284 research outputs found
Ad Hoc Multi-Input Functional Encryption
Consider sources that supply sensitive data to an aggregator. Standard encryption only hides the data from eavesdroppers, but using specialized encryption one can hope to hide the data (to the extent possible) from the aggregator itself. For flexibility and security, we envision schemes that allow sources to supply encrypted data, such that at any point a dynamically-chosen subset of sources can allow an agreed-upon joint function of their data to be computed by the aggregator. A primitive called multi-input functional encryption (MIFE), due to Goldwasser et al. (EUROCRYPT 2014), comes close, but has two main limitations:
- it requires trust in a third party, who is able to decrypt all the data, and
- it requires function arity to be fixed at setup time and to be equal to the number of parties.
To drop these limitations, we introduce a new notion of ad hoc MIFE. In our setting, each source generates its own public key and issues individual, function-specific secret keys to an aggregator. For successful decryption, an aggregator must obtain a separate key from each source whose ciphertext is being computed upon. The aggregator could obtain multiple such secret-keys from a user corresponding to functions of varying arity. For this primitive, we obtain the following results:
- We show that standard MIFE for general functions can be bootstrapped to ad hoc MIFE for free, i.e. without making any additional assumption.
- We provide a direct construction of ad hoc MIFE for the inner product functionality based on the Learning with Errors (LWE) assumption. This yields the first construction of this natural primitive based on a standard assumption.
At a technical level, our results are obtained by combining standard MIFE schemes and two-round secure multiparty computation (MPC) protocols in novel ways highlighting an interesting interplay between MIFE and two-round MPC
On the relationships between kinetic schemes and two-state single molecule trajectories
Trajectories of a signal that fluctuates between two states which originate
from single molecule activities have become ubiquitous. Common examples are
trajectories of ionic flux through individual membrane-channels, and of photon
counts collected from diffusion, activity, and conformational changes of
biopolymers. By analyzing the trajectory, one wishes to deduce the underlying
mechanism, which is usually described by a multi-substate kinetic scheme. In
previous works, we divided kinetic schemes that generate two-state trajectories
into two types: reducible schemes and irreducible schemes. We showed that all
the information in trajectories generated from reducible schemes is contained
in the waiting time probability density functions (PDFs) of the two states. It
follows that reducible schemes with the same waiting time PDFs are not
distinguishable. In this work, we further characterize the topologies of
kinetic schemes, now of irreducible schemes, and further study two-state
trajectories from the two types of scheme. We suggest various methods for
extracting information about the underlying kinetic scheme from the trajectory
(e. g., calculate the binned successive waiting times PDF and analyze the
ordered waiting times trajectory), and point out the advantages and
disadvantages of each. We show that the binned successive waiting times PDF is
not only more robust than other functions when analyzing finite trajectories,
but contains, in most cases, more information about the underlying kinetic
scheme than other functions in the limit of infinitely long trajectories. For
some cases however, analyzing the ordered waiting times trajectory may supply
unique information about the underlying kinetic scheme
The Quantum-Classical Crossover in the Adiabatic Response of Chaotic Systems
The autocorrelation function of the force acting on a slow classical system,
resulting from interaction with a fast quantum system is calculated following
Berry-Robbins and Jarzynski within the leading order correction to the
adiabatic approximation. The time integral of the autocorrelation function is
proportional to the rate of dissipation. The fast quantum system is assumed to
be chaotic in the classical limit for each configuration of the slow system. An
analytic formula is obtained for the finite time integral of the correlation
function, in the framework of random matrix theory (RMT), for a specific
dependence on the adiabatically varying parameter. Extension to a wider class
of RMT models is discussed. For the Gaussian unitary and symplectic ensembles
for long times the time integral of the correlation function vanishes or falls
off as a Gaussian with a characteristic time that is proportional to the
Heisenberg time, depending on the details of the model. The fall off is
inversely proportional to time for the Gaussian orthogonal ensemble. The
correlation function is found to be dominated by the nearest neighbor level
spacings. It was calculated for a variety of nearest neighbor level spacing
distributions, including ones that do not originate from RMT ensembles. The
various approximate formulas obtained are tested numerically in RMT. The
results shed light on the quantum to classical crossover for chaotic systems.
The implications on the possibility to experimentally observe deterministic
friction are discussed.Comment: 26 pages, including 6 figure
Hypoxia as a therapy for mitochondrial disease
Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide Cas9-mediated screen to identify factors that are protective during RC inhibition. Our results highlight the hypoxia response, an endogenous program evolved to adapt to limited oxygen availability. Genetic or small-molecule activation of the hypoxia response is protective against mitochondrial toxicity in cultured cells and zebrafish models. Chronic hypoxia leads to a marked improvement in survival, body weight, body temperature, behavior, neuropathology, and disease biomarkers in a genetic mouse model of Leigh syndrome, the most common pediatric manifestation of mitochondrial disease. Further preclinical studies are required to assess whether hypoxic exposure can be developed into a safe and effective treatment for human diseases associated with mitochondrial dysfunction.National Institute of Mental Health (U.S.) (Grant 5DP1-MH100706)National Institute of Mental Health (U.S.) (Grant 1R01-MH110049)National Institute of Neurological Diseases and Stroke (U.S.) (Grant 5R01DK097768-03
Higher media multi-tasking activity is associated with smaller gray-matter density in the anterior cingulate cortex
Media multitasking, or the concurrent consumption of multiple media forms, is increasingly prevalent in today’s society and has been associated with negative psychosocial and cognitive impacts. Individuals who engage in heavier media-multitasking are found to perform worse on cognitive control tasks and exhibit more socio-emotional difficulties. However, the neural processes associated with media multi-tasking remain unexplored. The present study investigated relationships between media multitasking activity and brain structure. Research has demonstrated that brain structure can be altered upon prolonged exposure to novel environments and experience. Thus, we expected differential engagements in media multitasking to correlate with brain structure variability. This was confirmed via Voxel-Based Morphometry (VBM) analyses: Individuals with higher Media Multitasking Index (MMI) scores had smaller gray matter density in the anterior cingulate cortex (ACC). Functional connectivity between this ACC region and the precuneus was negatively associated with MMI. Our findings suggest a possible structural correlate for the observed decreased cognitive control performance and socio-emotional regulation in heavy media-multitaskers. While the cross-sectional nature of our study does not allow us to specify the direction of causality, our results brought to light novel associations between individual media multitasking behaviors and ACC structure differences
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An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery.
Despite major progress in defining the genetic basis of Mendelian disorders, the molecular etiology of many cases remains unknown. Patients with these undiagnosed disorders often have complex presentations and require treatment by multiple health care specialists. Here, we describe an integrated clinical diagnostic and research program using whole-exome and whole-genome sequencing (WES/WGS) for Mendelian disease gene discovery. This program employs specific case ascertainment parameters, a WES/WGS computational analysis pipeline that is optimized for Mendelian disease gene discovery with variant callers tuned to specific inheritance modes, an interdisciplinary crowdsourcing strategy for genomic sequence analysis, matchmaking for additional cases, and integration of the findings regarding gene causality with the clinical management plan. The interdisciplinary gene discovery team includes clinical, computational, and experimental biomedical specialists who interact to identify the genetic etiology of the disease, and when so warranted, to devise improved or novel treatments for affected patients. This program effectively integrates the clinical and research missions of an academic medical center and affords both diagnostic and therapeutic options for patients suffering from genetic disease. It may therefore be germane to other academic medical institutions engaged in implementing genomic medicine programs
Spontaneous regression of congenital epulis: a case report and review of the literature
<p>Abstract</p> <p>Introduction</p> <p>Congenital epulis is a rare lesion found on the alveolar process of a newborn child, diagnosed soon after birth. The lesion has a site predilection for the anterior maxillary alveolar process and a 9:1 sex predilection for females. Once diagnosed the traditional management of the lesion has been surgical excision under general anesthesia.</p> <p>Case presentation</p> <p>The purpose of this case report is to describe spontaneous regression of congenital epulis in a three week old healthy African American female child. She presented with a 1.5 cm bilobed sessile nodular lesion in the region of the right maxillary cuspid. The clinical impression was congenital epulis. Since the lesion was not interfering with feeding and respiration, a conservative approach was taken. The child was followed-up for 18 months, during which the lesion progressively regressed.</p> <p>Conclusions</p> <p>Conservative management prevented unnecessary surgery and anesthesia exposure in a neonate.</p
BCL11B Regulates Epithelial Proliferation and Asymmetric Development of the Mouse Mandibular Incisor
Mouse incisors grow continuously throughout life with enamel deposition uniquely on the outer, or labial, side of the tooth. Asymmetric enamel deposition is due to the presence of enamel-secreting ameloblasts exclusively within the labial epithelium of the incisor. We have previously shown that mice lacking the transcription factor BCL11B/CTIP2 (BCL11B hereafter) exhibit severely disrupted ameloblast formation in the developing incisor. We now report that BCL11B is a key factor controlling epithelial proliferation and overall developmental asymmetry of the mouse incisor: BCL11B is necessary for proliferation of the labial epithelium and development of the epithelial stem cell niche, which gives rise to ameloblasts; conversely, BCL11B suppresses epithelial proliferation, and development of stem cells and ameloblasts on the inner, or lingual, side of the incisor. This bidirectional action of BCL11B in the incisor epithelia appears responsible for the asymmetry of ameloblast localization in developing incisor. Underlying these spatio-specific functions of BCL11B in incisor development is the regulation of a large gene network comprised of genes encoding several members of the FGF and TGFβ superfamilies, Sprouty proteins, and Sonic hedgehog. Our data integrate BCL11B into these pathways during incisor development and reveal the molecular mechanisms that underlie phenotypes of both Bcl11b−/− and Sprouty mutant mice
Regularities of ultrasonography of suspensions of alumina nanoparticles in biological media
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