Cadmium contamination and dietary exposure assessment in rice in Nanning City

Objective To understand the content of cadmium (Cd) in rice and evaluate the potential health risk to local residents. Methods Total of 886 rice samples were collected from Nanning City during 2015-2019, and the content of Cd in rice was determined by inductively coupled plasma-mass spectrometry (ICP-MS). The health risk assessment model recommended by the United States Environmental Protection Agency was used to assess the health risk of local residents. Results The detection rate of Cd in 886 rice samples was 94.92% (841/886), and the violation rate was 19.19% (170/886). The content of Cd range from 1.50 to 915.00 μg/kg, of which mean and median were 126.85 and 79.00 μg/kg, respectively. The dietary Cd exposure of people aged 6-17 was higher than that of people aged 18 and above. The dietary exposure to Cd was 12.43-23.95 μg/kg BW for people aged 18 and above, and the target hazard quotient (THQ) was below 1; however, the dietary exposure of Cd was 15.42-29.80 μg/kg BW for people aged 6-17, with THQ between 0.62 and 1.19. In Mashan, Shanglin and Longan, the THQ of people aged 6-17 was greater than 1. Conclusion There was a certain contamination of Cd in rice in this city, and might pose potential health risks to the people aged 6-17. Therefore, it is necessary to strengthen the monitoring and control of the contamination

Follow-up of the manganese-exposed workers healthy cohort (MEWHC) and biobank management from 2011 to 2017 in China

Abstract Background Long-term excess exposure to environmental manganese (Mn) can lead to multi-system damage, especially in occupational populations. Therefore, we established a manganese-exposed workers healthy cohort (MEWHC), focusing on the systemic health effects related to Mn exposure. Here, we aimed to describe the follow-up activity for the MEWHC study and establish a standardized biological sample bank for the scientific management of high-quality biospecimens and the attached data from 2011 to 2017. Methods Baseline examinations for onsite workers were conducted, and the biobank for the MEWHC was first established in 2011; follow-up examinations occurred four times between July 2012 and November 2017. All questionnaires, clinical data and biological samples were routinely collected during each follow-up activity. Additional workers were recruited in 2016, which further enriched the resources of the biobank. Results A total of 2359 onsite workers and 612 retired workers at a ferromanganese refinery were enrolled in the prospective cohort, and their biological samples were obtained in the preliminary baseline survey and the follow-up investigation, including 2971 blood and urine samples from the cohort. In addition, 1524 hair samples, 1404 nail (toe and finger nails) and 1226 fecal samples were also collected. All specimens were preserved in the biobank, and the data were scientifically managed using a computer system. Conclusions The MEWHC study in China provides an effective way to obtain biological samples such as plasma, DNA, hair and urine for storage in a biobank for further study. The standardized management of various samples is crucial for accessing high-quality biospecimens

Association Between Chinese Cooking Oil Fumes and Sleep Quality Among a Middle-Aged Chinese Population

Poor sleep quality is an important symptom of many medical or psychiatric disorders. However, the impact of cooking oil fumes (COFs) on sleep quality has not been studied. This population-based cross-sectional study was conducted to examine the association between COFs of Chinese household cooking and sleep quality. Individual sleep quality assessment was completed in 2197 participants with an average age of 37.52 years, through Pittsburgh Sleep Quality Index (PSQI). Information about their cooking practice were also collected by self-reported questionnaire. As an internal biomarker of COFs, urinary 1-hydroxypyrene (1-HOP) (n = 562) was further measured using high-performance liquid chromatography. Binary logistic regression models were performed to evaluate the association between exposure to COFs and individual sleep quality. We found that, subjective poor kitchen ventilation, preheating oil to smoking, and cooking for over 30 minutes were positively associated with overall poor sleep quality (global PSQI score \u3e5) [odds ratio (OR) = 1.75, 95% confidence interval (CI) = 1.43–2.16; 1.25, (1.03–1.52); 1.42, (1.15–1.76), respectively]. After adjusting for potential confounders, subjective poor kitchen ventilation still tend to increase the risk of long sleep latency, sleep disturbances, and daytime dysfunction [OR = 1.37, 95% CI = 1.09–1.73; 1.91, (1.39–2.61); 1.54, (1.23–1.93), respectively]. Similar results were observed in participants who preheated oil to smoking [OR = 1.36, 95% CI = 1.08–1.72; 1.55, (1.14–2.14); 1.25, (1.02–1.55), respectively] and cooked for over 30 minutes [OR = 1.34, 95% CI = 1.05–1.72; 1.46, (1.03–2.06); 1.36, (1.08–1.72), respectively]. Furthermore, high urinary 1-HOP level was also positively associated with overall poor sleep quality (OR = 2.30, 95% CI = 1.31–4.05). The results indicated that exposure to COFs from Chinese household cooking may be a risk factor for poor sleep quality among middle-aged Chinese population

Additional file 3: of Follow-up of the manganese-exposed workers healthy cohort (MEWHC) and biobank management from 2011 to 2017 in China

Table S2. Summary of the number of samples deposited in the biobank obtained from the heavy-metal cohort (MEWHC) initiated in 2011. (PDF 89 kb

Additional file 1: of Follow-up of the manganese-exposed workers healthy cohort (MEWHC) and biobank management from 2011 to 2017 in China

Table S1. Air monitoring of different workshops and jobs in the ferro-Mn alloy production plant in 2017. (PDF 107 kb

Additional file 2: of Follow-up of the manganese-exposed workers healthy cohort (MEWHC) and biobank management from 2011 to 2017 in China

Supplementary information for the biobank of the MEWHC. (PDF 398 kb