Community perceptions of a malaria vaccine in the Kintampo districts of Ghana.

BACKGROUND: Malaria remains the leading cause of morbidity and mortality in sub-Saharan Africa despite tools currently available for its control. Making malaria vaccine available for routine use will be a major hallmark, but its acceptance by community members and health professionals within the health system could pose considerable challenge as has been found with the introduction of polio vaccinations in parts of West Africa. Some of these challenges may not be expected since decisions people make are many a time driven by a complex myriad of perceptions. This paper reports knowledge and perceptions of community members in the Kintampo area of Ghana where malaria vaccine trials have been ongoing as part of the drive for the first-ever licensed malaria vaccine in the near future. METHODS: Both qualitative and quantitative methods were used in the data collection processes. Women and men whose children were or were not involved in the malaria vaccine trial were invited to participate in focus group discussions (FGDs). Respondents, made up of heads of religious groupings in the study area, health care providers, traditional healers and traditional birth attendants, were also invited to participate in in-depth interviews (IDIs). A cross-sectional survey was conducted in communities where the malaria vaccine trial (Mal 047RTS,S) was carried out. In total, 12 FGDs, 15 IDIs and 466 household head interviews were conducted. RESULTS: Knowledge about vaccines was widespread among participants. Respondents would like their children to be vaccinated against all childhood illnesses including malaria. Knowledge of the long existing routine vaccines was relatively high among respondents compared to hepatitis B and Haemophilus influenza type B vaccines that were introduced more recently in 2002. There was no clear religious belief or sociocultural practice that will serve as a possible barrier to the acceptance of a malaria vaccine. CONCLUSION: With the assumption that a malaria vaccine will be as efficacious as other EPI vaccines, community members in Central Ghana will accept and prefer malaria vaccine to malaria drugs as a malaria control tool. Beliefs and cultural practices as barriers to the acceptance of malaria vaccine were virtually unknown in the communities surveyed

Effects of Harvest Time and Storage Form on Insect Population and Damage of Maize

The aim of this study was to determine the effects of harvest time and storage form on population levels of insect pests and their damage on stored maize. Maize was cultivated on a total land area of 19 x 23m2 during the major season (April to August 2020) and minor season (September to December 2020). Maize was harvested at three stages; early harvest, mid harvest and late harvest. Harvested maize was stored in three ways; husked, de-husked and shelled. Analysis of variance (ANOVA) was applied to the data through Sisvar version 5.6. Insect pests that were sampled during the study were Sitophilus zeamais, Cathartus quadricollis, Carpophilus dimidiatus and Tribolium castaneum. Carpophilus dimidiatus were sampled from treatments during the major season whereas Tribolium castaneum was sampled during the minor season. Sitophilus zeamais and Cathartus quadricollis were sampled in both seasons.  In the major season, late harvest shelled maize (LHS) recorded 689% more S. zeamais numbers as compared to early harvest husked maize (EHH). Mid-harvest husked maize (MHH) had 307% less number of S. zeamais compared to LHS in the minor season. Late-harvest shelled maize (LHS) had the highest percentage insect damaged kernels (86.94%) in the major season

A Metaheuristic for Tactical Inventory Planning in Closed-Loop Supply Chains

International audienc

Model and Combinatorial Optimization Methods for Tactical Planning in Closed-Loop Supply Chains

International audienc

Strategies for handling uncertainty in tactical distribution planning - an empirical study

International audienc

Tactical Supply Chain Distribution Planning In The Telecommunications Service Industry

Supply chains are ubiquitous across industries and a considerable e ort has been invested in supply chain management techniques over the last two decades. In equipment-intensive service industries, it often involves repair operations. In this context, tactical inventory planning is concerned with optimally planning supplies and repairs based on demand forecasts and in face of con icting business objectives. It is based on a case study in the telecommunications sector where large quantities and varieties of spare parts are required for service maintenance and repair tasks at customer premises or company exchanges. Speci cally, we consider a multi-echelon spare parts supply chain and tackle the problem of determining an optimal stock distribution plan given a demand forecast. We propose a mixed integer programming and a metaheuristic approach to this problem. The model is open to a variety of network topologies, site functions and transfer policies. It also accommodates multiple objectives by the means of a weighted cost function. We report experiments on pseudo-random instances designed to evaluate plan quality and impact of cost weightings. In particular, we show how appropriate weightings allow to emulate common planning strategies (e.g., just-in-time replenishment, minimal repair). We also assess plan quality and system performance against di erent classes of pseudo-random instances featuring different volume and distribution of stock and demand

Environmental Performance and Corporate Innovation in China: The Moderating Impact of Firm Ownership

Data availability statement: Data available on request from the authors.Copyright © 2022 The Authors. In this study, we examine the impact of environmental performance on corporate innovation based on a sample of 11,014 Chinese A-share firm-year observations during the period from 2010 to 2017. Also, we investigate the moderating impact of firm ownership on the above relation. Our results suggest a significant positive association between environmental performance and corporate innovation. By analyzing the moderating effect of ownership structure, our findings suggest that institutional ownership strengthened the positive relation between environmental performance and corporate innovation, while state ownership played a partial role. Our findings are robust for using advanced techniques, such as reverse causality, omitted variable bias, two-stage least square, and propensity score matching. This study contributes to the literature by shedding light on the stakeholder and resource dependence perspectives on the relation between environmental performance and corporate innovation.“Funds for High-Level Talents of Xijing University (2019), Grant/Award Number: XJ19B02; “The Fundamental Research Funds for the Central Universities” in UIBE, grant number: CXTD12-01

Spatial Analysis of Health Care Utilization among Medicare Beneficiaries with Coal Workers’ Pneumoconiosis and Other Related Pneumoconiosis

Overview of Key Findings The states with the highest number of Medicare beneficiaries with coal workers’ pneumoconiosis (CWP) were Kentucky, West Virginia, Virginia, and Pennsylvania. Significant clustering of health care utilization rates for Medicare beneficiaries with CWP was observed in the central Appalachian states of Kentucky, West Virginia, and Virginia. Significant clustering of health care utilization rates for Medicare beneficiaries with Other Related Pneumoconiosis was observed in Appalachia and the southeast parts of Texas and Louisiana. This clustering merits additional research to understand underlying disease etiology

Spread of African cassava mosaic virus from cassava (Manihot esculenta Crantz) to physic nut (Jatropha curcas L.) in Ghana

Investigations were made on the susceptibility of physic nut (Jatropha curcas L.) to African cassava mosaic virus (ACMV) and its possible role as an alternative host of the virus in Ghana. Ten J. curcas accessions in a field trial were interplanted with ACMV-infected cassava (Manihot esculenta Crantz) and left to natural spread of the virus from the cassava to the J. curcas plants for a period of 12 months. Populations of the whitefly vector, Bemisia tabaci (Gennadius) and the incidence of African cassava mosaic disease (ACMD) were monitored during the period. The J. curcas plants had low whitefly numbers, both in the wet (September – October, 2008) season and in the dry (January – February, 2009) season. By the end of the experimental period, 37.7% of the 120 J. curcas plants tested in all the accessions were found to be infected by ACMV, as assessed by symptom expression, double antibody-sandwich (DAS) ELISA or sap inoculation to Nicotiana benthamiana indicator plants. There were wide variations within and between the J. curcas accessions in their response to ACMV infection. This work is the first report of the natural infection of J. curcas by ACMV

Digyalipopeptide A, an antiparasitic cyclic peptide from the Ghanaian Bacillus sp. strain DE2B.

Acknowledgements We acknowledge the mass spectrometry data received from the laboratory of Professor Pieter C. Dorrestein and Andrés Mauricio Caraballo Rodrígueze. Funding K.K., H.D and M.J. are grateful for the financial support of Leverhulme Trust-Royal Society Africa award (AA090088) and the jointly funded UK Medical Research Council–UK Department for International Development (MRC/DFID) Concordat Agreement African Research Leaders Award (MR/S00520X/1). A.P.N. is thankful for the award of a Ph.D. scholarship by the Organization for Women in Science for the Developing World (OWSD), the Swedish International Development Cooperation Agency (SIDA) and the Carnegie BANGA-Africa Project Award for a Ph.D. scholarship.Peer reviewedPublisher PD