Enterotoxemia de los equinos: reporte inicial sobre la reproducción de la enterotoxemia equina (cólico inespecífico-infladera o sopladera).

Se reporta por primera vez en Colombia la enfermedad conocida como pastoreo de los equinos, al mismo tiempo que la reproducción de los síntomas clínicos y de los hallazgos de necropsia e histopatológicos mediante la inoculación endovenosa de un producto metabólico elaborado por Clostridium perfringens que se aisló de casos de campo. Manifestaciones clíncas: el animal se encuentra generalmente en hipotermia, el pulso es rápido, las respiraciones están disminuidas con disnea abdominal, las mucosas se encuentran cianóticas, hay secreción nasal serosa bilateral, sudoraciones copiosas, se presentan temblores musculares incoordinados y erráticos. Hallazgos de necropsia: la piel es reseca y poco elástica, con múltiples escoriaciones, los líquidos pericárdico y peritoneal se encuentran generalmente aumentados, se observan hilos de fibrina sobre las asas intestinales, se presentan múltiples petequias o equimosis subepicárdicas y subendocárdicas, la musculatura está congestionada, la mucosa traqueal se encuentra arborizada, en los pulmones se puede hallar edema incipiente y contenido gástrico en algunos bronquios. El estómago y el intestino delgado se encuentran muy dilatados y con contenidos líquidos fétidos, la mucosa intestinal presenta extensas áreas de hemorragia equimótica, así como la del ciego y el colon, los ganglios linfáticos mesentéricos se encuentran generalmente edematosos, congestionados y hemorrágicosEquinos-Caballo - caballo

SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants.

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody neutralization response and its evasion by emerging viral variants and variant of concern (VOC) are unknown, but critical to understand reinfection risk and breakthrough infection following vaccination. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus-cell fusion, and infectious SARS-CoV-2 neutralization were characterized in 807 serial samples from 233 reverse transcription polymerase chain reaction (RT-PCR)-confirmed Coronavirus Disease 2019 (COVID-19) individuals with detailed demographics and followed up to 7 months. A broad and sustained polyantigenic immunoreactivity against SARS-CoV-2 Spike, Membrane, and Nucleocapsid proteins, along with high viral neutralization, was associated with COVID-19 severity. A subgroup of "high responders" maintained high neutralizing responses over time, representing ideal convalescent plasma donors. Antibodies generated against SARS-CoV-2 during the first COVID-19 wave had reduced immunoreactivity and neutralization potency to emerging Spike variants and VOC. Accurate monitoring of SARS-CoV-2 antibody responses would be essential for selection of optimal responders and vaccine monitoring and design

SARS-CoV-2 neutralizing antibodies : longevity, breadth, and evasion by emerging viral variants

The Severe Acute Respiratory Syndrome Coronavirus 2 (SAU ARS-CoV-2) antibody neutralization response and its evasion by emerging viral variants and variant of concern (VOC) are unknown, but critical to understand reinfection risk and breakthrough infection following vaccination. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus–cell fusion, and infectious SARS-CoV-2 neutralization were characterized in 807 serial samples from 233 reverse transcription polymerase chain reaction (RT-PCR)–confirmed Coronavirus Disease 2019 (COVID-19) individuals with detailed demographics and followed up to 7 months. A broad and sustained polyantigenic immunoreactivity against SARS-CoV-2 Spike, Membrane, and Nucleocapsid proteins, along with high viral neutralization, was associated with COVID-19 severity. A subgroup of “high responders” maintained high neutralizing responses over time, representing ideal convalescent plasma donors. Antibodies generated against SARS-CoV-2 during the first COVID-19 wave had reduced immunoreactivity and neutralization potency to emerging Spike variants and VOC. Accurate monitoring of SARS-CoV-2 antibody responses would be essential for selection of optimal responders and vaccine monitoring and design

Virus isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for diagnostic and research purposes.

Isolation of the new pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for diagnostic and research purposes including assessment of novel therapeutics. Several primary and continuous cell lines are currently used, and new organoid and engineered cell lines are being developed for improved investigation and understanding of the human immune response to this virus. Here we review the growth of SARS-CoV-2 in reference standard cell lines, engineered cell lines and new developments in this field

Investigación para la constitución de la paz y la convivencia, concurso Hernán Henao Delgado, mejores propuestas monográficas de pregrado.

IP 1115-10-208-99Son 6 tesis de grado.v.1. Sociedades campesinas de la alta montaña. Sobreviviendo entre ganado,amapola, ambientalistas y grupos armados en el paramo de Las Hermosas, cordillera Central (departamentos deValle y Tolima) / Guillermo Ospina ; director: Jairo Tocancipa -- v.2. Analisis de las representaciones sociales del conflicto en la comisaria 17 de familia de Santa Fe de Bogotá : una mirada reflexiva ala conciliacioncomo herramienta educativa / Juanita Arango Restrepo -- v.3. Piel mulata, ritmo libre :identidad y relaciones de convivencia interetnica en la costa Pacifica de Nariño, Colombia / Stella Rodriguez Caceres ; director: Jaime Arocha Rodriguez -- v.4. Formas de violencia urbano populares. Monografias barriales :Bogotá, Medellin y Cali / Leandro Ramos Castiblanco -- v.5. Violencia, secretos y rumores : critica delos sistemas juridicos en Colombia / David Esteban Molina Castaño ; directora: Gloria Isabel Ocampo -'- v.6.Tercerosinocentes, consecuencias de vivir en medio de la violencia politica / Maria Ines Toro Martinez; directora: Sandra Turbay Ceballos.LIBRO(S): Violencia y criminalidad en Santander : 1985-1990,333333333333333analisis desus costos economicos / Jose;Nelson Camelo Mancilla. Bucaramanga : UIS, 2002. -- 271 p; 20cm. (Coleccion encuentros). -- ISBN 9589318940; Economia, violencia y paz / compiladores: Luis M. PerezGonzalez, Nelson Camelo Mancilla, Amado A. Guerrero;Rincon. -- Bucaramanga : UIS, 2002. -- 326 p. ; 20 cm. --ISBN9589318983

LRRC15 suppresses SARS-CoV-2 infection and controls collagen production

The coronavirus pandemic has given everyone in society an education on the harms of spread of respiratory illness. Young healthy athletes are far less likely to suffer severe adverse consequences of viral illnesses than the elderly and frail, but they are not completely immune. Chronic fatigue (overtraining) is an uncommon outcome and myocarditis a rare one, but they both warrant due consideration. It is, therefore, a sensible individual strategy to 'stay home when sick' if only for these risks. Traditionally though, athletes have tended to push through (train and play when ill) because of competing concerns, such as key events/matches and 'not wanting to let teammates down'. Data from both low COVID-19 and high COVID-19 countries show that the number of cardiovascular deaths in a society correlates with the number of respiratory deaths at the same time, further linking respiratory viruses to cardiovascular deaths. We are now more aware of public health obligations to prevent the spread of respiratory illnesses, in particular to protect the more vulnerable members the community. This hopefully will correspond with a change in the culture of sport to one where it is considered 'the right thing to do', to 'stay home when sick'

Yo soy Fidel : pensamiento y legado de una inmensidad histórica

Hay momentos en que la palabra no alcanza, no contiene, no hace falta, porque el silencio grita, aúlla, acompaña y entibia. Momentos en que los sentires se hacen música y poesía y canto, en que la austeridad ante el dolor, no es menos dolor, sino la respuesta digna ante quien te enseñó que la vida solo es viva en dignidad. Ha transcurrido casi un mes, que puede ser un día o un siglo, y aún sigue ante mis ojos la visión de un pueblo, una multitud, un océano de voces, que te nombran. "Fidel", dicen, y el eco va y viene en oleadas. Imposible describir el apretado aliento de esa multitud, la humedad salada de esas miles de voces, que nos están diciendo que te has multiplicado como los panes, que te has repartido entre los otros, lo que solo puede suceder cuando el amor es tan intenso que yéndote, regresas y de repente has dejado de ser ese hombre tan alto y tan fuerte para ser esos millones a los que te has entregado en cada acto de tu vida. Yo soy Fidel grita la multitud y el viento lleva las voces y las siembra y siguen naciendo Fideles por todas partes, y como nunca ahora, inalcanzable para el enemigo que acecha y cuyas garras no pudieron alcanzarte nunca, te conviertes en su pesadilla, algo que ni la más avanzada tecnología puede curar. Ya eres su sombra, pero además los has condenado a verte en cada uno de aquellos en que te has repartido, en cada mujer, hombre o niño, que salga de las oscuridades de la sumisión para alzarse como lo hacías tú ante cada injusticia en el mundo. Del capítulo "Yo soy Fidel", de Stella Callon

Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.

Although ACE2 is the primary receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to SARS-CoV-2 spike protein has not been described. Here, we use whole-genome CRISPR activation to identify host factors controlling cellular interactions with SARS-CoV-2. Our top hit was a TLR-related cell surface receptor called leucine-rich repeat-containing protein 15 (LRRC15). LRRC15 expression was sufficient to promote SARS-CoV-2 spike binding where they form a cell surface complex. LRRC15 mRNA is expressed in human collagen-producing lung myofibroblasts and LRRC15 protein is induced in severe Coronavirus Disease 2019 (COVID-19) infection where it can be found lining the airways. Mechanistically, LRRC15 does not itself support SARS-CoV-2 infection, but fibroblasts expressing LRRC15 can suppress both pseudotyped and authentic SARS-CoV-2 infection in trans. Moreover, LRRC15 expression in fibroblasts suppresses collagen production and promotes expression of IFIT, OAS, and MX-family antiviral factors. Overall, LRRC15 is a novel SARS-CoV-2 spike-binding receptor that can help control viral load and regulate antiviral and antifibrotic transcriptional programs in the context of COVID-19 infection

SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents.

Coronavirus disease 2019 (COVID-19) convalescents living in regions with low vaccination rates rely on post-infection immunity for protection against re-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We evaluate humoral and T cell immunity against five variants of concern (VOCs) in mild-COVID-19 convalescents at 12 months after infection with ancestral virus. In this cohort, ancestral, receptor-binding domain (RBD)-specific antibody and circulating memory B cell levels are conserved in most individuals, and yet serum neutralization against live B.1.1.529 (Omicron) is completely abrogated and significantly reduced for other VOCs. Likewise, ancestral SARS-CoV-2-specific memory T cell frequencies are maintained in >50% of convalescents, but the cytokine response in these cells to mutated spike epitopes corresponding to B.1.1.529 and B.1.351 (Beta) VOCs were impaired. These results indicate that increased antigen variability in VOCs impairs humoral and spike-specific T cell immunity post-infection, strongly suggesting that COVID-19 convalescents are vulnerable and at risk of re-infection with VOCs, thus stressing the importance of vaccination programs