Exposure to Video Display Terminals and Associated Neuromuscular Pain and Discomfort in Male and Female Undergraduate University Students

This paper explores the gender differences with respect to potential negative physical effects associated with prolonged Video Display Terminal (VDT) use. In this cross-sectional survey, we distributed self- reported health questionnaire along with the Nordic Musculoskeletal Questionnaire (NMQ) to 278 University of Ontario students (95 males and 183 females, aged between 17-32 years) in Oshawa, Ontario, Canada. Results showed that female students suffered more pain/discomfort in the neck/shoulder/hand and wrist (64.1%) in comparison to males (45.7%). Location of pain was also different in female students when compared to male students. This study provides preliminary evidence to suggest that female UOIT students experienced increased negative health effects on exposure to VDTs in comparison to male students. This study will help facilitate more targeted interventions towards millennials and assist them in reducing pain/discomfort they may experience when using devices with VDTs

The Place of Ethics in Young Marx's Critique of Political Economy

O presente artigo visa analisar os Manuscritos econômico-filosóficos de 1844 em vista da dimensão ética presente na crítica da economia política. Em linhas gerais, trata-se de compreender em que medida certa concepção da essência humana baliza a crítica. Para tanto, a investigação é dividida em quatro momentos, nas críticas ao “cinismo da economia política”, ao “trabalho alienado”, ao dinheiro e à “moral da economia política”.This paper aims to analyze the 1844 Economic-Philosophical Manuscripts in view of the ethical dimension present in the critique of political economy. In general terms, the aim is to understand to what extent a certain conception of the human essence guides the critique. To this end, the investigation is divided into four moments, in the critiques of the “cynicism of political economy”, “alienated labor”, money and the “morality of political economy”

SC83288 is a clinical development candidate for the treatment of severe malaria

Severe malaria is a life-threatening complication of an infection with the protozoan parasite Plasmodium falciparum, which requires immediate treatment. Safety and efficacy concerns with currently used drugs accentuate the need for new chemotherapeutic options against severe malaria. Here we describe a medicinal chemistry program starting from amicarbalide that led to two compounds with optimized pharmacological and antiparasitic properties. SC81458 and the clinical development candidate, SC83288, are fast-acting compounds that can cure a P. falciparum infection in a humanized NOD/SCID mouse model system. Detailed preclinical pharmacokinetic and toxicological studies reveal no observable drawbacks. Ultra-deep sequencing of resistant parasites identifies the sarco/endoplasmic reticulum Ca(2+) transporting PfATP6 as a putative determinant of resistance to SC81458 and SC83288. Features, such as fast parasite killing, good safety margin, a potentially novel mode of action and a distinct chemotype support the clinical development of SC83288, as an intravenous application for the treatment of severe malaria

Tecnologias da informação e da comunicação, vigilância e neoliberalismo

Em vista da discussão acerca da legitimidade do emprego de tecnologias de vigilância em massa no combate à pandemia do novo coronavírus, este artigo pretende investigar aquilo que, no fenômeno da vigilância, não é fruto de seu uso contextual, mas decorre da própria estrutura da produção e do consumo das Tecnologias da informação e comunicação, como argumenta Julian Assange. Nossa exposição considera que essas tecnologias operam segundo a racionalidade do neoliberalismo, entendida aqui no sentido de Dardot e Laval, enquanto expansão da lógica de mercado para todos os âmbitos da vida.

Graded elevation of c-Jun in Schwann cells in vivo: gene dosage determines effects on development, remyelination, tumorigenesis, and hypomyelination

Schwann cell c-Jun is implicated in adaptive and maladaptive functions in peripheral nerves. In injured nerves, this transcription factor promotes the repair Schwann cell phenotype and regeneration and promotes Schwann-cell-mediated neurotrophic support in models of peripheral neuropathies. However, c-Jun is associated with tumor formation in some systems, potentially suppresses myelin genes, and has been implicated in demyelinating neuropathies. To clarify these issues and to determine how c-Jun levels determine its function, we have generated c-Jun OE/+ and c-Jun OE/OE mice with graded expression of c-Jun in Schwann cells and examined these lines during development, in adulthood, and after injury using RNA sequencing analysis, quantitative electron microscopic morphometry, Western blotting, and functional tests. Schwann cells are remarkably tolerant of elevated c-Jun because the nerves of c-Jun OE/+ mice, in which c-Jun is elevated ∼6-fold, are normal with the exception of modestly reduced myelin thickness. The stronger elevation of c-Jun in c-Jun OE/OE mice is, however, sufficient to induce significant hypomyelination pathology, implicating c-Jun as a potential player in demyelinating neuropathies. The tumor suppressor P19ARF is strongly activated in the nerves of these mice and, even in aged c-Jun OE/OE mice, there is no evidence of tumors. This is consistent with the fact that tumors do not form in injured nerves, although they contain proliferating Schwann cells with strikingly elevated c-Jun. Furthermore, in crushed nerves of c-Jun OE/+ mice, where c-Jun levels are overexpressed sufficiently to accelerate axonal regeneration, myelination and function are restored after injury.SIGNIFICANCE STATEMENT In injured and diseased nerves, the transcription factor c-Jun in Schwann cells is elevated and variously implicated in controlling beneficial or adverse functions, including trophic Schwann cell support for neurons, promotion of regeneration, tumorigenesis, and suppression of myelination. To analyze the functions of c-Jun, we have used transgenic mice with graded elevation of Schwann cell c-Jun. We show that high c-Jun elevation is a potential pathogenic mechanism because it inhibits myelination. Conversely, we did not find a link between c-Jun elevation and tumorigenesis. Modest c-Jun elevation, which is beneficial for regeneration, is well tolerated during Schwann cell development and in the adult and is compatible with restoration of myelination and nerve function after injury

Deletion of the glycosyltransferase bgsB of Enterococcus faecalis leads to a complete loss of glycolipids from the cell membrane and to impaired biofilm formation

<p>Abstract</p> <p>Background</p> <p>Deletion of the glycosyltransferase <it>bgsA </it>in <it>Enterococcus faecalis </it>leads to loss of diglucosyldiacylglycerol from the cell membrane and accumulation of its precursor monoglucosyldiacylglycerol, associated with impaired biofilm formation and reduced virulence in vivo. Here we analyzed the function of a putative glucosyltransferase EF2890 designated <it>biofilm-associated glycolipid synthesis B (bgsB) </it>immediately downstream of <it>bgsA</it>.</p> <p>Results</p> <p>A deletion mutant was constructed by targeted mutagenesis in <it>E. faecalis </it>strain 12030. Analysis of cell membrane extracts revealed a complete loss of glycolipids from the cell membrane. Cell walls of 12030Δ<it>bgsB </it>contained approximately fourfold more LTA, and ¹H-nuclear magnetic resonance (NMR) spectroscopy suggested that the higher content of cellular LTA was due to increased length of the glycerol-phosphate polymer of LTA. 12030Δ<it>bgsB </it>was not altered in growth, cell morphology, or autolysis. However, attachment to Caco-2 cells was reduced to 50% of wild-type levels, and biofilm formation on polystyrene was highly impaired. Despite normal resistance to cationic antimicrobial peptides, complement and antibody-mediated opsonophagocytic killing in vitro, 12030Δ<it>bgsB </it>was cleared more rapidly from the bloodstream of mice than wild-type bacteria. Overall, the phenotype resembles the respective deletion mutant in the <it>bgsA </it>gene. Our findings suggest that loss of diglucosyldiacylglycerol or the altered structure of LTA in both mutants account for phenotypic changes observed.</p> <p>Conclusions</p> <p>In summary, BgsB is a glucosyltransferase that synthesizes monoglucosyldiacylglycerol. Its inactivation profoundly affects cell membrane composition and has secondary effects on LTA biosynthesis. Both cell-membrane amphiphiles are critical for biofilm formation and virulence of <it>E. faecalis</it>.</p

Caspase-8 Inactivation in T Cells Increases Necroptosis and Suppresses Autoimmunity in Bim−/−Bim^{−/−} Mice

Dysregulation of either the extrinsic or intrinsic apoptotic pathway can lead to various diseases including immune disorders and cancer. In addition to its role in the extrinsic apoptotic pathway, caspase-8 plays nonapoptotic functions and is essential for T cell homeostasis. The pro-apoptotic BH3-only Bcl-2 family member Bim is important for the intrinsic apoptotic pathway and its inactivation leads to autoimmunity that is further exacerbated by loss of function of the death receptor Fas. We report that inactivation of caspase-8 in T cells of $Bim^{−/−}$ mice restrained their autoimmunity and extended their life span. We show that, similar to $caspase-8^{−/−}$ T cells, $Bim^{−/−}$ T cells that also lack caspase-8 displayed elevated levels of necroptosis and that inhibition of this cell death process fully rescued the survival and proliferation of these cells. Collectively, our data demonstrate that inactivation of caspase-8 suppresses the survival and proliferative capacity of $Bim^{−/−}$ T cells and restrains autoimmunity in $Bim^{−/−}$ mice

Exploring Student and Advisor Experiences in a College-University Pathway Program: A Study of the Bachelor of Commerce Pathway

Currently, there is great interest across Ontario in the expansion of pathway programs between colleges and universities. Through strategic partnerships, two Ontario-based postsecondary institutions (a college and a university) have developed innovative and effective pathway programs that facilitate the transition of students between institutions for the completion of degrees, diplomas, and certificates. These programs support the training of highly qualified, market-ready graduates. This paper reports on a mixed-methods study of the successes and challenges of a particular Ontario college and university pathway program, with a focus on the Bachelor of Commerce Pathway program. Preliminary results indicate that pathway students were more academically successful than their traditional university student counterparts but did experience a number of challenges in transitioning from college into university. Principal challenges included inefficient communication between program administrators, academic advisors, and students; lack of orientation activities for pathway students; lack of college student preparedness in communication and critical thinking skills; and difficulties experienced by college students integrating into the social-cultural life of the university. &nbsp;Il existe présentement un grand intérêt partout en Ontario pour l’expansion de programmes de transfert entre collèges et universités. Grâce à des partenariats stratégiques, deux établissements postsecondaires localisés en Ontario (un collège et une université) ont créé des programmes de transferts innovateurs et efficaces qui facilitent la transition des élèves entre les établissements pour l’obtention de diplômes et de certificats. Ces programmes soutiennent la formation de diplômés hautement qualifiés, prêts pour le marché du travail. Le présent article présente une étude de méthodes mixtes portant sur les succès et les défis d’un programme de transfert particulier entre une université et un collège de l’Ontario, en misant particulièrement sur le programme de transfert du baccalauréat en commerce. Les résultats préliminaires indiquent que les étudiants du programme de transfert obtenaient de meilleurs résultats scolaires que leurs homologues aux études universitaires traditionnelles, mais qu’ils ont dû surmonter quelques défis pendant la transition du collège à l’université. Parmi les principaux défis, on trouve une communication inefficace entre les administrateurs de programmes, les conseillers pédagogiques et les étudiants; un manque d’activités d’orientation pour les étudiants des programmes de transfert; un manque de préparation en matière de communication et de pensée critique chez les collégiens; et des difficultés pour les collégiens à intégrer la vie sociale et culturelle de l’université

Population Genomics of Early Events in the Ecological Differentiation of Bacteria

Genetic exchange is common among bacteria, but its effect on population diversity during ecological differentiation remains controversial. A fundamental question is whether advantageous mutations lead to selection of clonal genomes or, as in sexual eukaryotes, sweep through populations on their own. Here, we show that in two recently diverged populations of ocean bacteria, ecological differentiation has occurred akin to a sexual mechanism: A few genome regions have swept through subpopulations in a habitat-specific manner, accompanied by gradual separation of gene pools as evidenced by increased habitat specificity of the most recent recombinations. These findings reconcile previous, seemingly contradictory empirical observations of the genetic structure of bacterial populations and point to a more unified process of differentiation in bacteria and sexual eukaryotes than previously thought.National Science Foundation (U.S.) (Grant DEB-0918333)Woods Hole Center for Oceans & Human HealthGordon and Betty Moore FoundationUnited States. Dept. of Energy. Genomes To Lif

Hematoma espontaneo de pared abdominal en gestantes con leucemia mieloide crónica: Reporte de caso

Se presenta el caso de una paciente de 43 años, con cuadro de Leucemia Mieloide Crónica en tratamiento con Imatinib, a quien se le suspende tratamiento por gestación de 15 semanas, no recibiendo medicación alguna el resto del embarazo. En la semana 26 de gestación cursa con dolor abdominal brusco, en hipocondrio derecho, opresivo, asociado a masa renitente, de crecimiento progresivo, a lo largo de recto abdominal derecho, que no pasa línea media, persiste con la contractura muscular y con caída del nivel de hemoglobina. Sometida a tratamiento quirúrgico, se encuentra un hematoma que es drenado, presentando sobreinfección del mismo y desarrollando un absceso de pared abdominal. Recibe tratamiento antibiótico prolongado y tiene una evolución favorable