3,525 research outputs found
Non-Pauli Effects from Noncommutative Spacetimes
Noncommutative spacetimes lead to nonlocal quantum field theories (qft's)
where spin-statistics theorems cannot be proved. For this reason, and also
backed by detailed arguments, it has been suggested that they get corrected on
such spacetimes leading to small violations of the Pauli principle. In a recent
paper \cite{Pauli}, Pauli-forbidden transitions from spacetime noncommutativity
were calculated and confronted with experiments. Here we give details of the
computation missing from this paper. The latter was based on a spacetime
different from the Moyal plane. We argue that it
quantizes time in units of . Energy is then conserved only mod
. Issues related to superselection rules raised by non-Pauli
effects are also discussed in a preliminary manner.Comment: 15 Pages, 1 Table, Full details and further developments of
arXiv:1003.2250. This version is close to the one accepted by JHE
Substantial subpial cortical demyelination in progressive multiple sclerosis: have we underestimated the extent of cortical pathology?
Aim: Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease. Much of the complex symptomatology relates to pathology outside the classic white matter plaque, whereby lesions of the cortical grey matter, which are difficult to resolve by conventional clinical imaging, are in part predictive of outcome. We investigated the extent of grey matter pathology in whole coronal macrosections to reassess the contribution of cortical pathology to total demyelinating lesion area in progressive MS. Methods: Twenty-two cases of progressive MS were prepared as whole bi-hemispheric macrosections for histology, immunostaining and quantitative analysis of lesion number and relative area, leptomeningeal inflammation and microglial/macrophage activation. Results: Cortical grey matter demyelination was seen in all cases, which was more extensive than in white and deep grey matter (hippocampus, thalamus and basal ganglia) and accounted for 0.8%-60.2% of the entire measurable cortical ribbon. The pattern of cortical grey matter demyelination was predominantly subpial (mean 90.9%, range 60%-100%, of total cortical grey matter lesion area) and cases with the largest areas of subpial cortical lesions had more and larger deep grey matter lesions, greater numbers of activated microglia/macrophages, both in lesions as well as in normal cortical grey matter, together with elevated leptomeningeal inflammation and lymphoid-like structures. White matter lesion area was unchanged when compared with the progressive MS cases with little subpial cortical demyelination. Conclusion: Analysis of whole coronal macrosections reveals cortical demyelination is more extensive than reported by conventional histological methods. Cases of progressive MS with substantial subpial cortical demyelination that is independent of underlying white matter lesion area support the implications that these lesions may in-part arise through different pathogenetic mechanisms. Biomarkers and/or imaging correlates of this subpial pathology are required if we are to fully comprehend the clinical disease process
The longitudinal effect of dysglycaemia on the ventilatory and aerobic function in children and adults with cystic fibrosis
This is the author accepted manuscript. The final version is available from BMJ Publishing Group via the DOI in this recordPaper P127 presented at the British Thoracic Society Winter Meeting, 17 - 19 February 202
The Effect of Dysglycaemia on Changes in Pulmonary and Aerobic Function in Cystic Fibrosis
This is the final version. Available on open access from Frontiers media via the DOI in this recordData Availability Statement:
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. Please contact the corresponding author, CW.Cross-sectional studies have reported lower pulmonary and aerobic function during exercise in people with cystic fibrosis-related diabetes (CFRD) compared to non-CFRD counterparts. However, this association has yet to be longitudinally investigated. Therefore, this study examines these differences over time between people with cystic fibrosis (CF) of differing glycaemic status. Annual review data, including cardiopulmonary exercise tests and pulmonary function tests, were retrospectively analysed at baseline (T0, n = 82) and at a one-year follow-up (T1, n = 54). Data was analysed in three groups: normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and CFRD. Further analyses were undertaken, with a dichotomous split of NGT and a combined IGT/CFRD group. At baseline, a significant reduction in the majority of variables, including forced expiratory volume in one second (FEV1) and maximal oxygen uptake (VO2max), was observed in the CFRD (n = 19) group compared to NGT (n = 58). At follow-up, no significant differences were observed, and no interaction effect between CFRD status and time was identified. FEV1 and VO2max presented with varying directions and magnitudes of change within patients. In summary, patients with CFRD have a reduced aerobic and pulmonary function compared to non-CFRD counterparts, although such changes disappeared at follow up. Varying responses for FEV1 and VO2max highlight the need to consider both variables as independent markers of function in CF
Optimum temperatures for net primary productivity of three tropical seagrass species
Rising sea water temperature will play a significant role in responses of the world’s seagrass meadows to climate change. In this study, we investigated seasonal and latitudinal variation (spanning more than 1,500 km) in seagrass productivity, and the optimum temperatures at which maximum photosynthesis and net productivity (for the leaf and the whole plant) occurs, for three seagrass species (Cymodocea serrulata, Halodule uninervis, and Zostera muelleri). To obtain whole plant net production, photosynthesis, and respiration rates of leaves and the root/rhizome complex were measured using oxygen-sensitive optodes in closed incubation chambers at temperatures ranging from 15 to 43◦C. The temperature-dependence of photosynthesis and respiration was fitted to empirical models to obtain maximum metabolic rates and thermal optima. The thermal optimum (T) for gross photosynthesis of Z. muelleri, which is more commonly distributed in sub-tropical to temperate regions, was 31◦C. The T for photosynthesis of the tropical species, H. uninervis and C. serrulata, was considerably higher (35◦C on average). This suggests that seagrass species are adapted to water temperature within their distributional range; however, when comparing among latitudes and seasons, thermal optima within a species showed limited acclimation to ambient water temperature (T varied by 1◦C in C. serrulata and 2◦C in H. uninervis, and the variation did not follow changes in ambient water temperature). The T for gross photosynthesis were higher than T calculated from plant net productivity, which includes above- and below-ground respiration for Z. muelleri (24◦C) and H. uninervis (33◦C), but remained unchanged at 35◦C in C. serrulata. Both estimated plant net productivity and T are sensitive to the proportion of below-ground biomass, highlighting the need for consideration of below- to above-ground biomass ratios when applying thermal optima to other meadows. The thermal optimum for plant net productivity was lower than ambient summer water temperature in Z. muelleri, indicating likely contemporary heat stress. In contrast, thermal optima of H. uninervis and C. serrulata exceeded ambient water temperature. This study found limited capacity to acclimate: thus the thermal optima can forewarn of both the present and future vulnerability to ocean warming during periods of elevated water temperature
Brick Walls and AdS/CFT
We discuss the relationship between the bulk-boundary correspondence in
Rehren's algebraic holography (and in other 'fixed-background' approaches to
holography) and in mainstream 'Maldacena AdS/CFT'. Especially, we contrast the
understanding of black-hole entropy from the viewpoint of QFT in curved
spacetime -- in the framework of 't Hooft's 'brick wall' model -- with the
understanding based on Maldacena AdS/CFT. We show that the brick-wall
modification of a Klein Gordon field in the Hartle-Hawking-Israel state on
1+2-Schwarzschild AdS (BTZ) has a well-defined boundary limit with the same
temperature and entropy as the brick-wall-modified bulk theory. One of our main
purposes is to point out a close connection, for general AdS/CFT situations,
between the puzzle raised by Arnsdorf and Smolin regarding the relationship
between Rehren's algebraic holography and mainstream AdS/CFT and the puzzle
embodied in the 'correspondence principle' proposed by Mukohyama and Israel in
their work on the brick-wall approach to black hole entropy. Working on the
assumption that similar results will hold for bulk QFT other than the Klein
Gordon field and for Schwarzschild AdS in other dimensions, and recalling the
first author's proposed resolution to the Mukohyama-Israel puzzle based on his
'matter-gravity entanglement hypothesis', we argue that, in Maldacena AdS/CFT,
the algebra of the boundary CFT is isomorphic only to a proper subalgebra of
the bulk algebra, albeit (at non-zero temperature) the (GNS) Hilbert spaces of
bulk and boundary theories are still the 'same' -- the total bulk state being
pure, while the boundary state is mixed (thermal). We also argue from the
finiteness of its boundary (and hence, on our assumptions, also bulk) entropy
at finite temperature, that the Rehren dual of the Maldacena boundary CFT
cannot itself be a QFT and must, instead, presumably be something like a string
theory.Comment: 54 pages, 3 figures. Arguments strengthened in the light of B.S. Kay
`Instability of Enclosed Horizons' arXiv:1310.739
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