3 research outputs found
A core outcome set for preâeclampsia research: an international consensus development study
Objective
To develop a core outcome set for preâeclampsia.
Design
Consensus development study.
Setting
International.
Population
Two hundred and eightâone healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated.
Methods
Modified Delphi method and Modified Nominal Group Technique.
Results
A longâlist of 116 potential core outcomes was developed by combining the outcomes reported in 79 preâeclampsia trials with those derived from thematic analysis of 30 inâdepth interviews of women with lived experience of preâeclampsia. Fortyâseven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, smallâforâgestationalâage, neonatal mortality, seizures, admission to neonatal unit required and respiratory support.
Conclusions
The core outcome set for preâeclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies
Importance of neonatal immunoglobulin transfer for hippocampal development and behaviour in the newborn pig - Fig 1
<p><b>A) The left hippocampus of the piglet after dissection. Scale barâ 1.5 cm. B) Immunostaining of the subiculum of piglets. Synaptopodin- positive punctae (red) and synaptophysin- positive punctae (green). Scale barâ 100 ÎŒm. C) The density of stained regions for the synaptic proteins, synaptophysin (SPhys) and synaptopodin (SPod), in the hippocampus of piglets as analysed with immunohistochemistry. D)The colocalisation coefficients M1 and M2 of synaptophysin-positive and synaptopodin-positive puncta in the hippocampus of piglets as analysed with immunohistochemistry.</b> Unsuckled newborn piglets (NB, n = 6) and newborn piglets fed with either an infant formula (IF, n = 6), bovine colostrum (BC, n = 6), an infant formula + i.v. infusion of sow serum (IF+IGLD, n = 6), an infant formula + i.v. infusion of porcine immunoglobulins (IF+IGHD, n = 6), or swine colostrum (SC, n = 6). Data are presented as mean±SD. Small letters given with result bars describe significant differences when p<0.05.</p