Transformation Characteristics of Large Steel Forgings

Inspite of voluminous papers hitherto published on the heat treatment of large steel forgings,it would not he exaggerated to say that the transformation characteri-stics of them are not fully known yet. The cause is attributed , to our best knowledge, to those factors as inner local properties of original ingots , effects of forging and accompanied soaking, liberation and trans-mission of latent heat of transformation , Hydrogen retained at the deep portions, thermal and transformat- ion stresses etc. which refuse analogy with the results obtained by means of small specimens

Investigation of the thermal expansion and heat capacity of the CaCu3Ti4O12 ceramics

The thermal expansion of the CaCu3Ti4O12 ceramics has been measured over a wide temperature range 120–1200 K. The high quality of the samples under study has been confirmed by good agreement of the results of measurements of the heat capacity in the range 2–300 K and in the vicinity of the phase transition of magnetic nature at 25 K with the data for the single crystal. No anomalies in the thermal expansion that can be associated with the phase transition at 726–732 K assumed by other investigators have been found. The influence exerted on the thermal expansion by the heat treatment of the sample in a helium atmosphere and in air has been investigated

Magnetic interactions in transition metal doped ZnO : An abinitio study

We calculate the nature of magnetic interactions in transition-metal doped ZnO using the local spin density approximation and LSDA+\textit{U} method of density functional theory. We investigate the following four cases: (i) single transition metal ion types (Cr, Mn, Fe, Co, Ni and Cu) substituted at Zn sites, (ii) substitutional magnetic transition metal ions combined with additional Cu and Li dopants, (iii) substitutional magnetic transition metal ions combined with oxygen vacancies and (iv) pairs of magnetic ion types (Co and Fe, Co and Mn, etc.). Extensive convergence tests indicate that the calculated magnetic ground state is unusually sensitive to the k-point mesh and energy cut-off, the details of the geometry optimizations and the choice of the exchange-correlation functional. We find that ferromagnetic coupling is sometimes favorable for single type substitutional transition metal ions within the local spin density approximation. However, the nature of magnetic interactions changes when correlations on the transition-metal ion are treated within the more realistic LSDA + \textit{U} method, often disfavoring the ferromagnetic state. The magnetic configuration is sensitive to the detailed arrangement of the ions and the amount of lattice relaxation, except in the case of oxygen vacancies when an antiferromagnetic state is always favored.Comment: 11 pages, 17 figure

Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.

Well-differentiated papillary mesothelioma is an uncommon mesothelial neoplasm that most frequently arises in the peritoneal cavity of women of reproductive age. Whereas malignant mesothelioma is an aggressive tumor associated with poor outcome, well-differentiated papillary mesothelioma typically exhibits indolent behavior. However, histologically differentiating between these two entities can be challenging, necessitating the development of distinguishing biomarkers. While the genetic alterations that drive malignant mesothelioma have recently been determined, the molecular pathogenesis of well-differentiated papillary mesothelioma is unknown. Here we performed genomic profiling on a cohort of ten well-differentiated papillary mesothelioma of the peritoneum. We identified that all tumors harbored somatic missense mutations in either the TRAF7 or CDC42 genes, and lacked alterations involving BAP1, NF2, CDKN2A, DDX3X, SETD2, and ALK that are frequent in malignant mesothelioma. We recently identified that another mesothelial neoplasm, adenomatoid tumor of the genital tract, is genetically defined by somatic missense mutations in the TRAF7 gene, indicating a shared molecular pathogenesis between well-differentiated papillary mesothelioma and adenomatoid tumors. To the best of our knowledge, well-differentiated papillary mesothelioma is the first human tumor type found to harbor recurrent mutations in the CDC42 gene, which encodes a Rho family GTPase. Immunohistochemistry demonstrated intact BAP1 expression in all cases of well-differentiated papillary mesothelioma, indicating that this is a reliable marker for distinguishing well-differentiated papillary mesothelioma from malignant mesotheliomas that frequently display loss of expression. Additionally, all well-differentiated papillary mesothelioma demonstrated robust expression of L1 cell adhesion molecule (L1CAM), a marker of NF-kB pathway activation, similar to that observed in adenomatoid tumors. In contrast, we have previously shown that L1CAM staining is not observed in normal mesothelial cells and malignant mesotheliomas of the peritoneum. Together, these studies demonstrate that well-differentiated papillary mesothelioma is genetically defined by mutually exclusive mutations in TRAF7 and CDC42 that molecularly distinguish this entity from malignant mesothelioma

A wide area survey for high-redshift massive galaxies. I. Number counts and clustering of BzKs and EROs

We have combined deep BRIz' imaging over 2x940 arcmin^2 fields obtained with the Suprime-Cam on the Subaru telescope with JKs imaging with the SOFI camera at the New Technology Telescope to search for high-redshift massive galaxies. K-band selected galaxies have been identified over an area of ~920 arcmin^2 to K_Vega=19.2, of which 320 arcmin^2 are complete to K_Vega=20. The BzK selection technique was used to obtain complete samples of ~500 candidate massive star-forming galaxies (sBzKs) and ~160 candidate massive, passively-evolving galaxies (pBzKs), both at 1.4 5 criterion we also identified ~850 extremely red objects (EROs). The surface density of sBzKs and pBzKs is found to 1.20+/-0.05 arcmin^{-2} and 0.38+/-0.03 arcmin^{-2}, respectively. Both sBzKs and pBzKs are strongly clustered, at a level at least comparable to that of EROs, with pBzKs appearing more clustered than sBzKs. We estimate the reddening, star formation rates (SFRs) and stellar masses (M_*) of the sBzKs, confirming that to K_Vega~20 median values are M_*~10^{11}M_sun, SFR 190M_sun yr^{-1}, and E(B-V)~0.44. The most massive sBzKs are also the most actively star-forming, an effect which can be seen as a manifestation of downsizing at early epochs. The space density of massive pBzKs at z~1.4-2 is 20%+/-7% that of similarly massive early-type galaxies at z~0, and similar to that of sBzKs of the same mass. We argue that star formation quenching in these sBzKs will result in nearly doubling the space density of massive early-type galaxies, thus matching their local density.Comment: 19 pages, 13 figures, accepted by ApJ. While checking the proofs we became aware of a material mistake of non-trivial scientific relevance. In the original it was reported that the comoving volume density of passive BzK-selected galaxies with =1.7 and more massive than 10^{11}M_sun was 45%+/-15% of the local number density of similarly massive early-type galaxies. This fraction actually turns out to be 20%+/-7%. Section 6.4, point 5 in section 7, and the abstract have been modified accordingl

Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X.

Malignant mesothelioma is a rare cancer that arises from the mesothelial cells that line the pleural cavity and less commonly from the peritoneal lining of the abdomen and pelvis. Most pleural mesotheliomas arise in patients with a history of asbestos exposure, whereas the association of peritoneal mesotheliomas with exposure to asbestos and other potential carcinogens is less clear, suggesting that the genetic alterations that drive malignant peritoneal mesothelioma may be unique from those in pleural mesothelioma. Treatment options for all malignant mesotheliomas are currently limited, with no known targeted therapies available. To better understand the molecular pathogenesis of malignant peritoneal mesothelioma, we sequenced 510 cancer-related genes in 13 patients with malignant mesothelioma arising in the peritoneal cavity. The most frequent genetic alteration was biallelic inactivation of the BAP1 gene, which occurred in 9/13 cases, with an additional two cases demonstrating monoallelic loss of BAP1. All 11 of these cases demonstrated loss of BAP1 nuclear staining by immunohistochemistry, whereas two tumors without BAP1 alteration and all 42 cases of histologic mimics in peritoneum (8 multilocular peritoneal inclusion cyst, 6 well-differentiated papillary mesothelioma of the peritoneum, 16 adenomatoid tumor, and 12 low-grade serous carcinoma of the ovary) demonstrated intact BAP1 nuclear staining. Additional recurrently mutated genes in this cohort of malignant peritoneal mesotheliomas included NF2 (3/13), SETD2 (2/13), and DDX3X (2/13). While these genes are known to be recurrently mutated in pleural mesotheliomas, the frequencies are distinct in peritoneal mesotheliomas, with nearly 85% of peritoneal tumors harboring BAP1 alterations versus only 20-30% of pleural tumors. Together, these findings demonstrate the importance of epigenetic modifiers including BAP1, SETD2, and DDX3X in mesothelial tumorigenesis and suggest opportunities for targeted therapies

Wide-Supply-Range All-Digital Leakage Variation Sensor for On-Chip Process and Temperature Monitoring

Variation in process, voltage and temperature is a major obstacle in achieving energy-efficient operation of LSI. This paper proposes an all-digital on-chip circuit to monitor leakage current variations of both of the nMOSFET and pMOSFET independently. As leakage current is highly sensitive to threshold voltage and temperature, the circuit is suitable for tracking process and temperature variation. The circuit uses reconfigurable inhomogeneity to obtain statistical properties from a single monitor instance. A compact reconfigurable inverter topology is proposed to implement the monitor circuit. The compact and digital nature of the inverter enables cell-based design, which will reduce design costs. Measurement results from a 65 nm test chip show the validity of the proposed circuit. For a 124 sample size for both of the nMOSFET and pMOSFET, the monitor area is 4500 μm2 and active power consumption is 76 nW at 0.8 V operation. The proposed technique enables area-efficient and low-cost implementation thus can be used in product chips for applications such as dynamic energy and thermal management, testing and post-silicon tuning

Detailed Measurements of Characteristic Profiles of Magnetic Diffuse Scattering in ErB2_2C2_2

Detailed neutron diffraction measurements on a single crystalline ErB$_2$C$_2$ were performed. We observed magnetic diffuse scattering which consists of three components just above the transition temperatures, which is also observed in characteristic antiferroquadrupolar ordering compounds HoB$_2$C$_2$ and TbB$_2$C$_2$. The result of this experiments indicates that the antiferroquadrupolar interaction is not dominantly important as a origin of the magnetic diffuse scattering.Comment: 5 pages, 5 figures, submitted to J. Phys. Soc. Jp