The importance of strategic financial leadership in the UK public sector in a time of financial austerity

Given the severity of financial pressures on public authorities, this report is concerned with how finance managers in public services are coping with the demands placed on them and how they can demonstrate improved value by providing more effective strategic financial leadership. It considers how they are applying managerial approaches and solutions to the challenges of austerity and the role that the public sector finance function can play in this process

Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson's Disease

Oxidative stress arises when cellular antioxidant defences become overwhelmed by a surplus generation of reactive oxygen species (ROS). Once this occurs, many cellular biomolecules such as DNA, lipids, and proteins become susceptible to free radical-induced oxidative damage, and this may consequently lead to cellular and ultimately tissue and organ dysfunction. Mitochondria, as well as being a source of ROS, are vulnerable to oxidative stress-induced damage with a number of key biomolecules being the target of oxidative damage by free radicals, including membrane phospholipids, respiratory chain complexes, proteins, and mitochondrial DNA (mt DNA). As a result, a deficit in cellular energy status may occur along with increased electron leakage and partial reduction of oxygen. This in turn may lead to a further increase in ROS production. Oxidative damage to certain mitochondrial biomolecules has been associated with, and implicated in the pathophysiology of a number of diseases. It is the purpose of this review to discuss the impact of such oxidative stress and subsequent damage by reviewing our current knowledge of the pathophysiology of several inherited mitochondrial disorders together with our understanding of perturbations observed in the more commonly acquired neurodegenerative disorders such as Parkinson’s disease (PD). Furthermore, the potential use and feasibility of antioxidant therapies as an adjunct to lower the accumulation of damaging oxidative species and hence slow disease progression will also be discussed

The 1000 GeV gamma rays from ms pulsars

The detection of 1000 GeV gamma-rays with the characteristic 6.1 ms periodicity of the radio pulsar PSR 1953 +29 is reported. This result, significant at the 5.4 beta level, provides the first direct evidence for the association of the 6 ms radio pulsar PSR1953+29 with the gamma-ray source 2CG065+0. Extensive observations of the 1.5 ms pulsar PSR 1937 are also reported

The 1000 GeV gamma ray emission from radio pulsars

Radio pulsars have concentrated on long observations of the Crab pulsar and showed that it emits short intense bursts and a persistent weak periodic flux at gamma-ray energies 1000 GeV. It was shown that the light curve of the persistent emission was dominated by a single peak, coincident with the position of the radio and low energy gamma-ray main pulse. The results of a more detailed analysis of the structure of this main pulse are reported following an appraisal of the timing system. It is shown that at energies 1000 GeV the duration of the main pulse is not greater than 0.4 ms, which is less than that seen at all frequencies other than radio. Flux limits for the emission of 1000 GeV gamma-rays by seven other radio pulsars are reporte