Previous high-intensity activity affects lower limb strength ratios

Lower limb strength ratios are important in assessing muscular imbalances. Typically, these ratios are derived from assessment of explosive, maximum effort activities. Such assessment can be functional or isokinetic. The single-effort nature of these assessments does not provide information on imbalance changes after muscular contractions. Any such change could indicate an increased risk of injury after a period of activity, thus raising questions as to the correct procedure of muscle imbalance assessment. Therefore, the aim of the current study was to assess muscle imbalances over maximum effort repeated cycling sprints. Seventeen healthy, physically active young adults (females: n=4, height 1.62±0.03 m, body mass 68.0±6.5 kg; males: n=13, height 1.80±0.06 m, body mass 80.5±13.8 kg) performed five 6-s sprints with 24-s rest interval on a Lode Excalibur bike with torque and power data recorded for each leg. Average, average maximum (average of maximum from each sprint) and peak torque (TAv, TAvM and TP respectively) and power (PAv, PAvM and PP respectively) were obtained for each leg. Ratios of these variables were calculated as . Wilcoxon's test revealed a significantly stronger leg (p<0.05) for all torque and power variables. Friedman's test indicated a significant ratio increase between TAv (11.7±6.8%) and TAvM (4.6±3.0%, p=0.001) and TP (4.1±3.5%, p=0.001), as well as between PAv (8.8±5.0%) and PAvM (4.5±2.9%, p=0.003) and PP (4.2±2.6, p=0.003%) but not between TAvM and TP (p=0.421) or PAvM and PP (p=0.981). The results indicate that high-intensity activity increases lower limb strength imbalance, resulting in different ratios. The authors posit that muscle imbalance assessment activities conducted at rested state may not accurately reflect the true strength difference between limbs, leading to inaccurate training or rehabilitation advice

Application of Hamamatsu MPPC to T2K Neutrino Detectors

A special type of Hamamatsu MPPC, with a sensitive area of 1.3x1.3mm^2 containing 667 pixels with 50x50um^2 each, has been developed for the near neutrino detector in the T2K long baseline neutrino experiment. About 60 000 MPPCs will be used in total to read out the plastic scintillator detectors with wavelength shifting fibers. We report on the basic performance of MPPCs produced for T2K.Comment: Contribution to the proceedings of NDIP 2008, Aix-les-Bains, France, June 15-20, 200

Performance of Multi-Pixel Photon Counters for the T2K near detectors

We have developed a Multi-Pixel Photon Counter (MPPC) for the neutrino detectors of T2K experiment. About 64,000 MPPCs have been produced and tested in about a year. In order to characterize a large number of MPPCs, we have developed a system that simultaneously measures 64 MPPCs with various bias voltage and temperature. The performance of MPPCs are found to satisfy the requirement of T2K experiment. In this paper, we present the performance of 17,686 MPPCs measured at Kyoto University.Comment: 15 pages, 14 figure

Large scale surface structure formed during GaAs (001) homoepitaxy

Atomic force microscopy studies have been performed on GaAs (001) homoepitaxy films grown by molecular beam epitaxy. Multilayered features are seen to evolve when the growth conditions favor island nucleation. As the epilayer thickness is increased these features grow in all dimensions but the angle of inclination remains approximately constant at 1°. The mounding does not occur on surfaces grown in step flow. We propose that the multilayered features are an unstable growth mode which relies on island nucleation and the presence of a step edge barrier.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70983/2/APPLAB-64-7-860-1.pd

The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions

PURPOSE OF REVIEW: Dementia with Lewy bodies (DLB) is a neurodegenerative disease that can be clinically and pathologically similar to Parkinson’s disease (PD) and Alzheimer’s disease (AD). Current understanding of DLB genetics is insufficient and has been limited by sample size and difficulty in diagnosis. The first genome-wide association study (GWAS) in DLB was performed in 2017; a time at which the post-GWAS era has been reached in many diseases. RECENT FINDINGS: DLB shares risk loci with AD, in the APOE E4 allele, and with PD, in variation at GBA and SNCA. Interestingly, the GWAS suggested that DLB may also have genetic risk factors that are distinct from those in AD and PD. SUMMARY: Although off to a slow start, recent studies have reinvigorated the field of DLB genetics and these results enable us to start to have a more complete understanding of the genetic architecture of this disease

An Investigation of Orientational Symmetry-Breaking Mechanisms in High Landau Levels

The principal axes of the recently discovered anisotropic phases of 2D electron systems at high Landau level occupancy are consistently oriented relative to the crystal axes of the host semiconductor. The nature of the native rotational symmetry breaking field responsible for this preferential orientation remains unknown. Here we report on experiments designed to investigate the origin and magnitude of this symmetry breaking field. Our results suggest that neither micron-scale surface roughness features nor the precise symmetry of the quantum well potential confining the 2D system are important factors. By combining tilted field transport measurements with detailed self-consistent calculations we estimate that the native anisotropy energy, whatever its origin, is typically ~ 1 mK per electron.Comment: Reference added, minor notational changes; final published versio

Food for Thought: the Efficiency of Glucose Metabolism Predicts the Self-generation of Temporally Distant Cognition

The generation of thought independent of environmental input occupies almost half of mental life and is important for skills such as creativity and planning. To understand how this ubiquitous cognitive process relates to the brain's ‘energy budget’, a cross-sectional study is carried out to examine how the capacity for mental time travel relates to the efficiency with which adults metabolize glucose, the brain’s primary source of fuel. On day 1 the ability of a group of 36 younger and 36 older individuals to metabolize glucose was assessed using the gold standard two-hour glucose tolerance test. Twenty-four hours later, the same group of participants returned to the laboratory to perform a non-demanding choice reaction time task during which experience sampling was used to assess the frequency with which they generated thoughts that were unrelated to the here and now. Analysis indicated that younger individuals who were the most efficient at metabolizing glucose exhibited mental time travel that spanned longer time periods. Given the importance of self-generated thought in daily life these results suggest that the capacity to mentally simulate events not present in the immediate environment is highly dependent on efficient glucose metabolis

Aeolian sediment reconstructions from the Scottish Outer Hebrides: Late Holocene storminess and the role of the North Atlantic Oscillation

Northern Europe can be strongly influenced by winter storms driven by the North Atlantic Oscillation (NAO), with a positive NAO index associated with greater storminess in northern Europe. However, palaeoclimate reconstructions have suggested that the NAO-storminess relationship observed during the instrumental period is not consistent with the relationship over the last millennium, especially during the Little Ice Age (LIA), when it has been suggested that enhanced storminess occurred during a phase of persistent negative NAO. To assess this relationship over a longer time period, a storminess reconstruction from an NAO-sensitive area (the Outer Hebrides) is compared with Late Holocene NAO reconstructions. The patterns of storminess are inferred from aeolian sand deposits within two ombrotrophic peat bogs, with multiple cores and two locations used to distinguish the storminess signal from intra-site variability and local factors. The results suggest storminess increased after 1000 cal yrs BP, with higher storminess during the Medieval Climate Anomaly (MCA) than the LIA, supporting the hypothesis that the NAO-storminess relationship was consistent with the instrumental period. However the shift from a predominantly negative to positive NAO at c.2000 cal yrs BP preceded the increased storminess by 1000 years. We suggest that the long-term trends in storminess were caused by insolation changes, while oceanic forcing may have influenced millennial variability