Complete (O_7,O_8) contribution to B -> X_s gamma at order alpha_s^2

We calculate the set of O(alpha_s^2) corrections to the branching ratio and to the photon energy spectrum of the decay process B -> X_s gamma originating from the interference of diagrams involving the electromagnetic dipole operator O_7 with diagrams involving the chromomagnetic dipole operator O_8. The corrections evaluated here are one of the elements needed to complete the calculations of the B -> X_s gamma branching ratio at next-to-next-to-leading order in QCD. We conclude that this set of corrections does not change the central value of the Standard Model prediction for Br(B -> X_s gamma) by more than 1 %.Comment: 19 pages, 8 figure

On the Numerical Evaluation of One-Loop Amplitudes: the Gluonic Case

We develop an algorithm of polynomial complexity for evaluating one-loop amplitudes with an arbitrary number of external particles. The algorithm is implemented in the Rocket program. Starting from particle vertices given by Feynman rules, tree amplitudes are constructed using recursive relations. The tree amplitudes are then used to build one-loop amplitudes using an integer dimension on-shell cut method. As a first application we considered only three and four gluon vertices calculating the pure gluonic one-loop amplitudes for arbitrary external helicity or polarization states. We compare our numerical results to analytical results in the literature, analyze the time behavior of the algorithm and the accuracy of the results, and give explicit results for fixed phase space points for up to twenty external gluons.Comment: 22 pages, 9 figures; v2: references added, version accepted for publicatio

On the Rational Terms of the one-loop amplitudes

The various sources of Rational Terms contributing to the one-loop amplitudes are critically discussed. We show that the terms originating from the generic (n-4)-dimensional structure of the numerator of the one-loop amplitude can be derived by using appropriate Feynman rules within a tree-like computation. For the terms that originate from the reduction of the 4-dimensional part of the numerator, we present two different strategies and explicit algorithms to compute them.Comment: 14 pages, 3 figures, uses axodraw.st

Streptococcus pneumoniae as an UncommonCause of Superinfected Pancreatic Pseudocysts

Abstract.: We report a patient with pancreatic pseudocysts that were superinfected with Streptococcus pneumoniae. The literature on the prevalence of superinfection of pancreatic tissue by S. pneumoniae, as well as on its prophylaxis and treatment, is reviewed. In addition, a possible pathophysiologic pathway is discusse

MR- arthrography: anatomic variant from link between lateral meniscus and anterior and posterior cruciate ligaments. A case report and review of the literature

Menisci congenital anomalies are rare morphologic abnormalities including accessory meniscus, discoid meniscus, double-layered meniscus, hypoplastic meniscus and ring-shaped meniscus (RSM). In a 35 year-old male patient, MR arthrography showed a bridging accessory bundle connecting the anterior cruciate ligament and posterior cruciate ligament with the posterior horn of the lateral meniscus. Arthroscopic examination showed a fan-like obstacle embracing the posterior horn of the lateral meniscus. It would be important to correctly identify this anatomical variant, because the bundle connecting the external meniscus to the ligaments of the central pivot can be misinterpreted as a meniscal fragment

Optimizing the Reduction of One-Loop Amplitudes

We present an optimization of the reduction algorithm of one-loop amplitudes in terms of master integrals. It is based on the exploitation of the polynomial structure of the integrand when evaluated at values of the loop-momentum fulfilling multiple cut-conditions, as emerged in the OPP-method. The reconstruction of the polynomials, needed for the complete reduction, is rended very versatile by using a projection-technique based on the Discrete Fourier Transform. The novel implementation is applied in the context of the NLO QCD corrections to u d-bar --> W+ W- W+

CutTools: a program implementing the OPP reduction method to compute one-loop amplitudes

We present a program that implements the OPP reduction method to extract the coefficients of the one-loop scalar integrals from a user defined (sub)-amplitude or Feynman Diagram, as well as the rational terms coming from the 4-dimensional part of the numerator. The rational pieces coming from the epsilon-dimensional part of the numerator are treated as an external input, and can be computed with the help of dedicated tree-level like Feynman rules. Possible numerical instabilities are dealt with the help of arbitrary precision routines, that activate only when needed.Comment: Version published in JHE

Full one-loop amplitudes from tree amplitudes

We establish an efficient polynomial-complexity algorithm for one-loop calculations, based on generalized $D$-dimensional unitarity. It allows automated computations of both cut-constructible {\it and} rational parts of one-loop scattering amplitudes from on-shell tree amplitudes. We illustrate the method by (re)-computing all four-, five- and six-gluon scattering amplitudes in QCD at one-loop.Comment: 27 pages, revte

Damaged axons promote OPC differentiation

Oligodendrocyte progenitor cell (OPC) differentiation is an important therapeutic target to promote remyelination in multiple sclerosis (MS). We previously reported hyperphosphorylated and aggregated microtubule-associated protein tau in MS lesions, suggesting its involvement in axonal degeneration. However, the influence of pathological tau-induced axonal damage on the potential for remyelination is unknown. Therefore, we investigated OPC differentiation in human P301S tau (P301S-htau) transgenic mice, both in vitro and in vivo following focal demyelination. In 2-month-old P301S-htau mice, which show hyperphosphorylated tau in neurons, we found atrophic axons in the spinal cord in the absence of prominent axonal degeneration. These signs of early axonal damage were associated with microgliosis and an upregulation of IL-1β and TNFα. Following in vivo focal white matter demyelination we found that OPCs differentiated more efficiently in P301S-htau mice than wild type (Wt) mice. We also found an increased level of myelin basic protein within the lesions, which however did not translate into increased remyelination due to higher susceptibility of P301S-htau axons to demyelination-induced degeneration compared to Wt axons. In vitro experiments confirmed higher differentiation capacity of OPCs from P301S-htau mice compared with Wt mice-derived OPCs. Because the OPCs from P301S-htau mice do not ectopically express the transgene, and when isolated from newborn mice behave like Wt mice-derived OPCs, we infer that their enhanced differentiation capacity must have been acquired through microenvironmental priming. Our data suggest the intriguing concept that damaged axons may signal to OPCs and promote their differentiation in the attempt at rescue by remyelination. GLIA 2016;64:457-471.This project was funded by the Multiple Sclerosis Society UK via the Cambridge Centre for Myelin Repair consortium, and core support grant from the Wellcome Trust and MRC to the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute