N-acetylcysteine – antioxidant action and use in the small animal clinic

A N-acetilcisteína, durante muito tempo, teve seu uso restrito à ação mucolítica e expectorante e ao tratamento da intoxicação por paracetamol. Com o advento de estudos acerca de radicais livres, os antioxidantes ganharam destaque e, dentre eles, a N-acetilcisteína. Esta revisão de literatura tem por objetivo realçar a atividade farmacológica desse aminoácido em afecções da rotina clínica de pequenos animais, bem como apresentar as novas perspectivas de utilização em seres humanos, que poderão embasar, futuramente, estudos semelhantes em cães e gatos.For a long time, N-acetylcysteine was only used as a mucolytic and expectorant agent and in the treatment of paracetamol intoxication.  With the advent of studies on free radicals, antioxidants are gaining prominence and the N-acetylcysteine is among them.  The objective of this article is to highlight the farmacological activity of this amino acid in affections in the small animal clinical routine, as well as to present new perspectives in its use in human, which could, in the future, form the base for similar studies in dogs and cats

N-acetilcisteína - Ação antioxidante e utilização na clínica de pequenos animais

For a long time, N-acetylcysteine was only used as a mucolytic and as an expectorant agent in the treatment of paracetamol/ acetaminophen intoxication. With the advent of studies on free radicals, antioxidants are gaining prominence and the N-acetylcysteine is amongst them. The objective of this article is to emphazise the farmacological activity of this amino acid in affections in the small animal clinical routine, as well as to show new perspectives of its use in humans, which could, in the future, form the base for similar studies in dogs and cats

Thoraco-Lumbar Intervertebral Disc Disease in Domestic Feline - Case Report

A Doença do Disco Intervertebral (DDIV) tóraco-lombar ocorre frequentemente em cães, sobretudo de raças condrodistróficas. Os gatos, no entanto, raramente apresentam sinais clínicos da doença, sendo pouco corriqueiro o atendimento da afecção, e consequentemente, os relatos e trabalhos científicos sobre DDIV para a espécie. O presente artigo refere-se a um caso clínico de felino doméstico com sinais clínicos neuro-ortopédicos de discopatia. Ressalta-se a importância de um bom plano de exame clínico e da utilização de técnicas radiográficas simples e contrastadas, uma vez que estas ferramentas são certamente mais acessíveis à maioria dos médicos veterinários do que tomografia computadorizada e ressonância magnética, por exemplo.Thoraco-lumbar intervertebral disc disease occurs frequently in dogs, especially in chondrodystrophic breeds. Cats, however, rarely have clinical signs of the disease, being not common the service of this affection, and consequently, reports and scientific works about thoraco-lumbar intervertebral disc disease in the species. The present article refers to a clinical case of a domestic feline with clinical signs of neuro-orthopedic disc disease. The importance of a good plan of clinical examination and the use of simple and contrasted radiographic techniques is emphasized, once that these tools are certainly more accessible to the majority of the veterinarians than computed tomography and magnetic resonance, for example