259 research outputs found
The brezis-ekeland-nayroles minimization principle with mixed finite element method for elastoplastic dynamic problems
We propose a modiïŹcation of the Hamiltonian formalism which can be used for dissipative systems, the Brezis-Ekeland-Nayroles principle. The formalism is specialized to the standard plasticity in small strains and dynamics. We apply it to solve the classical problem of a thin tube in plane strain subjected to an internal pressure. The continuum is discretized with mixed ïŹnite elements
The emergence of quantum capacitance in epitaxial graphene
We found an intrinsic redistribution of charge arises between epitaxial
graphene, which has intrinsically n-type doping, and an undoped substrate. In
particular, we studied in detail epitaxial graphene layers thermally elaborated
on C-terminated - (- ()). We have investigated
the charge distribution in graphene-substrate systems using Raman spectroscopy.
The influence of the substrate plasmons on the longitudinal optical phonons of
the substrates has been detected. The associated charge redistribution
reveals the formation of a capacitance between the graphene and the substrate.
Thus, we give for the first time direct evidence that the excess negative
charge in epitaxial monolayer graphene could be self-compensated by the
substrate without initial doping. This induced a previously unseen
redistribution of the charge-carrier density at the substrate-graphene
interface. There a quantum capacitor appears, without resorting to any
intentional external doping, as is fundamentally required for epitaxial
graphene. Although we have determined the electric field existing inside the
capacitor and revealed the presence of a minigap () for
epitaxial graphene on - face terminated carbon, it remains small in
comparison to that obtained for graphene on face terminated . The
fundamental electronic properties found here in graphene on substrates
may be important for developing the next generation of quantum technologies and
electronic/plasmonic devices.Comment: 26 pages, 8 figures, available online as uncorrected proof, Journal
of Materials Chemistry C (2016
Policy measures for reducing aquifer depletion in a context of climate change: the case of the coastal area of Cap-Bon
Groundwater resources are critically important for irrigated agriculture in Tunisia. However, excessive irrigation extractions where groundwater is slowly renewed are causing a widespread depletion of the aquifer systems, with the impacts of climate change expected to further exacerbate this problem. These circumstances call for the development of methodologies and analyses that can support the design of sustainable groundwater management policies. This paper presents a hydro-economic mathematical programming model that is used to evaluate the effects of different policy measures for reducing aquifer depletion in the Cap-Bon region of Tunisia. Three policies have been evaluated: a quota defining the maximum quantity of groundwater extractions, environmental taxation, and supply expansion with subsidized desalinated seawater. Overall, results highlight the economic and social tradeoffs among these different policy choices and the challenges facing the implementation of sustainable groundwater management in Tunisia. More specifically, results show the advantages of using subsidized desalinated seawater compared to the other two policy alternatives in terms of the value of agricultural production, farmersâ profits, and employment, despite of its sizeable budgetary burden
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Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study
Introduction: Sepsis is the leading cause of acute kidney injury (AKI) in critically ill patients. The Kidney in Sepsis and Septic Shock (Kid-SSS) study evaluated the value of proenkephalin A 119-159 (penkid)âa sensitive biomarker of glomerular function, drawn within 24 hours upon intensive care unit (ICU) admission and analyzed using a chemiluminescence immunoassayâfor kidney events in sepsis and septic shock. Methods: The Kid-SSS study was a substudy of Adrenomedullin and Outcome in Severe Sepsis and Septic Shock (AdrenOSS) (NCT02393781), a prospective, observational, multinational study including 583 patients admitted to the intensive care unit with sepsis or septic shock and a validation cohort of 525 patients from the French and euRopean Outcome reGistry in Intensive Care Units (FROG-ICU) study. The primary endpoint was major adverse kidney events (MAKEs) at day 7, composite of death, renal replacement therapy, and persistent renal dysfunction. The secondary endpoints included AKI, transient AKI, worsening renal function (WRF), and 28-day mortality. Results: Median age was 66 years (interquartile range 55â75), and 28-day mortality was 22% (95% confidence interval [CI] 19%â25%). Of the patients, 293 (50.3%) were in shock upon ICU admission. Penkid was significantly elevated in patients with MAKEs, persistent AKI, and WRF (median = 65 [IQR = 45â106] vs. 179 [114â242]; 53 [39â70] vs. 133 [79â196] pmol/l; and 70 [47â121] vs. 174 [93â242] pmol/l, all P < 0.0001), also after adjustment for confounding factors (adjusted odds ratio = 3.3 [95% CI = 1.8â6.0], 3.9 [95% CI = 2.1â7.2], and 3.4 [95% CI = 1.9â6.2], all P < 0.0001). Penkid increase preceded elevation of serum creatinine with WRF and was low in renal recovery. Conclusion: Admission penkid concentration was associated with MAKEs, AKI, and WRF in a timely manner in septic patients
Prevalence and associated risk factors of Shigella flexneri isolated from drinking water and retail raw foods in Peshawar, Pakistan
This study was designed to investigate the prevalence and associated risk factors of Shigella flexneri isolated from drinking water and retail raw food samples in Peshawar, Pakistan. A total of 1,020 different samples were collected from various areas of Peshawar between January 2016 and May 2017, followed by identification of S. flexneri through biochemical, serological, and 16S rRNA gene sequencing. Potential risk factors associated with the development and spreading of S. flexneri infection were also investigated. Overall, 45 (4.41%) samples were positive for Shigella species. Among these samples, the predominant species was S. flexneri (n = 44) followed by S. boydii (n = 1). Interestingly, S. sonnei and S. dysenteriae isolates were not found in any sample. The isolation rate of S. flexneri in drinking water samples, market raw milk, and fruits/vegetables from Peshawar were 6.47%, 3.5%, and 2.9%, respectively. The phylogenetic reconstruction showed genetic diversity among three clades, as clades I and II have isolates of S. flexneri that were circulating within the drinking water, milk, fruits/vegetables, while clade III isolates were recovered from milk samples. Most of S. flexneri were detected in June to September. Potential risk factors of S. flexneri were water sources contaminated by toilet wastes (p = 0.04), surface water drainage (p = 0.0002), hospital wastes (p = 0.01), unhygienic handling (p < 0.05), and transportation of raw food (p = 0.04). In conclusion, S. flexneri isolates of closely related lineage originating from non-clinical samples might be associated with an increased human risk to shigellosis in Pakistan, as significant numbers of S. flexneri were observed in the drinking water and retail raw food samples. PRACTICAL APPLICATION: This study demonstrated the presence of S. flexneri in drinking water and retail raw food samples which seem to possess a serious threat to public health. Potential sources of food and water contamination should properly be monitored by public health authorities to reduce cases of shigellosis
Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study
Background: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. Methods: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. Results: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM †70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8). Conclusions: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. Trial registration: ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015
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