A search for periodic and quasi-periodic photometric behavior in the cataclysmic variable TT arietis

Observations of TT Ari obtained at 11 observatories (campaign TT Ari-94) during 258 hr were carried out to study optical variability on timescales from minutes to weeks. The best-fit primary photometric period determined from 16 nights of data obtained at the Dushak-Eregdag station of the Odessa State University is P = 0d.133160 ± 0d.000004 with a mean amplitude of 0.0513 ± 0.0008 mag. This new primary photometric period is larger than that obtained during the TT Ari-88 campaign and is well outside the range of estimates published since 1961. Contrary to previous findings, the "5-7 hr" secondary photometric period is not seen. Our observations do show evidence for periods of 2d.916 and 0d.3040 with amplitudes of 43 and 25 mmag, respectively. The beat period between the spectroscopic and photometric periods is not seen. No coherent oscillations in the range f = 10-2500 cycles day-1 are found. The highest peaks in the power spectrum cover the wide range of 24-139 cycles day-1. In the mean periodogram, the highest peak corresponds to 21 and 30 minutes for the largest sets of observations, i.e., those obtained at Odessa and Krakow Universities, respectively. In the instrumental B system, variations with an amplitude exceeding 0.011 mag occur 8 times (from 33 runs) at 24 minutes. We conclude that quasi-periodic variations occur at a few preferred timescales rather than at a relatively stable period with a secular decrease. In the frequency range 90-900 cycles day-1, the power spectrum obeys a power law with a slope ranging from γ = 1.3 to 2.6 for different runs

NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways

Dysfunction of β-cell is one of major characteristics in the pathogenesis of type 2 diabetes. The combination of obesity and type 2 diabetes, characterized as ‘diabesity’, is associated with elevated plasma free fatty acids (FFAs). Oxidative stress has been implicated in the pathogenesis of FFA-induced β-cell dysfunction. However, molecular mechanisms linking between reactive oxygen species (ROS) and FFA-induced β-cell dysfunction and apoptosis are less clear. In the present study, we test the hypothesis that NOX2-derived ROS may play a critical role in dysfunction and apoptosis of β-cells induced by FFA. Our results show that palmitate and oleate (0.5 mmol/L, 48 h) induced JNK activation and AKT inhibition which resulted in decreased phosphorylation of FOXO1 following nuclear localization and the nucleocytoplasmic translocation of PDX-1, leading to the reducing of insulin and ultimately dysfunction of pancreatic NIT-1 cells. We also found that palmitate and oleate stimulated apoptosis of NIT-1 cells through p38MAPK, p53 and NF-κB pathway. More interestingly, our data suggest that suppression of NOX2 may restore FFA-induced dysfunction and apoptosis of NIT-1 cells. Our findings provide a new insight of the NOX2 as a potential new therapeutic target for preservation of β-cell mass and function

Allele-specific RNA interference prevents neuropathy in Charcot-Marie-Tooth disease type 2D mouse models.

Gene therapy approaches are being deployed to treat recessive genetic disorders by restoring the expression of mutated genes. However, the feasibility of these approaches for dominantly inherited diseases - where treatment may require reduction in the expression of a toxic mutant protein resulting from a gain-of-function allele - is unclear. Here we show the efficacy of allele-specific RNAi as a potential therapy for Charcot-Marie-Tooth disease type 2D (CMT2D), caused by dominant mutations in glycyl-tRNA synthetase (GARS). A de novo mutation in GARS was identified in a patient with a severe peripheral neuropathy, and a mouse model precisely recreating the mutation was produced. These mice developed a neuropathy by 3-4 weeks of age, validating the pathogenicity of the mutation. RNAi sequences targeting mutant GARS mRNA, but not wild-type, were optimized and then packaged into AAV9 for in vivo delivery. This almost completely prevented the neuropathy in mice treated at birth. Delaying treatment until after disease onset showed modest benefit, though this effect decreased the longer treatment was delayed. These outcomes were reproduced in a second mouse model of CMT2D using a vector specifically targeting that allele. The effects were dose dependent, and persisted for at least 1 year. Our findings demonstrate the feasibility of AAV9-mediated allele-specific knockdown and provide proof of concept for gene therapy approaches for dominant neuromuscular diseases

Sociological Perspectives Regarding the Effects in Tourism in the Southern Area of the Romanian Coast, Considering the Sociological and Economical Changes of the Area: Olimp Resort

The article is an analysis of the Phoenician tourism concept in the South of the Romanian coast, respectively the parallel generation-gentrification given the changes that have taken place over the years, with different generational, political, and social imprints and last but not least with different economic imprint over time. Thus, the zonal social elements, respectively the inhabitants and investors, participated directly and indirectly in the evolution and involution of the area and that of tourism. Currently, the area enjoys a social, touristic, and economic rise, and the main factor is the influence given by the development and rebirth of zonal tourism as an effect of the Romanian Phoenician tourism concept. The present study highlights the connection between tourism, the gentrification of Olimp Resort, and the imprint of generations in the reconstruction of a current social episteme