Search CORE

5 research outputs found

Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold

Author: Biftu T.
Borne R. F.
Chutian S.
Drucker D. J.
Drucker D. J.
Hawkins P. C. D.
Herman G. A.
Juillerat-Jeanneret L.
Kim D.
Nauck M.
Occhiato E. G.
Orsakov C.
Schwehm C.
Thomsen I.
Thornberry N. A.
Publication venue: 'American Chemical Society (ACS)'
Publication date: 13/01/2015
Field of study

A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown

Nottingham ePrints

Nottingham eTheses

Repository@Nottingham

The Francis Crick Institute

Discovery of 2-[4-{{2-(2S, 5R)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]-4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes

Author: Abbott C. A.
Ahrén B.
Ahrén B.
Ahrén B.
Ahrén B.
Ashworth D. M.
Augeri D. J.
Beal L. M.
Deacon C. F
Fulop V.
Kieffer T. J.
Knudsen L. B.
Lankas G. R.
Larsen J.
Li J.
Longenecker K. L.
Madar D. J.
Mcdonald J. K.
Mentlein R.
Moller D. E
Olsen C.
Orsakov C
Rachman J.
Scallan M. J.
Several
Villhauer E. B.
Villhauer E. B.
While
Publication venue: 'American Chemical Society (ACS)'
Publication date
Field of study

(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5, 6-dihydro[1, 2, 4]triazolo[4, 3-a]pyrazin-7(8H)-yl]-1-(2, 4, 5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Author: Abbot C. A.
Ashton W. T.
Ashworth D. M.
Branner K. A.
Brockunier L.
Brünger A. T.
Caldwell C. G.
Coppola G. M.
Deacon C. F.
Deng C.
Engel M.
Evans D. A.
Flint A.
Huynh-Dinh T.
Kieffer T. J.
Magnin D. R.
Marguet D.
McDonald J. K.
Muller A.
Nauck M. A.
Nelson P. J.
Oefner C.
Olsen C.
Orsakov C
Parmee E. R.
Peters J.-U.
Peters J.-U.
Peters J.-U.
Pospisilik J. A.
Rasmussen H. B.
Reimer M. K..
Scallan M. J.
Spingarn N. E.
Thoma R.
Vagin A.
Villhauer E. B.
Villhauer E. B.
Weber A E.
Wettergren A.
Xu J.
Zander M.
Zhao K.
Publication venue: 'American Chemical Society (ACS)'
Publication date
Field of study

The role of GLP-1 in the regulation of islet cell mass

1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-( S

Author: Abraham E. J.
Ahren B.
Ahrén B.
Ahrén B.
Ashworth D. M.
Ashworth D. M.
Aspelun F.
Augustyns K. J. L.
Balkan B.
Balkan B.
Barth A.
Belyaev A.
Burcelin R.
Chiravuri M.
Deacon C. F.
Deacon C. F.
Deacon C. F.
DeMeester I.
Demuth H.
Doyle M. E.
Drucker D. J
Drucker D. J.
Duke-Cohan J. S.
Egan J.
Egan J.
Farilla L.
Flint A.
Habener J. F
Heins J.
Holst J. J
Holst J. J.
Hughes T. E.
Jacotot E.
Jenkins P. D.
Juana F.
Kemp D. M.
Kieffer T. J.
Kubota T.
Lene H.
Li J.
Li Y.
Ling Z.
Macnair R. D.
Mantle D
Marguet D.
Mentlein R.
Mentlein R.
Mitani H.
Mitani H.
Momand J.
Nagatsu T.
Nauck M. A.
Nauck M. A.
Nauck M. A.
Nauck M. A.
Niedermeyer J.
Orsakov C.
Parkes D. G.
Pauly R. P.
Pederson R. P.
Perfetti R.
Pospisilik J. A.
Pospisilik J. A.
Rachman J.
Rasmussen H. P.
Reimer M. K.
Reisher S. R.
Rothenberg P.
Sandhu H.
Schneider B. L.
Schön E.
Sudre B.
Suicide
These
Tourrel C.
Villanueva-Peñacarrillo M. L.
Villhauer E. B.
Villhauer E. B.
Villhauer E. B.
Villhauer E. B.
Wettergren A.
Yaron A.
Publication venue: 'American Chemical Society (ACS)'
Publication date
Field of study

core