Multidrug efflux pumps:structure, function and regulation

Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities

EUREC⁴A

The science guiding the EUREC⁴A campaign and its measurements is presented. EUREC⁴A comprised roughly 5 weeks of measurements in the downstream winter trades of the North Atlantic – eastward and southeastward of Barbados. Through its ability to characterize processes operating across a wide range of scales, EUREC⁴A marked a turning point in our ability to observationally study factors influencing clouds in the trades, how they will respond to warming, and their link to other components of the earth system, such as upper-ocean processes or the life cycle of particulate matter. This characterization was made possible by thousands (2500) of sondes distributed to measure circulations on meso- (200 km) and larger (500 km) scales, roughly 400 h of flight time by four heavily instrumented research aircraft; four global-class research vessels; an advanced ground-based cloud observatory; scores of autonomous observing platforms operating in the upper ocean (nearly 10 000 profiles), lower atmosphere (continuous profiling), and along the air–sea interface; a network of water stable isotopologue measurements; targeted tasking of satellite remote sensing; and modeling with a new generation of weather and climate models. In addition to providing an outline of the novel measurements and their composition into a unified and coordinated campaign, the six distinct scientific facets that EUREC⁴A explored – from North Brazil Current rings to turbulence-induced clustering of cloud droplets and its influence on warm-rain formation – are presented along with an overview of EUREC⁴A's outreach activities, environmental impact, and guidelines for scientific practice. Track data for all platforms are standardized and accessible at https://doi.org/10.25326/165 (Stevens, 2021), and a film documenting the campaign is provided as a video supplement

Miteinander arbeiten, miteinander reden

Miteinander arbeiten, miteinander reden : vom Gespräch in unserer Arbeitswelt. - München : Bayer. Staatsministerium für Arbeit u. Sozialordnung, 1981. - 91 S

Über einen Fall von Geistersehen

Über einen Fall von Geistersehen : d. Professionalisierung d. Personalwesens. - In: Die Betriebswirtschaft. 47. 1987. S. 508-51

Organisationstheorien

Organisationstheorien. - In: Organisationspsychologie / hrsg. von Erwin Roth ... - Göttingen u.a. : Hogrefe, 1989. - S. 205-250. - (Enzyklopädie der Psychologie ; D III,3

Der Mensch ist Mittelpunkt, der Mensch ist Mittel - Punkt

Der Mensch ist Mittelpunkt, der Mensch ist Mittel - Punkt : 8 Thesen zum Personalwesen. - In: Personalführung. 1990.1. S. 3-1

Das Konzept der Selbstentwicklung

Das Konzept der Selbstentwicklung. - In: Ergänzungen / Matthias Haller ... (Hrsg.) - Bern u.a. : Haupt, 1990. - S. 199-20

Pfützner, Robert: Kooperativ führen

Pfützner, Robert: Kooperativ führen : e. Führungslehre für Vorgesetzte / von Robert Pfützner. Mitarb. u. Fachberatung: Oswald Neuberger. - 6., überarb. Aufl. - Köln : Bachem, 1994. - 147 S

Humor. - Oppertunismus. - Spiel. - Witz

Humor. - Oppertunismus. - Spiel. - Witz. - In: Wörterbuch der Mikropolitik / Peter Heinrich ... (Hrsg.). - Opladen : Leske + Budrich, 1998. - S. 101-103, 196-198, 259-262, 300 f