Non –Hodgkin lymphoma in Sudanese Children

Background: Non-Hodgkin Lymphoma is a very heterogeneous  lymphoproliferative disease with clinical and histological pattern different from children to adults.Objective: To characterize the clinical and pathological pattern of Non -Hodgkin`s lymphoma among Sudanese children.Materials and Methods: This study was undertaken prospectively on paediatric cases (≤16 years) referred to histopathology department, Radio-Isotope Centre, Khartoum which is the main Centre for cancer  management in Sudan from January 2008 to December 2012. The clinical and demographical data of these patients were recorded. The H&E stained slides of each case were examined initially, then the confirmed cases of non-Hodgkin`s lymphoma were classified according to the 2008 WHO classification of neoplastic diseases of the haematopoietic lymphoid tissue following immunostaining of sections cut from formalin-fixed, paraffin embedded (FFPE) tissue blocks with the following panel of antibodies:-LCA, CD3, CD5, CD10, CD20, CD23, BCL2, CyclinD1, MUM1,CD15,CD30 andKi67.Results: Age range was 9 months to 16years. Fifty percent of the cases occurred between the age 2-5 years and only one case below one year. Male to female ratio was 1.6. Extranodal lymphoma (60%) was higher than nodal type (40%).The most commonly affected site was the  gastrointestinal tract. Most of the gastrointestinal lymphoma presented with abdominal mass. The most common histological type was Burkitt`s  lymphoma. None of the cases were small lymphocytic, follicular or T- cell type. Bone marrow involvement was in 87.5% of the cases at the time of diagnosis.Conclusion: Burkitt`s lymphoma is the predominant paediatric lymphoma in Sudan. The majority of the cases presented late with bone marrow involvement.Key words: Non -Hodgkin`s lymphoma, immunohistochemistry, Paediatric, Sudan

Mainstreaming Islamic Religious Education and Secular Education in Schools as Per the Kenyan Basic Education Act 2013

This paper is an attempt to harmonize the local Quranic schools, the Islamic schools (Madarasa) and the secular schools in Kenya. The article is based on existing literature review, the author’s personal experiences and opinions. It is felt that a change be made to integrate the three-parallel curricula. The curriculum of the Quranic and the Arabic schools can be accommodated into the secular curriculum to give time for the pupils for rest or play or do their homework adequately. The current system makes the child run from one school to another. This starts at the age of six and continues until the child completes primary school. This is strenuous for the child. It is hoped that the integrated approach will alleviate this problem. The child needs to be given a chance to interact with his \ her environment so that he \ she can react to it. It should be concerned with the intellectual, emotional, physical and social growth of the child. Keywords: Quranic Schools, integrated curriculum, secular education, colonial administration DOI: 10.7176/JEP/10-27-10 Publication date:September 30th 201

Moderate ischemic mitral regurgitation (IMR) and metabolic syndrome: where are we now and where are we going?

BACKGROUND: The metabolic syndrome appears to affect 10% to 25% of adult population worldwide. Several studies have described the association between metabolic syndrome and ischaemic heart disease, however, none linked metabolic syndrome to ischemic mitral regurgitation, a serious clinical problem facing both the cardiologists and cardiac surgeons. Ischemic mitral regurgitation is mitral insufficiency caused by myocardial infarction. The myocardial ischemia can result in altered ventricular geometry, leading to mitral insufficiency. Interestingly metabolic syndrome showed more pronounced alteration of left ventricular geometry and function especially in obese subjects. PRESENTATION OF THE HYPOTHESIS: We have recently proposed that there is link between metabolic syndrome and ischemic mitral regurgitation and associated complications. Operative strategy for moderate ischaemic mitral regurgitation continues to be debated between revascularisation alone and concomitant valve repair at the time of coronary artery bypass surgery. Each of the above group has published studies, with results supporting each argument. TESTING THE HYPOTHESIS: Generally speaking the treatments available for metabolic syndrome are based in both life style modification (dietary advice and advice to increase physical activity) and medical treatment to enhance insulin sensitivity. Randomised controlled trials may show whether the current available treatment of metabolic syndrome may have an impact on moderate ischemic mitral regurgitation. IMPLICATIONS OF THE HYPOTHESIS: Metabolic syndrome was shown to alter left ventricular geometry and therefore it is possible to postulate that the variation in the response of different patients with moderate ischemic mitral regurgitation to current management may be attributed to the absence and presence of metabolic syndrome. Research testing of this hypothesis in the future may reveal whether concomitant treatment of metabolic syndrome will play part in the management of moderate ischemic mitral regurgitation

FINE NEEDLE ASPIRATION CYTOLOGY (FNAC) IN DIAGNOSIS OF TUMORAL CALCINOSIS, A REPORT OF THREE CASES

Introduction: Tumoral calcinosis (T.C.) is very rare and generally of unknown aetiology characterized by calcific deposits in the soft tissues. Commonly seen in the second decade of life (reported age range 15 months to 83 years). We are reporting 3 cases of T. C. who were initially diagnosed by FNAC. Two of the 3 cases were female siblings who were referred to us as possible cases of recurrent fibrosarcomas following surgical excision. Case reports:  (1) Two female siblings aged 17 and 14 years  complaining of large swelling in the upper   outer right thigh and the left outer upper thigh around the hip joints respectively. There was no limitation of movement. The masses recurred within a short period after total excision. Neither specimen was subjected to histopathology. Clinical examination showed two masses each approximately 30cm maximum diameter and 10 cm width. In addition the younger sister showed an additional mass 4.5 cm in the outer aspect of her right elbow. (2) 18 months old female child, unrelated to the above two cases, presented with an egg-sized mass in the mid-lateral aspect of her right thigh  cystic and mobile.There is a history of quinine injection in the same area. No positive family history of a similar condition. All three cases showed normocalcaemia and hyperphosphataemia with specks of calcification on x - ray and cysts in ultrasound. FNAC showed structureless gung , calcium granules and inflammatory cells including foreign body type multinucleated giant cells. Histopathology confirmed the diagnosis of T. C. Discussion: Described the three types of T. C. (familial, idiopathic, and that in patients of chronic renal failure on dialysis). The differential diagnoses were also discussed as well as lines of management such as Ca++ supplementation, phosphate restriction, acetazolamide, parathyroidectomy and the treatment of choice is total surgical excision. To our best knowledge this is the first time to report the use of fine needle aspiration cytology in the diagnosis of T. C. in Sudan.&nbsp

Low loss waveguide-based Butler matrix with iris coupling control method for millimeterwave applications

This paper proposes a low loss 4×4 Butler matrix based on rectangular waveguide cavity resonators technology for millimeterwave beamforming network using iris coupling method. This method has the advantage of controlling the electrical fields and the coupling factor inside a complex medium such as waveguide cavity resonators. The coupling factor of 6 dB for 4×4 Butler matrix is achieved by tuning the iris coupling k-value between the waveguide cavity resonators. Thus, avoiding a higher phase difference losses and component losses at upper millimeterwave bands. To validate the proposed method, CST software simulations are performed under several iris coupling k-values to achieve a 6 dB coupling factor. Then, the proposed 4×4 Butler matrix is 3D metal printed using selective laser melting (SLM) technique. The measured reflection and isolation coefficients are observed below −10 dB, with coupling coefficients ranging between −6 and −7 dB. The phase differences of −42.02°, 42.02°, −130.95°, and 133.3° are achieved at the outputs. It confirmed that using this proposed method has the superiority over the conventional microstrip and waveguide coupling methods by a 1 dB coupling factor loss and a 3° phase difference error

Exposure to the News Networks Through Social Media Sites and Their Reflections on Spreading Rumors among Students – Field Study

The scientific study aimed to identify rumors in the students society in the age of social media sites and confrontation mechanisms. The research community included a sample of experts who use new media. Descriptive and statistical approaches (interviews and questionnaires) are used to analyze and understand rumors through social media sites and how to confront them. The study came up with results, the most important of them are as follows: 62% of the research community believes that students (young people) use of news networks via social media sites affects the spread of rumors, while 63% of the research community considers that the quality of social media sites used by young people helps spread rumors, and 43% of the research community agree that technology users are predominantly young people, which helps spread the rumor. Finally, the study recommended that news sites pay attention to the method of dealing with crises, investigate accuracy and credibility, and increase the effective communication between the leaders and students institutions

Demographical and population dynamics impact on public health of cutaneous Leishmaniasis in Al-Madinah Almonawra, Saudi Arabia

Background: A cross-sectional study conducted in Al-Madinah Almonawra in KSA held during the period from March 2014-March 2015.Aim of the study: This study aimed at analyzing the effect of population dynamics on the current situation of cutaneous leishmaniasis in Al-Madinah Almonawarah area, a holy city that attracts millions of muslims annually.Methodology: Epidemiological and clinical data were collected by especial questionnaire and laboratory specimens were collected using skin scraping and needle aspiration. Staining and direct microscopy were done. LST was conducted. Analysis was done using SPSS program.Results: The study included 164 patients, all of them were men. Saudi nationality comprised around 20% of the study group, the majority were Egyptians, 26.2%, followed by Pakistani, 21.3%.Conclusion: The presence of non-Saudi nationality as foreign workers, immigrants and refugees has worsened the current situation of the disease.Keywords: Cutaneous leishmaniasis, refugees, immigration, L. tropica, L. major. Sandfly