Statistics of a hydrophobic chain near a hydrophobic boundary

We study the behaviour of a hydrophobic chain near a hydrophobic boundary in two dimensions, using the decorated lattice model of Berkema and Widom [G.T. Barkema and B. Widom, J. Chem. Phys. 113, 2349 (2000)] to obtain effective, temperature dependent intrachain and chain-boundary interactions. We use these interactions to construct two model hamiltonians which can be solved exactly. Our results compare favorably with preliminary Monte Carlo computations, using the same effective interactions. At relatively low temperatures and at high temperatures, we find that the chain is randomly configured in the ambient water, and detached from the wall, whereas at intermediate temperatures it adsorbs onto the wall in a stretched or partially folded state, again depending upon the temperature, and the energy of solvation.Comment: 6 pages text, 11 figure

A Tale of an Uneven Urban Development: The socio-economic and socio-cultural contradictions of Tarlabasi Renewal Project

This paper audits, theoretically and empirically, how the nature of the renewal projects in Turkey and social justice are closely connected by looking at spatial and urban politics with a special emphasis on the case of Tarlabasi Neighborhood in Istanbul. Based upon the theoretical framework of Henri Lefebvre's spatial triad, the study aims to illustrate the socio-economic and socio-cultural contradictions of the urban regime in Turkey. This study asks two questions from the standpoint of urban politics and spatial social justice: 1) How can the social and economic transformations be understood within Lefebvre's spatial triad? 2) How can the concepts of construction of truth, power and space be applied to Tarlabasi Renewal Project? By exploring neoliberal shift of urban politics in Turkey it will be argued that the current neoliberal policies of the new urban regime does not include participatory methods and therefore lacks social justice. Within a qualitative research approach, critical discourse analysis will be used, with an emphasis on Foucauldian discourse, and semi-structured interviews to analyze the Tarlabasi case to demonstrate the unfavorable impacts of the urban renewal projects on urban poverty. This study will suggest that public participatory methods should be included within urban renewal processes in order to achieve a just urban development

Chimeric Antigen Receptor T Cell (Car T Cell) Therapy In Hematology

It is well demonstrated that immune system can control and eliminate cancer cells. Immune-mediated elimination of tumor cells has been discovered and is the basis of both cancer vaccines and cellular therapies including hematopoietic stem cell transplantation (HSCT). Adoptive T cell transfer has been improved to be more specific and potent and cause less off-target toxicities. Currently, there are two forms of engineered T cells being tested in clinical trials: T cell receptor (TCR) and chimeric antigen receptor (CAR) modified T cells. On July 1, 2014, the United States Food and Drug Administration granted ‘breakthrough therapy’ designation to anti-CD19 CAR T cell therapy. Many studies were conducted to evaluate the beneficiaries of this exciting and potent new treatment modality. This review summarizes the history of adoptive immunotherapy, adoptive immunotherapy using CARs, the CAR manufacturing process, preclinical-clinical studies, effectiveness and drawbacks of this strategy

Discovering patterns for architecture simulation by using sequence mining

The goal of computer architecture research is to design and build high performance systems that make effective use of resources such as space and power. The design process typically involves a detailed simulation of the proposed architecture followed by corrections and improvements based on the simulation results. Both simulator development and result analysis are very challenging tasks due to the inherent complexity of the underlying systems. The motivation of this work is to apply episode mining algorithms to a new domain, architecture simulation, and to prepare an environment to make predictions about the performance of programs in different architectures. We describe our tool called Episode Mining Tool (EMT), which includes three temporal sequence mining algorithms, a preprocessor, and a visual analyzer. We present empirical analysis of the episode rules that were mined from datasets obtained by running detailed micro-architectural simulations

Lipocalin Gene Expression Is Varied in Developmental Stages by Larval Nutritional Stress in Drosophila

Lipocalin genes NLaz, GLaz, and Karl are evolutionarily conserved genes in Drosophila melanogaster. There are studies on lipocalin gene expression differences under diverse diet conditions, but these studies have focused mainly on age-dependent expression profiles of these genes. The main aim of our study is to determine lipocalin expression in the developmental period by nutritional manipulation with an isofemale-based design. Three larval developmental periods have been researched under normal and restricted diets. We found significant differences between lines during their developmental time-related lipocalin expression. Here, we demonstrate that upregulations in the early developmental stages of lipocalin genes under stressful conditions resulted in unaffected developmental time. The possible reason for high expression is the activation of stress signal pathways in order to buffer the harmful effects of nutritional restriction. Our data showed that the early developmental period (48-72 h) is especially crucial to tolerate the dietary stress with respect to GLaz and NLaz expression. Results of this experiment have shown that the expression profiles of lipocalin genes have line-specific pathways to nutritional stress. Their expression depends on the genetic background corresponding to development time results. Our results highlight the transcriptional changes of lipocalins associated with developmental time in larvae, developed in a dietary-restricted medium.WoSScopu

Generalized livedo reticularis like eruption induced Generalized livedo reticularis like eruption induced by trimethoprim/sulfamethoxazole: A case report with by trimethoprim/sulfamethoxazole: A case report with concomitant myelosuppression

Livedo reticularis is a reticular discoloration of the skin because of the vascular anatomy of the skin. The condition most commonly affects the legs. Drug induced livedo reticularis which is an acknowledged side effect of amantadine, tends to be widespread, asymptomatic, benign rash. There are also reports of livedoid eruption induced with drugs including dapsone, imatinibe, gefitinibe. We describe a case of livedo reticularis like eruption and haemotological toxicity with trimetophrim-sulfamethoxazole. The purpose of this report is to remind clinicians of this rare, benign side effect of the common prescribed medication

Altitudinal variation in lifespan of Drosophila melanogaster populations from the Firtina Valley, northeastern Turkey

Studies of attitudinal changes in phenotype and genotype can complement studies of latitudinal patterns and provide evidence of natural selection in response to climatic factors. In Drosophila melanogaster, latitudinal variation in phenotype and genotype has been well studied, but attitudinal patterns have rarely been investigated. We studied populations from six different altitudes varying between 35 m and 2173 m in the Firtina Valley in northeastern part of Turkey to evaluate clinal trends in lifespan under experimental conditions. Lifespan in the D. melanogaster populations was examined in relation to altitude, sex, temperature (25 degrees C and 29 degrees C), and dietary yeast concentration (5 g/L and 25 g/L). As expected high temperature decrease lifespan in all populations. However, it was shown that lifespan was slightly affected by dietary stress. We found that lifespan decreases significantly under thermal stress conditions with increasing altitude. Moreover, there was a slightly negative relationship between altitude and lifespan, which was closely associated with climatic factors such as temperature and precipitation, may suggest local adaptation to climate. (C) 2016 Elsevier Ltd. All rights reserved

Coronally advanced flap with connective tissue graft or xenogeneic acellular dermal matrix in the treatment of multiple gingival recessions: A split-mouth randomized clinical trial

nizam, Nejat/0000-0003-2739-3919WOS: 000498259100001PubMed: 31762155Objective To evaluate the clinical efficacy of xenogeneic acellular dermal matrix (XADM) or connective tissue graft (CTG) combined with modified-coronally advanced flap (M-CAF) in the treatment of multiple gingival recessions. Materials and methods Twelve participants with bilateral MGRs (multiple gingival recession) (82 gingival recessions) randomly received XADM (test group, 41 teeth) on one side and subepithelial CTG (control group, 41 teeth) on the other side in conjunction with M-CAF in the same session and completed the 18-months study period. Recession depth (RD), recession width (RW), keratinized tissue width (KTW), probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, and 6-, 18-months postoperatively. Results PD was significantly higher in the test group at 18-months (P .05). Conclusion Within the limits of the study, M-CAF combined with XADM or CTG seems to be similarly effective in RD reduction of class I and II MGRs at least in the short term. Soft tissue shrinkage and increase in PD may be observed with XADM, while; CTG seems to provide stable clinical outcomes for 18-months follow-up. Clinical significance Even though the CTG and XADM in conjunction with M-CAF may provide similar RD reduction in class I and II multiple gingival recessions in the short term. CTGs may be superior in terms of soft tissue shrinkage and PD values

Clinicopathologic challenge: Linear brown macules on the chest and arm

WOS: 000255833200001PubMed: 18477139What is your diagnosis

EGFR immunoexpression, RAS immunoexpression and their effects on survival in lung adenocarcinoma cases

Background: The impacts of epidermal growth factor receptor (EGFR) immunoexpression and RAS immunoexpression on the survival and prognosis of lung adenocarcinoma patients are debated in the literature