Potentialities Crisis Management in Area Industry 4.0

Tvorba globálneho kybernetického priestoru (GCS), digitalizácia procesov, využívanie M2M komunikácie (Machine To Machine) a oblasti služieb Internetu vecí (IoT), vytvárajú podmienky pre identifikovanie, analyzovanie a riadenie procesov v reálnom čase s novými možnosťami aj v oblasti krízového manažmentu. V tomto GCS sú záchranárskej činnosti poskytnuté možnosti, ktoré je vhodné využiť.Creating global cyber space (GCS), process digitization, M2M use and IoT services create the conditions for real-time identification, analysis, and management of new opportunities in the area of crisis management. Rescue activities in this GCS area provided with options that should be used

Image Encryption Algorithm with Plaintext Related Chaining

This paper describes a plaintext related image encryption algorithm that utilizes the Mojette transform for computation of bins that are subsequently combined with pixels of the processed image. While the bins are computed solely from pixel intensities of a plain image and also the combination depends only on intensities of plain image pixels, the parameters of bins are rearranged according to used key. This design results in a great sensitivity of the proposed image encryption algorithm to both plain images and keys, which is verified by a set of experiments. The paper also tests the resistance of the proposal against statistical and differential attacks by means of commonly used measures as correlation coefficients, entropy, NPCR and UACI. Furthermore, the paper analyses computation speed reached by the proposed solution. Computed values of all parameters are discussed and then compared with results obtained by some recent plaintext related image encryption algorithms

Biological activities and ADMET-related properties of novel set of cinnamanilides

A series of nineteen novel ring-substituted N-arylcinnamanilides was synthesized and characterized. All investigated compounds were tested against Staphylococcus aureus as the reference strain, two clinical isolates of methicillin-resistant S. aureus (MRSA), and Mycobacterium tuberculosis. (2E)-N-[3-Fluoro-4-(trifluoromethyl)phenyl]-3-phenylprop-2-enamide showed even better activity (minimum inhibitory concentration (MIC) 25.9 and 12.9 M) againstMRSAisolates than the commonly used ampicillin (MIC 45.8 M). The screening of the cell viability was performed using THP1-Blue NF- B cells and, except for (2E)-N-(4-bromo-3-chlorophenyl)-3-phenylprop-2-enamide (IC50 6.5 M), none of the discussed compounds showed any significant cytotoxic e ect up to 20 M. Moreover, all compounds were tested for their anti-inflammatory potential; several compounds attenuated the lipopolysaccharide-induced NF- B activation and were more potent than the parental cinnamic acid. The lipophilicity values were specified experimentally as well. In addition, in silico approximation of the lipophilicity values was performed employing a set of free/commercial clogP estimators, corrected afterwards by the corresponding pKa calculated at physiological pH and subsequently cross-compared with the experimental parameters. The similarity-driven property space evaluation of structural analogs was carried out using the principal component analysis, Tanimoto metrics, and Kohonen mapping

Plasma proteome changes in cardiovascular disease patients: novel isoforms of apolipoprotein A1

<p>Abstract</p> <p>Background</p> <p>The aim of this proteomic study was to look for changes taking place in plasma proteomes of patients with acute myocardial infarction (AMI), unstable angina pectoris (UAP), and stable angina pectoris (SAP).</p> <p>Methods</p> <p>Depleted plasma proteins were separated by 2D SDS-PAGE (pI 4-7), and proteomes were compared using Progenesis SameSpots statistical software. Proteins were identified by nanoLC-MS/MS. Proteins were quantified using commercial kits. Apolipoprotein A1 was studied using 1D and 2D SDS-PAGE, together with western blotting.</p> <p>Results</p> <p>Reciprocal comparison revealed 46 unique, significantly different spots; proteins in 34 spots were successfully identified and corresponded to 38 different proteins. Discrete comparisons of patient groups showed 45, 41, and 8 significantly different spots when AMI, UAP, and SAP were compared with the control group. On the basis of our proteomic data, plasma levels of two of them, alpha-1 microglobulin and vitamin D-binding protein, were determined. The data, however, failed to prove the proteins to be suitable markers or risk factors in the studied groups. The plasma level and isoform representation of apolipoprotein A1 were also estimated. Using 1D and 2D SDS-PAGE, together with western blotting, we observed extra high-molecular weight apolipoprotein A1 fractions presented only in the patient groups, indicating that the novel high-molecular weight isoforms of apolipoprotein A1 may be potential new markers or possible risk factors of cardiovascular disease.</p> <p>Conclusion</p> <p>The reported data show plasma proteome changes in patients with AMI, UAP, and SAP. We propose some apolipoprotein A1 fractions as a possible new disease-associated marker of cardiovascular disorders.</p

The determination of effective dose to workers at workplaces with increased irradiation from natural radionuclides

Katalógy rizík (katastre rizík) sú v súčasnosti dostatočne popisované v rôznych odborných publikáciách, [1],[2], ako aj softwarových produktoch. V menšej miere sa tieto katalógy venujú oblasti elektromagnetických polí (EMP), resp. nízkofrekvenčným elektromagnetickým poliam (ENP).At present, Risk Catalogues (risk inventories) are described sufficiently in various specialized publications [1], [2] as well as in software products. To a lesser extent, these catalogues are concerned with the area of electromagnetic fields (EMP), or low frequency electromagnetic fields (ENP)

Continuity Plan - Tool for Critical Infrastructure Security

Článok sa zaoberá oblasťou procesného prístupu v rámci zvýšenia odolnosti kritickej infraštruktúry, konkrétne popisuje právny rámec pre oblasť kritickej infraštruktúry v EÚ a ČR. Následne sa zaoberá problematikou plánov kontinuity a podrobne popisuje postup tvorby plánov kontinuity pre technické systémy.The article deals with the area of process approach in the upgrading of critical infrastructure, specifically describes the legal framework for critical infrastructure in the EU and CR. Article then deals with business continuity plans and describes how the development of plans for continuity of technical systems

Selection of barrier models based on economic tools

Príspevok poukazuje na efektívny výber bariér v bariérových modeloch v procese minimalizovania rizík. Klasifikácia použitých bariér je smerovaná pre aplikáciu v oblasti bezpečnosti práce.Article shows the effective selection barriers in barrier models in the process of risk minimizing. The classification of the barriers is directed to the application in traditional safety

Problémy selekcie zdrojov pre kvantitatívne posúdenie rizík podľa CPR štandardov

Najrozšírenejším postupom pre výber zdrojov pre kvantitatívne posúdenie rizík (QRA) v oblasti závažných priemyselných havárií (ZPH) podľa Directive 2012/18/EU (SEVESO III) v Európe je holandský prístup. Je založený na CPR štandardoch. CPR18E z roku 1999 bolo modifikované doposiaľ 2-krát. Posledná úprava je v podobe Reference Manual Bevi Risk Assessments version 3.2, z roku 2009 (Bevi). Selekcia podľa CPR štandardov doposiaľ nepokrýva niektoré špecifiká nebezpečných látok (NL) podľa SEVESO III, ktoré majú toxické a horľavé vlastnosti. Posledné odporúčania pre túto oblasť sú z roku 2018. Sú zamerané na chladom skvapalnený horľavý zemný plyn (LNG). Pre chladom skvapalnené látky, zmesi s toxickými a horľavými vlastnosťami súčasne doposiaľ nie sú vypracované nové postupy pre selekciu pre QRA, ale ani pre výpočet dôsledkov. V príspevku sa porovnávajú vybrané metódy selekcie pred rokom 1999 so súčasnými CPR štandardami s cieľom výberu vhodných zdrojov pre QRA v oblasti ZPH. Dospelo sa k poznaniu, že metódy primárnej selekcie podľa CPR18E, Bevi manuálu je vhodné modifikovať, alebo použiť aj ďalšiu metódu pre selekciu pre QRA pri chladom skvapalnených NL s toxickými a súčasne horľavými vlastnosťami akým je čpavok.The Dutch approach is the most widely used procedure for selecting sources for quantitative risk assessment (QRA) in the field of major industrial accidents (QRA) under Directive 2012/18/EU (SEVESO III) in Europe. It is based on CPR standards. The 1999 CPR18E has been modified 2 times so far. The last modification is in the form of Reference Manual Bevi Risk Assessments version 3.2, from 2009 (Bevi). Selection according to CPR standards does not yet cover some specificities of hazardous substances (NL) according to SEVESO III, which have toxic and flammable properties. The latest recommendations in this area are from 2018. They target cold-liquefied flammable natural gas (LNG). For cold- liquefied substances, mixtures with toxic and flammable properties, new selection procedures for QRA, but also for calculating the consequences, have not yet been developed. The paper compares selected selection methods before 1999 with current CPR standards in order to select suitable sources for QRA in the field of ZPH. It has been established that primary selection methods according to CPR18E, Bevi should be modified, or use another selection method for QRA in cold-liquefied NL with toxic and flammable properties such as ammonia