According to Mann-Whitney U test analysis results, the change in the mean Oswestry Disability Index score for the intervention group and the difference in the mean scores between the two groups was statistically significant. ConclusionsA four-week exercise program including individualized health counselling to relieve low back and pelvic pain improved the functional status in pregnant women

CCDC 213568: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.,Related Article: H.Arslan, D.VanDerveer, I.Ozdemir, B.Cetinkaya, S.Demir|2005|J.Chem.Cryst.|35|491|doi:10.1007/s10870-005-2442-