In vitro comparison of primary stability of two implant designs in D3 bone

Primary stability (PS) is a key factor for implant survival rate and depends on implant design or bone quality. The aim of this study was to compare different thread designs implants, evaluating PS with periotest values (PV) and implant stability quotient (ISQ) values through resonance frequency analysis (RFA). A total of 60 implants (Radhex®, Inmet-Garnick S.A., Guadalajara, Spain) were placed in freshly bovine ribs in vitro. Two designs were used: 30 tapered body with single thread design (PHI) and 30 tapered body with double thread design implants (PHIA). Both designs were 4mm wide and 12mm long. Implants were placed according to manufacturer?s guidelines. Osstell? and Periotest® devices were used to evaluate PS by a blinded independent observer. Computed tomographies (CTs) of the ribs were made (BrightSpeed Series CT systems, GE Healthcare, Milwaukee, WI, USA) and bone quality surrounding each implant was evaluated in Hounsfield Units (HU) using Ez3D Plus software (Vatech Co., Korea). Bone quality was classified according to Misch and Kircos in D1, D2, D3 or D4. All implants were mechanically stable. Only implants placed in D3 bone (350-850 HU) were selected for the study: 28 PHI and 26 PHIA. The one way ANOVA showed significant difference (p<0.005) among two implants designs in ISQ values (61,55 ± 6,67 in PHI and 68,94 ± 5,82 in PHIA). No significant difference (p = 0,171) was shown in PV between two designs (-4,47 ± 1,39 in PHI and -4,77 ± 0,87 in PHIA). Higher PS was found using Osstell? device in implants with double thread design (PHIA) in comparison to implants with single thread design (PHI) in D3 bone

SEQUENTIAL INDUCTION OF CHIRALITY IN POLY(PHENYLACETYLENE)S

Several hierarchical levels of chirality have been detected in functionalized poly(phenylacetylene)s (PPA).1 In this work we have studied the chirality induction throughout these levels in PPA functionalized with phenylglycine methyl ester groups, Fig. 1.2 These pendant groups force the PPA chain to lose its planar all-transoid shape to form helical structures. The chiral seed of the pendants, [(R)- or (S)-], dictates the preferent handedness of the helices, both the internal polyacetylene helical covalent backbone and the external helix formed by the side pendants which forms a complementary helix or counter-helix. In this work, we afford a full assessment of the interconnection between stereocenter and helix sources of chirality and the action of these polymers as chiral templates of other supra-molecular structures with inherited chiral properties. We then used VCD spectroscoy to demonstrate the chiral induction from the stereogenic centers to the backbone helix and from this to the pendant helix, which are largely promoted by two mechanisms: steric effects and hydrogen bonding. In addition, the VCD spectra supported that the helical setup of the pendants induces the solvent DMSO molecules to adopt a solvation helix around the polymer, thus proving how an achiral solvent becomes chirally organized owing to the template effect of the covalent polymer helices. A similar effect was observed in DMSO solutions of the monomeric units. Interestingly, this resulted in opposite helical sense to the one observed in the polymer with identical enantiomeric form.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Relationship between apoptosis and the BH2 domain sequence of the VP5 peptide of infectious pancreatic necrosis virus

Objective. To determine whether the level of apoptosis induced by infectious pancreatic necrosis virus (IPNV) is related to the amino acid sequence of the BH2 domain of the VP5 protein and the level of infectivity. Materials and methods. Three IPNV strains were used, the VP2 protein gene was amplified for genotyping and the VP5 sequence was also obtained. The infectivity of the strains was calculated using the viral titer obtained at 12, 24, 36 and 45 hpi in CHSE-214 cells. The percentage of apoptosis in infected cells was visualized by TUNEL assay and immunohistochemistry (caspase 3 detection). Results. The V70/06 and V33/98 strains corresponded to genotype Sp, while V112/06 to VR-299; the amino acid analysis of the V70/06 strain allows its classification as middle virulent strain and V33/98 and V112/06 strains as low virulent ones; infection with the V112/06 strain produced a lower viral titer (p<0.05). The VP5 gene of the 3 strains showed four homologous domains to Bcl-2, however, the BH2 domain was truncated in V70/06 and V33/98 (12 kDa), being complete (15kDa) in V112/06, which also showed the Trp155 residue, equivalent to Trp188 considered as a critical factor for the function of Bcl-2. The average apoptosis was below 12%, showing no differences between strains (p>0.05). Conclusions. The results showed that the differences in the BH2 sequence of the VP5 protein, infectivity and the VP2 sequence are not associated with the modulation of apoptosis

Enabling Remote Responder Bio-Signal Monitoring in a Cooperative Human–Robot Architecture for Search and Rescue

The roles of emergency responders are challenging and often physically demanding, so it is essential that their duties are performed safely and effectively. In this article, we address real-time bio-signal sensor monitoring for responders in disaster scenarios. In particular, we propose the integration of a set of health monitoring sensors suitable for detecting stress, anxiety and physical fatigue in an Internet of Cooperative Agents architecture for search and rescue (SAR) missions (SAR-IoCA), which allows remote control and communication between human and robotic agents and the mission control center. With this purpose, we performed proof-of-concept experiments with a bio-signal sensor suite worn by firefighters in two high-fidelity SAR exercises. Moreover, we conducted a survey, distributed to end-users through the Fire Brigade consortium of the Provincial Council of Málaga, in order to analyze the firefighters’ opinion about biological signals monitoring while on duty. As a result of this methodology, we propose a wearable sensor suite design with the aim of providing some easy-to-wear integrated-sensor garments, which are suitable for emergency worker activity. The article offers discussion of user acceptance, performance results and learned lessons.This work has been partially funded by the Ministerio de Ciencia, Innovación y Universidades, Gobierno de España, projects RTI2018-093421-B-I00 and PID2021-122944OB-I00. Partial funding for open access charge: Universidad de Málag

Economic growth and local development in the Central–Bajio region of Mexico

This paper starts from the idea that development is a more complex process than simply economic growth. The human development perspective proposed by Amartya Sen and promoted by the United Nations Program for Development (UNDP), it seems appropriate to analyze territorially at the local level the necessary institutional conditions and political policy to impact and to improving the quality of life of people through the expansion of capabilities and opportunities. The research results presented in this article seek to identify the level of development of the Central-Bajio region in Mexico, through inter and intra-municipal analysis of indicators of local development (using the Development Human Index) in order to make them useful and to improve design and evaluation instrument for public policies of local governments that affect the regional development strategy. Keywords: human development, economic growth, regional development, public policies.Este trabajo parte de la idea que desarrollo es un proceso más complejo que crecimiento económico. La perspectiva del desarrollo humano, propuesta por Amartya Sen e impulsada por el Programa de Naciones Unidas para el Desarrollo (PNUD) parece ser adecuada para analizar territorialmente en el orden local las condiciones institucionales y de política pública necesarias para impactar en la mejora de la calidad de vida de las personas a través de la ampliación de capacidades y oportunidades. Los resultados de investigación que aquí se presentan buscan identificar el nivel de Desarrollo de la Región Centro-Bajío de México a partir de un análisis inter e intramunicipal; además, evalúa los indicadores de medición del desarrollo local (a partir del Índice de Desarrollo Humano) con el propósito de hacerlos útiles para mejorar los instrumentos de diseño y evaluación de políticas públicas de los gobiernos locales que incidan en una estrategia de Desarrollo Regional. Palabras clave: desarrollo humano, crecimiento económico, desarrollo regional, políticas públicas

Study of available bone for interforaminal implant treatment using cone-beam computed tomography

Objectives: To analyze the availability of bone in the interforaminal region and to demonstrate the variation in diagnosis between panoramic x-ray and cone-beam computed tomography (CBCT). Material and methods: In 50 patients and in 5 areas of each, a series of parameters concerning available bone were measured on both the panoramic and the CT images. Results: Panoramic images underestimate the vertical and horizontal measurements when compared with CBCT. Regarding implant treatment, the interforaminal region presents the same remaining bone height throughout its full extent, the correlation between one side of the midline and the other was highly significant for all the parameters studied, and 20% of the sample showed some buccal and/or lingual concavity. Conclusion: Cone-beam CT is an advantageous system for interforaminal implant treatment planning, especially since the reported radiation dose is minimal and geometric accuracy is very high

Presentación

Issue introduction.Introducción del número

Presentación

Introduction of number 8 issue of Documentación Administrativa journalPresentación del número 8 de la revista Documentación Administrativ

Presentación

Issue introduction.Introducción del número