Pulmonary Hypertension in ICI Myocarditis: Insights from Right Heart Catheterization and EMR Data

A retrospective cohort study of ICI myocarditis patients, studying clinical outcomes of patients with different forms of hypertension, using validated RHC data.https://openworks.mdanderson.org/soar24/1005/thumbnail.jp

Nutrient fluxes through boundaries in the hypolimnion of Sau reservoir : expected patterns and unanticipated processes

By contrast to many natural lakes, the summer hypolimnion in advection-dominated systems like canyon-shaped reservoirs is not isolated from direct inputs from the river. This has important implications in the evolution of limnological features of the hypolimnion through the stratified period, especially if the river water directly plunges as a density current into the hypolimnion as a consequence of temperature differences. Taking the Sau Reservoir (Spain) as a prototype for this kind of systems, we present data from 11 years of monitoring to show how the river water entering the reservoir during summer is the main factor determining hypolimnetic nutrient concentrations. The empirical regression approach used all through the paper also stressed the effect of the improvement in water quality experienced by the river during the studied period on the improvement of the water quality stored in the summer hypolimnion of the reservoir. Since the change in river water quality was the consequence of the implementation of remediation measures at the basin scale, we advocate these solutions to manage reservoir eutrophication problems in this type of systems, which, in addition, had other unexpected benefits for the hypolimnetic water quality in Sau Reservoir.A diferencia de muchos lagos naturales, el hipolimnion que se forma en verano en sistemas dominados por la advección, como los embalses que inundan valles profundos y estrechos, no está aislado de las entradas directas desde el río. Esto tiene importantes implicaciones en la evolución de las características limnológicas del hipolimnion durante el periodo de estratificación, especialmente si el agua del río entra al embalse como una corriente de densidad directamente en el hipolimnion debido a diferencias de temperatura. Tomando el Embalse de Sau (España) como prototipo de este tipo de sistemas, mostramos 11 años de datos de un programa de monitoreo para ejemplificar cómo el agua del río que entra en verano al embalse es el factor determinante de la concentración de nutrientes en el hipolimnion. La aproximación de regresión empírica utilizada en el artículo también puso de manifiesto el efecto de la mejora en la calidad del agua que sufrió el río durante el periodo de estudio en la mejora del agua del agua embalsada en el hipolimnion. Ya que esta mejora en el río fue consecuencia de la implementación de medidas de restauración a nivel de la cuenca, promovemos estas soluciones para la gestión de problemas de eutrofización en este tipo de sistemas, que por otra parte mostraron ventajas inesperadas en el caso del hipolimnion del Embalse de Sau

Aniridia congénita y microcefalia en dos gemelas

Revisar casos y literatura sobre presencia de aniridia y microcefalia

Inestabilidad microsatelital en pacientes con cáncer colorectal hereditario sin poliposis (cchsp)

Determinar la frecuencia de Inestabilidad Microsatelital (IM) en pacientes con sospecha clínica de CCHSP, con el fin de iniciar el desarrollo de programas de aproximación diagnóstica

Amenorrea, baja talla y alteraciones cromosómicas ligadas al cromosoma x en la consulta de genética de la facultad de ciencias de la salud y el hospital universitario de neiva (1987-2001)

Identificar patologías frecuentes asociadas al cromosoma X, destacando edad y motivo de consultas de los pacientes

Caracterización de los sistemas de producción agropecuarios: caso municipio de Cumaral

El objetivo final de la caracterización de los sistemas de producción agropecuarios del Municipio de Cumara es el de tener una visión holística y multivariada de la situación actual y retrospectiva de las diferentes actividades que enmarcan el sector productivo agrícola y pecuario que permita tener elementos para la planificación de su desarrollo agropecuario así como también reorientar acciones de investigación y transferencia de tecnología por parte de las instituciones. El trabajo arroja información de tipo cualitativo y cuantitativo, incluye una metodología que forma parte de la investigación participativa y busca la integración de los diferentes actores que conforman la cadena productiva desde el momento de la siembra hasta la comercialización y/o destino final. En el presente artículo se exponen resultados que muestran al municipio de Cumaral con una tendencia marcaba al monocultivo (75% del área municipal está ocupada por pradera mejorada, arroz, palma africana y cítricos). Así mismo se determinan los arreglos agropecuarios teniendo en cuenta la dinámica espacial y temporal definiendo así cuatro arreglos agrícolas, un arreglo pecuario, uno agropecuario y dos forestales. Considerando que el área total del municipio" es de 61.861,97 ha y que el área ocupada por los arreglos agropecuarios representa el 98.54% se puede deducir y entrever la marcada vocación agropecuaria de esta región del departamento del Meta. De estos ocho arreglos agropecuarios, el comprendido por la pradera mejorada ocupa el 65.35% del área total del municipio

The HIV-1 reservoir landscape in persistent elite controllers and transient elite controllers.

BACKGROUNDPersistent controllers (PCs) maintain antiretroviral-free HIV-1 control indefinitely over time, while transient controllers (TCs) eventually lose virological control. It is essential to characterize the quality of the HIV reservoir in terms of these phenotypes in order to identify the factors that lead to HIV progression and to open new avenues toward an HIV cure.METHODSThe characterization of HIV-1 reservoir from peripheral blood mononuclear cells was performed using next-generation sequencing techniques, such as full-length individual and matched integration site proviral sequencing (FLIP-Seq; MIP-Seq).RESULTSPCs and TCs, before losing virological control, presented significantly lower total, intact, and defective proviruses compared with those of participants on antiretroviral therapy (ART). No differences were found in total and defective proviruses between PCs and TCs. However, intact provirus levels were lower in PCs compared with TCs; indeed the intact/defective HIV-DNA ratio was significantly higher in TCs. Clonally expanded intact proviruses were found only in PCs and located in centromeric satellite DNA or zinc-finger genes, both associated with heterochromatin features. In contrast, sampled intact proviruses were located in permissive genic euchromatic positions in TCs.CONCLUSIONSThese results suggest the need for, and can give guidance to, the design of future research to identify a distinct proviral landscape that may be associated with the persistent control of HIV-1 without ART.FUNDINGInstituto de Salud Carlos III (FI17/00186, FI19/00083, MV20/00057, PI18/01532, PI19/01127 and PI22/01796), Gilead Fellowships (GLD22/00147). NIH grants AI155171, AI116228, AI078799, HL134539, DA047034, MH134823, amfAR ARCHE and the Bill and Melinda Gates Foundation

Polyester urethane urea (PEUU) functionalization for enhanced anti-thrombotic performance: advancing regenerative cardiovascular devices through innovative surface modifications

Introduction: Thrombogenesis, a major cause of implantable cardiovascular device failure, can be addressed through the use of biodegradable polymers modified with anticoagulating moieties. This study introduces a novel polyester urethane urea (PEUU) functionalized with various anti-platelet deposition molecules for enhanced antiplatelet performance in regenerative cardiovascular devices.Methods: PEUU, synthesized from poly-caprolactone, 1,4-diisocyanatobutane, and putrescine, was chemically oxidized to introduce carboxyl groups, creating PEUU-COOH. This polymer was functionalized in situ with polyethyleneimine, 4-arm polyethylene glycol, seleno-L-cystine, heparin sodium, and fondaparinux. Functionalization was confirmed using Fourier-transformed infrared spectroscopy and X-ray photoelectron spectroscopy. Bio-compatibility and hemocompatibility were validated through metabolic activity and hemolysis assays. The anti-thrombotic activity was assessed using platelet aggregation, lactate dehydrogenase activation assays, and scanning electron microscopy surface imaging. The whole-blood clotting time quantification assay was employed to evaluate anticoagulation properties.Results: Results demonstrated high biocompatibility and hemocompatibility, with the most potent anti-thrombotic activity observed on pegylated surfaces. However, seleno-L-cystine and fondaparinux exhibited no anti-platelet activity.Discussion: The findings highlight the importance of balancing various factors and addressing challenges associated with different approaches when developing innovative surface modifications for cardiovascular devices

Heterostructured electrode with concentration gradient shell for highly efficient oxygen reduction at low temperature

Heterostructures of oxides have been widely investigated in optical, catalytic and electrochemical applications, because the heterostructured interfaces exhibit pronouncedly different transport, charge, and reactivity characteristics compared to the bulk of the oxides. Here we fabricated a three-dimensional (3D) heterostructured electrode with a concentration gradient shell. The concentration gradient shell with the composition of Ba0.5-xSr0.5-yCo0.8Fe0.2O3-δ (BSCF-D) was prepared by simply treating porous Ba0.5Sr0.5Co0.8Fe0.2O3-δ (BSCF) backbone with microwave-plasma. Electrochemical impedance spectroscopy reveals that the oxygen surface exchange rate of the BSCF-D is enhanced by ~250% that of the pristine BSCF due to the appearance of the shell. The heterostructured electrode shows an interfacial resistance as low as 0.148 Ω cm2 at 550°C and an unchanged electrochemical performance after heating treatment for 200 h. This method offers potential to prepare heterostructured oxides not only for electrochemical devices but also for many other applications that use ceramic materials