Growth hormone secretory in healthy aged women and men of Tunisian population

With aging, men and women experience multiple hormonal changes, and in particular the activity of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis. This perturbation may be involved inaggravations of numerous abnormalities. In 64 healthy elderly, we determined the concentrations of GH in both sexes and its correlation with thyroid-stimulating hormone (TSH), the descriptive data, BMI,electrolytic assessment and some biochemical parameters. Collected data suggest that there was an age-dependent decrease in GH secretion. For TSH, there was a slight increase. The simple regressionanalysis revealed non-significant direct relation between these two hormones. We also found that BMI values were inversely related to the serum concentrations of these hormones. For the lipid metabolism,the positively correlated relation only exists between GH and total-cholesterol, on one hand, and between GH and LDL-cholesterol, on the other. For the other parameters such as glucose and triglycerides as well as HDL-cholesterol, this relation does not exist. For the BMI, this index shows a positively correlated relation with glucose and triglycerides. The electrolytic assessment shows that inmen, phosphorus was positively related to GH. In women, calcium and sodium were positively related to GH. Aging was found to be associated with decreased morning serum GH levels and slightly increased TSH levels in healthy elderly Tunisian population. Reduction of the GH-IGF-I axis in the elderly has important clinical implications. Indeed, this deficiency in GH could contribute to the decline of various functions associated with normal aging

Perinatal-lethal Gaucher disease presenting as hydrops fetalis

Perinatal-lethal Gaucher disease is very rare and is considered a variant of type 2 Gaucher disease that occurs in the neonatal period. The most distinct features of perinatal-lethal Gaucher disease are non-immune hydrops fetalis. Less common signs of the disease are hepatosplenomegaly, ichthyosis and arthrogryposis. We report a case of Gaucher's disease (type 2) diagnosed in a newborn who presented with Hydrops Fetalis

Accuracy of the Arabic HCL - 32 and MDQ in detecting patients with bipolar disorder

Background: Studies about the two most used and validated instruments for the early detection of Bipolar Disorder (BD), the 32 - item Hypomania Checklist (HCL - 32) and the Mood Disorder Questionnaire (MDQ), are scarce in non-Western countries. This study aimed to explore the reliability, factor structure, and criterion validity of their Arabic versions in a sample of Tunisian patients diagnosed with mood disorders. Methods: The sample included 59 patients with BD, 86 with unipolar Major Depressive Disorder (MDD) and 281 controls. Confirmatory factor analysis was applied to show that a single global score was an appropriate summary measure of the screeners in the sample. Receiver Operating Characteristic analysis was used to assess the capacity of the translated screeners to distinguish patients with BD from those with MDD and controls. Results: Reliability was good for both tools in all samples. The bifactor implementation of the most reported two-factor model had the best fit for both screeners. Both were able to distinguish patients diagnosed with BD from putatively healthy controls, and equally able to distinguish patients diagnosed with BD from patients with MDD. Conclusion: Both screeners work best in excluding the presence of BD in patients with MDD, which is an advantage in deciding whether or not to prescribe an antidepressant

Risk Sources Affecting the Asset Management Decision-Making Process in Manufacturing: A Systematic Review of the Literature

Part 4: Product and Asset Life Cycle Management in Smart Factories of Industry 4.0International audienceAsset Management (AM) is promising for value creation from assets in the long term. A major concern to this end relates with the capabilities to achieve effective AM decision-making at every organisational level, i.e. operational, tactical, and strategical. Therefore, the goal of this research, grounded on a systematic literature review, is to identify which are the main sources of uncertainty that may influence the achievement of AM system related objectives and, as such, should be taken into consideration in a risk-informed decision-making process. Taking the manufacturing sector as a reference, the risk sources addressed by the extant literature are identified and mapped against a reference classification scheme. As a result, the research offers a comprehensive framework where risk sources, affecting the AM decision-making process, are systematically mapped. Information management is found to be the main risk source when making asset-related decisions

A highly efficient green synthesis of 1, 8-dioxo-octahydroxanthenes

SmCl3 (20 mol%) has been used as an efficient catalyst for reaction between aromatic aldehydes and 5,5-dimethyl-1,3-cyclohexanedione at 120°C to give 1,8-dioxo-octahydroxanthene derivatives in high yield. The same reaction in water, at room temperature gave only the open chain analogue of 1,8-dioxo-octahydroxanthene. Use of eco-friendly green Lewis acid, readily available catalyst and easy isolation of the product makes this a convenient method for the synthesis of either of the products

A framework to embed Asset Management in production companies

open2noThe aim of this article is to investigate how to embed asset management in production companies. A framework is defined based on literature analysis and focus groups findings, in which the fundamentals to guide the integration of asset management are systematized. Two dimensions are identified—the asset life cycle and the hierarchical level of the asset-control activities—and four founding principles—life cycle, system, risk and asset-centric orientation—as levers to integrate asset management within an industrial organization. An empirical investigation is then developed through multiple case study involving eight production companies in Italy, with the purpose to map the elements of the framework against the real mechanisms in the industrial practices. This allows testing the relevance of the framework itself and demonstrating its potential as a support for companies to implement gap analysis on asset management practices. Empirical evidence on current practices of asset management in production companies is contextually unveiled.openRoda, Irene*; Macchi, MarcoRoda, Irene; Macchi, Marc

Cross-national variations in reported discrimination among people treated for major depression worldwide: The ASPEN/INDIGO international study

Background: No study has so far explored differences in discrimination reported by people with major depressive disorder (MDD) across countries and cultures. Aims: To (a) compare reported discrimination across different countries, and (b) explore the relative weight of individual and contextual factors in explaining levels of reported discrimination in people with MDD. Method: Cross-sectional multisite international survey (34 countries worldwide) of 1082 people with MDD. Experienced and anticipated discrimination were assessed by the Discrimination and Stigma Scale (DISC). Countries were classified according to their rating on the Human Development Index (HDI). Multilevel negative binomial and Poisson models were used. Results: People living in 'very high HDI' countries reported higher discrimination than those in 'medium/low HDI' countries. Variation in reported discrimination across countries was only partially explained by individual-level variables. The contribution of country-level variables was significant for anticipated discrimination only. Conclusions: Contextual factors play an important role in anticipated discrimination. Country-specific interventions should be implemented to prevent discrimination towards people with MDD