4,741 research outputs found
Summary of the NOW'98 Phenomenology Working Group
Summary of the Phenomenology Working Group at the Europhysics Neutrino
Oscillation Workshop (NOW'98), 7-9 September 1998, Amsterdam.Comment: 66 page
Magnetic structure and charge ordering in Fe3BO5 ludwigite
The crystal and magnetic structures of the three-leg ladder compound Fe3BO5
have been investigated by single crystal x-ray diffraction and neutron powder
diffraction. Fe3BO5 contains two types of three-leg spin ladders. It shows a
charge ordering transition at 283 K, an antiferromagnetic transition at 112 K,
ferromagnetism below 70 K and a weak ferromagnetic behavior below 40K. The
x-ray data reveal a smooth charge ordering and an incomplete charge
localization down to 110K. Below the first magnetic transition, the first type
of ladders orders as ferromagnetically coupled antiferromagnetic chains, while
below 70K the second type of ladders orders as antiferromagnetically coupled
ferromagnetic chains
Crystal structure of A3B3 complex of V-ATPase from Thermus thermophilus
Vacuolar-type ATPases (V-ATPases) exist in various cellular membranes of many organisms to regulate physiological processes by controlling the acidic environment. Here, we have determined the crystal structure of the A3B3 subcomplex of V-ATPase at 2.8 Å resolution. The overall construction of the A3B3 subcomplex is significantly different from that of the α3β3 sub-domain in FoF1-ATP synthase, because of the presence of a protruding ‘bulge' domain feature in the catalytic A subunits. The A3B3 subcomplex structure provides the first molecular insight at the catalytic and non-catalytic interfaces, which was not possible in the structures of the separate subunits alone. Specifically, in the non-catalytic interface, the B subunit seems to be incapable of binding ATP, which is a marked difference from the situation indicated by the structure of the FoF1-ATP synthase. In the catalytic interface, our mutational analysis, on the basis of the A3B3 structure, has highlighted the presence of a cluster composed of key hydrophobic residues, which are essential for ATP hydrolysis by V-ATPases
Collective-coordinate analysis of inhomogeneous nonlinear Klein-Gordon field theory
Two different sets of collective-coordinate equations for solitary solutions
of Nonlinear Klein-Gordon (NKG) model is introduced. The collective-coordinate
equations are derived using different approaches for adding the inhomogeneities
as exrernal potentials to the soliton equation of motion. Interaction of the
NKG field with a local inhomogeneity like a delta function potential wall and
also delta function potential well is investigated using the presented
collective-coordinate equations and the results of two different models are
compared. Most of the characters of the interaction are derived analytically.
Analytical results are also compared with the results of numerical simulations.Comment: 16 pages, 8 figures. Accepted for publication in Volume 43 of the
Brazilian Journal of Physic
Measurement of the muon decay spectrum with the ICARUS liquid Argon TPC
Examples are given which prove the ICARUS detector quality through relevant
physics measurements. We study the muon decay energy spectrum from a sample of
stopping muon events acquired during the test run of the ICARUS T600 detector.
This detector allows the spatial reconstruction of the events with fine
granularity, hence, the precise measurement of the range and dE/dx of the muon
with high sampling rate. This information is used to compute the calibration
factors needed for the full calorimetric reconstruction of the events. The
Michel rho parameter is then measured by comparison of the experimental and
Monte Carlo simulated muon decay spectra, obtaining rho = 0.72 +/- 0.06(stat.)
+/- 0.08(syst.). The energy resolution for electrons below ~50 MeV is finally
extracted from the simulated sample, obtaining (Emeas-Emc)/Emc =
11%/sqrt(E[MeV]) + 2%.Comment: 16 pages, 8 figures, LaTex, A4. Some text and 1 figure added. Final
version as accepted for publication in The European Physical Journal
Search for anomalies in the neutrino sector with muon spectrometers and large LArTPC imaging detectors at CERN
A new experiment with an intense ~2 GeV neutrino beam at CERN SPS is proposed
in order to definitely clarify the possible existence of additional neutrino
states, as pointed out by neutrino calibration source experiments, reactor and
accelerator experiments and measure the corresponding oscillation parameters.
The experiment is based on two identical LAr-TPCs complemented by magnetized
spectrometers detecting electron and muon neutrino events at Far and Near
positions, 1600 m and 300 m from the proton target, respectively. The ICARUS
T600 detector, the largest LAr-TPC ever built with a size of about 600 ton of
imaging mass, now running in the LNGS underground laboratory, will be moved at
the CERN Far position. An additional 1/4 of the T600 detector (T150) will be
constructed and located in the Near position. Two large area spectrometers will
be placed downstream of the two LAr-TPC detectors to perform charge
identification and muon momentum measurements from sub-GeV to several GeV
energy range, greatly complementing the physics capabilities. This experiment
will offer remarkable discovery potentialities, collecting a very large number
of unbiased events both in the neutrino and antineutrino channels, largely
adequate to definitely settle the origin of the observed neutrino-related
anomalies.Comment: Contribution to the European Strategy for Particle Physics - Open
Symposium Preparatory Group, Kracow 10-12 September 201
The Structure of the NPC1L1 N-Terminal Domain in a Closed Conformation
NPC1L1 is the molecular target of the cholesterol lowering drug Ezetimibe and mediates the intestinal absorption of cholesterol. Inhibition or deletion of NPC1L1 reduces intestinal cholesterol absorption, resulting in reduction of plasma cholesterol levels.Here we present the 2.8 Å crystal structure of the N-terminal domain (NTD) of NPC1L1 in the absence of cholesterol. The structure, combined with biochemical data, reveals the mechanism of cholesterol selectivity of NPC1L1. Comparison to the cholesterol free and bound structures of NPC1(NTD) reveals that NPC1L1(NTD) is in a closed conformation and the sterol binding pocket is occluded from solvent.The structure of NPC1L1(NTD) reveals a degree of flexibility surrounding the entrance to the sterol binding pocket, suggesting a gating mechanism that relies on multiple movements around the entrance to the sterol binding pocket
The effect of local crystalline environment on hydrogen atom behavior in molecular complexes of a proton sponge
Proton behavior within the hydrogen
bond (HB) networks of five
molecular complexes of the proton sponge DMAN and different organic
acids is investigated by single-crystal neutron diffraction. The complexes
form with either 2:1 (acid:DMAN) or 1:1 stoichiometric ratios and
contain common structural motifs. All show proton transfer from an
acid to DMAN, forming a DMANH<sup>+</sup> moiety and hydrogen-bonded
acid dimers; complexes with halobenzoic acids have acid molecules
linked by short, strong, charge-assisted HBs, while all complexes
contain a short, strong, intramolecular N–H···N
HB in DMANH<sup>+</sup>. The hydrogen atom behavior within the short,
strong HBs, accurately described from the neutron data, is rationalized
in terms of weak interactions in the local crystal environment, with
the position of the proton within both sets of short, strong HBs affected
by a combination of the weak interactions in the vicinity of the HBs.
A correlation is also found between the thermal motion of the bound
proton in the N–H···N HB of DMANH<sup>+</sup> and nearby oxygen atoms when they are sufficiently close to one
another. This work shows that all interactions in the local environment
combine to determine the behavior of protons within short, strong
HBs and that, by taking these interactions into account, further control
over the crystal structure and properties may be achievable
- …