3 research outputs found
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
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- Ammar Ahmed Siddique
- Amro Dana
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- Atia Ahmed
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- Yahya Bilal Shuaibu
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- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
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- Yong Nathania
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- You Ha Seong
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- Young Stevie
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- Yousri Mohamed
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- Youssef Arkan
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- Yuan Grace
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- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Abstract
- Author
- A. Denault
- A. Fortier
- Abdulaziz Boker
- Abtin Heydarzadeh
- Adam D. Oxner
- Adam Law
- Adriaan Van Rensburg
- Akifumi Kanai
- Alain Deschamps
- Alain Deschamps
- Alan D. Baxter
- Alese M. Wagner
- Alexandre Lallo
- Ali Mirmansouri
- Alison Macarthur
- Amy Cho
- Andreas H. Taenzer
- Andrew G. Usher
- Andrew J. Baker
- Anna Lee
- Anoush D. Moghadam
- Anthony M. -H. Ho
- Arsenio Avila
- Asaha Suzuki
- Ashraf A. Fayad
- Atul Prahbu
- Ayman Hyder
- Ban C. H. Tsui
- Barnaby Ward
- Barry A. Finegan
- Barry Finegan
- Basem Naser
- Bertrand Lau
- Beverley A. Orser
- Bill Y. Ong
- Bobby Metha
- Bradley H. Strauss
- Brent Graham
- Brian Milne
- Bruna Curti
- C. David Mazer
- Cantwell Clark
- Carl C. P. Leipoldt
- Carla Coackley
- Carolyn Sibbick
- Carolyne J. Montgomery
- Cathy Charles
- Cathy Tang
- Charles Imarengiaye
- Chris Chan
- Christine A. Vandebeek
- Christine Kurtz-Landy
- Claudio DiQuinzio
- Clifford Carter
- Clint J. Torok-Both
- Clint Torok-Both
- Colin J. L. McCartney
- Colin M. Shapiro
- Colleen A. Court
- Crystal Chettle
- Cynthia A. Lien
- D. Babin
- Dajun Song
- Dany Côté
- David A. Latter
- David C. Campbell
- David H. Goldstein
- David R. Sinclair
- David Streiner
- David Sutton
- Deborah A. Tod
- Denise Rohan
- Derek Levangie
- Desmond Lam
- Devashish Chakravarty
- Diane R. Biehl
- Dimitri Anastakis
- Dmitri Chamchad
- Dmitri Souzdalnitski
- Dominic A. Cave
- Donald Livingstone
- Doreen Cleave-Hogg
- Dorothy E. Thompson
- Doug Maguire
- Duminda N. Wijeysundera
- Duminda Wijeysundera
- E. Stockton
- Elena Sourovtseva
- Elizabeth G. VanDen Kerkhof
- Elizabeth Ling
- Eric Goldszmidt
- Eric Yeo
- Erik D. Skarsgard
- Erin M. Elliot
- Esam Abdelnaem
- Fadi Basile
- Frances Chung
- Frances Chung
- Frances F. Chung
- Fraser Rubens
- George Djaiani
- Geraldine Jose
- Gil Faclier
- Gilbert Blaise
- Glen Atlas
- Grant Miller
- Gregory M. Hirsch
- Gregory M. T. Hare
- Guillaume Michaud
- Guillaume Trager
- H. Yang
- Haiheng Dong
- Harry Lapierre
- Heather L. Mollison
- Henry J. Moller
- Herbert von Schroeder
- Holly Muir
- Homer Yang
- Howard M. Leong-Poi
- Howard Nathan
- Hugo Nova
- Humara Poonwala
- Hyun Ju Jung
- Ignatio Prieto
- Isabella Devito
- Ivan L. Rapchuk
- J. C. Tardif
- J. Mark Ansermino
- J. Parlow
- J. S. Dali
- Jacek Karski
- James E. Paul
- James S. Galton
- Janet Hsu
- Jason A. Hayes
- Jason Sawyer
- Javad Peirovy
- Jean E. Kronberg
- Jean S. Bussières
- Jean-François Olivier
- Jean-Yves Dupuis
- Jelka Lujic
- Jennifer A. Yee
- Jeong-Yeon Hong
- Jerome M. Teitel
- Jie Yi
- Jo Carroll
- Jo Watson MacDonnell
- Joan Ivano
- Joanne Guay
- Joel Katz
- Joel L. Parlow
- John F. MacDonald
- John H. Braxton
- John T. Granton
- Johnson R. Symon
- Joseph Kay
- Joseph Tjan
- Josiane Léveillé
- Juliana M. Tan
- Julie Soucy
- K. Raymer
- Karen J. Buth
- Karen Loo
- Karen M. Caputo
- Karen McRae
- Karolinah Lukitto
- Kathleen Datillo
- Kathryn DeKoven
- Keya Quader
- Keyvan Karkouti
- Kim Vicente
- Kirsten Cunningham
- Kong E. You-Ten
- Kristen M. Sullivan
- Kristi Downey
- Kristine A. Hirsch
- Kristine I. Stewart
- Lan Gao
- Leonid Kayumov
- Lie Ming Lie
- Lisa C. Silcox
- Louie Wang
- Louie Wang
- Louise Lortie
- Ludwik Fedorko
- M. Carrier
- Mahendra Kumar
- Manoj K. Karmakar
- Marius D. Gangal
- Mark D. Peterson
- Mark W. Crawford
- Martin Chapman
- Masao Yamashita
- Matthew R. Belmont
- May S. M. Cheung
- Michael A. Borger
- Michael B. Lukins
- Michael Borger
- Michael J. Jacka
- Michael Ronayne
- Michelle Clunie
- Mohammed Ghannam
- Monakshi Sawhney
- Mrinalini Balki
- Munisha Agarwal
- Murray Hong
- Mélanie Lacroix
- Nao Nakatsuka
- Ngozi N. Imasogie
- Nhiên Lê
- Niall L. Purdie
- Niamh I. Donnelly
- October Negraeff
- Orlando Hung
- Osama A. Al-Abdulhadi
- P. Couture
- P. U. Ramanayake
- Pamela J. Angle
- Pamela J. Morgan
- Pamela J. Morgan
- Patricia Murphy
- Patrick Cheng
- Paul B. S. Lai
- Paul Brousseau
- Paul Hendry
- Paul K. Tenenbein
- Peter C. Duke
- Peter H. Mak
- Peter L. Gross
- Peter Slinger
- Pierre Drolet
- Pirjo H. Manninen
- Qinghua Wang
- R. Butler
- R. Roberts
- Rajesh Patel
- Rajiv Chawla
- Rakhi Kawatra
- Ralph Kern
- Rana Karam
- Rangamani K. Raman
- Ravi K. Agrawal
- Reed D. Quinn
- Regan Rawson
- Reginald Edward
- Richard Brull
- Richard F. McLean
- Richard Liu
- Rita Katznelson
- Robert Byrick
- Robert J. Cusimano
- Robert Nunn
- Roland Debrouwere
- Ronald Cheverie
- Rong Qu
- Rose Kung
- Rose Kung
- Ross Barlow
- Roy Masters
- S. Gowrie-Mohan
- S. Jothilingam
- Salmaan Kanji
- Sanjay Patel
- Sean J. Barbour
- Sean R. Hall
- Shaf Keshavjee
- Sherif Abbas
- Shirley Perry
- Soochang Son
- Stephane Deschamps
- Stephen E. Kowalski
- Stephen H. Halpern
- Stephen Halpern
- Stuart A. McCluskey
- Stuart McCluskey
- Sumio Hoka
- Sunil Desai
- Suntheralingam Yogendran
- Susan A. Shaw
- Susan DeSousa
- Susan K. Palmer
- Ted L. Ashbury
- Tejinder S. Chhina
- Terrance W. Breen
- Terrence M. Yau
- Terry M. Yau
- Thierry Mesana
- Thomas M. Hemmerling
- Thomas Waddell
- Toshimi Arai
- Valerie Arkoosh
- Valerie B. Caraiscos
- Vance Chow
- Victor Y. Cheng
- Vincent W. S. Chan
- Vivek Rao
- W. Scott Beattie
- Wei-Yang Lu
- William P. S. McKay
- William P. S. Mckay
- Wing Cheung
- Winnie Samy
- Xiamao Li
- Yuji Hirasaki
- Yunhee Kim
- Zane S. Jackson
- Zoya Potyomkina
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study
- Author
- Aaliya Mohammed (12499327)
- Abdulkader Mohammad (12499324)
- Abdulmalek Aljafari (12498697)
- Abdulmoiz Aljafari (12498700)
- Abigail Hobill (12499126)
- Abigail Reynolds (9119102)
- Adam Budzikoski (12498805)
- Adam Gordon (825422)
- Adam H Dyer (12498967)
- Adam Seed (2367799)
- Agnieszka Felska (12499003)
- Ahmad Bouhuwaish (9757988)
- Ahmed A Momen (12499330)
- Ahmed Cordie (12498865)
- Ahmed KM Hadreiez (12499093)
- Ahmed O Elmehrath (12498979)
- Ahmed SA Taher (12499558)
- Ahmed Y Azzam (12229460)
- Aidan Haslam (12499108)
- Aimee Leadbetter (12499234)
- Aina Ibukunoluwakitan (12499159)
- Aine McGovern (10174331)
- Akhil Kanzaria (12499198)
- Alberto Porcu (5473763)
- Aldo Rocca (10650326)
- Alexander Emery (12498988)
- Alexander Hickman (12499123)
- Alexander Noar (12499387)
- Alexandra Richardson (12499465)
- Alexandros Charalabopoulos (12498838)
- Alexis Carr (12498829)
- Ali Ali (3510386)
- Ali Muhtaroglu (12499357)
- Aliae AR Mohamed Hussein (12499321)
- Alice Devaney (12498922)
- Alice O'Docherty (12499393)
- Alison Eastaugh (12498970)
- Almontacer EB Masood (12499279)
- Alodia Gabre-Kidan (12499027)
- Alshaimaa M Saad (12499483)
- Amalia Karapanou (12499201)
- Amanda Stafford (12499537)
- Ambreen Sadiq (12499489)
- Amelia Roberts (12499468)
- Amir Abdelmalak (12498673)
- Amy Birchenough (12498781)
- Amy Gray (4541533)
- Amybel Taylor (12499564)
- Andra Caracostea (12498823)
- Andrea Mingoli (11397024)
- Andrew Crowe (450839)
- Andrew Ghobrial (12499045)
- Aneliya Kuzeva (12499228)
- Angeline Price (10174343)
- Anna Barnard (1987999)
- Anna Fleck (12499021)
- Anne Karunatilleke (12499210)
- Anthony Grubb (12499081)
- Anthony Umeadi (12499591)
- Antia Fernandez (12499006)
- Antonella Ferraiolo (696685)
- Antonio Buondonno (12498811)
- Arjun Desai (12498919)
- Asad J Choudhry (12498850)
- Asma Khan (8140407)
- Avinash Aujayeb (12229442)
- Awolkhier Mohammedseid-Nurhussien (12498631)
- Ayushi Gupta (9031847)
- Baguiasri Mandane (12499264)
- Barbara Hart (12499105)
- Baris Mantoglu (12499270)
- Benjaman To (12499579)
- Benjamin Jelley (12498613)
- Benyamin Deldar (12498916)
- Bruno Cirillo (9503960)
- Bryony Brown (12498586)
- Bushra Muzammil (12499369)
- Carly Welch (6206861)
- Caroline Tait (12499561)
- Carolyn Akladious (12498694)
- Cassandra Fairhead (12498997)
- Caterina Cattel (12498835)
- Catherine Atkin (12498733)
- Catherine Bryant (5072462)
- Catherine Dotchin (5983973)
- Catherine O'Mahony (12499405)
- Catherine Wilcock (12499639)
- Catrin Cox (12498874)
- Charlotte Greene (12499072)
- Charlotte Roberts-Rhodes (12499471)
- Chee Soo (12498658)
- Cheran Anandarajah (12498721)
- Chiara Kratochwila (12499225)
- Chloe Warner (12499618)
- Christina Page (12499414)
- Christopher N Osuafor (12498634)
- Claire McDonald (627409)
- Claire Morris (2019940)
- Claire Spice (12499534)
- Claire Steves (5144204)
- Clara Gimenez-Frances (12499063)
- Clare Baguneid (12498754)
- Claudio Gustavino (12499087)
- Cliona Ni Cheallaigh (9617430)
- Corrina Bentley (12498778)
- Daisy Wilson (6011324)
- Daniel Curley (12498886)
- Daniel Muller (3244128)
- Daniel N Guerero (12499084)
- Danielle Hunsley (12499150)
- Danielle Lis (12499240)
- David Williams (229939)
- Declan C Murphy (12499366)
- Deepthy Hari Madhavan (12499102)
- Deevia Hanji (12499099)
- Deirdre Green (12499069)
- Dina Radenkovic (4676860)
- Dominic Maxfield (12499288)
- Dominique Vervoort (8468494)
- Efstratia Baili (12258342)
- Eirene Yeung (210321)
- Eleanor Lunt (12499252)
- Eleanor Watkins (12499621)
- Elinor Burn (12498589)
- Elinor Edwards (12498973)
- Elisha Whelan (12499630)
- Elizabeth Holmes (12499135)
- Ellanna Griffin (12499075)
- Ellen James (12499174)
- Ellen Tullo (2880158)
- Ellie Shaw (12499513)
- Elliott R Haut (12499111)
- Elsayed M Awad (12498736)
- Eltayeb A Ahmed (12498685)
- Emily Bailey (5754929)
- Emily Lyon (12499255)
- Emily Ross-Skinner (12499474)
- Emma Livesey (12499243)
- Emma Stratton (12499546)
- Emma Swinnerton (12499555)
- Emre Gonullu (12258426)
- Enrico Fiori (12499012)
- Enrico Pinotti (12499438)
- Eric W Etchill (12498991)
- Esther Medina-Manuel (12499300)
- Evelyn Charsley (12498841)
- Fabio Barra (12229463)
- Fabio Speranza (3594422)
- Farhana Moomo (12499333)
- Fatih Altintoprak (12467228)
- Fatma D Collins (12498859)
- Favour Nwolu (12499390)
- Fawsiya Mohamed (12499315)
- Felicity Evison (12498994)
- Flavia Ciccarone (12498853)
- Francesco Alessandri (6787682)
- Francesco Pugliese (792375)
- Gabriel Lee (838259)
- Gabrielle Budd (12498799)
- Gaetano Gallo (6173327)
- Gavriella Levinson (12499237)
- George Tzovaras (12499588)
- Georgia F Gilbert (12499057)
- Georgina Muir (12499360)
- Giancarlo Ceccarelli (648611)
- Gilda De Paola (12498907)
- Gioia Brachini (12498790)
- Giorgio De Toma (12498910)
- Giovanni B Fonsi (12499024)
- Gitanjali Amaratungaz (12498709)
- Giulia Duranti (12498958)
- Giuseppe Cecere (1928059)
- Giuseppe Sammarco (575750)
- Giuseppina Vescio (12499600)
- Gordon Dick (12498934)
- Grace Lewis (6813344)
- Grace ME Pearson (12498640)
- Gracie Fisk (12499018)
- Gurinder Dogra (12498940)
- Hakan Demir (1454902)
- Hamilton Morrin (12499342)
- Hanna Nguyen (12499384)
- Hannah Bashir (12498766)
- Hannah Bridgwater (12498796)
- Hannah C Dooley (8214468)
- Hannah Cheney-Lowe (12498844)
- Hannah Currie (12498889)
- Hannah Dowell (12498949)
- Hannah Gerretsen (12499039)
- Hannah Moorey (3548264)
- Hannah Shaw (12499516)
- Hannah Street (12499549)
- Hannah Thould (12499573)
- Hannah Tobiss (12499582)
- Hannah Watson (71406)
- Haris Khan (8748504)
- Harjinder Kainth (12499192)
- Harnish Patel (3532901)
- Harsha Malapati (11091047)
- Hayley Jarvis (12499177)
- Hayley R Boden (12498787)
- Hazel Sanghvi (12499495)
- Hazem Ahmed (2734090)
- Hedra Ghobrial (12499048)
- Heena Khiroya (12498616)
- Hein Zaw (5772269)
- Hejab Butt (12498817)
- Helal F Hetta (12499120)
- Helena Lee (7481552)
- Henry Maynard (12499294)
- Hesham Khalid (12499213)
- Hiren Dusara (12498961)
- Hope Elrick (12498982)
- Hossam Aldein S Abd Elazeem (12498667)
- Hrisheekesh Vaidya (4241539)
- Humza Yusuf (12499666)
- Iain Wilkinson (11210310)
- Ioan M Draghita (12498952)
- Ioannis Baloyiannis (12498760)
- Irem Ishlek (12499162)
- Ishmam Ibtida (9849214)
- Islam A Ahmed (12498688)
- Ismael Mora-Guzman (12499336)
- Ismini Panayotidis (4778079)
- Isobel Sleeman (12498655)
- Jack Cullen (12498877)
- Jack Stewart (11781983)
- Jade Man (12499261)
- Jake Gibbon (12499054)
- James Belcher (12498772)
- James M Dundas (12498955)
- Jamie Mawhinney (12499285)
- Jane Masoli (3540020)
- Jarita Sivam (12499528)
- Jason Kalloo (12499195)
- Jay Darley (12498895)
- Jean Cummings (12498880)
- Jenni K Burton (12498592)
- Jennifer Pigott (12498649)
- Jennifer Smith (172056)
- Jessica Parkin (12499420)
- Jiannis Hajiioannou (12499096)
- Joanne Taylor (49271)
- Joanne Wagland (12499612)
- Jocelyn Amer (12498712)
- John Millwood-Hargrave (12499309)
- Jolene Atia (3172896)
- Jonathan Sheldrake (12499519)
- Jordan Mayer (12499291)
- Joshua H Gray (12499066)
- Jugdeep Dhesi (12498928)
- Julie Whitney (12499633)
- Kar Yee Law (12499231)
- Karl Jackson (12499168)
- Karla Griffith (12499078)
- Katharine Hood (12499138)
- Katharine Stambollouian (12499540)
- Katherine Hopkinson (12499141)
- Katherine Patterson (12498637)
- Kathleen T Shakespeare (12499510)
- Kathryn Toppley (12499585)
- Katie Honney (7799858)
- Katie Thin (12499570)
- Katy Madden (12498622)
- Kelli Torsney (12498664)
- Kelvin Miu (12499312)
- Kelvin Okoth (10307754)
- Kent A Stevens (12499543)
- Kingsley Appiah (12498730)
- Konstantinos Perivoliotis (12499432)
- Krishnarajah Nirantharakumar (154539)
- Lara Howells (12499144)
- Lara Reilly (12499462)
- Laura Babb (12498748)
- Laura Bremner (12498793)
- Laura Magill (4399846)
- Laura Winter (12499651)
- Lauren C Passby (12499423)
- Lauren McCluskey (12498625)
- Laurenny Guzman (12499090)
- Laxmi Babar (12498745)
- Li Kok (12499222)
- Lia Orlando (12499408)
- Liam Townsend (9617403)
- Lily Lowes (12499249)
- Lindsay Hennah (12499117)
- Lindsey Dew (12498925)
- Lizzie Moriarty (12499339)
- Lobna Al-Sodani (12498706)
- Luca Scott (12499501)
- Lucy Beishon (7298981)
- Luigi Simonelli (12499525)
- Madeleine Daly (12498892)
- Madeleine Garner (12499033)
- Madiha Virk (12499606)
- Mahmoud M Saad (12499486)
- Mairead Kelly (346537)
- Manpreet Badh (12498751)
- Marc Osterdahl (12499411)
- Margherita Faulkner (12499000)
- Maria Dias (12498931)
- Maria Mpoura (12499351)
- Maria Qurashi (12499450)
- Maria Valero-Soriano (12499594)
- Mariam Albatoul Nageh (12499375)
- Marie Giles (12499060)
- Marie Goujon (12498604)
- Mark Vettasseri (12499603)
- Mark Whitsey (12499636)
- Martha Pinkney (12499435)
- Martina Zambon (12499669)
- Mary Ni Lochlainn (11419458)
- Matthew Hale (9045264)
- Matthew King (782718)
- Megan Williamson (11996525)
- Melanie Dani (6397982)
- Mertcan Akcay (12498691)
- Merve Yigit (12499660)
- Mettha Wimalasundera (12499645)
- Michael Sen (12499504)
- Michael Surtees (12499552)
- Michail A Sampanis (12499492)
- Michala Pettitt (12498646)
- Michelle Metcalf (12499306)
- Miguel Ruiz-Marin (12499477)
- Milagros Carrasco-Prats (12498832)
- Miles Witham (4355218)
- Miriam Thake (12499567)
- Mohamed Eltaher AA Ibrahim (12499156)
- Mohamed M Moustafa (12499348)
- Mohammad T Azam (12498739)
- Mohammed A Azab (12229448)
- Mohammed Ahmad (9120880)
- Mohammed Al-Sadawi (12498703)
- Mohammed H Abdelhafez (12498670)
- Mohammed Mubin (12499354)
- Monica Bawor (516749)
- Mosab AA Shaban (12499507)
- Mostafa El-Shazly (12498985)
- Moulinath Bannerjee (12498763)
- Muhammad S Khan (12499216)
- Muhammed Elhadi (9689965)
- Muhammed H Ansari (12498727)
- Mustafa Alsahab (12498583)
- Natalie Cox (12498595)
- Natalie McNeela (12498628)
- Natalie Yeo (12499657)
- Nathan Jenko (12499183)
- Necattin Firat (12499015)
- Niamh Cunningham (12498883)
- Nicholas Moss (12499345)
- Nick Coulthard (12498871)
- Nicola Kelly (9194178)
- Nicole Burden (12498814)
- Nicole Hrouda (12499147)
- Nik Sanyal (12498652)
- Nikhita Dattani (12498898)
- Nikolaos Georgiou (12499036)
- Nikolaos Sipsas (8687409)
- Nirali Desai (10956418)
- Nourhan AA Ghannam (12499042)
- Nuha Kardaman (12499204)
- Nuria Martinez-Sanz (12499273)
- Olebu Ogochukwu (12499402)
- Olubayode Adewole (12498682)
- Omar A Abdelwahab (12498676)
- Omar Zein Elabedeen (12499672)
- Omoteniola Odutola (12499396)
- Osama MAS Abdulhadi (12498679)
- Paolo Sapienza (11397021)
- Parveen Doddamani (12498937)
- Patricia Pastor-Perez (12499426)
- Patrick CP Hogan (12499129)
- Patrick Harrison (11805810)
- Paul Reynolds (382180)
- Pedro Fernandez-Fernandez (12499009)
- Pedro Lopez-Morales (12499246)
- Pierfrancesco Lapolla (10232340)
- Pierfranco M Cicerchia (12498856)
- Prabhleen Puri (12499441)
- Rachael Anders (12498724)
- Rachael Webb (12499624)
- Rajesh Dwivedi (12498964)
- Rajni Lal (12498619)
- Rand A Hussein (12499153)
- Ratnam Gandhi (12499030)
- Ravindra Belgamwar (12498775)
- Rebecca Lau (3664084)
- Rebecca Ryall (12499480)
- Rebecca Wright (12339118)
- Recayi Capoglu (12498820)
- Reem Bulla (12498808)
- Rifa Cardoso (12498826)
- Rishi Iyer (12499165)
- Rita Perry (12498643)
- Rosanna Varden (12499597)
- Rose Penfold (7537139)
- Rosie Jackson (12499171)
- Ross Sayers (12499498)
- Rowan Davies (12498904)
- Rupini Perinpanathan (12499429)
- Ruth H Willott (12499642)
- Ruth West (8003159)
- Sally Aziz (12498742)
- Samiullah Dost (12498946)
- Samuel North (4070647)
- Sandeep Karthikeyan (12499207)
- Sarah Baldwin (12498757)
- Sarah Evans (270764)
- Sarah F Rapaport (12499456)
- Sarah Freshwater (12498598)
- Sarah H Manning (12499267)
- Sarah H Welsh (12499627)
- Sarah Richardson (698187)
- Sasha Jeyakumar (12499186)
- Sergio Del Valle-Ruiz (12498913)
- Shahriar Kabir (12499189)
- Sharon Budd (12498802)
- Shefali Patel (11154648)
- Shivam Pancholi (12499417)
- Shrouk M Elghazaly (12498976)
- Simona Meneghini (12499303)
- Simone Ferrero (4614157)
- Sinead O'Dwyer (12499399)
- Sing Yang Sim (12499522)
- Siobhan Coulter (12498868)
- Soha M Mohamed (12499318)
- Sophie Jeffs (12499180)
- Sophie Mclachlan (12499297)
- Spyridon Davakis (12498901)
- Sri Sivarajan (12499531)
- Stephanie Mulhern (12499363)
- Stephanie Wallis (12499615)
- Stephanie Worrall (12499654)
- Stephen Lim (149062)
- Suvira Madan (12499258)
- Sylvia Amini (12498715)
- Sylvia Pytraczyk (12499444)
- Taha Amir (12498718)
- Tahir Masud (804313)
- Tahmina Razzak (12499459)
- Tanya Robinson (11016672)
- Terence Quinn (3717607)
- Teresa Perra (12258519)
- Terry Hughes (12498607)
- Theodore Chevallier (12498847)
- Theodore Liakakos (3475031)
- Thomas A Jackson (12498610)
- Thomas Kneen (12499219)
- Thomas Pinkney (467511)
- Thurkka Rajeswaran (12499453)
- Thyn Thyn (12499576)
- Tina Doll (12498943)
- Tom Maughan (12499282)
- Torben Heinsohn (12499114)
- Vaishali Vyas (12499609)
- Varun Nadkarni (12499372)
- Vesna Hogan (12499132)
- Victoria Comerford (12498862)
- Victoria Cox (325585)
- Victoria Gaunt (12498601)
- Victoria Haunton (7755344)
- Vittoria Vergani (4846690)
- W David Strain (12498661)
- Wasim Nawaz (12499381)
- William Hurst (4229008)
- William Marx (12499276)
- Yasin A Yildiz (12499663)
- Yasmin K NasrEldin (12499378)
- Yen Nee J Bo (12498784)
- Yu Lelt Win (12499648)
- Yue Guan (2178228)
- Yusra Qaiser (12499447)
- Zaynub Ghufoor (12499051)
- Zeinab Majid (9957176)
- Zulfu Bayhan (12498769)
- Publication venue
- Publication date
- 05/02/2021
- Field of study
Introduction: Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear.
Methods: This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables.
Results: Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54–83; 55.2% male). The risk of death increased independently with increasing age (>80 versus 18–49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54–5.02), frailty (CFS 8 versus 1–3: HR 3.03, CI 2.29–4.00) inflammation, renal disease, cardiovascular disease and cancer, but not delirium. Age, frailty (CFS 7 versus 1–3: odds ratio 7.00, CI 5.27–9.32), delirium, dementia and mental health diagnoses were all associated with increased risk of higher care needs on discharge. The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9.
Conclusion: Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.</p