EFFECT OF CONTACT ANGLE AND TANK GEOMETRY ON THE CONFIGURATION OF THE LIQUID-VAPOR INTERFACE DURING WEIGHTLESSNESS

Effect of contact angle and space vehicle tank geometry on configuration of rocket propellant liquid-vapor interface during weightlessnes

A latent class analysis of parental bipolar disorder: examining associations with offspring psychopathology

Bipolar disorder (BD) is highly heterogeneous, and course variations are associated with patient outcomes. This diagnostic complexity challenges identification of patients in greatest need of intervention. Additionally, course variations have implications for offspring risk. First, latent class analysis (LCA) categorized parents with BD based on salient illness characteristics: BD type, onset age, polarity of index episode, pole of majority of episodes, rapid cycling, psychosis, anxiety comorbidity, and substance dependence. Fit indices favored three parental classes with some substantively meaningful patterns. Two classes, labeled “Earlier-Onset Bipolar-I” (EO-I) and “Earlier-Onset Bipolar-II” (EO-II), comprised parents who had a mean onset age in mid-adolescence, with EO-I primarily BD-I parents and EO-II entirely BD-II parents. The third class, labeled “Later-Onset BD” (LO) had an average onset age in adulthood. Classes also varied on probability of anxiety comorbidity, substance dependence, psychosis, rapid cycling, and pole of majority of episodes. Second, we examined rates of disorders in offspring (ages 4–33, Mage=13.46) based on parental latent class membership. Differences emerged for offspring anxiety disorders only such that offspring of EO-I and EO-II parents had higher rates, compared to offspring of LO parents, particularly for daughters. Findings may enhance understanding of BD and its nosologyThis study was funded by two Brain & Behavior Research Foundation (formerly NARSAD) Independent Investigator Awards (PI: Nierenberg), a Brain & Behavior Research Foundation Young Investigator Award (PI: Henin) generously supported in part by the SHINE Initiative, and an MGH Claflin Award (PI: Henin). We thank David A. Langer, Ph.D., Thomas M. Olino, Ph.D., and Meredith Lotz Wallace, Ph.D. for their consultation. (Brain & Behavior Research Foundation; Brain & Behavior Research Foundation Young Investigator Award; SHINE Initiative; MGH Claflin Award)Accepted manuscrip

Modeling Two-Oscillator Circadian Systems Entrained by Two Environmental Cycles

Several experimental studies have altered the phase relationship between photic and non-photic environmental, 24 h cycles (zeitgebers) in order to assess their role in the synchronization of circadian rhythms. To assist in the interpretation of the complex activity patterns that emerge from these “conflicting zeitgeber” protocols, we present computer simulations of coupled circadian oscillators forced by two independent zeitgebers. This circadian system configuration was first employed by Pittendrigh and Bruce (1959), to model their studies of the light and temperature entrainment of the eclosion oscillator in Drosophila. Whereas most of the recent experiments have restricted conflicting zeitgeber experiments to two experimental conditions, by comparing circadian oscillator phases under two distinct phase relationships between zeitgebers (usually 0 and 12 h), Pittendrigh and Bruce compared eclosion phase under 12 distinct phase relationships, spanning the 24 h interval. Our simulations using non-linear differential equations replicated complex non-linear phenomena, such as “phase jumps” and sudden switches in zeitgeber preferences, which had previously been difficult to interpret. Our simulations reveal that these phenomena generally arise when inter-oscillator coupling is high in relation to the zeitgeber strength. Manipulations in the structural symmetry of the model indicated that these results can be expected to apply to a wide range of system configurations. Finally, our studies recommend the use of the complete protocol employed by Pittendrigh and Bruce, because different system configurations can generate similar results when a “conflicting zeitgeber experiment” incorporates only two phase relationships between zeitgebers

Physics of Quantum Relativity through a Linear Realization

The idea of quantum relativity as a generalized, or rather deformed, version of Einstein (special) relativity has been taking shape in recent years. Following the perspective of deformations, while staying within the framework of Lie algebra, we implement explicitly a simple linear realization of the relativity symmetry, and explore systematically the resulting physical interpretations. Some suggestions we make may sound radical, but are arguably natural within the context of our formulation. Our work may provide a new perspective on the subject matter, complementary to the previous approach(es), and may lead to a better understanding of the physics.Comment: 27 pages in Revtex, no figure; proof-edited version to appear in Phys.Rev.

Comments on the classification of the finite subgroups of SU(3)

Many finite subgroups of SU(3) are commonly used in particle physics. The classification of the finite subgroups of SU(3) began with the work of H.F. Blichfeldt at the beginning of the 20th century. In Blichfeldt's work the two series (C) and (D) of finite subgroups of SU(3) are defined. While the group series Delta(3n^2) and Delta(6n^2) (which are subseries of (C) and (D), respectively) have been intensively studied, there is not much knowledge about the group series (C) and (D). In this work we will show that (C) and (D) have the structures (C) \cong (Z_m x Z_m') \rtimes Z_3 and (D) \cong (Z_n x Z_n') \rtimes S_3, respectively. Furthermore we will show that, while the (C)-groups can be interpreted as irreducible representations of Delta(3n^2), the (D)-groups can in general not be interpreted as irreducible representations of Delta(6n^2).Comment: 15 pages, no figures, typos corrected, clarifications and references added, proofs revise

Recombination dramatically speeds up evolution of finite populations

We study the role of recombination, as practiced by genetically-competent bacteria, in speeding up Darwinian evolution. This is done by adding a new process to a previously-studied Markov model of evolution on a smooth fitness landscape; this new process allows alleles to be exchanged with those in the surrounding medium. Our results, both numerical and analytic, indicate that for a wide range of intermediate population sizes, recombination dramatically speeds up the evolutionary advance

FACING A CHANGING WORLD: THERMAL PHYSIOLOGY OF AMERICAN PIKAS (OCHOTONA PRINCEPS)

American pikas (Ochotona princeps) are of concern with respect to warming montane temperatures; however, little information exists regarding their physiological ability to adapt to warming temperatures. Previous studies have shown that pikas have high metabolism and low thermal conductance, which allow survival during cold winters. It has been hypothesized that these characteristics may be detrimental, given the recent warming trends observed in montane ecosystems. We examined resting metabolic rate, surface activity, and den and ambient temperatures (Ta) of pikas in late summer (August 2011 and 2012) at 2 locations in the Rocky Mountains. Resting metabolic rate was calculated to be 2.02 mL O2 ⋅ g−1h−1, with a lower critical temperature (LCT) of 28.1 –+ 0.2 °C. No upper critical temperature (UCT) could be determined from our data; therefore, the estimated thermoneutral zone (TNZ) was 28.1 °C to at least 35.0 °C (upper experimental temperature). Pikas in this study showed the same bimodal above-talus activity patterns reported in previous studies. Den temperatures in Colorado were correlated with, but consistently lower than, current ambient temperatures. Wyoming den temperatures showed a weak correlation with Ta 20 min prior to the current den temperature. This study is one of few to present data on the physiological response pikas may have to current warming conditions, and the first to perform metabolic measurements in situ. Our data support conclusions of previous studies, specifically MacArthur and Wang (1973, 1974) and Smith (1974), which indicated American pikas may not have the physiological ability to cope with high Ta. Our results also highlight the importance of shaded regions below the talus rocks for behavioral thermoregulation by pikas. RESUMEN.—La pica americana (Ochotona princeps) es una especie considerada de preocupación debido al aumento de la temperatura en las montañas. Sin embargo, existe poca información relacionada a su capacidad fisiológica para adaptarse a temperaturas más cálidas. Estudios previos han mostrado que las picas tienen un metabolismo alto y una conductividad térmica baja, lo que les permite sobrevivir en los inviernos fríos. Se ha planteado la hipótesis de que estas características pueden ser perjudiciales, dadas a las tendencias recientes de calentamiento en los ecosistemas de montaña. Examinamos la tasa metabólica en reposo, la actividad superficial y la temperatura en las madrigueras y la temperatura ambiente (Ta) de las picas a finales del verano (agosto de 2011 y 2012) en 2 áreas de las Montañas Rocosas. Calculamos que la tasa metabólica en reposo sería 2.02 mL O2 ⋅ g−1h−1, con una temperatura crítica inferior (LCT) de 28.1 –+ 0.2 °C. No pudimos determinar la temperatura crítica superior (UCT) a partir de nuestros datos; por lo tanto, la zona termoneutral estimada (TNZ) fue 28.1 a al menos 35.0 °C (temperatura experimental superior). Las picas en este estudio mostraron los mismos patrones bimodales de actividad por encima del talud que los reportados en estudios anteriores. La temperatura de las madrigueras en Colorado se correlacionaron con, pero siendo siempre inferiores, la temperatura am - biental actual. La temperatura de las madrigueras en Wyoming mostraron una correlación débil con la temperatura ambiente 20 minutos antes de la temperatura actual de la madriguera. Este estudio es uno de los pocos que presentan datos de las respuestas fisiológicas que las picas podrían tener en las condiciones actuales de calentamiento climático, y el primero en realizar mediciones metabólicas in situ. Nuestros datos respaldan conclusiones de estudios previos, particularmente MacArthur y Wang 1973 y 1974, y Smith 1974, que indican que las picas americanas pueden no tener la capacidad fisiológica para enfrentar las altas temperaturas ambientales y resalta la importancia de las regiones sombreadas bajo las rocas del talud para el comportamiento de termorregulación de las picas

Targeted disruption of py235ebp-1: Invasion of erythrocytes by Plasmodium yoelii using an alternative Py235 erythrocyte binding protein

Plasmodium yoelii YM asexual blood stage parasites express multiple members of the py235 gene family, part of the super-family of genes including those coding for Plasmodium vivax reticulocyte binding proteins and Plasmodium falciparum RH proteins. We previously identified a Py235 erythrocyte binding protein (Py235EBP-1, encoded by the PY01365 gene) that is recognized by protective mAb 25.77. Proteins recognized by a second protective mAb 25.37 have been identified by mass spectrometry and are encoded by two genes, PY01185 and PY05995/PY03534. We deleted the PY01365 gene and examined the phenotype. The expression of the members of the py235 family in both the WT and gene deletion parasites was measured by quantitative RT-PCR and RNA-Seq. py235ebp-1 expression was undetectable in the knockout parasite, but transcription of other members of the family was essentially unaffected. The knockout parasites continued to react with mAb 25.77; and the 25.77-binding proteins in these parasites were the PY01185 and PY05995/PY03534 products. The PY01185 product was also identified as erythrocyte binding. There was no clear change in erythrocyte invasion profile suggesting that the PY01185 gene product (designated PY235EBP-2) is able to fulfill the role of EBP-1 by serving as an invasion ligand although the molecular details of its interaction with erythrocytes have not been examined. The PY01365, PY01185, and PY05995/PY03534 genes are part of a distinct subset of the py235 family. In P. falciparum, the RH protein genes are under epigenetic control and expression correlates with binding to distinct erythrocyte receptors and specific invasion pathways, whereas in P. yoelii YM all the genes are expressed and deletion of one does not result in upregulation of another. We propose that simultaneous expression of multiple Py235 ligands enables invasion of a wide range of host erythrocytes even in the presence of antibodies to one or more of the proteins and that this functional redundancy at the protein level gives the parasite phenotypic plasticity in the absence of differences in gene expression