A laser velocimeter system for large-scale aerodynamic testing

A unique laser velocimeter was developed that is capable of sensing two orthogonal velocity components from a variable remote distance of 2.6 to 10 m for use in the 40- by 80-Foot and 80- by 120-Foot Wind Tunnels and the Outdoor Aerodynamic Research Facility at Ames Research Center. The system hardware, positioning instrumentation, and data acquisition equipment are described in detail; system capabilities and limitations are discussed; and expressions for systematic and statistical accuracy are developed. Direct and coupled laboratory measurements taken with the system are compared with measurements taken with a laser velocimeter of higher spatial resolution, and sample data taken in the open circuit exhaust flow of a 1/50-scale model of the 80- by 120-Foot Wind Tunnel are presented

Laser velocimetry in the low-speed wind tunnels at Ames Research Center

The historical development of laser velocimetry and its application to low-speed (less than 100 m/sec) aerodynamic flows in the subsonic wind tunnels at Ames Research Center is reviewed. A fully three dimensional velocimeter for the Ames 7- by 10-Foot Wind Tunnel is described, and its capabilities are presented through sample data from a recent experiment. Finally, a long-range (2.6 to 10 m) velocimeter that is designed to be installed within the test section of the Ames 40- by 80-Foot Wind Tunnel is described and sample data are presented

Gender and the welfare state

Gender relations, as embodied in the sexual division of labor, compulsory heterosexuality, discourses and ideologies of citizenship, motherhood, masculinity and femininity, and the like, profoundly shape the character of welfare states. Likewise, the institutions of social provision the set of social assistance and social insurance programs, universal citizenship entitlements, and public services to which we refer as "the welfare state" affect gender relations in various ways. Although many recent studies of the welfare state use a comparative analysis to study the factors shaping the welfare state, few of these studies have paid systematic attention to gender. Similarly, most feminist work has not been systematically comparative. This paper summarizes the current state of understanding of the varying effects of welfare states on gender relations, and vice versa.

Breaking of B-L in superstring inspired E6 model

In the framework of the superstring inspired E6 model, low-energy extensions of the standard model compatible with leptogenesis are considered and masses of right-handed neutrinos in two scenarios allowed by long-lived protons are discussed. The presence of two additional generations allows breaking of B-L without generating nonzero vacuum expectation values of right-handed sneutrinos of the three known generations. After the symmetry breaking, right-handed neutrinos acquire Majorana masses of order of 10^11 GeV. Within the framework of a simple discrete symmetry, assumptions made to provide a large mass of right-handed neutrinos are shown to be self-consistent. Supersymmetric structure of the theory ensures that large corrections, associated with the presence of a (super)heavy gauge field, cancel out.Comment: 18 pages, 6 tables, axodraw use

Predictions of selected flavour observables within the Standard Model

This letter gathers a selection of Standard Model predictions issued from the metrology of the CKM parameters performed by the CKMfitter group. The selection includes purely leptonic decays of neutral and charged B, D and K mesons. In the light of the expected measurements from the LHCb experiment, a special attention is given to the radiative decay modes of B mesons as well as to the B-meson mixing observables, in particular the semileptonic charge asymmetries a^d,s_SL which have been recently investigated by the D0 experiment at Tevatron. Constraints arising from rare kaon decays are addressed, in light of both current results and expected performances of future rare kaon experiments. All results have been obtained with the CKMfitter analysis package, featuring the frequentist statistical approach and using Rfit to handle theoretical uncertainties.Comment: 8 pages, 1 figure, 2 tables. Typos corrected and discussion of agreement between SM and data update

Fine-mapping using the weighted average method for a case-control study

We present a new method for fine-mapping a disease susceptibility locus using a case-control design. The new method, termed the weighted average (WA) statistic, averages the Cochran-Armitage (CA) trend test statistic and the difference between the Hardy-Weinberg disequilibrium test statistic for cases and controls (the HWD trend). The main characteristics of the WA statistic are that it improves on the weaknesses, and maintains the strengths, of both the CA trend test and the HWD trend test. Data from three different populations in the Genetic Analysis Workshop 14 (GAW14) simulated dataset (Aipotu, Karangar, and Danacaa) were first subjected to model-free linkage analysis to find regions exhibiting linkage. Then, for fine-scale mapping, 140 SNPs within the significant linkage regions were analyzed with the WA test statistic on replicates of the three populations, both separately and combined. The regions that were significant in the multipoint linkage analysis were also significant in this fine-scale mapping. The most significant regions that were obtained using the WA statistic were regions in chromosome 3 (B03T3056–B03T3058, p-value < 1 × 10(-10 )) and chromosome 9 (B09T8332–B09T8334, p-value 1 × 10(-6 )). Based on the results of the simulated GAW14 data, the WA test statistic showed good performance and could narrow down the region containing the susceptibility locus. However, the strength of the signal depends on both the strength of the linkage disequilibrium and the heterozygosity of the linked marker

Cytomegalovirus MicroRNA Expression Is Tissue Specific and Is Associated with Persistence

MicroRNAs (miRNAs) are a class of small noncoding RNAs involved in posttranscriptional regulation. miRNAs are utilized in organisms ranging from plants to higher mammals, and data have shown that DNA viruses also use this method for host and viral gene regulation. Here, we report the sequencing of the small RNAs in rat cytomegalovirus (RCMV)-infected fibroblasts and persistently infected salivary glands. We identified 24 unique miRNAs that mapped to hairpin structures found within the viral genome. While most miRNAs were detected in both samples, four were detected exclusively in the infected fibroblasts and two were specific for the infected salivary glands. The RCMV miRNAs are distributed across the viral genome on both the positive and negative strands, with clusters of miRNAs at a number of locations, including near viral genes r1 and r111. The RCMV miRNAs have a genomic positional orientation similar to that of the miRNAs described for mouse cytomegalovirus, but they do not share any substantial sequence conservation. Similar to other reported miRNAs, the RCMV miRNAs had considerable variation at their 3′ and 5′ ends. Interestingly, we found a number of specific examples of differential isoform usage between the fibroblast and salivary gland samples. We determined by real-time PCR that expression of the RCMV miRNA miR-r111.1-2 is highly expressed in the salivary glands and that miR-R87-1 is expressed in most tissues during the acute infection phase. Our study identified the miRNAs expressed by RCMV in vitro and in vivo and demonstrated that expression is tissue specific and associated with a stage of viral infection