Predicting Graph Categories from Structural Properties

Complex networks are often categorized according to the underlying phenomena that they represent such as molecular interactions, re-tweets, and brain activity. In this work, we investigate the problem of predicting the category (domain) of arbitrary networks. This includes complex networks from different domains as well as synthetically generated graphs from five different network models. A classification accuracy of 96.6% is achieved using a random forest classifier with both real and synthetic networks. This work makes two important findings. First, our results indicate that complex networks from various domains have distinct structural properties that allow us to predict with high accuracy the category of a new previously unseen network. Second, synthetic graphs are trivial to classify as the classification model can predict with near-certainty the network model used to generate it. Overall, the results demonstrate that networks drawn from different domains (and network models) are trivial to distinguish using only a handful of simple structural properties

Risk factors for postobstructive diuresis in pediatric patients with ureteropelvic junction obstruction, following open pyeloplasty in three high complexity institutions

Q4Q2Summary Introduction Postobstructive diuresis (POD) is a polyuric state in which large quantities of salt and water are eliminated after solving a urinary tract obstruction. These patients are at increased risk of severe dehydration, electrolytic disturbances, hypovolemic shock, and death. Ureteropelvic junction obstruction (UPJO) is the most common etiology of collecting system dilatation in the fetal kidney, and a significant number of patients require pyeloplasty. There are limited data regarding prognostic risk factors for POD in this scenario. Study design This was a retrospective case series study of consecutive patients diagnosed with UPJO at three high complexity centers, managed with open pyeloplasty from 2006 to 2016. Multiple qualitative and quantitative variables possibly associated with POD were included according to the literature review. They were statistically analyzed with STATA 14 software. Results A total of 88 patients with UPJO following open pyeloplasty were analyzed. Twenty-seven patients (30%) had POD. A tendency to present POD in younger patients was found, with a mean age of 20.2 months vs. 72.3 months. There was also an increased risk of POD in patients with previous diagnosis of tubular acidosis. Conclusions There are no data about prognostic clinical risk factors for POD after open pyeloplasty in the pediatric population. Our study corresponds to one of the larger series reported so far. It suggests that younger patients and patients with a previous diagnosis of tubular acidosis could be at greater risk of POD. Consequently, prospective studies are required for validation of our results, and possible impact on patient follow-up.Summary table. Risk factors for POD: results of the univariate analysis with statistical significance.VariablePatients with no PODPatients with PODpn = 61n = 27Median (range) age, months72.3 (1–192)20.2 (2–120)0.005Previous tubular acidosis, n (%)1 (2)3 (11)0.049.https://orcid.org/0000-0003-3275-7019https://orcid.org/0000-0003-4152-9747https://orcid.org/0000-0002-2231-4321Revista Internacional - Indexad

Frequency of psichiatric comorbidities in patients with post- traumatic stress dissorder

Por medio de un estudio observacional descriptivo de corte transversal realizado en pacientes con diagnóstico de Trastorno por Estrés Postraumático (TEPT) con antecedente de exposición a combates, con grado militar de profesional, suboficial u oficial, hospitalizados por el Servicio de Psiquiatría del Hospital Militar Central de Bogotá entre enero y junio de 2008, se describe la presentación clínica de las co-morbilidades psiquiátricas asociadas al TEPT. Se detectó agorafobia en el 45,5% de los sujetos, fobia social en el 18,2%, fobias específicas (según el tipo) entre el 36,4% y el 45,5%, una prevalencia del 63,3% para trastornos depresivos y del 10% para distimia, concluyéndose que los trastornos afectivos, seguidos de ansiedad, eran las co-morbilidades más frecuentes, sin que se encontraran datos positivos para consumo de sustancias. Aunque se trata de un estudio piloto, con una muestra pequeña de tan solo once pacientes, es una primera aproximación a la investigación de co-morbilidades en una población de especial interés para la Sanidad Militar y la Defensa Nacional, que a futuro y con mayor numero de pacientes, permitirá establecer y fortalecer protocolos para su manejo.20-25The clinical presentation of the psychiatric co-morbidities associated to the Post-traumatic Stress Disorder (TEPT) is described by means of a descriptive cross section observational study made in patients with a diagnosis of TEPT with antecedent of exhibition to combats, with military rank of professional, sergeant major or official, hospitalized by the Service of Psychiatry of the Central Military Hospital of Bogota between January and June of 2008,. One detected agoraphobia in 45.5% of the subjects, social phobia in 18.2%, specific phobias (according to the type) between 36.4% and 45.5%, a prevalence of 63.3% for depressive upheavals and 10% for distimia, concluding that the affective upheavals, followed by anxiety, were the most frequent co-morbidities, without positive data for consumption of illegal substances. Although this is a pilot study, with a small sample of only eleven patients, it is the first approach to the investigation of co-morbidities in a population of special interest for the Military Health and the National Defense, which in the future and with greater number of patients, will allow to establish and to fortify protocols for its management

Genomes-based phylogeny of the genus Xanthomonas

<p>Abstract</p> <p>Background</p> <p>The genus <it>Xanthomonas </it>comprises several plant pathogenic bacteria affecting a wide range of hosts. Despite the economic, industrial and biological importance of <it>Xanthomonas</it>, the classification and phylogenetic relationships within the genus are still under active debate. Some of the relationships between pathovars and species have not been thoroughly clarified, with old pathovars becoming new species. A change in the genus name has been recently suggested for <it>Xanthomonas albilineans</it>, an early branching species currently located in this genus, but a thorough phylogenomic reconstruction would aid in solving these and other discrepancies in this genus.</p> <p>Results</p> <p>Here we report the results of the genome-wide analysis of DNA sequences from 989 orthologous groups from 17 <it>Xanthomonas </it>spp. genomes available to date, representing all major lineages within the genus. The phylogenetic and computational analyses used in this study have been automated in a Perl package designated Unus, which provides a framework for phylogenomic analyses which can be applied to other datasets at the genomic level. Unus can also be easily incorporated into other phylogenomic pipelines.</p> <p>Conclusions</p> <p>Our phylogeny agrees with previous phylogenetic topologies on the genus, but revealed that the genomes of <it>Xanthomonas citri </it>and <it>Xanthomonas fuscans </it>belong to the same species, and that of <it>Xanthomonas albilineans </it>is basal to the joint clade of <it>Xanthomonas </it>and <it>Xylella fastidiosa</it>. Genome reduction was identified in the species <it>Xanthomonas vasicola </it>in addition to the previously identified reduction in <it>Xanthomonas albilineans</it>. Lateral gene transfer was also observed in two gene clusters.</p

Análisis geoquímico de la calidad de agua en el Valle de Chaschuil-Catamarca

El agua es uno de los recursos más significativos de consumo en todo el planeta y especialmente en zonas áridas, como las localidades del departamento Tinogasta, donde las áreas de cultivos presentan una actividad alternativa para el desarrollo de la región. Dado que la cantidad y calidad de agua disponible para diferentes usos es variable, la calidad de agua del acuífero fue evaluado para el uso en cultivos. Por ello, se realizó un estudio para analizar la distribución espacial del acuífero de acuerdo a los parámetros de calidad y para identificar lugares con la mejor calidad basado en el análisis fisicoquímico de las muestras. Los resultados fueron comparados con los valores recomendados por la Organización Mundial de la Salud para el consumo y salud público. Del análisis realizado se puede clasificar las muestras como Aceptable para el riego con moderada restricción de uso, teniendo en cuenta la concentración de carbonatos/bicarbonatos encontrada.Water is one of the most significant consumption resources in the whole planet, especially in arid areas, such as the localities from Tinogasta Department, where crop areas represent an alternative activity for regional development. Since the quantity and quality of water available for different uses is variable, water quality of the aquifer was evaluated for use in crops. Therefore, a study was carried out to analyze the spatial distribution of the aquifer according to quality parameters and to identify places with the best quality based on the physicochemical analysis of the samples. Results were compared with the values recommended by the World Health Organization for public health and consumption. From the analysis carried out, the samples could be classified as acceptable for irrigation with moderate restriction of use, taking into account the carbonate / bicarbonate concentration found.Fil: Ortiz, Erlinda del Valle. Universidad Nacional de Catamarca. Facultad de Tecnología y Ciencias Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Niz, Adriana Edith. Universidad Nacional de Catamarca. Facultad de Tecnología y Ciencias Aplicadas; ArgentinaFil: Savio, M. E.. Universidad Nacional de Catamarca. Facultad de Tecnología y Ciencias Aplicadas; ArgentinaFil: Lamas, C. A.. Universidad Nacional de Catamarca. Facultad de Tecnología y Ciencias Aplicadas; ArgentinaFil: Barbieri, N. R.. Universidad Nacional de Catamarca. Facultad de Tecnología y Ciencias Aplicadas; ArgentinaFil: Duchowicz, Pablo Román. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentin

Information System of Assistant Technology in Bogotá

El Objetivo fue caracterizar los dispositivos de tecnología de asistencia disponibles en Bogotá como parte del desarrollo de un sistema de información en esta área. Dirigido a personas con discapacidad, a sus familias y a profesionales del área de la rehabilitación. Metodología: éste es un estudio descriptivo para el cual se desarrolló un instrumento de recolección de la información. El procedimiento consistió en visitas a los fabricantes y distribuidores de los dispositivos, diligenciamiento del instrumento, toma de fotografías y caracterización de cada producto basándose en la Norma Técnica Colombiana (NTC)-ISO 9999 (Ayudas técnicas para personas con limitación). Resultados: de los 95 productos caracterizados, se encontró que los de mayor disponibilidad están representados por ortesis y prótesis (52,6%) y ayudas para la movilización personal (23,15%). El 24,25% restante está representado por ayudas para el cuidado y la protección personal, mobiliario y adaptaciones para vivienda, ayudas para el manejo de bienes y productos y ayudas para actividades domésticas. Conclusiones: en Bogotá D.C. la mayoría de los fabricantes y distribuidores de dispositivos de tecnología en rehabilitación producen dispositivos ortésicos y ayudas para caminar, es mínimo el número de ayudas disponibles para apoyo en las actividades de la vida diaria y para la comunicación y el acceso a la información.This project has the objective to create a system of information that includes and manages data related to devices of Assistive Technology available in Colombia and its main characteristics; the project is directed to people with disability, their families and professionals in been the rehabilitation area. For the development of this project four phases have settled down: Bibliographical revision, Gathering of Information, Development of Engineering of the Software and Amplification of the study at National level. At the moment the project is at the phase II, during the time of investigation the results obtained have been tools for gathering of Information, Instructive which explains the correct form for obtaining this tools, home visits to orthopedic facilities, analysis of diverse products and development road of user’s way access

Genetic characterization by amplified fragment length polymorphism (AFLP) markers and morphochemical traits of Carica papaya L. genotypes

Carica papaya L. is a native fruit from Central America and Mexico and it is an economically important fruit. As a pre-breeding genetic study, the variability of both parents (L7 and M22) and the F1 individuals derived from their crosses (L7 × M22), was evaluated in terms of 32 morphochemical traits, and contrasted with their genetic diversity indicated by amplified fragment length polymorphism (AFLP) markers. According to morphochemical traits, L7 and M22 were grouped in two different clades. The first group included L7 and 13 genotypes from the F1, while a second group included the parent M22 and 15 other genotypes from the F1 progeny. The analysis based on morphochemical traits showed an average correlation of 0.652 among genotypes. For AFLP analysis the combination of the primers E-ACA/M-CTA had the best polymorphic index (72.73%). When they were grouped based on AFLPs markers, it was confirmed that both parents are genetically distant, and they were again grouped in two different clades. Five genotypes from the F1 population were grouped in the same clade as L7 and shared 55% similarity. Twenty six genotypes were grouped in the same clade as M22, showing 63.3% similarity. Another 12 genotypes (mainly female genotypes) were grouped in a third independent clade. This relative general agreement between the grouping based on a large number of morphochemical traits (including both plant and fruit traits) and that based on its genetic diversity using AFLPs, suggests that morphochemical characterization, together with genetic analysis by AFLPs, can be complementary and useful techniques for the identification and assessment of genetic diversity within C. papaya L. genotypes, that should be useful for genetic breeding programs of this important species.Key words: Morphological markers, AFLP markers, genetic similarity, Carica papaya L

Protective Effects of C-Type Natriuretic Peptide on Linear Growth and Articular Cartilage Integrity in a Mouse Model of Inflammatory Arthritis

Objective: The C-type natriuretic peptide (CNP) signaling pathway is a major contributor to postnatal skeletal growth in humans. This study was undertaken to investigate whether CNP signaling could prevent growth delay and cartilage damage in an animal model of inflammatory arthritis. Methods: We generated transgenic mice that overexpress CNP (B6.SJL-Col2a1-NPPC) in chondrocytes. We introduced the CNP transgene into mice with experimental systemic inflammatory arthritis (K/BxN T cell receptor [TCR]) and determined the effect of CNP overexpression in chondrocytes on the severity of arthritis, cartilage damage, and linear growth. We also examined primary chondrocyte cultures for changes in gene and protein expression resulting from CNP overexpression. Results: K/BxN TCR mice exhibited linear growth delay (P < 0.01) compared to controls, and this growth delay was correlated with the severity of arthritis. Diminished chondrocyte proliferation and matrix production was also seen in K/BxN TCR mice. Compared to non–CNP-transgenic mice, K/BxN TCR mice with overexpressed CNP had milder arthritis, no growth delay, and less cartilage damage. Primary chondrocytes from mice overexpressing CNP were less sensitive to inflammatory cytokines than wild-type mouse chondrocytes. Conclusion: CNP overexpression in chondrocytes can prevent endochondral growth delay and protect against cartilage damage in a mouse model of inflammatory arthritis. Pharmacologic or biologic modulation of the CNP signaling pathway may prevent growth retardation and protect cartilage in patients with inflammatory joint diseases, such as juvenile idiopathic arthritis

Trypanosoma cruzi infection, discrete typing units and feeding sources among Psammolestes arthuri (Reduviidae: Triatominae) collected in eastern Colombia

Background: Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi, and is transmitted by hematophagous insects of the family Reduviidae. Psammolestes arthuri is a sylvatic triatomine distributed in Colombia and Venezuela which feeds on birds and there are a few studies that have reported Ps. arthuri naturally infected with T. cruzi. In Colombia, Ps. arthuri has been found in dwellings, making it important to evaluate its possible role in the T. cruzi transmission cycle. We aimed to evaluate the presence of T. cruzi and feeding sources of Ps. arthuri to elucidate new possible scenarios of T. cruzi transmission in the country. Methods: A total of 60 Ps. arthuri were collected in Arauca and Casanare, Colombia. We detected and genotyped T. cruzi and identified feeding sources. The frequency of the presence of T. cruzi was obtained and compared with different eco-epidemiological variables. Multiple correspondence analysis was conducted to explore associations between eco-epidemiological variables and the presence of T. cruzi; with these results, a logistic regression was used to determine statistical associations. Results: The infection rate of T. cruzi was 70.7% and was mostly associated with insect stage, sex, bird nest and feeding source. Regarding discrete typing units (DTUs), TcI was found in 54.7% samples, of which 21.7% (5/23) were TcI Dom , 52.1% (12/23) had mixed infection (TcI Dom -TcI Sylv ), and single infection with TcI Sylv was not detected. Mixed infections (TcI/TcII-TcVI) were found in 9.52% (4/42) of the samples; of these, 14.2% (6/42) were TcII-TcVI. A total of 15 feeding sources were identified and the most frequent were: Cranioleuca baroni (35.85%), Homo sapiens (26.42%), Thraupis episcopus (11.32%) and Serinus albogularis (3.77%). Conclusions: Although Ps. arthuri is mainly ornithophilic, this species may be feeding on other animals that can be infected with T. cruzi, possibly playing a role maintaining the zoonotic cycle of the parasite. Further studies with molecular techniques and wider sampling are needed to improve information regarding infection rates, ecotopes and habits with the aim of evaluating whether Ps. arthuri could be a potential T. cruzi vector. © 2019 The Author(s)