In search of recognition

Existing scholarship on the active citizenship of undocumented migrants is inconclusive on its perils and promises. While some scholars see it as symptomatic of the moral economy that makes legal recognition dependent on demonstrating civic deservingness, others argue that it represents a potential site of contestation against illegalisation. In this paper, we argue that we need to focus on the complex processes that drive undocumented migrants’ quest for recognition in order to understand the political ambiguities implicated in how they civically engage themselves. We use the case of CollectActif (CA), an undocumented-led anti-food waste collective in Brussels, to argue that methods of participatory action research (PAR) are better placed than ex-post analyses to show how recognition processes unfold and evolve over time. We show that recognition depends on establishing ‘equivalence’ to prevailing norms and forms of civic organisation. Hence, CA members generated solidarity and created new publics by behaving as active citizens. Yet, despite increased visibility, CA struggled to be recognised by established actors in the field as actors with equal rights t

Anti-TNF-α treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial

BACKGROUND: Endometriosis is associated with an inflammatory response. Hence infliximab, an anti-TNF-alpha monoclonal antibody, might relieve pain. METHODS: A randomized placebo-controlled trial was designed with 21 women with severe pain and a rectovaginal nodule of at least 1 cm. After 1 month of observation, three infusions of infliximab (5 mg/kg) or placebo were given. Surgery was performed 3 months later and follow-up continued for 6 months. The primary end-point was pain (dysmenorrhea, deep dyspareunia and non-menstrual pain) rated at each visit by the clinician and on a daily basis by the patient who in addition scored pain by visual analog pain scale and analgesia intake. Secondary end-points included the volume of the endometriotic nodule, pelvic tenderness and the visual appearance of endometriotic lesions at laparoscopy. RESULTS: Pain severity decreased during the treatment by 30% in both the placebo (P < 0.001) and infliximab groups (P < 0.001). However, no effect of infliximab was observed for any of the outcome measures. After surgery, pain scores decreased in both groups to less than 20% of the initial value. CONCLUSIONS: Infliximab appears not to affect pain associated with deep endometriosis. Treatment is associated with an important placebo effect. After surgery, pain decreases to less than 20%. Trials registration number ClinicalTrials.gov: NCT00604864

Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach

Endometriosis, a chronic disease characterized by endometrial tissue located outside the uterine cavity, affects one fourth of young women and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology and effective treatment strategies of endometriosis is still largely elusive. Inadequate immune and neuroendocrine responses are significantly involved in the pathophysiology of endometriosis, and key findings are summarized in the present review. We discuss here the role of different immune mechanisms particularly adhesion molecules, protein–glycan interactions, and pro-angiogenic mediators in the development and progression of the disease. Finally, we introduce the concept of endometrial dissemination as result of a neuroendocrine-immune disequilibrium in response to high levels of perceived stress caused by cardinal clinical symptoms of endometriosis

The Peritoneum Is Both a Source and Target of TGF-β in Women with Endometriosis

Transforming growth factor-β (TGF-β) is believed to play a major role in the aetiology of peritoneal endometriosis. We aimed to determine if the peritoneum is a source of TGF-β and if peritoneal TGF-β expression, reception or target genes are altered in women with endometriosis. Peritoneal fluid, peritoneal bushings and peritoneal biopsies were collected from women with and without endometriosis. TGF-β1, 2 and 3 protein concentrations were measured in the peritoneal fluid. TGF-β1 was measured in mesothelial cell conditioned media. Control peritoneum and peritoneum prone to endometriosis (within Pouch of Douglas) from women without disease (n = 16) and peritoneum distal and adjacent to endometriosis lesions in women with endometriosis (n = 15) and were analysed for TGF-β expression, reception and signalling by immunohistochemistry, qRT-PCR and a TGF-β signalling PCR array. TGF-β1 was increased in the peritoneal fluid of women with endometriosis compared to those without disease (P<0.05) and peritoneal mesothelial cells secrete TGF-β1 in-vitro. In women with endometriosis, peritoneum from sites adjacent to endometriosis lesions expressed higher levels of TGFB1 mRNA when compared to distal sites (P<0.05). The TGF-β-stimulated Smad 2/3 signalling pathway was active in the peritoneum and there were significant increases (P<0.05) in expression of genes associated with tumorigenesis (MAPK8, CDC6), epithelial-mesenchymal transition (NOTCH1), angiogenesis (ID1, ID3) and neurogenesis (CREB1) in the peritoneum of women with endometriosis. In conclusion, the peritoneum, and in particular, the peritoneal mesothelium, is a source of TGF-β1 and this is enhanced around endometriosis lesions. The expression of TGF-β-regulated genes is altered in the peritoneum of women with endometriosis and this may promote an environment favorable to lesion formation

Locating the global financial crisis: variegated neoliberalization in four European cities

Locating the global financial crisis: variegated neoliberalization in four European cities. Territory, Politics, Governance. This paper looks at the variegated impact of the 2008 global financial crisis and the different ways in which local strategic actors imagined and responded to it through a comparative study of Barcelona, Brussels, Leeds and Turin. Drawing on cultural political economy, we see crisis moments as fertile territory for the analysis of variegation in urban neoliberalization processes as they can break path dependencies and open up alternatives. Inspired by the comparative turn in critical urban studies, our case studies are not offered as representative samples but as dense sites to explore the various interpretations and uses of the crisis, particularly at the elite level. This analysis suggests considerable variegation in how the crisis was both felt and interpreted locally across the four cities. The local elites did not regard this as a crisis of or in their own urban growth models, but as something external. However, as the global financial crisis morphed into national sovereign debt crises and austerity programmes, the experience in each city has been relatively similar. The paper concludes by emphasizing the continuity function of specific local actors through the processes of meaning-making in which they engage, something that existing work on variegated neoliberalization has so far overlooked

Conviviaal samenleven in de superdiverse stad

Na Brussel en Genk, is nu ook Antwerpen een stad waar de meerderheid van de inwoners een migratieachtergrond heeft. Maakt dat een verschil voor het samenleven?status: publishe