Opportunities in UK primary and secondary healthcare settings to prevent alcohol misuse

Background Alcohol-related deaths and hospital admissions have risen steeply in the United Kingdom and little is known about whether there are opportunities for preventive interventions or opportunities for the earlier detection of alcohol misuse. The purpose of this research was to investigate and describe patterns of healthcare utilisation in the pre-diagnosis period of alcoholic cirrhosis and alcoholic psychosis, two alcohol-related disorders which contribute significantly to alcohol related morbidity and mortality. This information is important as it could greatly facilitate a better understanding of opportunities for the earlier detection of alcohol misuse, and could also potentially encourage and assist practitioners in the timely identification of those who are at high risk of developing significant alcohol-related illnesses. Specific research objectives 1)To estimate rates of primary and secondary healthcare contacts before the diagnosis of alcoholic cirrhosis/psychosis and assess whether this differs from rates in the general population 2)To characterise the healthcare contacts and establish whether such consultations were for other conditions known to be related to alcohol. 3)As a secondary objective, to establish whether prior healthcare contacts led to recognition of alcohol problems and consequent interventions. Methods UK general practice and hospital admissions data were used for this research. A population of patients diagnosed with alcoholic cirrhosis and subsequently, a population of patients with alcoholic psychosis were identified. For each case, 10 patients without the disease who were of similar age and from the same general practice were selected as controls. For each disease group, a case-control study design was used to compare rates of primary care contacts and hospital admissions in cases to that of the control population. Further, the reasons for primary care visits and hospital admissions were assessed to describe the frequency of other alcohol-attributable morbidities in cases and controls, and to assess whether there were any morbidities which were strongly associated with the later development of alcoholic cirrhosis and psychosis. Finally, the proportions of patients who had a record of their alcohol use status or a record of an offer of brief alcohol intervention/referral were estimated. Results Alcoholic cirrhosis 2,479 patients with alcoholic cirrhosis and 24,790 controls matched on age and GP practice were available for analysis. Assessment of healthcare utilisation showed that people with alcoholic cirrhosis had 50% higher rate of GP visits and twice as many hospital admissions compared to the control population. This excess healthcare use was apparent as far as 10 years pre-diagnosis of alcoholic cirrhosis, but greater excesses were seen within 5 years of diagnosis. Cases of alcoholic cirrhosis did have a higher frequency of other conditions that are partly alcohol-attributable, especially diabetes, epileptic seizures, hypertensive diseases, injuries and digestive diseases. Of all these conditions, injuries, seizures and digestive diseases had the strongest association with the development of alcoholic cirrhosis. Overall, a high proportion of patients with alcoholic cirrhosis (84%) had their alcohol use documented on an average of 4 years before diagnosis and 58% of these records indicated harmful/hazardous drinking. However, only 1 in 5 patients (22%) had any record of a brief alcohol intervention or an alcohol referral. Alcoholic psychosis 1,731 patients with alcoholic psychosis and 17,310 matched controls were included in the study. As with alcoholic cirrhosis, there was a substantially higher rate of primary and secondary care use in cases which was apparent up to 10 years prior to disease diagnosis. Cases of alcoholic psychosis also had a higher frequency of partly alcohol attributable morbidities. However, the strongest associations were seen for intentional and unintentional injuries and seizures. 78% of cases of alcoholic psychosis did have their alcohol use recorded, 50% had a harmful/hazardous drinking record but only 1 in 5 (19%) had any intervention record. Conclusion and Implications: This research has shown that patients who misuse alcohol make frequent contacts with both primary and secondary care, suggesting that there are high number of opportunities within these healthcare settings to improve the early identification and treatment of alcohol use. Relatively few patients were identified to have received brief alcohol interventions/referral despite the large proportion of people with documented drinking problems, suggesting potential inadequacy in the treatment of alcohol problems. However, this may also partly be an artefact of recording biases. Considering that alcohol is one of the leading preventable causes of morbidity and mortality in the UK, these findings should encourage healthcare professionals to, at the very least, screen for alcohol misuse in patients presenting with any alcohol-attributable condition, and for policy makers to consider directing more effort towards integrating alcohol screening and brief intervention into routine clinical practice

Changes in testing for and incidence of celiac disease in the UK: a population-based cohort study

The diagnosis rates of coeliac disease differ substantially between countries. Intriguingly, there has been recent evidence from Olmstead County, USA and Finland that in the last 5-10 years incidence has plateaued or even declined. In most populations the prevalence also varies widely, serological prevalence from 0% to 1.87% and clinical prevalence from 0.9 to 12.9 per 100000. Understanding of why this variation exists is minimal, yet one of the key aspects governing incidence rates of any disease are “health system drivers”, such as the availability and use of diagnostic tests. We previously reported rising incidence rates of coeliac disease from 1990 to 2011with inequality by deprivation in the UK. Although national guidance on recognition and diagnosis of coeliac disease published in 2009 suggested widening the patient groups that should be tested for coeliac disease, NHS financial constraints could have hindered implementation of these guidelines. Indeed in the USA it has been observed that over the period 2000-2010 there was a marked decrease in treated prevalence of many diseases alongside a sustained period of reduced spending on health care

Healthcare Utilisation, Morbidities and Alcohol Use Monitoring Prior to Alcoholic Psychosis Diagnosis

Aims The aim of this study was to describe healthcare utilisation, morbidities and monitoring of alcohol use in patients prior to a diagnosis of alcoholic psychosis in order to inform the early identification of patients at risk. Methods Using linked general practice and hospitalisation data in England (April 1997 to June 2014), we identified 1731 individuals (≥18 years) with a clinical recorded diagnosis of alcoholic psychosis and 17,310 matched controls without the disorder, we examined all prior general practitioner (family doctor) visits, hospitalisations, medically recorded morbidities and alcohol assessment/interventions records. Poisson regression models were used to compare rates of healthcare utilisation in people with alcoholic psychosis to those without. Logistic regression models were used to evaluate the association between alcoholic psychosis and prior morbidities. Results Patients with alcoholic psychosis showed increased levels of healthcare utilisation at least 5 years prior to their diagnosis. The most common reasons for prior healthcare visits were seizures and injuries and there was >4-fold higher rate of seizures, unintentional injuries and self-harm incidents among these patients up to 10 years prior to diagnosis, compared to the control population. A high proportion (78%) of patients had their alcohol consumption recorded, 50% had a record of heavy drinking but only one in five had any evidence of receiving an alcohol-related intervention. Conclusion Patients present more often with seizures and injuries than the general population several years prior to a diagnosis of alcoholic psychosis. These visits represent opportunities for preventive action and imply that we may be missing opportunities to intervene

Sex and age differences in the early identification and treatment of alcohol use: a population-based study of patients with alcoholic cirrhosis

Aim: To estimate sex differences in health-care utilization among harmful/hazardous drinkers in the period before alcoholic cirrhosis diagnosis, and estimate sex differences in the extent to which alcohol use and brief alcohol interventions were documented for these individuals compared with a control cohort. Design: Retrospective study using linked general practice and hospital admissions data in England. Setting: Three hundred and fifty-seven general practitioner (GP) practices in England. Participants: A total of 2479 individuals with alcoholic cirrhosis (mean age at diagnosis = 56years), of whom 67% were men; and 24 790 controls without the disease. Measurements: Rates of primary care visits and hospital admissions prior to the diagnosis of alcoholic cirrhosis for men and women, and the proportion of men and women with alcohol consumption and/or alcohol brief intervention documented in their medical record. Findings: Compared with the general population, patients with alcoholic cirrhosis used primary and secondary health-care services more frequently in the years leading up to their diagnosis. In the years prior to diagnosis, men used primary and secondary health-care services more than did women (P for sex interaction P < 0.0001). Men were more likely than women to have their alcohol use recorded [odds ratio (OR) men = 1.96, 95% confidence interval (CI) = 1.7–2.3; women = 1.63, 95% CI = 1.4–1.8, P for sex interaction P < 0.0017]. By contrast, alcohol interventions were recorded more commonly among women (OR men = 4.3, 95% CI = 3.7–4.9; women = 5.8, 95% CI = 4.7–6.9, P for sex interaction = 0.07), although less common with increasing age (P for age interaction = 0.009). Conclusions: In the United Kingdom, prior to alcoholic cirrhosis diagnosis, excess health-care utilization is higher in men than women and men are more likely than women to have their alcohol use recorded. However, women appear to be more likely than men to receive alcohol brief interventions

Incidence, prevalence, and mortality of autoimmune hepatitis in England 1997‐2015. A population‐based cohort study

Background & Aims There are few population‐based studies of the incidence and mortality of autoimmune hepatitis. The burden of the disease and how it has changed over time have not been fully explored. We conducted a population‐based cohort study on the incidence and mortality of autoimmune hepatitis in England, 1997–2015. Methods From the Clinical Practice Research Datalink we included 882 patients diagnosed with autoimmune hepatitis in England, 1997‐2015. The patients were followed through 2015, and we calculated the sex‐ and age‐ standardised incidence and prevalence of autoimmune hepatitis. We examined variation in incidence by sex, age, calendar year, geographical region, and socioeconomic status, and incidence rate ratios were calculated with Poisson regression. We calculated all‐cause and cause‐specific mortality. Results The overall standardised incidence rate of autoimmune hepatitis was 2.08 (95% confidence interval 1.94‐2.22) per 100,000 population per year, higher in women, higher in older age, and independent of region and socioeconomic status. From 1997 to 2015 the incidence doubled from 1.27 (95% confidence interval 0.51‐2.02) to 2.56 (95% confidence interval 1.79‐3.33) per 100,000 population per year. The 10‐year cumulative all‐cause mortality was 31.9% (95% confidence interval 27.6‐36.5), and the 10‐year cumulative liver‐related mortality, including hepatocellular carcinoma was ~ 10.5%. Conclusions This population‐based study showed that the incidence of autoimmune hepatitis doubled over an eighteen‐year period. The incidence was particularly high in older women and was similar across all regions of England and independent of socioeconomic status. Patients with autoimmune hepatitis had a high mortality

Effectiveness of travel restrictions in the rapid containment of human influenza: a systematic review

To assess the effectiveness of internal and international travel restrictions in the rapid containment of influenza.We conducted a systematic review according to the requirements of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Health-care databases and grey literature were searched and screened for records published before May 2014. Data extraction and assessments of risk of bias were undertaken by two researchers independently. Results were synthesized in a narrative form.The overall risk of bias in the 23 included studies was low to moderate. Internal travel restrictions and international border restrictions delayed the spread of influenza epidemics by one week and two months, respectively. International travel restrictions delayed the spread and peak of epidemics by periods varying between a few days and four months. Travel restrictions reduced the incidence of new cases by less than 3%. Impact was reduced when restrictions were implemented more than six weeks after the notification of epidemics or when the level of transmissibility was high. Travel restrictions would have minimal impact in urban centres with dense populations and travel networks. We found no evidence that travel restrictions would contain influenza within a defined geographical area.Extensive travel restrictions may delay the dissemination of influenza but cannot prevent it. The evidence does not support travel restrictions as an isolated intervention for the rapid containment of influenza. Travel restrictions would make an extremely limited contribution to any policy for rapid containment of influenza at source during the first emergence of a pandemic virus

Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study

Abstract Background The management of perforated diverticular disease has changed in the past 10 years with a move towards less surgical intervention. This population-based cohort study aimed to define the risk of death and readmission following non-operative management of perforated diverticular disease. Methods Patients diagnosed with perforated diverticular disease and managed without surgery were identified from the linked Clinical Practice Research Datalink and Hospital Episode Statistics data from 2000 to 2013. The outcomes were 1-year case fatality, readmissions, and surgery at readmission. Results In total, 880 patients with perforated diverticular disease were managed without surgery, comprising 523 women (59.4 per cent). The 1-year case fatality rate was 33.2 per cent (293 of 880). The majority of deaths occurred in the first 90 days after the index admission, with a 90-day case fatality rate of 28.8 per cent. The 90-day survival rate varied by age, and was 97.2 per cent among those aged less than 65 years, compared with 85.0 per cent for those aged between 65 and 74 years, and 47.7 per cent in those at least 75 years old. Of 767 patients discharged from hospital, 250 (32.6 per cent) were readmitted (47 elective, 6.1 per cent; 203 emergency, 26.5 per cent) during a median of 1.6 (i.q.r. 0.1–3.9) years of follow-up, with similar proportions in each age category. In the first year of follow-up, only 5.1 per cent of patients required surgery, of whom 16 of 767 (2.1 per cent) required elective and 23 (3.0 per cent) emergency operation. Conclusion Non-operative management of perforated diverticulitis in those aged less than 65 years is feasible and safe. Reintervention rates following conservative management were low across all age categories

Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data

BACKGROUND & AIMS:Cirrhosis, the prevalence of which is increasing, is a risk factor for osteoporosis and fractures. However, little is known of the actual risk of hip fractures in patients with alcoholic cirrhosis. Using linked primary and secondary care data from the English and Danish nationwide registries, we quantified the hip fracture risk in two national cohorts of patients with alcoholic cirrhosis. METHODS:We followed 3,706 English and 17,779 Danish patients with a diagnosis of alcoholic cirrhosis, and we identified matched controls from the general populations. We estimated hazard ratios (HR) of hip fracture for patients vs. controls, adjusted for age, sex and comorbidity. RESULTS:The five-year hip fracture risk was raised both in England (2.9% vs. 0.8% for controls) and Denmark (4.6% vs. 0.9% for controls). With confounder adjustment, patients with cirrhosis had fivefold (adjusted HR 5.5; 95% CI 4.3-6.9), and 8.5-fold (adjusted HR 8.5; 95% CI 7.8-9.3) increased rates of hip fracture, in England and Denmark, respectively. This association between alcoholic cirrhosis and risk of hip fracture showed significant interaction with age (p <0.001), being stronger in younger age groups (under 45 years, HR 17.9 and 16.6 for English and Danish patients, respectively) than in patients over 75 years (HR 2.1 and 2.9, respectively). In patients with alcoholic cirrhosis, 30-day mortality following a hip fracture was 11.1% in England and 10.0% in Denmark, giving age-adjusted post-fracture mortality rate ratios of 2.8(95% CI 1.9-3.9) and 2.0(95% CI 1.5-2.7), respectively. CONCLUSIONS:Patients with alcoholic cirrhosis have a markedly increased risk of hip fracture and post-hip fracture mortality compared with the general population. These findings support the need for more effort towards fracture prevention in this population, to benefit individuals and reduce the societal burden. LAY SUMMARY:Alcoholic cirrhosis creates a large public health burden and is a risk factor for bone fractures. Based on data from England and Denmark, we found that hip fractures occur more than five times more frequently in people with alcoholic cirrhosis than in people without the disease. Additionally, the aftermath of the hip fracture is severe, such that up to 11% of patients with alcoholic cirrhosis die within 30 days after their hip fracture. These results suggest that efforts directed towards fracture prevention in people with alcoholic cirrhosis could be beneficial

GP incentives to design hypertension and atrial fibrillation local quality-improvement schemes: a controlled before-after study in UK primary care

Financial incentives in the UK such as the Quality and Outcomes Framework (QOF) reward GP surgeries for achievement of nationally defined targets. These have shown mixed results, with weak evidence for some measures, but also possible unintended negative effects. To look at the effects of a local intervention for atrial fibrillation (AF) and hypertension, with surgeries rewarded financially for work, including appointing designated practice leads, attendance at peer review workshops, and producing their own protocols. A controlled before-after study comparing surgery performance measures in UK primary care. This study used published QOF data to analyse changes from baseline in mean scores per surgery relating to AF and hypertension prevalence and management at T1 (12 months) and T2 (24 months) for the intervention group, which consisted of all 58 surgeries in East Lancashire Clinical Commissioning Group (CCG), compared to the control group, which consisted of all other surgeries in north-west England. There was a small acceleration between T0 (baseline) and T2 in recorded prevalence of hypertension in the intervention group compared to the controls, difference 0.29% (95% confidence interval [CI] = 0.05 to 0.53), = 0.017, but AF prevalence did not increase more in the intervention group. Improvement in quality of management of AF was significantly better in the intervention group, difference 3.24% (95% CI = 1.37 to 5.12), = 0.001. This intervention improved diagnosis rates of hypertension but not AF, though it did improve quality of AF management. It indicates that funded time to develop quality-improvement measures targeted at a local population and involving peer support can engage staff and have the potential to improve quality. [Abstract copyright: © British Journal of General Practice 2019.

Opportunities in UK primary and secondary healthcare settings to prevent alcohol misuse

Background Alcohol-related deaths and hospital admissions have risen steeply in the United Kingdom and little is known about whether there are opportunities for preventive interventions or opportunities for the earlier detection of alcohol misuse. The purpose of this research was to investigate and describe patterns of healthcare utilisation in the pre-diagnosis period of alcoholic cirrhosis and alcoholic psychosis, two alcohol-related disorders which contribute significantly to alcohol related morbidity and mortality. This information is important as it could greatly facilitate a better understanding of opportunities for the earlier detection of alcohol misuse, and could also potentially encourage and assist practitioners in the timely identification of those who are at high risk of developing significant alcohol-related illnesses. Specific research objectives 1)To estimate rates of primary and secondary healthcare contacts before the diagnosis of alcoholic cirrhosis/psychosis and assess whether this differs from rates in the general population 2)To characterise the healthcare contacts and establish whether such consultations were for other conditions known to be related to alcohol. 3)As a secondary objective, to establish whether prior healthcare contacts led to recognition of alcohol problems and consequent interventions. Methods UK general practice and hospital admissions data were used for this research. A population of patients diagnosed with alcoholic cirrhosis and subsequently, a population of patients with alcoholic psychosis were identified. For each case, 10 patients without the disease who were of similar age and from the same general practice were selected as controls. For each disease group, a case-control study design was used to compare rates of primary care contacts and hospital admissions in cases to that of the control population. Further, the reasons for primary care visits and hospital admissions were assessed to describe the frequency of other alcohol-attributable morbidities in cases and controls, and to assess whether there were any morbidities which were strongly associated with the later development of alcoholic cirrhosis and psychosis. Finally, the proportions of patients who had a record of their alcohol use status or a record of an offer of brief alcohol intervention/referral were estimated. Results Alcoholic cirrhosis 2,479 patients with alcoholic cirrhosis and 24,790 controls matched on age and GP practice were available for analysis. Assessment of healthcare utilisation showed that people with alcoholic cirrhosis had 50% higher rate of GP visits and twice as many hospital admissions compared to the control population. This excess healthcare use was apparent as far as 10 years pre-diagnosis of alcoholic cirrhosis, but greater excesses were seen within 5 years of diagnosis. Cases of alcoholic cirrhosis did have a higher frequency of other conditions that are partly alcohol-attributable, especially diabetes, epileptic seizures, hypertensive diseases, injuries and digestive diseases. Of all these conditions, injuries, seizures and digestive diseases had the strongest association with the development of alcoholic cirrhosis. Overall, a high proportion of patients with alcoholic cirrhosis (84%) had their alcohol use documented on an average of 4 years before diagnosis and 58% of these records indicated harmful/hazardous drinking. However, only 1 in 5 patients (22%) had any record of a brief alcohol intervention or an alcohol referral. Alcoholic psychosis 1,731 patients with alcoholic psychosis and 17,310 matched controls were included in the study. As with alcoholic cirrhosis, there was a substantially higher rate of primary and secondary care use in cases which was apparent up to 10 years prior to disease diagnosis. Cases of alcoholic psychosis also had a higher frequency of partly alcohol attributable morbidities. However, the strongest associations were seen for intentional and unintentional injuries and seizures. 78% of cases of alcoholic psychosis did have their alcohol use recorded, 50% had a harmful/hazardous drinking record but only 1 in 5 (19%) had any intervention record. Conclusion and Implications: This research has shown that patients who misuse alcohol make frequent contacts with both primary and secondary care, suggesting that there are high number of opportunities within these healthcare settings to improve the early identification and treatment of alcohol use. Relatively few patients were identified to have received brief alcohol interventions/referral despite the large proportion of people with documented drinking problems, suggesting potential inadequacy in the treatment of alcohol problems. However, this may also partly be an artefact of recording biases. Considering that alcohol is one of the leading preventable causes of morbidity and mortality in the UK, these findings should encourage healthcare professionals to, at the very least, screen for alcohol misuse in patients presenting with any alcohol-attributable condition, and for policy makers to consider directing more effort towards integrating alcohol screening and brief intervention into routine clinical practice