Functional Recovery and Serum Angiogenin Changes According to Intensity of Rehabilitation Therapy After Stroke

Rehabilitation is still the only treatment available to improve functional status after the acute phase of stroke. Most clinical guidelines highlight the need to design rehabilitation treatments considering starting time, intensity, and frequency, according to the tolerance of the patient. However, there are no homogeneous protocols and the biological effects are under investigation. To investigate the impact of rehabilitation intensity (hours) after stroke on functional improvement and serum angiogenin (ANG) in a 6-month follow-up study. A prospective, observational, longitudinal, and multicenter study with three cohorts: strokes in intensive rehabilitation therapy (IRT, minimum 15 h/week) vs. conventional therapy (NO-IRT, <15 h/week), and controls subjects (without known neurological, malignant, or inflammatory diseases). A total of seven centers participated, with functional evaluations and blood sampling during follow-up. The final cohort includes 62 strokes and 43 controls with demographic, clinical, blood samples, and exhaustive functional monitoring. The median (IQR) number of weekly hours of therapy was different: IRT 15 (15-16) vs. NO-IRT 7.5 (5-9), p < 0.01, with progressive and significant improvements in both groups. However, IRT patients showed earlier improvements (within 1 month) on several scales (CAHAI, FMA, and FAC; p < 0.001) and the earliest community ambulation achievements (0.89 m/s at 3 months). There was a significant difference in ANG temporal profile between the IRT and NO-IRT groups (p < 0.01). Additionally, ANG was elevated at 1 month only in the IRT group (p < 0.05) whereas it decreased in the NO-IRT group (p < 0.05). Our results suggest an association of rehabilitation intensity with early functional improvements, and connect the rehabilitation process with blood biomarkers

La interdisciplina en el estudio de la forma urbana

Con esta edición se busca crear una plataforma analítica y de discusión sobre la importancia de la interdisciplina en el estudio de la forma de la ciudad. Por ello, en esta publicación se aborda el tema “Forma urbana e interdisciplina” a partir de cuatro ejes temáticos: Análisis y diagnósticos de la forma urbana; procesos históricos de la forma urbana; planes y proyectos urbanos e impactos en la forma urbana. Se espera que el material presentado cumpla con sus objetivos y que su lectura contribuya a ampliar el panorama de reflexión y discusión sobre el tema de la interdisciplina en el estudio de la forma urbana.Elizabeth Espinosa Dorantes; Christof Göbel; Salomón González Arrellano (sic), coordinadore