On the Qualitative Analysis of Volterra IDDEs with Infinite Delay

This investigation deals with a nonlinear Volterra integro-differential equation with infinite retardation (IDDE).We will prove three new results on the stability, uniformly stability (US) and square integrability (SI) of solutions of that IDDE. The proofs of theorems rely on the use of an appropriate Lyapunov-Krasovskii functional (LKF). By the outcomes of this paper, we generalize and obtain some former results in mathematical literature under weaker conditions

İnvestigation Of Reaction Cross Sections Of 10,11B With Protons And Neutrons Of 0 – 30 Mev İncoming Energy Using Nuclear Models

Boron, plays an extremely important role in nuclear technology, comprised of 20% 10B and 80% 11B abundance rate in nature. Abundance of Turkey’s boron reserves makes these isotopes valuable in science and economy. In this work, for neutrons and protons in the 0 – 30 MeV energy range, cross section calculations of nuclear reactions with target 10B and 11B were obtained using different nuclear reactions codes as TALYS1.2, ALICE-ASH and CEM03. In preequilibrium calculations, Cascade Exciton Model is used. In equilibrium calculations, Weisskopf-Ewing model is used. Nuclear model calculation results were compared with experimental cross sections taken from Experimental Nuclear Reaction Data (EXFOR/CSISRS) library

CHITOSAN ADDED COMPOSITE VISCOSE YARN AND ITS POTENTIAL APPLICATION FOR DENIM FABRIC DEVELOPMENT

The rapid increase in consumption has led to the decrease and even extinction of natural resources on earth. The textile industry also has an important place in terms of consumption. The transition to more sustainable biodegradable products instead of established fossil-based materials has increased rapidly due to textile manufacturers and related industries, legal regulations, social responsibility commitments and increasing ecological awareness of customers. Developing new environmentally friendly, biodegradable material groups with new technologies or by modifying existing technologies has been the main goal of many researchers. In this context, we aimed to develop denim fabric that is effective against strong hospital bacteria by using the yarn containing biopolymer chitosan as a weft in denim production. Chitosan finds wide application in the textile industry due to its biodegradability, antibacterial activity and many more functionalities. Chitosan is used in biomedical textile applications in the textile industry, either as a wound healing, hemostatic (blood stopper), antibacterial, antifungal, either alone or modified to various derivatives or combined with other materials. In this context, instead of using chitosan as a coating material in our studies, chitosan-containing yarn was used in the production of denim fabric in order to distribute the chitosan more homogeneously and to increase the washing resistance. As a result, it was determined that the denim fabric developed by using chitosan-based yarn in weft in denim production reduces hospital bacteria (MRSA-Methicillin resistant staphylococcus aureus) by > 99%

Quantitative Assessment of Salivary Gland Parenchymal Vascularization Using Power Doppler Ultrasound and Superb Microvascular Imaging: A Potential Tool in the Diagnosis of Sjögren’s Syndrome

Background: Primary Sjögren’s syndrome is a chronic inflammatory autoimmune disease. Minor salivary gland biopsy is the gold standard for the diagnosis of primary Sjögren’s syndrome. Superb microvascular imaging, power Doppler ultrasound, and color Doppler of the salivary glands represent non-invasive, non-irradiating modality for evaluating the vascularity of the salivary glands in the diagnosis and follow-up of primary Sjögren’s syndrome. Aims: To evaluate the efficacy of superb microvascular imaging and vascularity index in salivary glands for the sonographic diagnosis of primary Sjögren’s syndrome. Study Design: Prospective case-control study. Methods: Twenty participants with primary Sjögren’s syndrome and 20 healthy subjects were included in the study. Both parotid glands and submandibular glands were evaluated by superb microvascular imaging, power Doppler ultrasound, and color Doppler. The diagnostic accuracy of superb microvascular imaging was compared using these techniques. Results: In the patient group, the vascularity index values of superb microvascular imaging in parotid glands and submandibular glands were 3.5±1.66, 5.06±1.94, respectively. While the same values were 1.0±0.98 and 2.44±1.34 in the control group (p?0.001). In the patient group, the vascularity index values of power Doppler ultrasound in parotid glands and submandibular glands were 1.3±1.20 and 2.59±1.82, respectively. While the same values were 0.3±0.32 and 0.85±0.68 in the control group (p?0.001). The superb microvascular imaging vascularity index cut-off value for the diagnosis of primary Sjögren’s syndrome in parotid glands that maximizes the accuracy was 1.85 (area under the curve: 0.906; 95% confidence interval: 0.844, 0.968), and its sensitivity and specificity were 87.5% and 72.5%, respectively. While the superb microvascular imaging vascularity index cut-off value for the diagnosis of primary Sjögren’s syndrome in submandibular gland that maximizes the accuracy was 3.35 (area under the curve: 0.873; 95% confidence interval: 0.800, 0.946), its sensitivity and specificity were 82.5% and 70%, respectively. Conclusion: Superb microvascular imaging with high reproducibility of the vascularity index has a higher sensitivity and specificity than the power Doppler ultrasound in the diagnosis of primary Sjögren’s syndrome. It can be a noninvasive technique in the diagnosis of primary Sjögren’s syndrome when used with clinical, laboratory and other imaging methods

Overview and evaluation of academic and industrial developments in last years on aluminum casting alloys

Alüminyum döküm alaşımları; hafifletme, enerji tasarrufu, geri dönüşüm ve çevre duyarlılığı gibi ülkemizin ve Dünya’nın öncelikli çalışma alanlarında yer alan konular göz önüne alındığında, endüstrinin gözde alaşım grubunu temsil etmektedir. Son yıllarda başta otomotiv ana ve yan sanayisi olmak üzere, havacılık, uçak ve uzay endüstrisinde kullanım alanlarının artmasıyla, alüminyum alaşımlarının sahip olduğu mukavemet, sertlik, kırılma tokluğu, yorulma ömrü gibi birtakım özelliklerin geliştirilmesi ihtiyaç haline gelmiştir. Alüminyum döküm endüstrisindeki teknolojik ilerlemeler, dönemin malzemesinin gelişimi ile paralellik gösterdiğinden, ürün ve sektör çeşitliliğinin artışını, alaşımların sahip oldukları özellikler sınırlandırmaktadır. Bu amaca yönelik olarak gerek akademik gerekse endüstriyel ölçekte pek çok çalışma yapılmış ve literatüre kazandırılmıştır. Bu çalışmada, alüminyum döküm alaşımları ile ilgili özellikle son yıllarda yapılan ulusal ve uluslararası araştırma makaleleri derlenmiştir. Makaleler, mikroyapısal ve mekanik özelliklerin iyileştirilmesine yönelik çalışmalar, tane inceltme ve modifikasyon çalışmaları, alüminyum dökümde hesaplamalı malzeme mühendisliği ve bilgisayar destekli simülasyon çalışmaları olmak üzere üç alt başlıkta sunulmuştur. Ayrıca, derleme çalışmasının son bölümünde alüminyum döküm endüstrisine yönelik, son yıllarda yayınlanan arge, inovasyon ve rekabetçilik konulu raporlara dayanarak, küresel ölçekte alüminyum döküm endüstrisinde ülkemizin statik ve dinamik durumuyla ilgili güncel bilgiler ve istatistik verileri aktarılmıştır.Aluminum casting alloys represents the industry's favorite alloy group, considering the issues in our country’s and the world’s priority research areas such as lightening, energy saving, recycling and environmental awareness. In recent years, it has become a necessity to develop some properties of aluminum alloys such as strength, hardness, fracture toughness, fatigue life, with the increase in usage areas in the aviation, aircraft and space industries, especially in the automotive key and sub-industry. As the technological advances in the aluminum casting industry are in parallel with the development of the material of the period, the increase in product and sector diversity limits the properties of alloys. For this purpose, many studies have been done on both academic and industrial scale and have been added to the literature. In this study, national and international research articles on aluminum casting alloys, especially in recent years, are reviewed. The articles are presented under three subheadings: studies for improving microstructural and mechanical properties, grain refinement and modification studies, computational material engineering in aluminum casting and computer aided simulation studies. In addition, in the last part of the compilation study, based on the reports on R&D, innovation and competitiveness published in the aluminum casting industry in recent years, current information and statistical data about the static and dynamic situation of our country in the aluminum casting industry on a global scale are presented

Assessment of Natural and Artifical Radioactivity Levels and Radiological Hazards in Soil Samples Collected in Karaman

In this study, the level of natural and artificial radioactivity in soil samples collected from the central region of Karaman was measured. Activity concentrations of the concerned radionuclides were determined by the technique of gamma ray spectrometry using HPGe detector. The obtained results of 238U-series (226Ra, 214Pb, 214Bi), 232Th-series (228Ac, 208Tl), 40K and fission 137 product Cs are discussed. In order to evaulate the radiological hazard of the natural and artificial radioactivity in samples, the radium equivalent activity (Raeq ), the absorbed dose rate (D), the annual effective dose and the external hazard index (Hex ) have been calculated. The present data were compared with data obtained from different areas in Turkey

Convalescent plasma therapy in patients with COVID-19

Introduction: Passive antibody therapy has been used to immunize vulnerable people against infectious agents. In this study, we aim to investigate the efficacy of convalescent plasma (CP) in the treatment of severe and critically ill patients diagnosed with COVID-19. Method: The data of severe or critically ill COVID-19 patients who received anti-SARS-CoV-2 antibody-containing CP along with the antiviral treatment (n = 888) and an age-gender, comorbidity, and other COVID-19 treatments matched severe or critically ill COVID-19 patients at 1:1 ratio (n = 888) were analyzed retrospectively. Results: Duration in the intensive care unit (ICU), the rate of mechanical ventilation (MV) support and vasopressor support were lower in CP group compared with the control group (p = 0.001, p = 0.02, p = 0.001, respectively). The case fatality rate (CFR) was 24.7 % in the CP group, and it was 27.7 % in the control group. Administration of CP 20 days after the COVID-19 diagnosis or COVID-19 related symptoms were associated with a higher rate of MV support compared with the first 3 interval groups (?5 days, 6-10 days, 11-15 days) (p=0.001). Conclusion: CP therapy seems to be effective for a better course of COVID-19 in severe and critically ill patients

Mirtazapine Augmentation for Selective Serotonin Reuptake Inhibitor-Induced Sexual Dysfunction: A Retropective Investigation

The aim of the present study was to retrospectively identify sexual dysfunction changes in the patients under mirtazapine-augmented serotonin reuptake inhibito (SSRI) treatment. The study comprised medical records of 20 outpatients, under mirtazapine-augmented SSRI treatment for their major depressive disorder, who had been selected among the patients that had developed sexual dysfunction to previous treatment as monotherapy, with SSRI for at least six weeks. These drugs were maintained and mirtazapine were added (15-45 mg/day). There was a significant difference in scores between baseline and week 4 or week 8 on the both Hamilton Depression Rating and Arizona Sexual Experience Scale. According to Clinical Global Impression-Improvement, 68.4% of the patients were responders. The use of low-dose mirtazapine as an add-on treatment to SSRIs appears to be an effective and well-tolerated augmenttaion for sexual dysfunction caused by SSRIs

Gilteritinib (XOSPATA (R)) in Turkey: Early access program results

Background And Objectives: Gilteritinib (XOSPATA (R), Astellas) is a type I oral FLT3 inhibitor, a tyrosine kinase AXL inhibitor, involved in both c-Kit and FMS-like tyrosine kinase 3 (FLT3) resistance. In the phase 3 ADMIRAL trial, gilteritinib was compared with the standard of care in (R/R) acute myeloid leukemia (AML) patients who harbored any FLT3 mutation and showed superior efficacy with regard to response and survival. Objectives: This research aimed to investigate the real-life efficacy and safety of gilteritinib in FLT3-positive R/R AML patients who were treated as a part of an early access program held in Turkey in April 2020 (NCT03409081). Results: The research included 17 R/R AML patients who had received gilteritinib from seven centers. The overall response rate was 100%. The most common adverse events were anemia and hypokalemia (7 patients, 41.2%). Grade 4 thrombocytopenia was observed in one patient only (5.9%), leading to permanent treatment discontinuation. Patients with peripheral edema had a 10.47 (95% CI: 1.64-66.82) times higher risk of death than those without peripheral edema (p<0.05). Conclusion: This research showed that patients with febrile neutropenia and peripheral edema were at a high risk of death when compared to patients without febrile neutropenia and peripheral edema

Evaluation of the Oxidative Effect of Long-Term Repetitive Hyperbaric Oxygen Exposures on Different Brain Regions of Rats

Hyperbaric oxygen (HBO2) exposure affects both oxidative and antioxidant systems. This effect is positively correlated with the exposure time and duration of the treatment. The present study aims enlightening the relation of HBO2 with oxidative/antioxidant systems when administered in a prolonged and repetitive manner in brain tissues of rats. Sixty rats were divided into 6 study (n = 8 for each) and 1 control (n = 12) group. Rats in the study groups were daily exposed 90-min HBO2 sessions at 2.8 ATA for 5, 10, 15, 20, 30 and 40 days. One day after the last session, animals were sacrificed; their whole brain tissue was harvested and dissected into three different regions as the outer grey matter (cortex), the inner white matter and cerebellum. Levels of lipid peroxidation and protein oxidation and activities of superoxide dismutase and glutathione peroxidase were measured in these tissues. Malondialdehyde, carbonylated protein and glutathione peroxidase levels were found to be insignificantly increased at different time-points in the cerebral cortex, inner white matter and cerebellum, respectively. These comparable results provide evidence for the safety of HBO treatments and/or successful adaptive mechanisms at least in the brain tissue of rats, even when administered for longer periods