telederm.org: Freely Available Online Consultations in Dermatology

Studies have shown that skin disorders can be reliably diagnosed by online consultations. These consultations are provided free of charge by a new nonprofit organization of skin doctors worldwid

Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation

Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple markers associated with melanoma, suggesting that these represent naevi with an increased potential for transformation to melanoma

Dermoscopic evaluation of nodular melanoma

Importance: Nodular melanoma (NM) is a rapidly progressing potentially lethal skin tumor for which early diagnosis is critical

MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort.

BACKGROUND: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls. METHODS: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. We gathered phenotypic and genetic data from children or adolescents diagnosed with sporadic single-primary cutaneous melanoma at age 20 years or younger, adult patients with sporadic single-primary cutaneous melanoma diagnosed at age 35 years or older, and healthy adult individuals as controls. We calculated odds ratios (ORs) for childhood and adolescent melanoma associated with MC1R variants by multivariable logistic regression. Subgroup analysis was done for children aged 18 or younger and 14 years or younger. FINDINGS: We analysed data from 233 young patients, 932 adult patients, and 932 healthy adult controls. Children and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1·54, 95% CI 1·02-2·33), including when analysis was restricted to patients aged 18 years or younger (1·80, 1·06-3·07). All investigated variants, except Arg160Trp, tended, to varying degrees, to have higher frequencies in young patients than in adult patients, with significantly higher frequencies found for Val60Leu (OR 1·60, 95% CI 1·05-2·44; p=0·04) and Asp294His (2·15, 1·05-4·40; p=0·04). Compared with those of healthy controls, young patients with melanoma had significantly higher frequencies of any MC1R variants. INTERPRETATION: Our pooled analysis of MC1R genetic data of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and adolescent melanoma than in adult melanoma, especially in patients aged 18 years or younger. Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility, with a potential clinical relevance for developing early melanoma detection and preventive strategies. FUNDING: SPD-Pilot/Project-Award-2015; AIRC-MFAG-11831

Nonmelanoma Skin Cancer of the Head and Neck Clinical Evaluation and Histopathology

WOS: 000311860700004PubMed ID: 23084295Clinical and histopathologic features of nonmelanoma skin cancer, physical examination, and diagnostic methods (biopsy, dermoscopy, confocal microscopy) are summarized. A diagnostic algorithm provides a useful summarization of differential diagnosis of basal cell carcinoma, actinic keratosis, Bowen's disease, and squamous cell carcinoma

A pigmented, hemorrhagic genital wart: Clinical, dermoscopic, and histopathologic features

65th Annual Meeting of the American-Academy-of-Dermatology -- FEB 02-06, 2007 -- Washington, DCWOS: 000243972800389Amer Acad Dermato

Variations in the dermoscopic features of acquired acral melanocytic nevi

WOS: 000250962200003PubMed ID: 18025361Objective: To investigate the dermoscopic features of acquired acral melanocytic nevi (AAMN) in a white population in Turkey. Design: Prospective population-based study. Setting: University dermatology department dermoscopy unit. Patients: A total of 2625 patients admitted to our dermoscopy unit. Interventions: Patients were examined for AAMN clinically and dermoscopically with a digital imaging system, and AAMN larger than 7 mm and dermoscopically suggestive lesions were excised and examined histopathologically. For other nevi, digital dermoscopic follow-up at 6-month intervals was recommended. Results: A total of 188 AAMN were observed in 138 patients. The most common dermoscopic pattern was the parallel furrow pattern (58.5%). The other patterns seen were fibrillar (12.2%), latticelike (6.4%), homogeneous (6.4%), globulostreaklike (5.3%), reticular (4.3%), globular (2.1%), nontypical (3.2%), and the pattern suggestive of malignancy (1.6%). All 39 excised lesions (20.7%) were benign. In addition, within I year, some changes in dermoscopic features were observed in 24 of the 33 lesions observed on digital dermoscopic follow-up (73%). Conclusions: There may be many variations in AAMN. In our population, although the parallel furrow pattern is the most common pattern, as reported in Japanese populations, fibrillar and latticelike patterns occurred in lower proportions. Conversely the homogeneous pattern is more frequent and may be considered one of the major patterns in the white population. In addition, changes in the dermoscopic features of AAMN may occur, even during short-term follow-up

Trichilemmal cyst with homogeneous blue pigmentation on dermoscopy

WOS: 000271495600015PubMed ID: 19916979A 61-year-old woman was referred to our dermoscopy unit for a pigmented lesion that had been present on her left arm for 8 years. The patient did not notice any enlargement or change in colour. On dermoscopy, homogeneous blue pigmentation was seen. The lesion was excised with the pre-operative diagnosis of melanoma, blue naevus and dermatofibroma. Histopathological examination showed a trichilemmal cyst in the mid-dermis. Although homogeneous blue pigmentation on dermoscopy is the hallmark of blue naevus, it may be seen in metastatic melanoma and exceptionally in hemosiderotic and cellular types of dermatofibroma. Trichilemmal cyst should be borne in mind also in the dermoscopic differential diagnosis

In vivo reflectance confocal microscopic imaging of Leishmania amastigotes (Leishman bodies): A case report

Yaman, Banu/0000-0002-2915-0788WOS:000630899100001PubMed: 33719119Cutaneous leishmaniasis (CL) is an intracellular parasitic infectious skin disease with a chronic self-limited course. in vivo reflectance confocal microscopy (RCM) findings in CL have been described in only two cases of CL. We report another case with RCM findings; however to our knowledge, this is the first demonstration of Leishmania amastigotes in RCM imaging. A centrally eroded reddish nodular lesion with a diameter of 12 mm was observed on the leg of a 36-years-old male with a 1-month history. on dermoscopy, a central yellowish crust, and irregularly distributed whitish opaque structures ranging in size and shape (round to polygonal) were observed. There were also irregular vessels mostly at the center and dotted/glomerular vessels at the periphery. on RCM, mild epidermal disarray with some scattered bright cells at the basal layer was observed. At the dermis, dense infiltration of polymorphic/roundish cells with heterogeneous reflectivity was seen. These large, mildly reflecting cells with fine granular structures in their cytoplasm were compatible with macrophages. Histopathology was concordant with CL. The Leishmania amastigotes seen as cytoplasmic granularity on RCM were the clue feature for the initial diagnosis