15 research outputs found
Computed Tomography evaluation of occipital bone tumor in a Doberman – Case study
A 6.5 years old intact Doberman female was brought to consultation showing sign of medullary compression. The neurological examination concludes a lesion in cervical part of the spine, given the fact that the patient presents mobility deficiency on all four limbs, having trouble maintaining a standing position. The mental status, the behavior and the evaluation of the central nervous system haven’t show any kind of changes. The CT examination of the spine show no changes in the vertebral alignment or sign of compression. The CT scanning of the head reveals an infiltrative osteolytic formation in the right side of the temporo-occipital bone of the skull
Comparison of the endocranial- and brain volumes in brachycephalic dogs, mesaticephalic dogs and Cavalier King Charles spaniels in relation to their body weight
BACKGROUND: A number of studies have attempted to quantify the relative volumes of the endocranial volume and brain parenchyma in association with the pathogenesis of the Chiari-like malformation (CLM) in the Cavalier King Charles spaniel (CKCS). In our study we examine the influence of allometric scaling of the brain and cranial cavity volume on morphological parameters in different dog breeds. MRI scans of 110 dogs (35 mesaticephalic dogs, 35 brachycephalic dogs, 20 CKCSs with SM, and 20 CKCSs without SM) have been used to create 3-dimensional volumetric models of skull and brain parts. Volumes were related to body weight calculating the adjusted means for different breeds.
RESULTS: There was a strong global dependency of all volumes to body weight (P<0.0001). The adjusted means of the absolute and relative volumes of brain parenchyma and cranial compartments are not significantly larger in CKCSs in comparison to brachycephalic and mesaticephalic dogs. A difference in absolute or relative volumes between CKCSs with and without SM after relating these values to body weight could not be identified. The relative volume of the hindbrain parenchyma (caudal fossa parenchyma percentage) was larger in brachycephalic dogs than in CKCSs, without causing herniation or SM.
CONCLUSION: An influence of body weight exist in dogs, which can be sufficiently large to render conclusions on the difference in volumes of the brain and skull unsafe unless some account of the body weight is taken in the analysis. The results of this study challenge the role of overcrowding for the development of SM in dogs
Increased CSF aquaporin-4, and interleukin-6 levels in dogs with idiopathic communicating internal hydrocephalus and a decrease after ventriculo-peritoneal shunting
Background: Studies in animal models, in which internal hydrocephalus has been induced by obstructing the cerebrospinal fluid pathways, have documented an up-regulation of the concentrations of aquaporin-4 (AQP4) in the brain. In this study, the concentrations of aquaporin-1 (AQP1), AQP1, AQP4 and interleukin-6 (IL-6) were determined in the CSF of dogs with idiopathic communicating hydrocephalus before and after the reduction of intraventricular volume following ventriculo-peritoneal shunt (VP-shunt) treatment. Results: The concentrations of AQP4 and IL-6 were increased in the cerebrospinal fluid of dogs with hydrocephalus compared to controls. Both parameters significantly decreased after surgical treatment, accompanied by decrease of ventricular size and the clinical recovery of the dogs. AQP1 was not detectable in CSF. Conclusions: Brain AQP4 up-regulation might be a compensatory response in dogs with hydrocephalus. Future determination of AQP4 at the mRNA and protein level in brain tissue is warranted to substantiate this hypothesis
Computed Tomography evaluation of peripheral nerve sheath tumor in an American Staffordshire Terrier – Case study
A 1 year old intact American Staffordshire Terrier male was brought to consultation being suspicioned by cervical compression. The neurological examination show proprioception deficiency of the front and hind legs and a diminution of the superficial proprioception was noted. Base on the neurological evaluation the lesion was located in the cervico-toracal area of the spine. A native CT was performed to identify the changes of the spine. The CT reveal a craniodorsal left paravertebral soft tissue mass associated with the segmental nerves of the brachial plexus and with extension into the vertebral canal through the left intervertebral foramen T2/3. A fine needle aspiration was performed from a formation localized intrathoracic in the close proximity of the nerve sheath tumor and the examination showed cell characteristically for a mesenchymal malignant process
Magnetic resonance imaging signs of high intraventricular pressure - comparison of findings in dogs with clinically relevant internal hydrocephalus and asymptomatic dogs with ventriculomegaly
Magnetic resonance imaging signs of high intraventricular pressure - comparison of findings in dogs with clinically relevant internal hydrocephalus and asymptomatic dogs with ventriculomegaly
Comparison of the Relationship between Cerebral White Matter and Grey Matter in Normal Dogs and Dogs with Lateral Ventricular Enlargement.
Large cerebral ventricles are a frequent finding in brains of dogs with brachycephalic skull conformation, in comparison with mesaticephalic dogs. It remains unclear whether oversized ventricles represent a normal variant or a pathological condition in brachycephalic dogs. There is a distinct relationship between white matter and grey matter in the cerebrum of all eutherian mammals. The aim of this study was to determine if this physiological proportion between white matter and grey matter of the forebrain still exists in brachycephalic dogs with oversized ventricles. The relative cerebral grey matter, white matter and cerebrospinal fluid volume in dogs were determined based on magnetic-resonance-imaging datasets using graphical software. In an analysis of covariance (ANCOVA) using body mass as the covariate, the adjusted means of the brain tissue volumes of two groups of dogs were compared. Group 1 included 37 mesaticephalic dogs of different sizes with no apparent changes in brain morphology, and subjectively normal ventricle size. Group 2 included 35 brachycephalic dogs in which subjectively enlarged cerebral ventricles were noted as an incidental finding in their magnetic-resonance-imaging examination. Whereas no significant different adjusted means of the grey matter could be determined, the group of brachycephalic dogs had significantly larger adjusted means of lateral cerebral ventricles and significantly less adjusted means of relative white matter volume. This indicates that brachycephalic dogs with subjective ventriculomegaly have less white matter, as expected based on their body weight and cerebral volume. Our study suggests that ventriculomegaly in brachycephalic dogs is not a normal variant of ventricular volume. Based on the changes in the relative proportion of WM and CSF volume, and the unchanged GM proportions in dogs with ventriculomegaly, we rather suggest that distension of the lateral ventricles might be the underlying cause of pressure related periventricular loss of white matter tissue, as occurs in internal hydrocephalus
Predominance of hypoechoic tissue changes in nine dogs with malignant prostatic lymphoma
Linear regression model analysis of the changes in relative grey matter (GM), white matter (WM)- and CSF volume and the WM/GMratio with increasing bodyweight in dogs.
<p>The relative grey matter (GM), white matter (WM), and CSF volume of the lateral venmtricles as well as the WM/GM-ratio is plotted against the bodyweight in two groups of dogs. The open circles represent dogs with subjectively normal ventricles, the filled circles represent dogs with enlarged ventricles. The adjusted means in the middle of the regression lines of the groups differs significantly.</p
Breed, body weight and diagnosis of the dogs included in groups one and two.
<p>Breed, body weight and diagnosis of the dogs included in groups one and two.</p