Positive time use: a missing link between time perspective, time management, and well-being

Introduction: The notion of satisfaction with the use of one’s time has not been operationalized previously. Based on qualitative interviews, we propose a concept of positive time use comprised by four components: self-congruence of daily activities, balance between activities, efficient use of time, and a sense of mastery over one’s time. Methods: Using data from two UK adult samples (N = 173 and N = 357), we developed a new measure, Positive Time Use Inventory (PTUI), and investigated its structural and convergent validity. Results and discussion: The associations of positive time use with balanced time perspective, affect balance, satisfaction with life, sense of coherence, and self-reported satisfaction with time use indicate convergent and discriminant validity of the new measure. Positive time use partially explained the associations of balanced time perspective with subjective well-being and fully mediated the effects of future time perspective and time management on subjective well-being. We propose positive time use as a new model of temporal well-being, which brings together the notions of work-life balance, time efficiency, and time mastery in a single comprehensive framework, helping to inform the time management coaching interventions

Relative hyperbolicity and similar properties of one-generator one-relator relative presentations with powered unimodular relator

A group obtained from a nontrivial group by adding one generator and one relator which is a proper power of a word in which the exponent-sum of the additional generator is one contains the free square of the initial group and almost always (with one obvious exception) contains a non-abelian free subgroup. If the initial group is involution-free or the relator is at least third power, then the obtained group is SQ-universal and relatively hyperbolic with respect to the initial group.Comment: 11 pages. A Russian version of this paper is at http://mech.math.msu.su/department/algebra/staff/klyachko/papers.htm V3: revised following referee's comment

Fluorescein-Loaded Solid Lipid Nanoparticles Based on Monoamine Pillar[5]arene: Synthesis and Interaction with DNA

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Present research is the first example to use pillar[5]arene for creation fluorescein-loaded solid lipid nanoparticles and release dye during interaction with DNA - potential delivery system of the imaging agent. Monoamine functionalized pillar[5]arene was synthesized for preparation of the solid lipid nanoparticles (SLN) with/without luminescent marker (fluorescein). Interestingly, presence of a single tail-group in the pillar[5]arene has opened wide opportunities for the formation of the various types of pillararene-based assemblies, i. e., pseudorotaxanes, supramolecular polymers and SLNs, varying the solvents

Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer

INTRODUCTION: Very few studies have investigated whether the time elapsed between surgical resection and tissue fixation or the difference between core-cut and excision biopsies impact on immunohistochemically measured biomarkers, including phosphorylated proteins in primary breast cancer. The aim of this study was to characterise the differences in immunoreactivity of common biomarkers that may occur (1) as a result of tissue handling at surgery and (2) between core-cuts and resected tumours. METHODS: Core-cuts taken from surgical breast cancer specimens immediately after resection (sample A) and after routine X-ray of the excised tumour (sample B) were formalin-fixed and paraffin-embedded and compared with the routinely fixed resection specimen (sample C). The variation in immunohistochemical expression of Ki67, oestrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor 2 (HER2), p-Akt and p-Erk1/2 were investigated. RESULTS: Twenty-one tissue sets with adequate tumour were available. Median time between collection of core-cuts A and B was 30 minutes (range, 20 to 80 minutes). None of the markers showed significant differences between samples A and B. Similarly, Ki67, ER, PgR and HER2 did not differ significantly between core-cuts and main resection specimen, although there was a trend for lower resection values for ER (P = 0.06). However, p-Akt and p-Erk1/2 were markedly lower in resections than core-cuts (median, 27 versus 101 and 69 versus 193, respectively; both P < 0.0001 [two-sided]). This difference was significantly greater in mastectomy than in lumpectomy specimens for p-Erk1/2 (P = 0.01). CONCLUSIONS: The delay in fixation in core-cuts taken after postoperative X-ray of resection specimens has no significant impact on expression of Ki67, ER, PgR, HER2, p-Akt or p-Erk1/2. However, extreme loss of phospho-staining can occur during routine fixation of resection specimens. These differences are likely attributable to suboptimal fixation and may have major repercussions for clinical research involving these markers

The pathology of familial breast cancer: Immunohistochemistry and molecular analysis

Extensive studies of BRCA1- and BRCA2-associated breast tumours have been carried out in the few years since the identification of these familial breast cancer predisposing genes. The morphological studies suggest that BRCA1 tumours differ from BRCA2 tumours and from sporadic breast cancers. Recent progress in immunohistochemistry and molecular biology techniques has enabled in-depth investigation of molecular pathology of these tumours. Studies to date have investigated issues such as steroid hormone receptor expression, mutation status of tumour suppressor genes TP53 and c-erbB2, and expression profiles of cell cycle proteins p21, p27 and cyclin D(1). Despite relative paucity of data, strong evidence of unique biological characteristics of BRCA1-associated breast cancer is accumulating. BRCA1-associated tumours appear to show an increased frequency of TP53 mutations, frequent p53 protein stabilization and absence of imunoreactivity for steroid hormone receptors. Further studies of larger number of samples of both BRCA1- and BRCA2-associated tumours are necessary to clarify and confirm these observations

On light scattering in transformer oil

GK transformer oil is studied using the methods of UV and visible spectroscopy, dynamic light scattering, small-angle light scattering, scanning electron microscopy, and element analysis. The effect exerted on the optical properties of transformer oil by colloidal, micelle-like, and solid particles formed in oil during its exploitation is investigated. © 2011 Pleiades Publishing, Ltd

Reduction-controlled substrate release from a polymer nanosphere based on a viologen-cavitand

© 2016 The Royal Society of Chemistry.In this article, we present a new polymeric nanosphere (p(MVCA-co-SS)) for redox-controlled substrate release. The nanosphere consists of a hydrophobic core with disulfide bridges stabilized by the viologen-resorcinarene cavitand shell. The nanosphere is sensitive to thiol-containing reducing agents: glutathione (GSH) and dithiothreitol (DTT). GSH destructs the hydrophobic core of p(MVCA-co-SS) while DTT integrates into the core increasing its size. The nanosphere as shown can be used as nanocarriers for the redox-controlled substrate release for the fluorescent dyes (pyrene, rhodamine b and fluorescein)

Application of Automated Microorganism Identification Systems for Verification of Taxonomic Appurtenance of the Collection Strains of Pathogenic Bacteria

Objective of the study is to optimize the algorithm for authenticity specification of pathogenic bacteria strains and to evaluate its efficacy for nomenclature examination of the isolates, Bacillus genus, from the State Collection of Pathogenic Bacteria functioning at the premises of RusRAPI “Microbe”, the authenticity of which bore scrutiny. Materials and methods. Methodological approach is based on application of automated microorganism identification systems: bacteriological analyzer Vitek 2, automatic ribotyping station DuPont Qualicon RiboPrinter System, and mass-spectrometer MicroFlex MALDI Biotyper, followed by complex assessment of the results obtained, using BioNumerics 7.1 software product. Results and conclusions. It is established that automated analyzers perform reasonably accurate identification of the investigated microorganisms in reference to their specie appurtenance. Vitek 2 shows the best efficiency. Unlike other analyzers, it allows for differentiation of B. anthracis STI-1 strain from a group of bacilli, B. cereus specie. It is of note that different systems range B. megaterium 5 strain in different ways. Carried out complex analysis of the results, obtained from all the three automated devices, using BioNumerics 7.1 software, relegates B. megaterium 5 to B. licheniformis with a high degree probability. Thus, it is necessary to include in the algorithm several techniques with subsequent complex analysis of the data obtained to specify authenticity and taxonomic appurtenance of the collection strains under nomenclature examination

High catalytic activity of palladium nanoparticle clusters supported on a spherical polymer network

© The Royal Society of Chemistry 2015. In this communication we report the synthesis of Pd nanoparticle clusters achieved via the assembly of Pd nanoparticles on the surface of a spherical polymer network. The network exhibits flexibility and adapts to the cluster formation. The nanoclusters display high catalytic activity toward p-nitrophenol reduction and the Suzuki-Miyaura coupling reaction