Bilateral Choroidal Detachment Induced by Unilateral Application of a Fixed Combination of Topical Timolol Maleate and Brinzolamide

We describe a 66-year-old man who developed bilateral choroidal detachment that was induced by unilateral topical administration of a fixed combination of 1% brinzolamide and 0.5% timolol maleate the day after an uneventful phacoemulsification surgery and intraocular lens implantation involving his right eye. We believe that the reaction was an idiosyncratic reaction, most likely against brinzolamide. The condition improved rapidly after the cessation of the fixed combination of brinzolamide and timolol maleate and treatment with 1% topical prednisolone acetate every hour and 1% cyclopentolate twice a day bilaterally. Although there are several similar cases involving choroidal detachment after oral acetazolamide and topical dorzolamide treatment mentioned in the literature, the present case is the first case report involving bilateral choroidal detachment after topical treatment with brinzolamide.Â

Bilateral Choroidal Detachment Induced by Unilateral Application of a Fixed Combination of Topical Timolol Maleate and Brinzolamide

We describe a 66-year-old man who developed bilateral choroidal detachment that was induced by unilateral topical administration of a fixed combination of 1% brinzolamide and 0.5% timolol maleate the day after an uneventful phacoemulsification surgery and intraocular lens implantation involving his right eye. We believe that the reaction was an idiosyncratic reaction, most likely against brinzolamide. The condition improved rapidly after the cessation of the fixed combination of brinzolamide and timolol maleate and treatment with 1% topical prednisolone acetate every hour and 1% cyclopentolate twice a day bilaterally. Although there are several similar cases involving choroidal detachment after oral acetazolamide and topical dorzolamide treatment mentioned in the literature, the present case is the first case report involving bilateral choroidal detachment after topical treatment with brinzolamide.

Nodular Scleritis in Association with Panuveitis in Behçet’s Disease

This case report involves a 32-year-old man with Behçet’s disease who had simultaneous bilateral anterior uveitis, unilateral nodular scleritis, and occlusive vasculitis with retinal hemorrhages. Although scleritis is not a classical feature of Behçet’s disease, a diagnosis of Behçet’s disease should be considered in patients with scleritis

Successful management of aniridic ocular surface disease with long-term bandage contact lens wear

Purpose: To present an aniridic patient with failed penetrating keratoplasties OU (PK) who underwent successful repeat PK OD, which has remained clear for 4 years with continuous bandage lens (BCL) wear

Use of intralimbal rigid gas-permeable lenses for pellucid marginal degeneration, keratoconus, and after penetrating keratoplasty

Purpose. To discuss the results of fitting Dyna Intra-Limbal lenses (Lens Dynamics, Inc., Golden, CO) (DIL) for pellucid marginal degeneration (PMD), keratoconus, and after penetrating keratoplasty (PK). Methods. The charts of patients fitted with DILs between January 2003 and December 2004 were retrospectively reviewed. Ocular diagnosis, indication for DIL, flat and steep curvatures by corneal topography, and age at the time of initial fitting were noted. The DIL data included initial base curve, power, and the number of changes made in parameters during the follow-up. The outcome data included visual acuity and the duration of follow-up and lens wear. Complications and complaints were also noted. Results. Twenty-seven eyes of 22 patients were reviewed. Fourteen eyes had PMD; seven had keratoconus; and six eyes had undergone PK. The mean age of patients was 52.7 ± 13.1 years. The mean follow-up was 8.9 ± 7.4 months. Nine (33.3%) eyes achieved 20/20 visual acuity; 13 (48.1%) eyes achieved 20/25 to 20/40; and five (18.5%) eyes achieved 20/50 to 20/70. Fifteen (55.6%) eyes achieved visual improvement (two lines or more). The mean number of refits was 1.1 ± 0.9. No infection or neovascularization was noted; a corneal abrasion occurred in one eye. Good wearing time was achieved in 18 (66.7%) eyes of 13 patients, who were still wearing DILs at the last follow-up. Conclusions. DILs may be a good alternative in selected patients with flat central and superior corneas and inferior peripheral steepening. © 2006 Contact Lens Association of Ophthalmologists, Inc

Transscleral fixation of a black diaphragm intraocular lens in severely traumatized eyes requiring vitreoretinal surgery

The records of 4 eyes of 4 patients who had transscleral fixation of black diaphragm intraocular lenses (IOLs) after vitreoretinal surgery due to complications of severe perforating trauma were retrospectively reviewed. The transscleral fixation was performed 4 to 13 months after the vitreoretinal surgery. All patients reported a subjective decrease in glare and photophobia, with improved visual acuity in 2 eyes during a mean follow-up of 3 years. Cystoid macular edema was noted in 1 eye and transitory intraocular pressure elevation due to intraocular silicone oil in 1 eye. Severe perforating eye injury is frequently associated with extensive iris defects and lenticular and vitreoretinal complications. Although visual acuity may not be the primary concern in these eyes, favorable visual rehabilitation can be achieved following proper management of the retinal complications and transscleral fixation of black diaphragm IOLs to overcome glare and photophobia

Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women

Studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT)

Can Subconjunctival Bevacizumab Injection Regress Corneal Neovascularization?

…..……………………….. Purpose: To determine the effect of subconjunctival bevacizumab injection on corneal neovascularization. Material and Methods: The study included 16 eyes of 8 New Zelland albin rabbits. A 6/0 silk suture was placed intrastromally near the superior limbus in bot eyes of rabbits to induce corneal neovascularization. Eyes were checked weekly fo neovascularization and adjacent conjunctival injection. Subconjunctival injections o 1.25mg and 2.5mg bevacizumab were given in right and left eyes respectively Eyes were examined under the operating microscope. Digital photographs wer taken weekly for 6 weeks and then evaluated by using a computerized imag processing technique and a transparent grid technique to quantify the area o corneal neovascularization and adjacent conjunctival injection. Results: Corneal neovascularization and adjacent conjunctival injection wer observed by the end of first week. Injections were performed at the second week Only four rabbits could complete the study. Conjunctival injection improve significantly at the first week following injection. Most significant reduction o corneal neovascularization was observed in the second week in both eyes of all rabbits. No recurrence was noted although no repeat injection was given