2,969 research outputs found
Thermal conductivity of diamond-loaded glues for the ATLAS particle physics detector
The ATLAS experiment is one of two large general-purpose particle detectors
at the Large Hadron Collider (LHC) at the CERN laboratory in Geneva,
Switzerland. ATLAS has been collecting data from the collisions of protons
since December 2009, in order to investigate the conditions that existed during
the early Universe and the origins of mass, and other topics in fundamental
particle physics. The innermost layers of the ATLAS detector will be exposed to
the most radiation over the first few years of operation at the LHC. In
particular, the layer closest to the beam pipe, the B-layer, will degrade over
time due to the added radiation. To compensate for its degradation, it will be
replaced with an Insertable B-Layer (IBL) around 2016. The design of and R&D
for the IBL is ongoing, as the hope is to use the most current technologies in
the building of this new sub-detector layer. One topic of interest is the use
of more thermally conductive glues in the construction of the IBL, in order to
facilitate in the dissipation of heat from the detector. In this paper the
measurement and use of highly thermally conductive glues, in particular those
that are diamond-loaded, will be discussed. The modified transient plane source
technique for thermal conductivity is applied in characterizing the glues
across a wide temperature range
Lagrangian Structure Functions in Turbulence: A Quantitative Comparison between Experiment and Direct Numerical Simulation
A detailed comparison between data from experimental measurements and
numerical simulations of Lagrangian velocity structure functions in turbulence
is presented. By integrating information from experiments and numerics, a
quantitative understanding of the velocity scaling properties over a wide range
of time scales and Reynolds numbers is achieved. The local scaling properties
of the Lagrangian velocity increments for the experimental and numerical data
are in good quantitative agreement for all time lags. The degree of
intermittency changes when measured close to the Kolmogorov time scales or at
larger time lags. This study resolves apparent disagreements between experiment
and numerics.Comment: 13 RevTeX pages (2 columns) + 8 figures include
Little angels: The mediation of parenting
This Article does not have an abstract
Gene expression in Leishmania is regulated predominantly by gene dosage
ABSTRACT Leishmania tropica, a unicellular eukaryotic parasite present in North and East Africa, the Middle East, and the Indian subcontinent, has been linked to large outbreaks of cutaneous leishmaniasis in displaced populations in Iraq, Jordan, and Syria. Here, we report the genome sequence of this pathogen and 7,863 identified protein-coding genes, and we show that the majority of clinical isolates possess high levels of allelic diversity, genetic admixture, heterozygosity, and extensive aneuploidy. By utilizing paired genome-wide high-throughput DNA sequencing (DNA-seq) with RNA-seq, we found that gene dosage, at the level of individual genes or chromosomal “somy” (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85% of total gene expression variation in genes with a 2-fold or greater change in expression. High gene copy number variation (CNV) among membrane-bound transporters, a class of proteins previously implicated in drug resistance, was found for the most highly differentially expressed genes. Our results suggest that gene dosage is an adaptive trait that confers phenotypic plasticity among natural Leishmania populations by rapid down- or upregulation of transporter proteins to limit the effects of environmental stresses, such as drug selection. IMPORTANCE Leishmania is a genus of unicellular eukaryotic parasites that is responsible for a spectrum of human diseases that range from cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL) to life-threatening visceral leishmaniasis (VL). Developmental and strain-specific gene expression is largely thought to be due to mRNA message stability or posttranscriptional regulatory networks for this species, whose genome is organized into polycistronic gene clusters in the absence of promoter-mediated regulation of transcription initiation of nuclear genes. Genetic hybridization has been demonstrated to yield dramatic structural genomic variation, but whether such changes in gene dosage impact gene expression has not been formally investigated. Here we show that the predominant mechanism determining transcript abundance differences (>85%) in Leishmania tropica is that of gene dosage at the level of individual genes or chromosomal somy
Identification of the DNA-Binding Domains of Human Replication Protein A That Recognize G-Quadruplex DNA
Replication protein A (RPA), a key player in DNA metabolism, has 6 single-stranded DNA-(ssDNA-) binding domains (DBDs) A-F. SELEX experiments with the DBDs-C, -D, and -E retrieve a 20-nt G-quadruplex forming sequence. Binding studies show that RPA-DE binds preferentially to the G-quadruplex DNA, a unique preference not observed with other RPA constructs. Circular dichroism experiments show that RPA-CDE-core can unfold the G-quadruplex while RPA-DE stabilizes it. Binding studies show that RPA-C binds pyrimidine- and purine-rich sequences similarly. This difference between RPA-C and RPA-DE binding was also indicated by the inability of RPA-CDE-core to unfold an oligonucleotide containing a TC-region 5′ to the G-quadruplex. Molecular modeling studies of
RPA-DE and telomere-binding proteins Pot1 and Stn1 reveal structural similarities between the proteins and illuminate potential DNA-binding sites for RPA-DE and Stn1. These data indicate that DBDs of RPA have different ssDNA recognition properties
Models of Individual Blue Stragglers
This chapter describes the current state of models of individual blue
stragglers. Stellar collisions, binary mergers (or coalescence), and partial or
ongoing mass transfer have all been studied in some detail. The products of
stellar collisions retain memory of their parent stars and are not fully mixed.
Very high initial rotation rates must be reduced by an unknown process to allow
the stars to collapse to the main sequence. The more massive collision products
have shorter lifetimes than normal stars of the same mass, while products
between low mass stars are long-lived and look very much like normal stars of
their mass. Mass transfer can result in a merger, or can produce another binary
system with a blue straggler and the remnant of the original primary. The
products of binary mass transfer cover a larger portion of the colour-magnitude
diagram than collision products for two reasons: there are more possible
configurations which produce blue stragglers, and there are differing
contributions to the blended light of the system. The effects of rotation may
be substantial in both collision and merger products, and could result in
significant mixing unless angular momentum is lost shortly after the formation
event. Surface abundances may provide ways to distinguish between the formation
mechanisms, but care must be taking to model the various mixing mechanisms
properly before drawing strong conclusions. Avenues for future work are
outlined.Comment: Chapter 12, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G.
Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe
Half Life of the Doubly-magic r-Process Nucleus 78Ni
Nuclei with magic numbers serve as important benchmarks in nuclear theory. In
addition, neutron-rich nuclei play an important role in the astrophysical rapid
neutron-capture process (r-process). 78Ni is the only doubly-magic nucleus that
is also an important waiting point in the r-process, and serves as a major
bottleneck in the synthesis of heavier elements. The half-life of 78Ni has been
experimentally deduced for the first time at the Coupled Cyclotron Facility of
the National Superconducting Cyclotron Laboratory at Michigan State University,
and was found to be 110 (+100 -60) ms. In the same experiment, a first
half-life was deduced for 77Ni of 128 (+27 -33) ms, and more precise half-lives
were deduced for 75Ni and 76Ni of 344 (+20 -24) ms and 238 (+15 -18) ms
respectively.Comment: 4 pages, 3 figure
Galactic Collapse of Scalar Field Dark Matter
We present a scenario for galaxy formation based on the hypothesis of scalar
field dark matter. We interpret galaxy formation through the collapse of a
scalar field fluctuation. We find that a cosh potential for the
self-interaction of the scalar field provides a reasonable scenario for
galactic formation, which is in agreement with cosmological observations and
phenomenological studies in galaxies.Comment: 4 pages, 3 figue
Does the Supreme Court Follow the Economic Returns? A Response to A Macrotheory of the Court
Today, there is a widespread idea that parents need to learn how to carry out their roles as parents. Practices of parental learning operate throughout society. This article deals with one particular practice of parental learning, namely nanny TV, and the way in which ideal parents are constructed through such programmes. The point of departure is SOS family, a series broadcast on Swedish television in 2008. Proceeding from the theorising of governmentality developed in the wake of the work of Michel Foucault, we analyse the parental ideals conveyed in the series, as an example of the way parents are constituted as subjects in the ‘advanced liberal society’ of today. The ideal parent is a subject who, guided by the coach, is constantly endeavouring to achieve a makeover. The objective of this endeavour, however, is self-control, whereby the parents will in the end become their own coaches.
The celebrity entrepreneur on television: profile, politics and power
This article examines the rise of the ‘celebrity entrepreneur’ on television through the emergence of the ‘business entertainment format’ and considers the ways in which regular television exposure can be converted into political influence. Within television studies there has been a preoccupation in recent years with how lifestyle and reality formats work to transform ‘ordinary’ people into celebrities. As a result, the contribution of vocationally skilled business professionals to factual entertainment programming has gone almost unnoticed. This article draws on interviews with key media industry professionals and begins by looking at the construction of entrepreneurs as different types of television personalities and how discourses of work, skill and knowledge function in business shows. It then outlines how entrepreneurs can utilize their newly acquired televisual skills to cultivate a wider media profile and secure various forms of political access and influence. Integral to this is the centrality of public relations and media management agencies in shaping media discourses and developing the individual as a ‘brand identity’ that can be used to endorse a range of products or ideas. This has led to policy makers and politicians attempting to mobilize the media profile of celebrity entrepreneurs to reach out and connect with the public on business and enterprise-related issues
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