La influencia de diferentes modelos de publicación en la presencia y detección de errores y fraude científico

This study attempts to test how different journal publishing models can favor or reduce the presence of errors and misconduct articles, as well as to measure the response of journals to problematic articles according to these publishing models. For this, a new approach for the study of scientific misconduct in publications is proposed. Comments expressed in PubPeer about 17,244 troublesome articles were compared with the editorial response of journals (i.e. editorial notices). Journals of these publications were classified according to several publishing criteria: publisher type, access type, publication fee model and peer review type. The results show that in spite of scholar-published journals suffer more from problematic papers, they release the same editorial notices than commercial journals; open access journals react better to problematic articles than paywall journals; open access journals without APC has a special presence of Publishing fraud; and journals that use open review suffer less from misconduct, slightly releasing more editorial notices.Este estudio pretende comprobar cómo diferentes modelos de publicación de revistas científica pueden favorecer o reducir la incidencia de artículos erróneos o fraudulentos, a la vez que busca medir la respuesta de revistas a estos problemas en función de estos modelos. Para esto, se propone una nueva forma de estudiar el fraude científico en las publicaciones. Los comentarios expresados en PubPeer sobre 17.244 artículos problemáticos fueron comparados con la respuesta editorial de las revistas (i.e. notas editoriales). Las revistas de estas publicaciones fueron clasificadas en función de diferentes criterios editoriales: tipo de editor, tipo de acceso, modelo de financiación y tipo de revisión por pares. Los resultados muestran que a pesar de que las revistas editadas por la academia sufren más de artículos problemáticos, emiten el mismo número de notas editoriales que las revistas comerciales; las revistas de acceso abierto reaccionan mejor ante artículos problemáticos que revistas de pago; revistas de acceso abierto sin APC tienen una incidencia especial de Fraude en la publicación; y revistas que emplean una revisión en abierto sufren menos de fraude científico y ligeramente emiten más notas editoriales

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain metastasis; however, its efficacy in preventing disease progression and the associated toxicity have questioned the clinical impact of this approach and emphasized the need for alternative treatments. Given the limited therapeutic options available for these patients and the poor understanding of the molecular mechanisms underlying the resistance of metastatic lesions to WBRT, we sought to uncover actionable targets and biomarkers that could help to refine patient selection. Through an unbiased analysis of experimental in vivo models of brain metastasis resistant to WBRT, we identified activation of the S100A9-RAGE-NF-κB-JunB pathway in brain metastases as a potential mediator of resistance in this organ. Targeting this pathway genetically or pharmacologically was sufficient to revert the WBRT resistance and increase therapeutic benefits in vivo at lower doses of radiation. In patients with primary melanoma, lung or breast adenocarcinoma developing brain metastasis, endogenous S100A9 levels in brain lesions correlated with clinical response to WBRT and underscored the potential of S100A9 levels in the blood as a noninvasive biomarker. Collectively, we provide a molecular framework to personalize WBRT and improve its efficacy through combination with a radiosensitizer that balances therapeutic benefit and toxicity.info:eu-repo/semantics/publishedVersio

REFERENCE ANALYSIS BASE ON A VECTORIAL SPACES MODEL: CONTEMPORANY HISTORY IN JAEN RESEARCH FOR 1990-1995

Bibliometry; Citation analysis; Vectorials Spaces Model (VSM); Multidimensional Scaling (MDS); Mapping of Science; Contemporany HistoryThe spatial perfomance of the relationships there are among researchers in Contemporany History of Jaén for 1990-1995 through their behaviour in citing process is the objetive of this work. Through reference analysis bases on Vectorial Spaces Model (VSM) and displayed in a graphic thanks to Multidimensional Scaling (MDS) are obtained results about research fronts, who lead them, who made up them, and the "disciple/master" relationships there are among researchers