Model and phase-diagram analysis of photothermal instabilities in an optomechanical resonator

A study of the phototermal instabilities in a Fabry-Perot cavity is reported, where one mirror consists of a silicon-nitride membrane coated by the molecular organic semiconductor tris(8-hydroxyquinoline) aluminum and silver layers. We propose a theoretical model to describe the back-action associated with the delayed response of the cavity field to the radiation pressure force and the photothermal force. For the case under investigation, the photothermal force response occurs on a timescale that is comparable to that of mirror oscillations and dominates over the radiation pressure force. A phase diagram analysis has been performed to map the stability of the static solution as a function of the control parameters. The model equations are integrated numerically and the time history is compared to experimental measurements of the transmitted field and displacement of the membrane. In both experimental and theoretical data we observe large amplitude oscillations when the cavity length is scanned at a low speed compared to the growth rate of the instability. The perturbation is found to evolve through three regimes: sinusoidal oscillations, double peaks and single peaks followed by a lethargic regime. When the cavity length is scanned in opposite directions, dynamical hysteresis is observed, whose extension has a power law dependence on the scanning rate

Alq3 coated silicon nanomembranes for cavity optomechanics

The optomechanical properties of a silicon-nitride membrane mirror covered by Alq3 and Silver layers are investigated. Excitation at two laser wavelengths, 780 and 405 nm, corresponding to different absorptions of the multilayer, is examined. Such dual driving will lead to a more flexible optomechanical operation. Topographic reconstruction of the whole static membrane deformation and cooling of the membrane oscillations are reported. The cooling, observed for blue laser detuning and produced by bolometric forces, is deduced from the optomechanical damping of the membrane eigenfrequency. We determine the presence of different contributions to the photothermal response of the membrane

Studio preliminare per la progettazione di un sistema RADAR per la rilevazione degli APR nell’ambito del progetto cluster top-down RADARDRONE

Lo scopo di questo rapporto interno è di illustrare lo studio preliminare effettuato nel biennio 2019-2020 per la progettazione di un sistema RADAR per la rilevazione degli APR (Aeromobili a Pilotaggio Remoto) nell’ambito del progetto RADARDRONE. RADARDRONE è la denominazione di un progetto cluster top down che intende mettere a sistema le competenze, conoscenze ed esperienze nel campo della Ricerca Tecnologica possedute dall’OAC (Osservatorio Astronomico di Cagliari), dal DIEE (Dipartimento di Ingegneria Elettrica ed Elettronica) dell’Università degli Studi di Cagliari e dalla compagine di aziende ed organizzazioni altamente innovative facenti parte del cluster

GAIA,Progettazione, realizzazione e caratterizzazione della GAIA Board

GAIA,Progettazione, realizzazione e caratterizzazione della GAIA Board. In questo report viene illustrata la GAIA board implementata per fornire e monitorare il BIAS degli LNA (Low Noise Amplifier) installati nei ricevitore radioastronomici

Progettazione e realizzazione di due unità RADAR modulari per il rilevamento di Aeromobili a Pilotaggio Remoto (APR) nell’ambito del progetto cluster Top-Down RADARDRONE.

Lo scopo di questo rapporto interno è quello di descrivere la progettazione e la realizzazione di due prototipi di unità radar volti al rilevamento degli APR (Aeromobili a Pilotaggio Remoto), realizzati nell’ambito del progetto cluster top-down RADARDRONE e la successiva attività sperimentale condotta. RADARDRONE è la denominazione di un progetto cluster top-down che mette a sistema le competenze ed esperienze nel campo della ricerca tecnologica possedute dall’OAC (Osservatorio Astronomico di Cagliari), dal DIEE (Dipartimento di Ingegneria Elettrica ed Elettronica) dell’Università degli Studi di Cagliari e dalla compagine di aziende ed organizzazioni altamente innovative facenti parte del cluster. L’obiettivo principale del progetto è lo sviluppo di piccoli RADAR modulari, facilmente installabili, per il monitoraggio e la sicurezza delle aree critiche (per esempio aeroporti, porti, stadi di calcio, zone dove si svolgono grandi assembramenti di persone) o obiettivi sensibili al fine di fronteggiare eventuali intrusioni non autorizzate

Adaptation of an IRAM W-Band SIS Receiver to the INAF Sardinia Radio Telescope: A Feasibility Study and Preliminary Tests

Radio telescopes are used by astronomers to observe the naturally occurring radio waves generated by planets, interstellar molecular clouds, galaxies, and other cosmic objects. These telescopes are equipped with radio receivers that cover a portion of the radio frequency (RF) and millimetre-wave spectra. The Sardinia Radio Telescope (SRT) is an Italian instrument designed to operate between 300 MHz and 116 GHz. Currently, the SRT maximum observational frequency is 26.5 GHz. A feasibility study and preliminary tests were performed with the goal of equipping the SRT with a W-band (84–116 GHz) mono-feed radio receiver, whose results are presented in this paper. In particular, we describe the adaptation to the SRT of an 84–116 GHz cryogenic receiver developed by the Institute de Radio Astronomie Millimétrique (IRAM) for the Plateau de Bure Interferometer (PdBI) antennas. The receiver was upgraded by INAF with a new electronic control system for the remote control from the SRT control room, with a new local oscillator (LO), and with a new refrigeration system. Our feasibility study includes the design of new receiver optics. The single side band (SSB) receiver noise temperature measured in the laboratory, Trec ≈ 66 K at 86 GHz, is considered sufficiently low to carry out the characterisation of the SRT active surface and metrology system in the 3 mm band

Multicenter Observational Retrospective Study on Febrile Events in Patients with Acute Myeloid Leukemia Treated with Cpx-351 in "Real-Life": The SEIFEM Experience

: In the present study, we aimed to evaluate the absolute risk of infection in the real-life setting of AML patients treated with CPX-351. The study included all patients with AML from 30 Italian hematology centers of the SEIFEM group who received CPX-351 from July 2018 to June 2021. There were 200 patients included. Overall, 336 CPX-351 courses were counted: all 200 patients received the first induction cycle, 18 patients (5%) received a second CPX-351 induction, while 86 patients (26%) proceeded with the first CPX-351 consolidation cycle, and 32 patients (10%) received a second CPX-351 consolidation. A total of 249 febrile events were recorded: 193 during the first or second induction, and 56 after the first or second consolidation. After the diagnostic work-up, 92 events (37%) were classified as febrile neutropenia of unknown origin (FUO), 118 (47%) were classifiable as microbiologically documented infections, and 39 (17%) were classifiable as clinically documented infections. The overall 30-day mortality rate was 14% (28/200). The attributable mortality-infection rate was 6% (15/249). A lack of response to the CPX-351 treatment was the only factor significantly associated with mortality in the multivariate analysis [p-value: 0.004, OR 0.05, 95% CI 0.01-0.39]. Our study confirms the good safety profile of CPX-351 in a real-life setting, with an incidence of infectious complications comparable to that of the pivotal studies; despite prolonged neutropenia, the incidence of fungal infections was low, as was infection-related mortality

Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study

Several small studies on patients with COVID-19 and haematological malignancies are available showing a high mortality in this population. The Italian Hematology Alliance on COVID-19 aimed to collect data from adult patients with haematological malignancies who required hospitalisation for COVID-19

Sensitivity and specificity of in vivo COVID-19 screening by detection dogs: Results of the C19-Screendog multicenter study

Trained dogs can recognize the volatile organic compounds contained in biological samples of patients with COVID-19 infection. We assessed the sensitivity and specificity of in vivo SARS-CoV- 2 screening by trained dogs. We recruited five dog-handler dyads. In the operant conditioning phase, the dogs were taught to distinguish between positive and negative sweat samples collected from volunteers’ underarms in polymeric tubes. The conditioning was validated by tests involving 16 positive and 48 negative samples held or worn in such a way that the samples were invisible to the dog and handler. In the screening phase the dogs were led by their handlers to a drive-through facility for in vivo screening of volunteers who had just received a nasopharyngeal swab from nursing staff. Each volunteer who had already swabbed was subsequently tested by two dogs, whose responses were recorded as positive, negative, or inconclusive. The dogs’ behavior was constantly monitored for attentiveness and wellbeing. All the dogs passed the conditioning phase, their responses showing a sensitivity of 83-100% and a specificity of 94-100%. The in vivo screening phase involved 1251 subjects, of whom 205 had a COVID-19 positive swab and two dogs per each subject to be screened. Screeningsensitivity and specificity were respectively 91.6-97.6% and 96.3-100% when only one dog was involved, whereas combined screening by two dogs provided a higher sensitivity. Dog wellbeing was also analysed: monitoring of stress and fatigue suggested that the screening activity did not adversely impact the dogs’ wellbeing. This work, by screening a large number of subjects, strengthen recent findings that trained dogs can discriminate between COVID-19 infected and healthy human subjects and introduce two novel research aspects: i) assessement of signs of fatigue and stress in dogs during training and testing, and ii) combining screening by two dogs to improve detection sensitivity and specificity. Using some precautions to reduce the risk of infection and spillover, in vivo COVID-19 screening by a dog-handler dyad can be suitable to quickly screen large numbers of people: it is rapid, non- invasiveand economical, since it does not involve actual sampling, lab resources or waste management, and is suitable to screen large numbers of people